The invention related to the design of dipole antennas for magnetic resonance imaging.
A static magnetic field is used by Magnetic Resonance Imaging (MRI) scanners to align the nuclear spins of atoms as part of the procedure for producing images within the body of a patient. This static magnetic field is referred to as the B0 field. It is commonly known that increasing the strength of the B0 field used for performing an MRI scan offers the opportunity of increasing the spatial resolution and contrast resolution of the diagnostics images. This increase in resolution and contrast benefits physicians using an MRI image to diagnose a patient.
During an MRI scan, Radio Frequency (RF) pulses generated by a transmitter coil cause perturbations to the local magnetic field. These perturbations are known as the B1 field. The B1 field is used to manipulate the orientation of the nuclear spins. The portion of the B1 field that is effectively used to manipulate the orientation of the nuclear spins is the B1+ field. RF signals that are emitted by the nuclear spins are detected by a receiver coil. These RF signals are used to construct the MRI images. These coils can also be referred to as antennas. Further, the transmitter and receiver coils can also be integrated into a single transceiver coil that performs both functions. It is understood that the use of the term transceiver coil also refers to systems where separate transmitter and receiver coils are used.
However, a technical challenge in increasing the B0 field strength used is that as the B0 field is increased, the frequency of the electromagnetic waves necessary to generate the B1+ field also increases. Conventional MRI transceiver coils, are resonant and rely on near field radiation to generate the B1+ field. As the frequency increases, the near field becomes confined to a smaller and smaller region. To image regions deep within the body of a subject, the surface regions of the subject can be exposed to levels of radiation which can overheat tissue. The term Specific Absorption Ratio (SAR) is the radio frequency power absorbed per unit mass in tissue and is a measure of this overheating. MRI transceiver coils which limit the SAR in a subject as the B0 field increases are needed.
United States patent application publication US2009/0015256A1 discloses the use of stripline conductors in combination with loop coils to form quadrature detectors.
The invention provides for an antenna array, a radio frequency system, a computer program product, and a magnetic resonance imaging system in the independent claims. Embodiments of the invention are given in the dependent claims.
Conventional Radio Frequency (RF) transmit coils in Magnetic Resonance
(MR) imaging are ‘near-field’ antennas. These antennas store magnetic (and electric) energy in the near-field region around the antenna, causing high levels of B1+. This region extends around the antenna for approximately a quarter of a wavelength (λ/4), which corresponds to ca. 20 cm for 1.5 T and 10 cm for 3 T imaging. However, at 7 Tesla, the near-field is extending only 4 cm into the subject. Many regions of interest for MR imaging are likely to be located outside the ‘near-field’ region. Resonant antennas are extremely inefficient in generating B1+ in the ‘far-field’ region. To solve this problem, embodiments of the invention provide for a different kind of antenna, which is known as a ‘radiative antenna’. This antenna is used in the field of RF hyperthermia. Instead of focusing the energy in the near-field region, the antenna is designed such that the energy will be radiated away from its source, resulting in more efficient B1+ generation at depths beyond a quarter of a wavelength. With a number of these elements in a belt-like array around the body, combined with phase-amplitude steering of the individual elements, both the B1+ level and B1+ homogeneity can be increased.
Radiative antennas are able to transmit higher levels of B1+ to regions inside the human body. Therefore, they will also be more sensitive to pick up signals from the body. This makes them suitable elements of RF coil arrays for both transmitting and receiving. For both applications, a belt-like coil array around the body with a number of these elements is used in combination with phase-amplitude steering of the elements. In this way, the RF interference patterns inside the body can be manipulated to avoid the appearance of signal voids in regions of interest, which would diminish the gain that the radiative elements inherently offer. The radiative antenna design that is presented here can operate over a wide range of frequencies, offering promising functionality for multi-nuclei MRI.
Embodiments of the invention may have the following advantages:
For MR imaging at ultra high field strengths, the radiative antenna is able to transmit higher (with respect to dipole) signal levels into the deeper parts of the body.
The Specific Absorption Ratio (SAR) levels at the surface of the subject are reduced because the ratio of the B1+ level at the point of interest versus the SAR level at the surface, is more favorable for a radiative antenna compared to traditional designs.
Due to the reduced surface SAR, the radiative antenna is also more suitable to deliver therapeutic levels of RF inside the subject e.g. for thermally activated drug delivery.
An array of radiative antenna elements allows for a multi-transmit approach, where the RF interference patterns can be controlled by varying phase and amplitude of the elements. In this way, signal voids can be removed from the target region.
This invention facilitates more effective MR spectroscopy for the prostate at 7 Tesla. This promises to become a valuable tool to characterize and/or distinguish tumor tissue, once the RF challenges of getting signal from deeper/more deeply located regions have been solved.
Although prostate cancer is given here as an example, many more tumor sites are eligible for investigation with MR spectroscopy once the RF challenges have been solved. Due to the increasing incidence of cancer all over the world, the characterization of tumor tissue by MR spectroscopy could in potential prove to be the first example where the 7 Tesla modality demonstrates clinical value for subjects. The application of the 7 Tesla for oncology is now hampered by the RF problems in the body. Any technique that can cope with these problems may in future become a valuable asset in MR imaging.
The broadband properties of this invention provide opportunities for multi-nuclei MRI.
Embodiments of the invention provide for an antenna array adapted for magnetic resonance imaging, where the antenna array comprises at least one element. Each element comprises a substrate with a first side and a second side. Each element further comprises at least one dipole antenna. The substrate comprises a dielectric material. The dipole antenna is attached to the second side of the substrate, and the dipole antenna comprises a first connection adapted for connecting the dipole antenna to a transmission line.
This embodiment is advantageous, because this antenna can be used for launching or receiving radio frequency waves for performing magnetic resonance imaging. In another embodiment the antenna array has a substrate comprising dielectric material which has a dielectric constant between 20 and 110. This embodiment is advantageous, because the antenna can be placed in the vicinity of a subject and the dielectric material reduces the fraction of the electromagnetic wave that will be reflected. The first connection can be a connection adapted for transmitting radio frequency power such as an “SMA” or “N” type connector. The first connection can also be a hardwired connection between the dipole antenna and a transmission line.
In another embodiment, the dielectric material has an electrical conductivity that is lower than 0.1 S/m at the operating frequency of the longest wavelength that the dipole antenna is adapted for launching. This embodiment is advantageous, because this conductivity allows magnetic resonance imaging to function without large losses in the dielectric.
In another embodiment, the substrate is ceramic. This embodiment is advantageous, if the ceramic has a conductivity and also dielectric constant which is similar to that of human tissue. This means that the dielectric material matches the electrical properties of the human body and reduces reflections from the interface between the substrate and the subject.
In another embodiment, the dielectric constant of the dielectric material is equal to the average dielectric constant of the human body. The average dielectric constant of the human body can be calculated in several ways. The average of the entire body for a group of subjects can be calculated or the average for a certain region of a body can be calculated. For instance the average dielectric constant of a hand for a group of subjects can be calculated and this can be used. The advantage of matching the dielectric constant of the substrate to that of the human body has already been discussed.
In another embodiment, the antenna array is adapted for receiving radio frequency signals from nuclei inside a subject excited during the acquisition of magnetic resonance imaging data. Magnetic resonance imaging data is defined herein as a measurement of the radio frequency signals emitted by atomic nuclei during magnetic resonance imaging.
In another embodiment, the antenna array is adapted for launching an electromagnetic wave from the dipole antenna through the substrate in the direction of the first side for manipulating the orientation of the nuclear spins inside a subject during the acquisition of magnetic resonance imaging data. This embodiment is advantageous, because the dielectric can be used to direct the launching of an electromagnetic wave, and also the dielectric can be constructed such that the specific absorption ratio on the surface of a subject or also within a subject is reduced.
In another embodiment, the thickness of the substrate is chosen for reducing the specific absorption ratio in a subject. The radiation pattern of a dipole antenna can be described using the near field and the far field approximation. The terms near field and far field radiation patterns are understood to reference these approximations. The substrate thickness can be chosen large enough such that the near field is located solely inside the substrate and therefore outside of a subject. This reduces the specific absorption ratio that a subject is exposed to.
In another embodiment, the thickness of a substrate is greater than one eighth of the wavelength in the dielectric at the frequency of the longest wavelength that the dipole antenna is adapted for launching, preferably the thickness of a substrate is greater than one quarter of the wavelength in the dielectric at the frequency of the longest wavelength that the dipole antenna is adapted for launching. This embodiment is advantageous, because of reasons that have already been discussed.
In another embodiment, the dipole antenna comprises two conductive strips. The conductive strips are aligned along an axis, and the substrate extends along the axis beyond the end of each of the conductive strips at least one eighth of a wavelength of the longest wavelength that the dipole antenna is adapted for launching. Preferably the substrate extends along the axis and beyond the end of each of the conductive strips at least one quarter of a wavelength of the longest wavelength the dipole antenna is adapted for launching. This embodiment is advantageous, because the field of the dipole antenna is better contained by the dielectric material. That is the near field of the dipole antenna is contained within the dielectric. If the dielectric is too short then the near field radiation field is not contained within the dielectric and it can cause a high specific absorption ratio when the antenna is in the vicinity of a subject.
In another embodiment, the dipole antenna comprises two conductive strips. The conductive strips are aligned along an axis. The length each conductive strip are equal one quarter of the wavelength inside the dielectric material. In this way, the antenna is far more efficient in transmitting a wave in the direction of the first side than in the direction of the second side, because the total length of the dipole antenna is now half a wavelength in the dielectric but not in air.
In another embodiment, the antenna is adapted for launching at least two different frequencies of electromagnetic waves. This is advantageous, because the antenna array can then be used for multi-nuclei nuclear magnetic resonance imaging. Nuclei of several different types can be manipulated with the antenna or their signals can be detected with the antenna.
In another embodiment, the antenna is further adapted for launching electromagnetic waves for performing radio frequency hyperthermia treatment of the subject. This embodiment is advantageous, because the antenna can be used for magnetic resonance imaging and also the same antenna could then be used for heating tissue for hyperthermia treatment. The combination of these two is advantageous, because the temperature of tissue can be measured directly using magnetic resonance imaging. In this way the hyperthermia could be precisely guided and controlled using magnetic resonance imaging.
In another embodiment, the dipole antenna comprises two conductive strips. Each conductive strip is V-shaped and the two conductive strips are attached to the substrate such that the points of the V for both conductive strips are adjacent to each other. This embodiment is advantageous, because the V-shape increases the size of the antenna and therefore increases the size of the radiation field of the antenna. The antenna array can then be used for imaging a larger portion of a subject.
In another embodiment, the first side is adapted for receiving a subject. This embodiment is advantageous, because the antenna can be placed directly against the subject and this reduces the amount of reflection of electromagnetic radiation at the border of the subject and at the first side.
In another embodiment, the dielectric substrate comprises a fluid.
In another embodiment, the second side is adapted for receiving a gel that facilitates the transmission of electromagnetic waves from the first side to the subject. Both of these embodiments are advantageous, because this reduces the amount of reflection at the boundary between the subject and the second side. This improves the quality of the magnetic resonance imaging images.
In another embodiment, a portion of the substrate is powdered ceramic. The ceramic is then placed into a cushion and the cushion is then able to be adapted to the surface of the subject.
In another aspect, the invention provides for a radio frequency system for a magnetic resonance imaging system. The radio frequency system comprises an antenna according to any one of the preceding claims. The radio frequency system further comprises a radio frequency generator adapted for supplying each dipole antenna of the antenna array with radio frequency power with at least a first frequency. The radio frequency generator is adapted for controlling the amplitude and phase of the radio frequency power supplied to each dipole antenna. This is advantageous, because the phase and amplitude of each array can be controlled and adjusted as well as the phase. This allows the B1+ field within the subject to be made more uniform and to improve the homogeneity of the B1+ field and the level. The radio frequency system further comprises a set of transmission lines adapted for connecting the first connection and the second connection. The radio frequency system further comprises a set of transmission lines adapted for connecting the first connection and the second connection. The radio frequency system further comprises a control system adapted for controlling the radio frequency generator. This control system can be a dedicated computer, microcontroller or control system. The control system can also be integrated as part of a computer system for controlling the magnetic resonance imaging system. The control system can therefore also comprise a software component.
In another embodiment, the radio frequency generator is further adapted for receiving radio frequency signals from excited nuclei by the antenna array, and wherein the radio frequency generator is a transceiver adapted for receiving the radio frequency signals from the antenna array.
In another aspect, embodiments of the invention provide for a computer program product comprising machine executable instructions for execution on the control system of the radio frequency system. The machine executable instructions comprise the steps of adjusting the amplitude of the radio frequency energy received by each dipole antenna from the radio frequency generator in order to increase the level of homogeneity of the B1+ field within the subject, and adjusting the phase of the radio frequency energy received by each dipole antenna from the radio frequency generator in order to increase the level of homogeneity of the B1+ field within the subject. This embodiment is advantageous, because increasing the level and/or homogeneity of the B1+ field within the subject improves the quality of the images acquired using magnetic resonance imaging.
In another aspect, embodiments of the invention provide for a magnetic resonance imaging system adapted for acquiring magnetic resonance imaging data. The magnetic resonance imaging system comprises a magnetic field generation means for generating a magnetic field for orientating the magnetic spins of nuclei, a radio frequency system according to an embodiment of the invention, a magnetic field gradient coil for spatial encoding and manipulating the orientation of the magnetic spins in the nuclei, and a magnetic field generation coil power supply for supplying current to the magnetic field of the gradient coil, and a second control system for reconstructing images from the magnetic resonance imaging data. The full system of the radio frequency system and the second control system of the magnetic resonance imaging system can be identical. They can also be separate control systems but can share software components on a shared computer.
In the following preferred embodiments of the invention will be described, by way of example only, and with reference to the drawings in which:
In
The antenna shown in
For a practical realization of the antenna, the permittivity of the substrate needs only be approximately equal to the permittivity of the body. A suitable substrate is distilled water (The permittivity of water is 80 and of muscle tissue is 60). The drawback of water, however, is that it generates MR signal. A better solution would be to use Fomblin as a high epsilon liquid with low conductivity that does not generate MR signal. If the subject's skin surface is flexible in the region of interest, then a more convenient solution is the usage of ceramic materials. They can be formed in any desired shape that fulfills the conditions, while good connection is guaranteed by pressing the elements slightly onto the skin. If the elements do not connect tight enough, a water-like gel (high permittivity) would ensure the transmission of the electromagnetic wave. The transverse transmit profile can be improved (widened) by cutting the conductive strips in a V-shape such as indicated in
The performance of the radiative antenna has been characterized by fdtd (finite difference time domain) simulations. The transmitted B1+ profile of the dipole antenna is presented plot 1312 of
Embodiments of antenna arrays may have another advantage with respect to conventional antennas. Because the antenna is not a resonant LC-circuit, the impedance is much more constant over a wide frequency range (
A prototype version of a dipole antenna has been realized using a ceramic substrate, Morgan Electro Ceramics K90, and a simple dipole antenna with two conducting strips. The dipole antenna is connected to a transmission line via a matching network to convert the antenna impedance to 50 ohms. After testing the antenna on a gelatine phantom, temperature measurements and MR thermometry show that the dipole antenna indeed causes less temperature rise in comparison to a conventional stripline antenna. Furthermore, measurements on a volunteer prostate at 7 T show that already just one dipole antenna element is able to image deep inside the body (
100 Antenna element
102 Substrate
104 First side
106 Second side
108 Dipole antenna
110 First connection
200 Antenna array
202 Radio frequency generator
204 Control system
206 Transmission line
208 Transversal cross section of a subject
302 Radio frequency generator
304 Control system
306 Transmission line
308 Transversal cross section of a subject
310 Antenna element
408 Subject
410 Antenna element
412 Belt
414 Subject support
502 Radio frequency power supply
506 Transmission line
508 subject
516 Dipole antenna
518 Substrate
520 Magnetic field gradient coils
522 Magnetic field gradient coil power supply
524 Computer system
526 Hardware interface
528 Microprocessor
530 Computer program product
532 Image reconstruction module
534 Radio frequency power supply control module
536 User interface
540 Antenna array
542 Imaging zone
544 Magnetic field means
600 Receive channel
602 Transmit channel
604 Vector modulator
606 Transmit amplifier
608 Receive amplifier
610 Transmit or receive switch
612 Quadrature hybrid power diverter and combiner
614 Transmission line
616 Antenna element
618 Transversal cross section of a subject
802 Substrate
806 Second side
810 First connection
850 Conductive strip
902 Substrate
906 Second side
952 First conductive strip
954 Second conductive strip
956 Direction of current flow
958 Direction of electric field
960 Direction of electromagnetic wave travel
962 Position and direction of magnetic field line
1000 Substrate with end less than one quarter wavelength long
1002 Substrate with end one quarter in wave length long
1004 Conductive strip of dipole antenna
1006 Color bar indicating specific absorption ratio
1100 Thickness
1102 Maximum specific absorption ratio
1104 B1+
1202 Substrate
1204 “v” shaped conductive strip
1300 Depth
1302 B1+ in arbitrary units
1304 Specific absorption ratio in arbitrary units
1306 B1+ divided by the maximum specific absorption ratio in arbitrary units
1308 Calculation for stripline antenna
1310 Calculation for dipole antenna
1312 B1+ profile for stripline antenna and dipole antenna
1314 B1+ profile for stripline antenna and dipole antenna
1316 Specific absorption ratio profile for stripline antenna and dipole antenna
1318 B1+ profiles normalized to maximum specific absorption level
1400 Frequency in MHz
1402 Impedance in ohms
1404 Real component of stripline antenna impedance
1406 Imaginary component of stripline antenna impedance
1408 Real component of dipole antenna impedance
1410 Imaginary component of dipole antenna impedance
Number | Date | Country | Kind |
---|---|---|---|
09155787.6 | Mar 2009 | EP | regional |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/IB10/51156 | 3/17/2010 | WO | 00 | 9/14/2011 |