Claims
- 1. The compound of the formula where:anthracycline is doxorubicin or daunorubicin; N is the 3′ nitrogen of daunosamine; Ra is H, methyl, ethyl, propyl or butyl; X is O, S, CRc2 or NRc, where Rc is H, methyl, ethyl, propyl or butyl; Rb is CH3, C2H5, C3H7 or C(CH3)3; n is 1 to 6; and m is 0 to 6.
- 2. The compound of claim 1 wherein Ra is H, Rb is C(CH3)3, X is CH2, n is 2 and m is 24.
- 3. The compound of claim 1 wherein Ra is CH3 or H, Rb is C(CH3)3, X is O, n is 2, and m is 1.
- 4. The compound of claim 1 wherein Ra H, Rb is C(CH3)3, X is CH2, n is 2 and m is 2.
- 5. The compound of claim 1 wherein Ra is a H, Rb is C(CH3)3, X is CH2, n is 2 and m is 0.
- 6. The compound of claim 1 wherein Ra is H; Rb is C(CH3)3, X is O, n is 2 and m is 2.
- 7. The compound of claim 1 wherein R1 is H, Rb is C(CH3)3, X is CH2, n is 2 and m is 4.
- 8. The compound of claim 1 wherein Rb is C(CH3)3.
- 9. The compound of claim 1 wherein X is CH2, and m+n is from 1 to 9.
- 10. The compound of claim 1 wherein X is O, S or NH.
- 11. The compound of claim 1 wherein the anthracycline is doxorubicin.
- 12. The compound of claim 1 wherein the anthracycline is daunorubicin.
Parent Case Info
This is a continuation of application Ser. No. 08/441,240, filed May 15, 1995, now U.S. Pat. No. 6,284,737, which is a continuation of application Ser. No. 08/034,904, filed Mar. 22, 1993, now abandoned, which is a continuation of application Ser. No. 07/608,149, filed Nov. 1, 1990, now U.S. Pat. No. 5,196,522, the entire content of which is hereby incorporated by reference in this application.
Government Interests
Work relating to the development of the present invention was supported by Grant CA 42708 from the National Institutes of Health, DHHS. This support gives the United States Government certain rights in the present invention.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4950738 |
King et al. |
Aug 1990 |
A |
5196522 |
Farquhar et al. |
Mar 1993 |
A |
Continuations (3)
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Number |
Date |
Country |
Parent |
08/441240 |
May 1995 |
US |
Child |
09/796606 |
|
US |
Parent |
08/034904 |
Mar 1993 |
US |
Child |
08/441240 |
|
US |
Parent |
07/608149 |
Nov 1990 |
US |
Child |
08/034904 |
|
US |