Claims
- 1. A method for treating retinal disease comprising adminstering to a patient in need thereof a pharmaceutically effective amount of a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, either alone or in combination with a pharmaceutically acceptable carrier, wherein R1 and R2 are the same or different, and are hydrogen, lower alkyl, lower alkanoyl, phenylcarbonyl, phenyl-lower alkyl or phenyl-lower alkoxycarbonyl;R3 and R4 are the same or different, and are hydroxy, lower alkoxy, amino or lower alkylamino; A1, A2 and A3 are the same or different, and are straight-chain or branched lower alkylene; and m is 0 or 1.
- 2. The method as claimed in claim 1, wherein the patient is a human.
- 3. The method as claimed in claim 2, wherein the retinal disease is selected from the group consisting of diabetic retinopathy, macular degeneration, retinal vein occlusion, retinal artery occlusion, neovascular glaucoma and hemangioma.
- 4. The method as claimed in claim 2, wherein the compound is N1-(6-aminohexyl)-N2-(2,2-dimethyl-3-mercaptopropionyl)-L-cysteinamide.
- 5. The method as claimed in claim 3, wherein the compound is N1-(6-aminohexyl)-N2-(2,2-dimethyl-3-mercaptopropionyl)-L-cysteinamide.
- 6. The method as claimed in claim 1, wherein the retinal disease is intraocular angiogenesis.
- 7. The method as claimed in claim 2, wherein the retinal disease is intraocular angiogenesis.
- 8. The method as claimed in claim 6, wherein the compound is N1-(6-aminohexyl)-N2-(2,2-dimethyl-3-mercaptopropionyl)-L-cysteinamide.
- 9. The method as claimed in claim 7, wherein the compound is N1-(6-aminohexyl)-N2-(2,2-dimethyl-3-mercaptopropionyl)-L-cysteinamide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
10-280655 |
Oct 1998 |
JP |
|
Parent Case Info
This application is a continuation-in-part application of International Application PCT/JP99/05359 (not published in English) filed Sep. 30, 1999.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5214181 |
Morita et al. |
May 1993 |
A |
Foreign Referenced Citations (3)
Number |
Date |
Country |
10-324625 |
Dec 1998 |
JP |
WO 9108199 |
Jun 1991 |
WO |
WO 9428014 |
Dec 1994 |
WO |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
PCT/JP99/05359 |
Sep 1999 |
US |
Child |
09/823360 |
|
US |