Claims
- 1. A method for controlling ocular hypertension associated with primary open angle glaucoma which comprises administering a pharmaceutically effective amount of a compound selected from the group consisting of 21-methyl-5.beta.-pregnan-3.alpha.11.beta., 17.alpha., 21-tetrol-20-one 21-methyl ether; 3.beta.-azido-21-acetoxy-5.beta.-pregnan-11.beta., 17.alpha.-diol-20-one; 3.beta.-acetamido-21-acetoxy-5.beta.-pregnan-11.beta., 17.alpha.-diol-20-one; 5.beta.-pregnan-11.beta., 17.alpha.,21-triol-20-one; and 4,9(11)-pregnadien-17.alpha.,21-diol-3,20-dione-21 -acetate.
- 2. A composition for controlling ocular hypertension comprising a pharmaceutically effective amount of a compound selected from the group consisting of: 21-methyl-5.beta.-pregnan-3.alpha.,11.beta.,17.alpha., 21-tetrol-20-one 21-methyl ether; 3.beta.-azido-21-acetoxy-5.beta.-pregnan-11.beta., 17.alpha.-diol-20-one; 3.beta.-acetamido-21-acetoxy-5.beta.-pregnan-11.beta., 17.alpha.-diol-20-one; 5.beta.-pregnan-11.beta., 17.alpha., 21-triol-20-one; and 4, 9(11)-pregnadien-17.alpha.,21-diol-3,20-dione-21-acetate.
- 3. The composition of claim 2 wherein the compound is present at a concentration between 0.005 and 5.0 weight percent.
Parent Case Info
This application is a continuation of application Ser. No. 08/349,342, filed Dec. 2, 1994, now abandoned which is a continuation of Ser. No. 07/941,485 filed Sep. 8, 1992, now U.S. Pat. No. 5,371,078, which is a continuation-in-part of Ser. No. 07/559,123 filed Jul. 27, 1990 now abandoned which is a continuation-in-part of Ser. No. 07/419,226 filed Oct. 10, 1989 now abandoned, which is a continuation of Ser. No. 07/264,918 filed Oct. 31, 1988, now U.S. Pat. No. 4,876,250.
US Referenced Citations (4)
Non-Patent Literature Citations (6)
Entry |
Crum, et al., Science, vol. 230, pp. 1375-1378 (Dec. 1985), "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment". |
Ingber, et al., Endocrinology, vol. 119, pp. 1768-1775 (1986), "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids" Induction of Capillary Basement Membrane Dissolution. |
Southern, et al., Investigative Ophthalmology and Visual Science, vol. 28, pp. 901-903 (May 1987), "Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite: 3-alpha-5, beta-tetrahydrocortisol". |
Folkman, et al., Ann. Surg., vol. 206(3):, pp. 374-382, (1987), "Angiostatic Steroids". |
Rohen, Johanness W., Ophthalmology, vol. 90(7), pp. 758-764, (1983), "Why is Intraocular Pressure Elevated in Chronic Simple Glaucoma?". |
Knepper, et al., Pediatric Neuroscience, vol. 12, pp. 240-251, (1985/86), "Glycosaminoglycans and Outflow Pathways of the Eye and Brain". |
Continuations (3)
|
Number |
Date |
Country |
Parent |
349342 |
Dec 1994 |
|
Parent |
941485 |
Sep 1992 |
|
Parent |
264918 |
Oct 1988 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
559123 |
Jul 1990 |
|
Parent |
419226 |
Oct 1989 |
|