Patent Application
20130083985
This application claims priority of German Patent Office application No. 10 2011 083 7043 filed Sep. 24, 2011. All of the applications are incorporated by reference herein in their entirety.
The disclosure relates to an angiographic examination method of an examination object for determining the morphology, histology and/or state of moving walls of vessels.
An examination method of this type may be used in an x-ray diagnostic facility for instance, which is known from U.S. Pat. No. 7,500,784 B2 and is described below with the aid of
By means of the articulated arm robot known for instance from U.S. Pat. No. 7,500,784 B2, which preferably has six axes of rotation and thus six degrees of freedom, the C-arm 2 can be adjusted in any spatial manner, for instance by being rotated about a center of rotation between the x-ray emitter 3 and the x-ray image detector 4. The angiographic x-ray system 1 to 4 can be rotated in particular about centers of rotation and axes of rotation in the C-arm plane of the x-ray image detector 4, preferably about the center point of the x-ray image detector 4 and about the axes of rotation intersecting the center point of the x-ray image detector 4.
The known articulated arm robot comprises a base frame, which is fixedly mounted on a base for instance. A horizontal rotating table is fastened thereto in a manner so as to rotate about a first axis of rotation. A robot rocker is attached to the horizontal rotating table so as to be pivotable about a second axis of rotation, to which horizontal rotating table a robot arm is fastened so as to be rotatable about a third axis of rotation. A robot hand is attached to the end of the robot arm in a manner so as to be rotatable about a fourth axis of rotation. The robot hand comprises a fastening element for the C-arm 2, which can be pivoted about a fifth axis of rotation and can be rotated about a sixth axis of rotation which runs at right angles thereto.
The realization of the x-ray diagnostics facility is not dependent on the industrial robot. Conventional C-arm devices can also be used.
The x-ray image detector 4 may be a rectangular or square 2-dimensional semiconductor detector, which is preferably made of amorphous silicon (a-Si). Integrating and possibly counting detectors can however also be used for instance in CMOS technology. The use of previously conventional x-ray image amplifier television networks is also possible.
A patient 6 to be examined, as an examination object, is located in the radiation path of the x-ray emitter 3 on a table plate 5 of a patient support couch. A system control unit 7 having an imaging system 8 is connected to the x-ray diagnostic facility, said imaging system 8 receiving and processing the image signals of the x-ray image detector 4 (control elements are not shown for instance). The x-ray images can then be observed on displays of a monitor lighting system 9.
Instead of the x-ray system shown in
Instead of the C-arm 2 shown by way of example, the angiographic x-ray system can also comprise separate ceiling and/or floor-mounted brackets for the x-ray emitter 3 and the x-ray image detector 4, which are electronically rigidly coupled for instance.
Sensors 10 which are applied to the chest of the patient 6 for instance can acquire the EKG signals of the patient 6 and relay them to a processing circuit 11 in the system control unit 7. The EKG signals of the patient 6 can however also be tapped intracardially by means of an EKG catheter (not shown).
Vessels, for instance coronary arteries, but also other vessels, were previously shown during interventional procedures in a 2D and/or 3D representation. This takes place by injecting contrast agent during an x-ray examination (angiography). The physician can conclude the pure morphology of the vessel from this examination, but not however the state of the vascular wall. Furthermore, stenoses or aneurysms can be detected and subsequently treated.
More and more methods such as for instance OCT (optical coherence tomography or FFR (fractional flow reserve) are being established and used to determine the characteristics of the vascular walls and subsequently to treat the patient in the best possible manner. The wall state of the vessel can then be determined for instance by means of IVUS (intravascular ultrasound) and/or IVUS-VH (virtual histology).
A second examination nevertheless indicates an additional burden for the patient, an additional load in terms of dose for the physician and patient and significant additional costs for the healthcare system.
To determine the morphology, histology and/or the state of vessels, a combination of x-ray and additional methods must always be used.
Alternatively, the morphology and state of the vascular wall may be concluded by means of other imaging methods such as CT and/or MR, but the angiography nevertheless is also deemed to be the gold standard in terms of imaging.
Moreover, further treatment will continue to take place in the heart catheter or angiography laboratory.
The disclosure is based on the object of easily enabling a representation of the morphology, histology and/or the state of vessels by means of just one diagnostic facility.
The object is achieved for an examination method of the type cited in the introduction by the features specified in the independent claims
The object is achieved for an angiographic examination method with the following steps.
S1 Acquiring a series of angiography images of a section of a vessel of interest,
S2 Quantitative analysis of the vascular wall of the section of the vessel,
S3 Calculating the inherent motion of the vascular wall from two consecutive angiography images in each instance in respect of the expansion and/or contraction and
S4 Visualizing the difference in the inherent motion of the vascular wall.
As a result, the examining person is shown a monitor image, from which he/she may easily identify the state of the examined vessel.
According to the disclosure, the morphology and/or histology of the vascular wall may be visualized in a fifth step S5.
The calculation of the movements of the vascular walls is more accurate when the acquisition of the angiography images is implemented by way of at least one EKG cycle in accordance with step S1.
Determination of the movements of the vascular walls may be improved, if the acquisition of the angiography images takes place with a high image refresh rate, for instance with 25/30 Hz, in accordance with step S1.
To reduce the motion blurs, the acquisition of the angiography images may be implemented with short x-ray pulses, for instance with a duration of 6 to 12 ms, in accordance with step S1.
The angiography images acquired in accordance with step S1 may be fluoroscopy images or subtraction images.
The calculation of the inherent motion of the vascular wall may be implemented in accordance with step S3 by determining the difference between the maximum extension and minimum contraction of the vascular wall.
The visualization of the inherent motion of the vascular wall may take place by means of arrows corresponding to the size of the inherent motion in accordance with step S4. Alternatively, the visualization of the inherent motion of the vascular wall may take place by means of markers corresponding to the extent of the inherent motion in accordance with step S4. The visualization of the inherent motion of the vascular wall may take place by means of a color marker corresponding to the extent of the inherent motion in accordance with step S4, wherein by way of example green and red may indicate an intact and a critical vascular wall in each instance.
The vessel to be examined may be an artery, in particular the aorta for instance.
The acquisition of the angiography images in accordance with step S1 may take place by means of an x-ray system. For example, an apparatus for creating rotation angiographies for soft tissue representation, such as by means of DynaCT®, for instance in 3D.
In order to acquire the angiography images in accordance with step S1, 2D series may be created or a 3D reconstruction may be generated from at least two 2D projections.
The disclosure is now explained in more detail with the aid of exemplary embodiments shown in the drawing, in which:
In a known DSA method shown for instance in
The object to be examined may, as shown by way of example with the aid of
The procedure is now shown and described in more detail in
A quantitative vessel analysis of the vascular wall 21 of the vascular section 20 of the vessel is then implemented in accordance with a second step S2, by means of which the morphology, histology and/or the state of vessels, above all the vascular wall, may be determined and displayed.
In accordance with a third step S3, the inherent motions 26 or 27 of the vascular wall 21 are calculated from two consecutive angiography images 14 or 17 in each instance, wherein the differences between the maximum expansion and minimal contraction of the vascular wall 21 are determined for instance for several points on the vascular wall 21.
A visualization of the differences between the inherent motions 26 or 27 of the vascular wall 21 takes place in a fourth step S4. This may take place for instance by means of the double arrows, which, in accordance with
According to a fifth and last step S5, the morphology and/or histology of the vascular wall 21 may be visualized.
The time-resolved representation (2D+time and/or 3D+time) of vessels enables the morphology, histology and/or state of the vascular wall to be determined simultaneously in an angiography examination.
The effect of the so-called “biological air vessel function” is exploited by the method. The so-called “physiological air vessel” consists of expanding and then constricting the wall of arteries close to the heart, above all the aorta or large arteries. The heart expels blood in the systole, while the blood flow comes to a stop in the diastole. The air vessel arteries expand during the systole, the phase of driving out blood by contracting the heart muscle, and thus also receive part of the stroke volume, which, in the diastole, the relaxation of the heart muscle, is passively contracted, thereby reducing the significant pressure difference between the systole and diastole.
The vascular diameter therefore varies with each pulse beat. This small variation is determined and displayed. Regions which are stenotic on account of a calcification, are to have less or even no variation compared with regions which have no stenosis.
This may be compared with the heart muscle, which, in the case of a heart muscle, is partially necrotic. A factor to be used in the so-called “quantitative detection of regional wall movements” during an examination of the left ventricle. In the area of the necrotic heart muscle tissue, almost no inherent motion can be identified (for instance akinesia). It is therefore possible to conclude that the coronary vessel which supplies this part of the myocardium is stenotic.
For implementation, the angiography images 14 or 17 of the vascular section of interest are recorded by way of at least one EKG cycle with the highest possible image refresh rate and the shortest possible pulses in order to reduce the motion blurs. With standard applications of the quantitative vascular analysis, the morphology and/or histology, above all the vascular wall, may subsequently be determined and displayed. The inherent motion (expansion and/or contraction) of the vascular wall is now calculated from two consecutive images in each instance. This delta of movement is subsequently visualized for further evaluation.
The time-resolved representation of vessels enables the morphology, histology and/or state of the vascular wall to be determined at the same time in the angiography examination. In this way both the dose and also the outlay in terms of time and costs may be drastically reduced. A further examination method such as IVUS, IVUS-VH, OCT, FFR, etc. may likewise be dispensed with, thus avoiding the additional x-ray exposure for examiner and patients for navigation of the additional methods with guide wires and/or catheters.
While specific embodiments have been described in detail, those with ordinary skill in the art will appreciate that various modifications and alternative to those details could be developed in light of the overall teachings of the disclosure. For example, elements described in association with different embodiments may be combined. Accordingly, the particular arrangements disclosed are meant to be illustrative only and should not be construed as limiting the scope of the claims or disclosure, which are to be given the full breadth of the appended claims, and any and all equivalents thereof. It should be noted that the term “comprising” does not exclude other elements or steps and the use of articles “a” or “an” does not exclude a plurality.
| Number | Date | Country | Kind |
|---|---|---|---|
| 102011083704.3 | Sep 2011 | DE | national |
