Claims
- 1. A method of treating diabetes by lowering the glucose levels in blood plasma comprising administering to a diabetic host a therapeutically effective amount of a compound of formula I: ##STR16## wherein R.sub.o is bromo, chloro, fluoro, nitro or trifluoromethyl,
- R is hydrogen, C.sub.1-6 alkyl or C.sub.2-18 alkanoyl, and
- R.sub.1 is hydrogen or C.sub.1-12 alkyl,
- or a pharmaceutically acceptable simple or acid addition salt thereof, said therapeutically effective amount being an amount effective for the treatment of diabetes.
- 2. A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula I wherein R.sub.o is as defined in claim 1; R is hydrogen, C.sub.1-6 alkyl or C.sub.2-4 alkanoyl; and R.sub.1 is hydrogen or C.sub.1-6 alkyl, or a pharmaceutically acceptable simple or acid addition salt thereof.
- 3. A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ia: ##STR17## wherein R.sub.o is as defined in claim 1, or a pharmaceutically acceptable salt thereof.
- 4. A method of treating diabetes according to claim 3 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4- or 6-position, or a pharmaceutically acceptable salt thereof.
- 5. A method of treating diabetes according to claim 4 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position, or a pharmaceutically acceptable salt thereof.
- 6. A method of treating diabetes according to claim 5 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR18## or a pharmaceutically acceptable salt thereof.
- 7. A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ib: ##STR19## wherein R.sub.o is as defined in claim 1 and R.sub.1 is C.sub.1-12 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 8. A method of treating diabetes according to claim 7 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R.sub.1 is C.sub.1-8 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 9. A method of treating diabetes according to claim 8 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position and R.sub.1 is C.sub.1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 10. A method of treating diabetes according to claim 9 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR20## or a pharmaceutically acceptable acid addition salt thereof.
- 11. A method of treating diabetes according to claim 7 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is as defined in claim 7 and R.sub.1 is C.sub.1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 12. A method of treating diabetes according to claim 11 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position and R.sub.1 is C.sub.1-4 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 13. A method of treating diabetes according to claim 12 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is trifluoromethyl in the 4-position and R.sub.1 is methyl or ethyl, or a pharmaceutically acceptable acid addition salt thereof.
- 14. A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ic: ##STR21## wherein R.sub.o is as defined in claim 1 and R is C.sub.2-18 alkanoyl or C.sub.1-6 alkyl, or a pharmaceutically acceptable salt thereof.
- 15. A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R is C.sub.2-18 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
- 16. A method of treating diabetes according to claim 15 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is trifluoromethyl in the 4- or 6-position and R is C.sub.2-18 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
- 17. A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R is C.sub.2-12 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
- 18. A method of treating diabetes according to claim 17 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position and R is C.sub.2-8 -alkanoyl, or a pharmaceutically acceptable simple salt thereof.
- 19. A method of treating diabetes according to claim 18 comprising administering to a diabetic host a therapeutically effective amount of a compound of the formula, ##STR22## or a pharmaceutically acceptable simple salt thereof.
- 20. A method of treating diabetes according to claim 18 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR23## or a pharmaceutically acceptable simple salt thereof.
- 21. A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is as defined in claim 14 and R is C.sub.2-4 alkanoyl or C.sub.1-6 alkyl, or a pharmaceutically acceptable salt thereof.
- 22. A method of treating diabetes according to claim 21 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position and R is C.sub.2-4 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
- 23. A method of treating diabetes according to claim 22 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is as defined in claim 22 and R is acetyl, or a pharmaceutically acceptable simple salt thereof.
- 24. A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Id: ##STR24## wherein R.sub.o is as defined in claim 1, R is C.sub.2-18 alkanoyl or C.sub.1-6 alkyl and R.sub.1 is C.sub.1-12 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 25. A method of treating diabetes according to claim 24 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4- or 6-position, R is C.sub.2-12 alkanoyl and R.sub.1 is C.sub.1-8 alkyl.
- 26. A method of treating diabetes according to claim 25 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is chloro, nitro or trifluoromethyl in the 4-position, R is C.sub.2-8 alkanoyl and R.sub.1 is C.sub.1-6 alkyl.
- 27. A method of treating diabetes according to claim 24 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is as defined in claim 24, R is C.sub.2-4 alkanoyl or C.sub.1-6 alkyl and R.sub.1 is C.sub.1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
- 28. A method of treating diabetes according to claim 27 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R.sub.o is as defined in claim 27, R is C.sub.2-4 alkanoyl and R.sub.1 is C.sub.1-6 alkyl.
Parent Case Info
This application is a continuation-in-part of U.S. application Ser. No. 38,419, filed May 14, 1979, which in turn is a continuation-in-part of U.S. application Ser. No. 898,160, filed Apr. 20, 1978, both now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2258367 |
Nov 1976 |
FRX |
Non-Patent Literature Citations (3)
Entry |
Mie Medical Journal, vol. XVII, No. 1, 1967, pp. 83-92. |
Research Chemicals Catalog, p. 96 (1976), Pfaltz and Bauer. |
Journal of Medicinal and Pharmaceutical Chemistry, vol. 1, No. 2, (1959), 121. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
38419 |
May 1979 |
|
Parent |
898160 |
Apr 1978 |
|