Claims
- 1. A compound of the formula: ##STR25## and the N-oxides and the pharmaceutically acceptable salts thereof wherein R.sub.1 is phenyl unsubstituted or substituted by fluoro chloro, bromo, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;
- R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms;
- R.sub.3 is hydrogen, nitro, amino, ##STR26## in which R.sub.4 is alkyl of 1 to 4 carbon atoms unsubstituted or substituted with up to three chlorine atoms or with three fluorine atoms on the same carbon atoms;
- R.sub.5 is alkyl of 1 to 4 carbon atoms
- n has a value of 0, 1 or 2.
- 2. A compound as claimed in claim 1 wherein R.sub.1 is phenyl, p-chlorophenyl, p-methylphenyl or p-methoxyphenyl.
- 3. A compound as claimed in claim 1 wherein R.sub.1 is phenyl.
- 4. A compound as claimed in claim 1 wherein R.sub.2 is hydrogen, methyl, ethyl, n-propyl or n-butyl.
- 5. A compound as claimed in claim 1 wherein R.sub.2 is hydrogen or methyl.
- 6. A compound as claimed in claim 1 wherein R.sub.2 is hydrogen.
- 7. A compound as claimed in claim 1 wherein n is 0.
- 8. A compound as claimed in claim 1 wherein R.sub.2 is hydrogen, n is 0 and R.sub.1 is phenyl.
- 9. A compound as claimed in claim 1 wherein R.sub.3 is hydrogen.
- 10. A compound as claimed in claim 1 wherein R.sub.3 is nitro.
- 11. A compound as claimed in claim 1 wherein R.sub.3 is amino, NHCOR, or NHCO.sub.2 R.sub.4 where R.sub.4 is alkyl of 1 to 4 carbon atoms.
- 12. A compound as claimed in claim 1 wherein R.sub.3 is amino, acetylamino, propionylamino, methoxycarbonylamino or ethoxycarbonylamino.
- 13. A compound as claimed in claim 1 wherein R.sub.3 is amino or acetylamino.
- 14. A compound as claimed in claim 1 wherein R.sub.3 is amino.
- 15. A compound of the formula: ##STR27## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is phenyl unsubstituted or substituted with fluoro, chloro, bromo, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;
- R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms;
- n is 0, 1 or 2;
- R.sub.5 is alkyl of 1 to 4 carbon atoms; and
- R.sub.6 is hydrogen, COR.sub.4 or CO.sub.2 R.sub.4 wherein R.sub.4 is alkyl of 1 to 4 carbon atoms unsubstituted or substituted with one, two or three chlorine atoms or with three fluorine atoms on the same carbon atom.
- 16. A compound as claimed in claim 15 wherein R.sub.6 is hydrogen.
- 17. A compound as claimed in claim 16 wherein R.sub.1 is phenyl, p-chlorophenyl, p-methoxyphenyl or p-methylphenyl.
- 18. A compound as claimed in claim 16 wherein R.sub.1 is phenyl.
- 19. A compound as claimed in claim 16 wherein R.sub.2 is hydrogen, methyl, ethyl, n-propyl or n-butyl.
- 20. A compound as claimed in claim 16 wherein R.sub.2 is hydrogen or methyl.
- 21. A compound as claimed in claim 16 wherein R.sub.2 is hydrogen.
- 22. A compound as claimed in claim 16 wherein n is 0.
- 23. A compound as claimed in claim 1 in the form of the free base.
- 24. A compound as claimed in claim 1 in the form of a pharmaceutically acceptable acid addition salt.
- 25. A compound as claimed in claim 16 in the form of a mono-acid addition salt.
Priority Claims (1)
Number |
Date |
Country |
Kind |
16765/77 |
Apr 1977 |
GBX |
|
Parent Case Info
This application is a division of Ser. No. 894,942, filed Apr. 10, 1978, now U.S. Pat. No. 4,223,034.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3647877 |
Weber et al. |
Mar 1972 |
|
4097487 |
Murakami et al. |
Jun 1978 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
894942 |
Apr 1978 |
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