ANTI-B7-H3 ANTIBODIES

Information

  • Patent Application
  • 20220235134
  • Publication Number
    20220235134
  • Date Filed
    May 27, 2020
    4 years ago
  • Date Published
    July 28, 2022
    a year ago
Abstract
Provided are antibodies that specifically recognize B7 homology 3 protein (B7-H3).
Description
INCORPORATION OF SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. The ASCII copy, created on May 26, 2020, is named SCT0007-401-PC_Sequence_Listing_ST5.txt, and is 581 kilobytes in size.


BACKGROUND

The B7 homology 3 protein (B7-H3) (also known as CD276 and B7RP-2, referred to herein as “B7-H3”) is a type I transmembrane glycoprotein of the immunoglobulin superfamily. Human B7-H3 contains a putative signal peptide, V-like and C-like Ig domains, a transmembrane region and a cytoplasmic domain. Exon duplication in humans results in the expression of two B7-H3 isoforms having either a single IgV-IgC-like domain (2IgB7-H3 isoform) or an IgV-IgC-IgV-IgC-like domain (4IgB7-H3 isoform) containing several conserved cysteine residues. The predominant B7-H3 isoform in human tissues and cell lines is the 4IgB7-H3 isoform (Steinberger et al., 2004).


B7-H3 has been reported as having both co-stimulatory and co-inhibitory signaling functions (Chapoval et al., 2001; Suh et al., 2003; Prasad et al., 2004; Wang et al., 2005). For example, in vitro studies have shown B7-H3's co-stimulatory function since B7-H3 was able to increase proliferation of cytotoxic T-lymphocytes (CTLs) and upregulate interferon gamma (IFN-7) production in the presence of anti-CD3 antibody to mimic the T cell receptor signal (Chapoval et al., 2001). Moreover, in vivo studies using cardiac allografts in B7-H3 −/− mice showed decreased production of key cytokine, chemokine and chemokine receptor mRNA transcripts {e.g., IL-2, IFN-γ, monocyte chemoattractant protein (MCP-1) and IFN-inducible protein (IP)-10) as compared to wild-type control (Wang et al., 2005). In contrast, B7-H3 co-inhibitory function has been observed, for example, in mice where B7-H3 protein inhibited T-cell activation and effector cytokine production (Suh et al., 2003). Although no ligands have been identified for human B7-H3, murine B7-H3 has been found to bind to the triggering receptor expressed on myeloid cells (TREM-) like transcript 2 (TLT-2), a modulator of adaptive and innate immunity cellular responses. Binding of murine B7-H3 to TLT-2 on CD8+ T-cells enhances T-cell effector functions such as proliferation, cytotoxicity and cytokine production (Hashiguchi et al., 2008).


B7-H3 is not constitutively expressed in many immune cells (e.g., natural killer (NK) cells, T-cells, and antigen-presenting cells (APCs)), however, its expression can be induced. Further, the expression of B7-H3 is not restricted to immune cells. B7-H3 transcripts are expressed in a variety of human tissues including colon, heart, liver, placenta, prostate, small intestine, testis, and uterus, as well as osteoblasts, fibroblasts, epithelial cells, and other cells of non-lymphoid lineage, potentially indicating immunological and non-immunological functions (Nygren et al., 2011). However, protein expression in normal tissue is typically maintained at a low level and thus, may be subject to post-transcriptional regulation.


B7-H3 is also expressed in a variety of human cancers, including prostate cancer, clear cell renal cell carcinoma, glioma, melanoma, lung cancer, non-small cell lung cancer (NSCLC), small cell lung cancer, pancreatic cancer, gastric cancer, acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), ovarian cancer, colorectal cancer, colon cancer, renal cancer, hepatocellular carcinoma, kidney cancer, head and neck cancer, hypopharyngeal squamous cell carcinoma, glioblastoma, neuroblastoma, breast cancer, endometrial cancer, and urothelial cell carcinoma (Chapoval et al., 2001; Saatian et al., 2004; Castriconi et al., 2004; Sun et al., 2002).


Although the role of B7-H3 in cancer cells is unclear, its expression may orchestrate signaling events that may protect cancer cells from innate and adaptive immune responses. For example, B7-H3 is overexpressed in high-grade prostatic intraepithelial neoplasia and adenocarcinomas of the prostate, and high expression levels of B7-H3 in these cancerous cells is associated with an increased risk of cancer progression after surgery (Roth et al., 2007). Further, tumor B7-H3 expression in NSCLC inversely correlated with the number of tumor-infiltrating lymphocytes and significantly correlated with lymph node metastasis (Sun et al., 2006). The level of circulating soluble B7-H3 in NSCLC patients has also been associated with higher tumor stage, tumor size, lymph node metastasis, and distant metastasis (Yamato et al., 2009). These lines of evidence suggest that B7-H3 is exploited by tumors as an immune evasion pathway (Hofmeyer et al., 2008).


B7-H3 may also play an important role in T-cell-mediated antitumor responses in a context dependent manner. For example, gastric cancer tumor cell expression of B7-H3 positively correlated with survival time, infiltration depth, and tissue type (Wu et al., 2006). Further, high expression of B7-H3 in pancreatic tumor cells was associated with patient survival after surgical resection and significantly correlated with the number of tumor-infiltrating CD8+ T-cells (Loos et al., 2009).


Thus, despite all prior advances, a need remains for improved compositions capable of binding to cancer cells and of facilitating or mediating an immune response against cancer cells. Such compositions may be used to diagnose and treat such cancers either by reducing or enhancing the capabilities of B7-H3 to mediate T-cell activation or by recognizing and killing cancer cells that express B7-H3. The present invention is directed to such compositions and to their uses in diagnostics and in the treatment of diseases such as cancer.


SUMMARY

Provided are antibodies that recognize and specifically bind to human B7-B3. In one embodiment, the disclosure provides an antibody that binds to SEQ ID NO:1.


BRIEF DESCRIPTION OF THE SEQUENCES










TABLE 1





SEQ ID NO.
Description of sequence
















1
Human B7-H3 protein sequence


2
Human B7-H3 (4Ig) His tagged protein sequence


3
Human B7-H3 (4Ig) Human Fc tagged protein sequence


4
SCT-Da001 mature heavy chain variable domain protein sequence


5
SCT-Da002 mature heavy chain variable domain protein sequence


6
SCT-Da003 mature heavy chain variable domain protein sequence


7
SCT-Da004 mature heavy chain variable domain protein sequence


8
SCT-Da005 mature heavy chain variable domain protein sequence


9
SCT-Da006 mature heavy chain variable domain protein sequence


9
SCT-Da007 mature heavy chain variable domain protein sequence


9
SCT-Da008 mature heavy chain variable domain protein sequence


9
SCT-Da009 mature heavy chain variable domain protein sequence


10
SCT-Da010 mature heavy chain variable domain protein sequence


11
SCT-Da011 mature heavy chain variable domain protein sequence


11
SCT-Da012 mature heavy chain variable domain protein sequence


12
SCT-Da013 mature heavy chain variable domain protein sequence


13
SCT-Da014 mature heavy chain variable domain protein sequence


14
SCT-Da015 mature heavy chain variable domain protein sequence


15
SCT-Da016 mature heavy chain variable domain protein sequence


16
SCT-Da017 mature heavy chain variable domain protein sequence


16
SCT-Da018 mature heavy chain variable domain protein sequence


17
SCT-Da019 mature heavy chain variable domain protein sequence


18
SCT-Da020 mature heavy chain variable domain protein sequence


19
SCT-Da021 mature heavy chain variable domain protein sequence


19
SCT-Da022 mature heavy chain variable domain protein sequence


21
SCT-Da023 mature heavy chain variable domain protein sequence


22
SCT-Da024 mature heavy chain variable domain protein sequence


22
SCT-Da025 mature heavy chain variable domain protein sequence


22
SCT-Da026 mature heavy chain variable domain protein sequence


22
SCT-Da027 mature heavy chain variable domain protein sequence


23
SCT-Da028 mature heavy chain variable domain protein sequence


24
SCT-Da029 mature heavy chain variable domain protein sequence


25
SCT-Da030 mature heavy chain variable domain protein sequence


26
SCT-Da031 mature heavy chain variable domain protein sequence


27
SCT-Da032 mature heavy chain variable domain protein sequence


28
SCT-Da033 mature heavy chain variable domain protein sequence


29
SCT-Da034 mature heavy chain variable domain protein sequence


30
SCT-Da035 mature heavy chain variable domain protein sequence


31
SCT-Da036 mature heavy chain variable domain protein sequence


32
SCT-Da037 mature heavy chain variable domain protein sequence


33
SCT-Da038 mature heavy chain variable domain protein sequence


34
SCT-Da039 mature heavy chain variable domain protein sequence


35
SCT-Da040 mature heavy chain variable domain protein sequence


36
SCT-Da041 mature heavy chain variable domain protein sequence


37
SCT-Da042 mature heavy chain variable domain protein sequence


38
SCT-Da043 mature heavy chain variable domain protein sequence


39
SCT-Da044 mature heavy chain variable domain protein sequence


39
SCT-Da045 mature heavy chain variable domain protein sequence


40
SCT-Da046 mature heavy chain variable domain protein sequence


41
SCT-Da047 mature heavy chain variable domain protein sequence


41
SCT-Da048 mature heavy chain variable domain protein sequence


42
SCT-Da049 mature heavy chain variable domain protein sequence


43
SCT-Da050 mature heavy chain variable domain protein sequence


44
SCT-Da051 mature heavy chain variable domain protein sequence


45
SCT-Da052 mature heavy chain variable domain protein sequence


46
SCT-Da053 mature heavy chain variable domain protein sequence


47
SCT-Da054 mature heavy chain variable domain protein sequence


48
SCT-Da055 mature heavy chain variable domain protein sequence


49
SCT-Da056 mature heavy chain variable domain protein sequence


50
SCT-Da057 mature heavy chain variable domain protein sequence


51
SCT-Da058 mature heavy chain variable domain protein sequence


52
SCT-Da059 mature heavy chain variable domain protein sequence


53
SCT-Da060 mature heavy chain variable domain protein sequence


54
SCT-Da061 mature heavy chain variable domain protein sequence


55
SCT-Da062 mature heavy chain variable domain protein sequence


56
SCT-Da063 mature heavy chain variable domain protein sequence


57
SCT-Da064 mature heavy chain variable domain protein sequence


57
SCT-Da065 mature heavy chain variable domain protein sequence


58
SCT-Da066 mature heavy chain variable domain protein sequence


59
SCT-Da067 mature heavy chain variable domain protein sequence


59
SCT-Da068 mature heavy chain variable domain protein sequence


60
SCT-Da069 mature heavy chain variable domain protein sequence


60
SCT-Da070 mature heavy chain variable domain protein sequence


60
SCT-Da071 mature heavy chain variable domain protein sequence


60
SCT-Da072 mature heavy chain variable domain protein sequence


61
SCT-Da073 mature heavy chain variable domain protein sequence


62
SCT-Da074 mature heavy chain variable domain protein sequence


62
SCT-Da075 mature heavy chain variable domain protein sequence


62
SCT-Da076 mature heavy chain variable domain protein sequence


63
SCT-Da077 mature heavy chain variable domain protein sequence


63
SCT-Da078 mature heavy chain variable domain protein sequence


64
SCT-Da079 mature heavy chain variable domain protein sequence


65
SCT-Da080 mature heavy chain variable domain protein sequence


66
SCT-Da081 mature heavy chain variable domain protein sequence


67
SCT-Da082 mature heavy chain variable domain protein sequence


68
SCT-Da083 mature heavy chain variable domain protein sequence


68
SCT-Da084 mature heavy chain variable domain protein sequence


69
SCT-Da085 mature heavy chain variable domain protein sequence


70
SCT-Da086 mature heavy chain variable domain protein sequence


71
SCT-Da087 mature heavy chain variable domain protein sequence


72
SCT-Da088 mature heavy chain variable domain protein sequence


72
SCT-Da089 mature heavy chain variable domain protein sequence


72
SCT-Da090 mature heavy chain variable domain protein sequence


73
SCT-Da091 mature heavy chain variable domain protein sequence


74
SCT-Da092 mature heavy chain variable domain protein sequence


75
SCT-Da093 mature heavy chain variable domain protein sequence


75
SCT-Da094 mature heavy chain variable domain protein sequence


75
SCT-Da095 mature heavy chain variable domain protein sequence


76
SCT-Da096 mature heavy chain variable domain protein sequence


77
SCT-Da097 mature heavy chain variable domain protein sequence


77
SCT-Da098 mature heavy chain variable domain protein sequence


77
SCT-Da099 mature heavy chain variable domain protein sequence


77
SCT-Da100 mature heavy chain variable domain protein sequence


78
SCT-Da101 mature heavy chain variable domain protein sequence


79
SCT-Da102 mature heavy chain variable domain protein sequence


80
SCT-Da103 mature heavy chain variable domain protein sequence


80
SCT-Da104 mature heavy chain variable domain protein sequence


80
SCT-Da105 mature heavy chain variable domain protein sequence


81
SCT-Da106 mature heavy chain variable domain protein sequence


82
SCT-Da107 mature heavy chain variable domain protein sequence


82
SCT-Da108 mature heavy chain variable domain protein sequence


82
SCT-Da109 mature heavy chain variable domain protein sequence


82
SCT-Da110 mature heavy chain variable domain protein sequence


83
SCT-Da111 mature heavy chain variable domain protein sequence


83
SCT-Da112 mature heavy chain variable domain protein sequence


83
SCT-Da113 mature heavy chain variable domain protein sequence


83
SCT-Da114 mature heavy chain variable domain protein sequence


84
SCT-Da115 mature heavy chain variable domain protein sequence


85
SCT-Da116 mature heavy chain variable domain protein sequence


85
SCT-Da117 mature heavy chain variable domain protein sequence


85
SCT-Da118 mature heavy chain variable domain protein sequence


85
SCT-Da119 mature heavy chain variable domain protein sequence


86
SCT-Da120 mature heavy chain variable domain protein sequence


87
SCT-Da121 mature heavy chain variable domain protein sequence


87
SCT-Da122 mature heavy chain variable domain protein sequence


87
SCT-Da123 mature heavy chain variable domain protein sequence


87
SCT-Da124 mature heavy chain variable domain protein sequence


87
SCT-Da125 mature heavy chain variable domain protein sequence


87
SCT-Da126 mature heavy chain variable domain protein sequence


87
SCT-Da127 mature heavy chain variable domain protein sequence


87
SCT-Da128 mature heavy chain variable domain protein sequence


88
SCT-Da129 mature heavy chain variable domain protein sequence


89
SCT-Da130 mature heavy chain variable domain protein sequence


89
SCT-Da131 mature heavy chain variable domain protein sequence


90
SCT-Da132 mature heavy chain variable domain protein sequence


91
SCT-Da133 mature heavy chain variable domain protein sequence


91
SCT-Da134 mature heavy chain variable domain protein sequence


91
SCT-Da135 mature heavy chain variable domain protein sequence


91
SCT-Da136 mature heavy chain variable domain protein sequence


92
SCT-Da137 mature heavy chain variable domain protein sequence


92
SCT-Da138 mature heavy chain variable domain protein sequence


92
SCT-Da139 mature heavy chain variable domain protein sequence


93
SCT-Da140 mature heavy chain variable domain protein sequence


94
SCT-Da141 mature heavy chain variable domain protein sequence


95
SCT-Da142 mature heavy chain variable domain protein sequence


96
SCT-Da143 mature heavy chain variable domain protein sequence


97
SCT-Da144 mature heavy chain variable domain protein sequence


98
SCT-Da145 mature heavy chain variable domain protein sequence


99
SCT-Da146 mature heavy chain variable domain protein sequence


99
SCT-Da147 mature heavy chain variable domain protein sequence


99
SCT-Da148 mature heavy chain variable domain protein sequence


99
SCT-Da149 mature heavy chain variable domain protein sequence


99
SCT-Da150 mature heavy chain variable domain protein sequence


99
SCT-Da151 mature heavy chain variable domain protein sequence


99
SCT-Da152 mature heavy chain variable domain protein sequence


99
SCT-Da153 mature heavy chain variable domain protein sequence


99
SCT-Da154 mature heavy chain variable domain protein sequence


100
SCT-Da155 mature heavy chain variable domain protein sequence


101
SCT-Da156 mature heavy chain variable domain protein sequence


101
SCT-Da157 mature heavy chain variable domain protein sequence


101
SCT-Da158 mature heavy chain variable domain protein sequence


101
SCT-Da159 mature heavy chain variable domain protein sequence


102
SCT-Da160 mature heavy chain variable domain protein sequence


103
SCT-Da161 mature heavy chain variable domain protein sequence


104
SCT-Da162 mature heavy chain variable domain protein sequence


105
SCT-Da163 mature heavy chain variable domain protein sequence


105
SCT-Da164 mature heavy chain variable domain protein sequence


105
SCT-Da165 mature heavy chain variable domain protein sequence


105
SCT-Da166 mature heavy chain variable domain protein sequence


106
SCT-Da167 mature heavy chain variable domain protein sequence


106
SCT-Da168 mature heavy chain variable domain protein sequence


106
SCT-Da169 mature heavy chain variable domain protein sequence


106
SCT-Da170 mature heavy chain variable domain protein sequence


106
SCT-Da171 mature heavy chain variable domain protein sequence


106
SCT-Da172 mature heavy chain variable domain protein sequence


106
SCT-Da173 mature heavy chain variable domain protein sequence


106
SCT-Da174 mature heavy chain variable domain protein sequence


107
SCT-Da175 mature heavy chain variable domain protein sequence


108
SCT-Da176 mature heavy chain variable domain protein sequence


108
SCT-Da177 mature heavy chain variable domain protein sequence


108
SCT-Da178 mature heavy chain variable domain protein sequence


109
SCT-Da179 mature heavy chain variable domain protein sequence


110
SCT-Da180 mature heavy chain variable domain protein sequence


111
SCT-Da181 mature heavy chain variable domain protein sequence


112
SCT-Da182 mature heavy chain variable domain protein sequence


113
SCT-Da183 mature heavy chain variable domain protein sequence


114
SCT-Da184 mature heavy chain variable domain protein sequence


115
SCT-Da185 mature heavy chain variable domain protein sequence


116
SCT-Da186 mature heavy chain variable domain protein sequence


117
SCT-Da187 mature heavy chain variable domain protein sequence


118
SCT-Da188 mature heavy chain variable domain protein sequence


119
SCT-Da189 mature heavy chain variable domain protein sequence


120
SCT-Da190 mature heavy chain variable domain protein sequence


121
SCT-Da191 mature heavy chain variable domain protein sequence


121
SCT-Da192 mature heavy chain variable domain protein sequence


122
SCT-Da193 mature heavy chain variable domain protein sequence


123
SCT-Da194 mature heavy chain variable domain protein sequence


124
SCT-Da195 mature heavy chain variable domain protein sequence


124
SCT-Da196 mature heavy chain variable domain protein sequence


125
SCT-Da197 mature heavy chain variable domain protein sequence


126
SCT-Da198 mature heavy chain variable domain protein sequence


126
SCT-Da199 mature heavy chain variable domain protein sequence


126
SCT-Da200 mature heavy chain variable domain protein sequence


127
SCT-Da201 mature heavy chain variable domain protein sequence


128
SCT-Da202 mature heavy chain variable domain protein sequence


128
SCT-Da203 mature heavy chain variable domain protein sequence


128
SCT-Da204 mature heavy chain variable domain protein sequence


128
SCT-Da205 mature heavy chain variable domain protein sequence


129
SCT-Da206 mature heavy chain variable domain protein sequence


130
SCT-Da207 mature heavy chain variable domain protein sequence


131
SCT-Da208 mature heavy chain variable domain protein sequence


132
SCT-Da209 mature heavy chain variable domain protein sequence


133
SCT-Da210 mature heavy chain variable domain protein sequence


134
SCT-Da211 mature heavy chain variable domain protein sequence


135
SCT-Da212 mature heavy chain variable domain protein sequence


136
SCT-Da213 mature heavy chain variable domain protein sequence


137
SCT-Da214 mature heavy chain variable domain protein sequence


138
SCT-Da215 mature heavy chain variable domain protein sequence


139
SCT-Da216 mature heavy chain variable domain protein sequence


139
SCT-Da217 mature heavy chain variable domain protein sequence


140
SCT-Da218 mature heavy chain variable domain protein sequence


141
SCT-Da219 mature heavy chain variable domain protein sequence


142
SCT-Da220 mature heavy chain variable domain protein sequence


143
SCT-Da221 mature heavy chain variable domain protein sequence


144
SCT-Da222 mature heavy chain variable domain protein sequence


144
SCT-Da223 mature heavy chain variable domain protein sequence


145
SCT-Da224 mature heavy chain variable domain protein sequence


146
SCT-Da225 mature heavy chain variable domain protein sequence


147
SCT-Da226 mature heavy chain variable domain protein sequence


148
SCT-Da227 mature heavy chain variable domain protein sequence


149
SCT-Da228 mature heavy chain variable domain protein sequence


150
SCT-Da229 mature heavy chain variable domain protein sequence


151
SCT-Da230 mature heavy chain variable domain protein sequence


152
SCT-Da231 mature heavy chain variable domain protein sequence


153
SCT-Da232 mature heavy chain variable domain protein sequence


154
SCT-Da233 mature heavy chain variable domain protein sequence


155
SCT-Da234 mature heavy chain variable domain protein sequence


156
SCT-Da235 mature heavy chain variable domain protein sequence


157
SCT-Da236 mature heavy chain variable domain protein sequence


157
SCT-Da237 mature heavy chain variable domain protein sequence


158
SCT-Da238 mature heavy chain variable domain protein sequence


159
SCT-Da239 mature heavy chain variable domain protein sequence


160
SCT-Da240 mature heavy chain variable domain protein sequence


161
SCT-Da241 mature heavy chain variable domain protein sequence


162
SCT-Da242 mature heavy chain variable domain protein sequence


163
SCT-Da243 mature heavy chain variable domain protein sequence


164
SCT-Da244 mature heavy chain variable domain protein sequence


165
SCT-Da245 mature heavy chain variable domain protein sequence


165
SCT-Da246 mature heavy chain variable domain protein sequence


166
SCT-Da247 mature heavy chain variable domain protein sequence


167
SCT-Da248 mature heavy chain variable domain protein sequence


168
SCT-Da249 mature heavy chain variable domain protein sequence


169
SCT-Da250 mature heavy chain variable domain protein sequence


170
SCT-Da251 mature heavy chain variable domain protein sequence


171
SCT-Da252 mature heavy chain variable domain protein sequence


172
SCT-Da253 mature heavy chain variable domain protein sequence


173
SCT-Da254 mature heavy chain variable domain protein sequence


173
SCT-Da255 mature heavy chain variable domain protein sequence


174
SCT-Da256 mature heavy chain variable domain protein sequence


175
SCT-Da257 mature heavy chain variable domain protein sequence


176
SCT-Da258 mature heavy chain variable domain protein sequence


177
SCT-Da259 mature heavy chain variable domain protein sequence


178
SCT-Da260 mature heavy chain variable domain protein sequence


179
SCT-Da261 mature heavy chain variable domain protein sequence


180
SCT-Da262 mature heavy chain variable domain protein sequence


181
SCT-Da263 mature heavy chain variable domain protein sequence


182
SCT-Da264 mature heavy chain variable domain protein sequence


183
SCT-Da265 mature heavy chain variable domain protein sequence


184
SCT-Da266 mature heavy chain variable domain protein sequence


185
SCT-Da267 mature heavy chain variable domain protein sequence


186
SCT-Da268 mature heavy chain variable domain protein sequence


187
SCT-Da269 mature heavy chain variable domain protein sequence


188
SCT-Da270 mature heavy chain variable domain protein sequence


188
SCT-Da271 mature heavy chain variable domain protein sequence


189
SCT-Da272 mature heavy chain variable domain protein sequence


190
SCT-Da273 mature heavy chain variable domain protein sequence


190
SCT-Da274 mature heavy chain variable domain protein sequence


191
SCT-Da275 mature heavy chain variable domain protein sequence


192
SCT-Da276 mature heavy chain variable domain protein sequence


193
SCT-Da277 mature heavy chain variable domain protein sequence


194
SCT-Da278 mature heavy chain variable domain protein sequence


194
SCT-Da279 mature heavy chain variable domain protein sequence


196
SCT-Da280 mature heavy chain variable domain protein sequence


197
SCT-Da281 mature heavy chain variable domain protein sequence


198
SCT-Da282 mature heavy chain variable domain protein sequence


199
SCT-Da283 mature heavy chain variable domain protein sequence


199
SCT-Da284 mature heavy chain variable domain protein sequence


199
SCT-Da285 mature heavy chain variable domain protein sequence


199
SCT-Da286 mature heavy chain variable domain protein sequence


199
SCT-Da287 mature heavy chain variable domain protein sequence


199
SCT-Da288 mature heavy chain variable domain protein sequence


199
SCT-Da289 mature heavy chain variable domain protein sequence


199
SCT-Da290 mature heavy chain variable domain protein sequence


199
SCT-Da291 mature heavy chain variable domain protein sequence


199
SCT-Da292 mature heavy chain variable domain protein sequence


199
SCT-Da293 mature heavy chain variable domain protein sequence


200
SCT-Da294 mature heavy chain variable domain protein sequence


200
SCT-Da295 mature heavy chain variable domain protein sequence


200
SCT-Da296 mature heavy chain variable domain protein sequence


200
SCT-Da297 mature heavy chain variable domain protein sequence


200
SCT-Da298 mature heavy chain variable domain protein sequence


200
SCT-Da299 mature heavy chain variable domain protein sequence


200
SCT-Da300 mature heavy chain variable domain protein sequence


200
SCT-Da301 mature heavy chain variable domain protein sequence


200
SCT-Da302 mature heavy chain variable domain protein sequence


200
SCT-Da303 mature heavy chain variable domain protein sequence


201
SCT-Da304 mature heavy chain variable domain protein sequence


202
SCT-Da305 mature heavy chain variable domain protein sequence


203
SCT-Da306 mature heavy chain variable domain protein sequence


204
SCT-Da307 mature heavy chain variable domain protein sequence


204
SCT-Da308 mature heavy chain variable domain protein sequence


205
SCT-Da309 mature heavy chain variable domain protein sequence


205
SCT-Da310 mature heavy chain variable domain protein sequence


206
SCT-Da311 mature heavy chain variable domain protein sequence


207
SCT-Da312 mature heavy chain variable domain protein sequence


208
SCT-Da313 mature heavy chain variable domain protein sequence


209
SCT-Da314 mature heavy chain variable domain protein sequence


210
SCT-Da315 mature heavy chain variable domain protein sequence


211
SCT-Da316 mature heavy chain variable domain protein sequence


212
SCT-Da317 mature heavy chain variable domain protein sequence


213
SCT-Da318 mature heavy chain variable domain protein sequence


214
SCT-Da319 mature heavy chain variable domain protein sequence


215
SCT-Da320 mature heavy chain variable domain protein sequence


215
SCT-Da321 mature heavy chain variable domain protein sequence


216
SCT-Da322 mature heavy chain variable domain protein sequence


217
SCT-Da323 mature heavy chain variable domain protein sequence


218
SCT-Da324 mature heavy chain variable domain protein sequence


219
SCT-Da325 mature heavy chain variable domain protein sequence


220
SCT-Da326 mature heavy chain variable domain protein sequence


221
SCT-Da327 mature heavy chain variable domain protein sequence


222
SCT-Da328 mature heavy chain variable domain protein sequence


222
SCT-Da329 mature heavy chain variable domain protein sequence


222
SCT-Da330 mature heavy chain variable domain protein sequence


223
SCT-Da331 mature heavy chain variable domain protein sequence


224
SCT-Da332 mature heavy chain variable domain protein sequence


225
SCT-Da333 mature heavy chain variable domain protein sequence


225
SCT-Da334 mature heavy chain variable domain protein sequence


225
SCT-Da335 mature heavy chain variable domain protein sequence


226
SCT-Da336 mature heavy chain variable domain protein sequence


227
SCT-Da337 mature heavy chain variable domain protein sequence


228
SCT-Da338 mature heavy chain variable domain protein sequence


229
SCT-Da339 mature heavy chain variable domain protein sequence


230
SCT-Da340 mature heavy chain variable domain protein sequence


231
SCT-Da341 mature heavy chain variable domain protein sequence


232
SCT-Da342 mature heavy chain variable domain protein sequence


233
SCT-Da343 mature heavy chain variable domain protein sequence


234
SCT-Da344 mature heavy chain variable domain protein sequence


235
SCT-Da345 mature heavy chain variable domain protein sequence


236
SCT-Da346 mature heavy chain variable domain protein sequence


237
SCT-Da347 mature heavy chain variable domain protein sequence


238
SCT-Da348 mature heavy chain variable domain protein sequence


239
SCT-Da349 mature heavy chain variable domain protein sequence


239
SCT-Da350 mature heavy chain variable domain protein sequence


239
SCT-Da351 mature heavy chain variable domain protein sequence


240
SCT-Da352 mature heavy chain variable domain protein sequence


241
SCT-Da353 mature heavy chain variable domain protein sequence


242
SCT-Da354 mature heavy chain variable domain protein sequence


242
SCT-Da355 mature heavy chain variable domain protein sequence


242
SCT-Da356 mature heavy chain variable domain protein sequence


242
SCT-Da357 mature heavy chain variable domain protein sequence


243
SCT-Da358 mature heavy chain variable domain protein sequence


244
SCT-Da359 mature heavy chain variable domain protein sequence


245
SCT-Da360 mature heavy chain variable domain protein sequence


246
SCT-Da361 mature heavy chain variable domain protein sequence


246
SCT-Da362 mature heavy chain variable domain protein sequence


247
SCT-Da001 mature light chain variable domain protein sequence


248
SCT-Da002 mature light chain variable domain protein sequence


249
SCT-Da003 mature light chain variable domain protein sequence


249
SCT-Da071 mature light chain variable domain protein sequence


249
SCT-Da073 mature light chain variable domain protein sequence


249
SCT-Da076 mature light chain variable domain protein sequence


250
SCT-Da004 mature light chain variable domain protein sequence


250
SCT-Da021 mature light chain variable domain protein sequence


250
SCT-Da022 mature light chain variable domain protein sequence


250
SCT-Da025 mature light chain variable domain protein sequence


251
SCT-Da005 mature light chain variable domain protein sequence


252
SCT-Da006 mature light chain variable domain protein sequence


252
SCT-Da283 mature light chain variable domain protein sequence


253
SCT-Da007 mature light chain variable domain protein sequence


254
SCT-Da008 mature light chain variable domain protein sequence


254
SCT-Da011 mature light chain variable domain protein sequence


254
SCT-Da013 mature light chain variable domain protein sequence


255
SCT-Da009 mature light chain variable domain protein sequence


256
SCT-Da010 mature light chain variable domain protein sequence


256
SCT-Da012 mature light chain variable domain protein sequence


257
SCT-Da014 mature light chain variable domain protein sequence


257
SCT-Da019 mature light chain variable domain protein sequence


257
SCT-Da080 mature light chain variable domain protein sequence


258
SCT-Da015 mature light chain variable domain protein sequence


259
SCT-Da016 mature light chain variable domain protein sequence


260
SCT-Da017 mature light chain variable domain protein sequence


261
SCT-Da018 mature light chain variable domain protein sequence


261
SCT-Da164 mature light chain variable domain protein sequence


262
SCT-Da020 mature light chain variable domain protein sequence


262
SCT-Da175 mature light chain variable domain protein sequence


263
SCT-Da023 mature light chain variable domain protein sequence


263
SCT-Da024 mature light chain variable domain protein sequence


264
SCT-Da026 mature light chain variable domain protein sequence


264
SCT-Da063 mature light chain variable domain protein sequence


264
SCT-Da068 mature light chain variable domain protein sequence


264
SCT-Da077 mature light chain variable domain protein sequence


264
SCT-Da285 mature light chain variable domain protein sequence


264
SCT-Da296 mature light chain variable domain protein sequence


265
SCT-Da027 mature light chain variable domain protein sequence


265
SCT-Da303 mature light chain variable domain protein sequence


265
SCT-Da357 mature light chain variable domain protein sequence


266
SCT-Da028 mature light chain variable domain protein sequence


266
SCT-Da034 mature light chain variable domain protein sequence


267
SCT-Da029 mature light chain variable domain protein sequence


267
SCT-Da163 mature light chain variable domain protein sequence


268
SCT-Da030 mature light chain variable domain protein sequence


269
SCT-Da031 mature light chain variable domain protein sequence


270
SCT-Da032 mature light chain variable domain protein sequence


271
SCT-Da033 mature light chain variable domain protein sequence


272
SCT-Da035 mature light chain variable domain protein sequence


273
SCT-Da036 mature light chain variable domain protein sequence


274
SCT-Da037 mature light chain variable domain protein sequence


275
SCT-Da038 mature light chain variable domain protein sequence


276
SCT-Da039 mature light chain variable domain protein sequence


277
SCT-Da040 mature light chain variable domain protein sequence


278
SCT-Da041 mature light chain variable domain protein sequence


279
SCT-Da042 mature light chain variable domain protein sequence


280
SCT-Da043 mature light chain variable domain protein sequence


281
SCT-Da044 mature light chain variable domain protein sequence


282
SCT-Da045 mature light chain variable domain protein sequence


283
SCT-Da046 mature light chain variable domain protein sequence


283
SCT-Da083 mature light chain variable domain protein sequence


283
SCT-Da176 mature light chain variable domain protein sequence


284
SCT-Da047 mature light chain variable domain protein sequence


284
SCT-Da146 mature light chain variable domain protein sequence


285
SCT-Da048 mature light chain variable domain protein sequence


286
SCT-Da049 mature light chain variable domain protein sequence


287
SCT-Da050 mature light chain variable domain protein sequence


287
SCT-Da053 mature light chain variable domain protein sequence


288
SCT-Da051 mature light chain variable domain protein sequence


289
SCT-Da052 mature light chain variable domain protein sequence


290
SCT-Da054 mature light chain variable domain protein sequence


291
SCT-Da055 mature light chain variable domain protein sequence


292
SCT-Da056 mature light chain variable domain protein sequence


293
SCT-Da057 mature light chain variable domain protein sequence


293
SCT-Da086 mature light chain variable domain protein sequence


293
SCT-Da090 mature light chain variable domain protein sequence


293
SCT-Da286 mature light chain variable domain protein sequence


294
SCT-Da058 mature light chain variable domain protein sequence


294
SCT-Da059 mature light chain variable domain protein sequence


294
SCT-Da134 mature light chain variable domain protein sequence


294
SCT-Da198 mature light chain variable domain protein sequence


294
SCT-Da202 mature light chain variable domain protein sequence


294
SCT-Da288 mature light chain variable domain protein sequence


295
SCT-Da060 mature light chain variable domain protein sequence


296
SCT-Da061 mature light chain variable domain protein sequence


296
SCT-Da147 mature light chain variable domain protein sequence


297
SCT-Da062 mature light chain variable domain protein sequence


298
SCT-Da064 mature light chain variable domain protein sequence


299
SCT-Da065 mature light chain variable domain protein sequence


300
SCT-Da066 mature light chain variable domain protein sequence


301
SCT-Da067 mature light chain variable domain protein sequence


301
SCT-Da284 mature light chain variable domain protein sequence


302
SCT-Da069 mature light chain variable domain protein sequence


303
SCT-Da070 mature light chain variable domain protein sequence


304
SCT-Da072 mature light chain variable domain protein sequence


304
SCT-Da116 mature light chain variable domain protein sequence


304
SCT-Da145 mature light chain variable domain protein sequence


304
SCT-Da148 mature light chain variable domain protein sequence


304
SCT-Da157 mature light chain variable domain protein sequence


304
SCT-Da299 mature light chain variable domain protein sequence


304
SCT-Da349 mature light chain variable domain protein sequence


305
SCT-Da074 mature light chain variable domain protein sequence


305
SCT-Da089 mature light chain variable domain protein sequence


305
SCT-Da247 mature light chain variable domain protein sequence


306
SCT-Da075 mature light chain variable domain protein sequence


307
SCT-Da078 mature light chain variable domain protein sequence


308
SCT-Da079 mature light chain variable domain protein sequence


309
SCT-Da081 mature light chain variable domain protein sequence


310
SCT-Da082 mature light chain variable domain protein sequence


311
SCT-Da084 mature light chain variable domain protein sequence


312
SCT-Da085 mature light chain variable domain protein sequence


312
SCT-Da172 mature light chain variable domain protein sequence


312
SCT-Da291 mature light chain variable domain protein sequence


313
SCT-Da087 mature light chain variable domain protein sequence


313
SCT-Da131 mature light chain variable domain protein sequence


314
SCT-Da088 mature light chain variable domain protein sequence


314
SCT-Da156 mature light chain variable domain protein sequence


315
SCT-Da091 mature light chain variable domain protein sequence


316
SCT-Da092 mature light chain variable domain protein sequence


316
SCT-Da140 mature light chain variable domain protein sequence


317
SCT-Da093 mature light chain variable domain protein sequence


317
SCT-Da209 mature light chain variable domain protein sequence


317
SCT-Da211 mature light chain variable domain protein sequence


318
SCT-Da094 mature light chain variable domain protein sequence


318
SCT-Da101 mature light chain variable domain protein sequence


318
SCT-Da105 mature light chain variable domain protein sequence


318
SCT-Da106 mature light chain variable domain protein sequence


318
SCT-Da112 mature light chain variable domain protein sequence


318
SCT-Da118 mature light chain variable domain protein sequence


318
SCT-Da129 mature light chain variable domain protein sequence


318
SCT-Da151 mature light chain variable domain protein sequence


318
SCT-Da289 mature light chain variable domain protein sequence


318
SCT-Da300 mature light chain variable domain protein sequence


319
SCT-Da095 mature light chain variable domain protein sequence


320
SCT-Da096 mature light chain variable domain protein sequence


321
SCT-Da097 mature light chain variable domain protein sequence


321
SCT-Da102 mature light chain variable domain protein sequence


322
SCT-Da098 mature light chain variable domain protein sequence


322
SCT-Da159 mature light chain variable domain protein sequence


323
SCT-Da099 mature light chain variable domain protein sequence


324
SCT-Da100 mature light chain variable domain protein sequence


324
SCT-Da301 mature light chain variable domain protein sequence


325
SCT-Da103 mature light chain variable domain protein sequence


326
SCT-Da104 mature light chain variable domain protein sequence


326
SCT-Da117 mature light chain variable domain protein sequence


326
SCT-Da123 mature light chain variable domain protein sequence


327
SCT-Da107 mature light chain variable domain protein sequence


328
SCT-Da108 mature light chain variable domain protein sequence


328
SCT-Da295 mature light chain variable domain protein sequence


329
SCT-Da109 mature light chain variable domain protein sequence


329
SCT-Da133 mature light chain variable domain protein sequence


329
SCT-Da191 mature light chain variable domain protein sequence


329
SCT-Da222 mature light chain variable domain protein sequence


330
SCT-Da110 mature light chain variable domain protein sequence


331
SCT-Da111 mature light chain variable domain protein sequence


331
SCT-Da327 mature light chain variable domain protein sequence


332
SCT-Da113 mature light chain variable domain protein sequence


332
SCT-Da119 mature light chain variable domain protein sequence


332
SCT-Da158 mature light chain variable domain protein sequence


333
SCT-Da114 mature light chain variable domain protein sequence


333
SCT-Da128 mature light chain variable domain protein sequence


333
SCT-Da135 mature light chain variable domain protein sequence


333
SCT-Da181 mature light chain variable domain protein sequence


333
SCT-Da183 mature light chain variable domain protein sequence


333
SCT-Da188 mature light chain variable domain protein sequence


333
SCT-Da189 mature light chain variable domain protein sequence


333
SCT-Da192 mature light chain variable domain protein sequence


333
SCT-Da200 mature light chain variable domain protein sequence


333
SCT-Da201 mature light chain variable domain protein sequence


333
SCT-Da205 mature light chain variable domain protein sequence


333
SCT-Da206 mature light chain variable domain protein sequence


333
SCT-Da207 mature light chain variable domain protein sequence


333
SCT-Da216 mature light chain variable domain protein sequence


333
SCT-Da220 mature light chain variable domain protein sequence


333
SCT-Da223 mature light chain variable domain protein sequence


333
SCT-Da255 mature light chain variable domain protein sequence


333
SCT-Da302 mature light chain variable domain protein sequence


333
SCT-Da321 mature light chain variable domain protein sequence


333
SCT-Da362 mature light chain variable domain protein sequence


334
SCT-Da115 mature light chain variable domain protein sequence


335
SCT-Da120 mature light chain variable domain protein sequence


336
SCT-Da121 mature light chain variable domain protein sequence


337
SCT-Da122 mature light chain variable domain protein sequence


337
SCT-Da287 mature light chain variable domain protein sequence


338
SCT-Da124 mature light chain variable domain protein sequence


339
SCT-Da125 mature light chain variable domain protein sequence


340
SCT-Da126 mature light chain variable domain protein sequence


341
SCT-Da127 mature light chain variable domain protein sequence


342
SCT-Da130 mature light chain variable domain protein sequence


342
SCT-Da132 mature light chain variable domain protein sequence


342
SCT-Da144 mature light chain variable domain protein sequence


343
SCT-Da136 mature light chain variable domain protein sequence


344
SCT-Da137 mature light chain variable domain protein sequence


345
SCT-Da138 mature light chain variable domain protein sequence


346
SCT-Da139 mature light chain variable domain protein sequence


347
SCT-Da141 mature light chain variable domain protein sequence


348
SCT-Da142 mature light chain variable domain protein sequence


349
SCT-Da143 mature light chain variable domain protein sequence


349
SCT-Da226 mature light chain variable domain protein sequence


350
SCT-Da149 mature light chain variable domain protein sequence


351
SCT-Da150 mature light chain variable domain protein sequence


352
SCT-Da152 mature light chain variable domain protein sequence


353
SCT-Da153 mature light chain variable domain protein sequence


354
SCT-Da154 mature light chain variable domain protein sequence


354
SCT-Da350 mature light chain variable domain protein sequence


355
SCT-Da155 mature light chain variable domain protein sequence


356
SCT-Da160 mature light chain variable domain protein sequence


356
SCT-Da161 mature light chain variable domain protein sequence


357
SCT-Da162 mature light chain variable domain protein sequence


358
SCT-Da165 mature light chain variable domain protein sequence


358
SCT-Da290 mature light chain variable domain protein sequence


359
SCT-Da166 mature light chain variable domain protein sequence


359
SCT-Da177 mature light chain variable domain protein sequence


359
SCT-Da203 mature light chain variable domain protein sequence


360
SCT-Da167 mature light chain variable domain protein sequence


361
SCT-Da168 mature light chain variable domain protein sequence


362
SCT-Da169 mature light chain variable domain protein sequence


363
SCT-Da170 mature light chain variable domain protein sequence


364
SCT-Da171 mature light chain variable domain protein sequence


365
SCT-Da173 mature light chain variable domain protein sequence


366
SCT-Da174 mature light chain variable domain protein sequence


366
SCT-Da293 mature light chain variable domain protein sequence


366
SCT-Da330 mature light chain variable domain protein sequence


367
SCT-Da178 mature light chain variable domain protein sequence


368
SCT-Da179 mature light chain variable domain protein sequence


368
SCT-Da180 mature light chain variable domain protein sequence


369
SCT-Da182 mature light chain variable domain protein sequence


370
SCT-Da184 mature light chain variable domain protein sequence


371
SCT-Da185 mature light chain variable domain protein sequence


371
SCT-Da292 mature light chain variable domain protein sequence


372
SCT-Da186 mature light chain variable domain protein sequence


373
SCT-Da187 mature light chain variable domain protein sequence


374
SCT-Da190 mature light chain variable domain protein sequence


375
SCT-Da193 mature light chain variable domain protein sequence


376
SCT-Da194 mature light chain variable domain protein sequence


377
SCT-Da195 mature light chain variable domain protein sequence


377
SCT-Da199 mature light chain variable domain protein sequence


378
SCT-Da196 mature light chain variable domain protein sequence


379
SCT-Da197 mature light chain variable domain protein sequence


380
SCT-Da204 mature light chain variable domain protein sequence


381
SCT-Da208 mature light chain variable domain protein sequence


382
SCT-Da210 mature light chain variable domain protein sequence


383
SCT-Da212 mature light chain variable domain protein sequence


384
SCT-Da213 mature light chain variable domain protein sequence


385
SCT-Da214 mature light chain variable domain protein sequence


386
SCT-Da215 mature light chain variable domain protein sequence


386
SCT-Da217 mature light chain variable domain protein sequence


387
SCT-Da218 mature light chain variable domain protein sequence


387
SCT-Da274 mature light chain variable domain protein sequence


388
SCT-Da219 mature light chain variable domain protein sequence


389
SCT-Da221 mature light chain variable domain protein sequence


390
SCT-Da224 mature light chain variable domain protein sequence


391
SCT-Da225 mature light chain variable domain protein sequence


392
SCT-Da227 mature light chain variable domain protein sequence


393
SCT-Da228 mature light chain variable domain protein sequence


394
SCT-Da229 mature light chain variable domain protein sequence


395
SCT-Da230 mature light chain variable domain protein sequence


396
SCT-Da231 mature light chain variable domain protein sequence


397
SCT-Da232 mature light chain variable domain protein sequence


397
SCT-Da244 mature light chain variable domain protein sequence


397
SCT-Da246 mature light chain variable domain protein sequence


397
SCT-Da248 mature light chain variable domain protein sequence


398
SCT-Da233 mature light chain variable domain protein sequence


399
SCT-Da234 mature light chain variable domain protein sequence


400
SCT-Da235 mature light chain variable domain protein sequence


400
SCT-Da333 mature light chain variable domain protein sequence


401
SCT-Da236 mature light chain variable domain protein sequence


402
SCT-Da237 mature light chain variable domain protein sequence


403
SCT-Da238 mature light chain variable domain protein sequence


404
SCT-Da239 mature light chain variable domain protein sequence


405
SCT-Da240 mature light chain variable domain protein sequence


406
SCT-Da241 mature light chain variable domain protein sequence


407
SCT-Da242 mature light chain variable domain protein sequence


408
SCT-Da243 mature light chain variable domain protein sequence


409
SCT-Da245 mature light chain variable domain protein sequence


410
SCT-Da249 mature light chain variable domain protein sequence


410
SCT-Da319 mature light chain variable domain protein sequence


411
SCT-Da250 mature light chain variable domain protein sequence


411
SCT-Da297 mature light chain variable domain protein sequence


412
SCT-Da251 mature light chain variable domain protein sequence


413
SCT-Da252 mature light chain variable domain protein sequence


413
SCT-Da298 mature light chain variable domain protein sequence


414
SCT-Da253 mature light chain variable domain protein sequence


415
SCT-Da254 mature light chain variable domain protein sequence


416
SCT-Da256 mature light chain variable domain protein sequence


417
SCT-Da257 mature light chain variable domain protein sequence


418
SCT-Da258 mature light chain variable domain protein sequence


419
SCT-Da259 mature light chain variable domain protein sequence


419
SCT-Da260 mature light chain variable domain protein sequence


420
SCT-Da261 mature light chain variable domain protein sequence


421
SCT-Da262 mature light chain variable domain protein sequence


422
SCT-Da263 mature light chain variable domain protein sequence


423
SCT-Da264 mature light chain variable domain protein sequence


424
SCT-Da265 mature light chain variable domain protein sequence


425
SCT-Da266 mature light chain variable domain protein sequence


426
SCT-Da267 mature light chain variable domain protein sequence


427
SCT-Da268 mature light chain variable domain protein sequence


428
SCT-Da269 mature light chain variable domain protein sequence


429
SCT-Da270 mature light chain variable domain protein sequence


429
SCT-Da273 mature light chain variable domain protein sequence


429
SCT-Da280 mature light chain variable domain protein sequence


429
SCT-Da304 mature light chain variable domain protein sequence


430
SCT-Da271 mature light chain variable domain protein sequence


430
SCT-Da275 mature light chain variable domain protein sequence


430
SCT-Da294 mature light chain variable domain protein sequence


431
SCT-Da272 mature light chain variable domain protein sequence


432
SCT-Da276 mature light chain variable domain protein sequence


433
SCT-Da277 mature light chain variable domain protein sequence


434
SCT-Da278 mature light chain variable domain protein sequence


434
SCT-Da279 mature light chain variable domain protein sequence


434
SCT-Da281 mature light chain variable domain protein sequence


435
SCT-Da282 mature light chain variable domain protein sequence


436
SCT-Da305 mature light chain variable domain protein sequence


437
SCT-Da306 mature light chain variable domain protein sequence


438
SCT-Da307 mature light chain variable domain protein sequence


438
SCT-Da310 mature light chain variable domain protein sequence


438
SCT-Da331 mature light chain variable domain protein sequence


439
SCT-Da308 mature light chain variable domain protein sequence


440
SCT-Da309 mature light chain variable domain protein sequence


441
SCT-Da311 mature light chain variable domain protein sequence


442
SCT-Da312 mature light chain variable domain protein sequence


443
SCT-Da313 mature light chain variable domain protein sequence


443
SCT-Da314 mature light chain variable domain protein sequence


444
SCT-Da315 mature light chain variable domain protein sequence


445
SCT-Da316 mature light chain variable domain protein sequence


446
SCT-Da317 mature light chain variable domain protein sequence


447
SCT-Da318 mature light chain variable domain protein sequence


448
SCT-Da320 mature light chain variable domain protein sequence


449
SCT-Da322 mature light chain variable domain protein sequence


450
SCT-Da323 mature light chain variable domain protein sequence


451
SCT-Da324 mature light chain variable domain protein sequence


452
SCT-Da325 mature light chain variable domain protein sequence


453
SCT-Da326 mature light chain variable domain protein sequence


454
SCT-Da328 mature light chain variable domain protein sequence


455
SCT-Da329 mature light chain variable domain protein sequence


456
SCT-Da332 mature light chain variable domain protein sequence


456
SCT-Da336 mature light chain variable domain protein sequence


457
SCT-Da334 mature light chain variable domain protein sequence


457
SCT-Da338 mature light chain variable domain protein sequence


458
SCT-Da335 mature light chain variable domain protein sequence


459
SCT-Da337 mature light chain variable domain protein sequence


460
SCT-Da339 mature light chain variable domain protein sequence


461
SCT-Da340 mature light chain variable domain protein sequence


462
SCT-Da341 mature light chain variable domain protein sequence


463
SCT-Da342 mature light chain variable domain protein sequence


464
SCT-Da343 mature light chain variable domain protein sequence


465
SCT-Da344 mature light chain variable domain protein sequence


466
SCT-Da345 mature light chain variable domain protein sequence


467
SCT-Da346 mature light chain variable domain protein sequence


468
SCT-Da347 mature light chain variable domain protein sequence


468
SCT-Da359 mature light chain variable domain protein sequence


469
SCT-Da348 mature light chain variable domain protein sequence


470
SCT-Da351 mature light chain variable domain protein sequence


471
SCT-Da352 mature light chain variable domain protein sequence


472
SCT-Da353 mature light chain variable domain protein sequence


473
SCT-Da354 mature light chain variable domain protein sequence


474
SCT-Da355 mature light chain variable domain protein sequence


475
SCT-Da356 mature light chain variable domain protein sequence


476
SCT-Da358 mature light chain variable domain protein sequence


477
SCT-Da360 mature light chain variable domain protein sequence


478
SCT-Da361 mature light chain variable domain protein sequence


973
SCT-Da363 mature heavy chain variable domain protein sequence


973
SCT-Da364 mature heavy chain variable domain protein sequence


974
SCT-Da363 mature light chain variable domain protein sequence


975
SCT-Da364 mature light chain variable domain protein sequence


976
SCT-Da365 mature heavy chain variable domain protein sequence


976
SCT-Da366 mature heavy chain variable domain protein sequence


976
SCT-Da367 mature heavy chain variable domain protein sequence


977
SCT-Da365 mature light chain variable domain protein sequence


977
SCT-Da368 mature light chain variable domain protein sequence


978
SCT-Da366 mature light chain variable domain protein sequence


978
SCT-Da369 mature light chain variable domain protein sequence


979
SCT-Da367 mature light chain variable domain protein sequence


979
SCT-Da370 mature light chain variable domain protein sequence


980
SCT-Da368 mature heavy chain variable domain protein sequence


980
SCT-Da369 mature heavy chain variable domain protein sequence


980
SCT-Da370 mature heavy chain variable domain protein sequence


981
SCT-Da371 mature heavy chain variable domain protein sequence


981
SCT-Da372 mature heavy chain variable domain protein sequence


982
SCT-Da371 mature light chain variable domain protein sequence


982
SCT-Da373 mature light chain variable domain protein sequence


983
SCT-Da372 mature light chain variable domain protein sequence


983
SCT-Da374 mature light chain variable domain protein sequence


984
SCT-Da373 mature heavy chain variable domain protein sequence


984
SCT-Da374 mature heavy chain variable domain protein sequence














DETAILED DESCRIPTION

The disclosure provides antibodies that bind to B7-H3. In one embodiment, the disclosure provides an isolated antibody that binds to SEQ ID NO:1.


Antibodies

The disclosure provides antibodies that bind specifically to SEQ ID NO:1. The term “antibody” as used herein, includes both full-length immunoglobulins and antibody fragments that bind to the same antigens. The antibodies can be, e.g., a monoclonal, polyclonal, chimeric, humanized, or single chain antibody. As used herein, the terms “antigen binding fragment,” “fragment,” and “antibody fragment” are used interchangeably to refer to any fragment that comprises a portion of a full-length antibody, generally at least the antigen binding portion or the variable region thereof. Examples of antibody fragments include, but are not limited to, diabodies, single-chain antibody molecules, multi-specific antibodies, Fab, Fab′, F(ab′)2, Fv or scFv.


The phrase “therapeutically effective” is intended to qualify the amount of active ingredients used in the treatment of a disease or disorder or on the effecting of a clinical endpoint.


The term “therapeutically acceptable” refers to those compounds (or salts, prodrugs, tautomers, zwitterionic forms, etc.) which are suitable for use in contact with the tissues of patients without undue toxicity, irritation, and allergic response, are commensurate with a reasonable benefit/risk ratio, and are effective for their intended use.


The terms “treating,” “treatment,” and the like, as used herein, mean ameliorating a disease, so as to reduce, ameliorate, or eliminate its cause, its progression, its severity, or one or more of its symptoms, or otherwise beneficially alter the disease in a subject. Reference to “treating,” or “treatment” of a patient is intended to include prophylaxis. Treatment may also be preemptive in nature, i.e., it may include prevention of disease in a subject exposed to or at risk for the disease. Prevention of a disease may involve complete protection from disease, for example as in the case of prevention of infection with a pathogen or may involve prevention of disease progression. For example, prevention of a disease may not mean complete foreclosure of any effect related to the diseases at any level, but instead may mean prevention of the symptoms of a disease to a clinically significant or detectable level. Prevention of diseases may also mean prevention of progression of a disease to a later stage of the disease.


The terms “subject” and “patient” are used interchangeably herein to mean all mammals including humans. Examples of subjects include, but are not limited to, humans, monkeys, dogs, cats, horses, cows, goats, sheep, pigs, and rabbits. In one embodiment, the subject or patient is a human.


In certain embodiments, the cancer treated with the anti-B7-H3 antibody molecule, alone or in combination, includes but is not limited to, a solid tumor, a hematological cancer (e.g., leukemia, lymphoma, myeloma), and a metastatic lesion thereof. In one embodiment, the cancer is a solid tumor. Examples of solid tumors include malignancies, e.g., sarcomas and carcinomas (e.g., adenocarcinomas), of the various organ systems, such as those affecting lung, breast, lymphoid, gastrointestinal or colorectal, genitals and genitourinary tract (e.g., renal, urothelial, bladder cells), pharynx, CNS (e.g., brain, neural or glial cells), skin (e.g., melanoma), head and neck (e.g., head and neck squamous cell carcinoma (HNCC)), and pancreas. For example, melanoma, colon cancers, gastric cancer, rectal cancer, renal-cell carcinoma, breast cancer (e.g., a breast cancer that does not express one, two or all of estrogen receptor, progesterone receptor, or Her2/neu, e.g., a triple negative breast cancer), liver cancer, a lung cancer (e.g., a non-small cell lung cancer (NSCLC) (e.g., a NSCLC with squamous and/or non-squamous histology) or small cell lung cancer), prostate cancer, cancer of head or neck (e.g., HPV+ squamous cell carcinoma), cancer of the small intestine and cancer of the esophagus. Examples of hematological cancer include, but is not limited to, leukemia (e.g., a myeloid leukemia, lymphoid leukemia, or chronic lymphocytic leukemia (CLL)), lymphoma (e.g., Hogdkin lymphoma (HL), non-Hogdkin lymphoma (NHL), Diffuse large B-cell lymphoma (DLBCL), T-cell lymphoma, or mantle cell lymphoma (MCL)), and myeloma, e.g., multiple myeloma. The cancer may be at an early, intermediate, late stage or metastatic cancer. For discovering and developing antibody therapeutics to B7-H3 generally known in the art, please see U.S. Pat. No. 9,207,238, which is incorporated in its entirety by reference.


The provided antibodies disclosed herein can be used to treat, prevent and/or diagnose cancerous or malignant disorders (e.g., cancers such melanoma, e.g., advanced stage melanoma; pancreatic cancer, e.g., advanced pancreatic cancer; solid tumors; breast cancer, e.g., metastatic breast carcinoma; renal cell carcinoma, e.g., advanced or metastatic renal cell carcinoma (MRCC) or clear cell renal cell carcinoma), as well as infectious diseases (e.g., hepatitis, e.g., hepatitis B; influenza).


The disclosure provides the antibodies SCT-Da001, SCT-Da002, SCT-Da003, SCT-Da004, SCT-Da005, SCT-Da006, SCT-Da007, SCT-Da008, SCT-Da009, SCT-Da010, SCT-Da011, SCT-Da012, SCT-Da013, SCT-Da014, SCT-Da015, SCT-Da016, SCT-Da017, SCT-Da018, SCT-Da019, SCT-Da020, SCT-Da021, SCT-Da022, SCT-Da023, SCT-Da024, SCT-Da025, SCT-Da026, SCT-Da027, SCT-Da028, SCT-Da029, SCT-Da030, SCT-Da031, SCT-Da032, SCT-Da033, SCT-Da034, SCT-Da035, SCT-Da036, SCT-Da037, SCT-Da038, SCT-Da039, SCT-Da040, SCT-Da041, SCT-Da042, SCT-Da043, SCT-Da044, SCT-Da045, SCT-Da046, SCT-Da047, SCT-Da048, SCT-Da049, SCT-Da050, SCT-Da051, SCT-Da052, SCT-Da053, SCT-Da054, SCT-Da055, SCT-Da056, SCT-Da057, SCT-Da058, SCT-Da059, SCT-Da060, SCT-Da061, SCT-Da062, SCT-Da063, SCT-Da064, SCT-Da065, SCT-Da066, SCT-Da067, SCT-Da068, SCT-Da069, SCT-Da070, SCT-Da071, SCT-Da072, SCT-Da073, SCT-Da074, SCT-Da075, SCT-Da076, SCT-Da077, SCT-Da078, SCT-Da079, SCT-Da080, SCT-Da081, SCT-Da082, SCT-Da083, SCT-Da084, SCT-Da085, SCT-Da086, SCT-Da087, SCT-Da088, SCT-Da089, SCT-Da090, SCT-Da091, SCT-Da092, SCT-Da093, SCT-Da094, SCT-Da095, SCT-Da096, SCT-Da097, SCT-Da098, SCT-Da099, SCT-Da100, SCT-Da101, SCT-Da102, SCT-Da103, SCT-Da104, SCT-Da105, SCT-Da106, SCT-Da107, SCT-Da108, SCT-Da109, SCT-Da110, SCT-Da111, SCT-Da112, SCT-Da113, SCT-Da114, SCT-Da115, SCT-Da116, SCT-Da117, SCT-Da118, SCT-Da119, SCT-Da120, SCT-Da121, SCT-Da122, SCT-Da123, SCT-Da124, SCT-Da125, SCT-Da126, SCT-Da127, SCT-Da128, SCT-Da129, SCT-Da130, SCT-Da131, SCT-Da132, SCT-Da133, SCT-Da134, SCT-Da135, SCT-Da136, SCT-Da137, SCT-Da138, SCT-Da139, SCT-Da140, SCT-Da141, SCT-Da142, SCT-Da143, SCT-Da144, SCT-Da145, SCT-Da146, SCT-Da147, SCT-Da148, SCT-Da149, SCT-Da150, SCT-Da151, SCT-Da152, SCT-Da153, SCT-Da154, SCT-Da155, SCT-Da156, SCT-Da157, SCT-Da158, SCT-Da159, SCT-Da160, SCT-Da161, SCT-Da162, SCT-Da163, SCT-Da164, SCT-Da165, SCT-Da166, SCT-Da167, SCT-Da168, SCT-Da169, SCT-Da170, SCT-Da171, SCT-Da172, SCT-Da173, SCT-Da174, SCT-Da175, SCT-Da176, SCT-Da177, SCT-Da178, SCT-Da179, SCT-Da180, SCT-Da181, SCT-Da182, SCT-Da183, SCT-Da184, SCT-Da185, SCT-Da186, SCT-Da187, SCT-Da188, SCT-Da189, SCT-Da190, SCT-Da191, SCT-Da192, SCT-Da193, SCT-Da194, SCT-Da195, SCT-Da196, SCT-Da197, SCT-Da198, SCT-Da199, SCT-Da200, SCT-Da201, SCT-Da202, SCT-Da203, SCT-Da204, SCT-Da205, SCT-Da206, SCT-Da207, SCT-Da208, SCT-Da209, SCT-Da210, SCT-Da211, SCT-Da212, SCT-Da213, SCT-Da214, SCT-Da215, SCT-Da216, SCT-Da217, SCT-Da218, SCT-Da219, SCT-Da220, SCT-Da221, SCT-Da222, SCT-Da223, SCT-Da224, SCT-Da225, SCT-Da226, SCT-Da227, SCT-Da228, SCT-Da229, SCT-Da230, SCT-Da231, SCT-Da232, SCT-Da233, SCT-Da234, SCT-Da235, SCT-Da236, SCT-Da237, SCT-Da238, SCT-Da239, SCT-Da240, SCT-Da241, SCT-Da242, SCT-Da243, SCT-Da244, SCT-Da245, SCT-Da246, SCT-Da247, SCT-Da248, SCT-Da249, SCT-Da250, SCT-Da251, SCT-Da252, SCT-Da253, SCT-Da254, SCT-Da255, SCT-Da256, SCT-Da257, SCT-Da258, SCT-Da259, SCT-Da260, SCT-Da261, SCT-Da262, SCT-Da263, SCT-Da264, SCT-Da265, SCT-Da266, SCT-Da267, SCT-Da268, SCT-Da269, SCT-Da270, SCT-Da271, SCT-Da272, SCT-Da273, SCT-Da274, SCT-Da275, SCT-Da276, SCT-Da277, SCT-Da278, SCT-Da279, SCT-Da280, SCT-Da281, SCT-Da282, SCT-Da283, SCT-Da284, SCT-Da285, SCT-Da286, SCT-Da287, SCT-Da288, SCT-Da289, SCT-Da290, SCT-Da291, SCT-Da292, SCT-Da293, SCT-Da294, SCT-Da295, SCT-Da296, SCT-Da297, SCT-Da298, SCT-Da299, SCT-Da300, SCT-Da301, SCT-Da302, SCT-Da303, SCT-Da304, SCT-Da305, SCT-Da306, SCT-Da307, SCT-Da308, SCT-Da309, SCT-Da310, SCT-Da311, SCT-Da312, SCT-Da313, SCT-Da314, SCT-Da315, SCT-Da316, SCT-Da317, SCT-Da318, SCT-Da319, SCT-Da320, SCT-Da321, SCT-Da322, SCT-Da323, SCT-Da324, SCT-Da325, SCT-Da326, SCT-Da327, SCT-Da328, SCT-Da329, SCT-Da330, SCT-Da331, SCT-Da332, SCT-Da333, SCT-Da334, SCT-Da335, SCT-Da336, SCT-Da337, SCT-Da338, SCT-Da339, SCT-Da340, SCT-Da341, SCT-Da342, SCT-Da343, SCT-Da344, SCT-Da345, SCT-Da346, SCT-Da347, SCT-Da348, SCT-Da349, SCT-Da350, SCT-Da351, SCT-Da352, SCT-Da353, SCT-Da354, SCT-Da355, SCT-Da356, SCT-Da357, SCT-Da358, SCT-Da359, SCT-Da360, SCT-Da361, and SCT-Da362. Each of these is a murine monoclonal antibody. In addition, the disclosure provides the antibodies SCT-Da363, SCT-Da364, SCT-Da365, SCT-Da366, SCT-Da367, SCT-Da368, SCT-Da369, SCT-Da370, SCT-Da371, SCT-Da372, SCT-Da373, and SCT-Da374. Each of these is a humanized monoclonal antibody.


Additionally, recombinant anti-B7-H3 antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the disclosure. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques such as, for example, the methods described in U.S. Pat. No. 7,112,421; Better et al. (1988) Science 240:1041-1043; or Liu et al. (1987) Proc. Natl. Acad. Sci. USA 84:3439-3443.


Antibody Variable Domain Sequence

The antibodies of the disclosure may comprise the heavy chain variable domain sequences of SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:110, SEQ ID NO:111, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:116, SEQ ID NO:117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID NO:123, SEQ ID NO:124, SEQ ID NO:125, SEQ ID NO:126, SEQ ID NO:127, SEQ ID NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID NO:141, SEQ ID NO:142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, SEQ ID NO:147, SEQ ID NO:148, SEQ ID NO:149, SEQ ID NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154, SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID NO:159, SEQ ID NO:160, SEQ ID NO:161, SEQ ID NO:162, SEQ ID NO:163, SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID NO:168, SEQ ID NO:169, SEQ ID NO:170, SEQ ID NO:171, SEQ ID NO:172, SEQ ID NO:173, SEQ ID NO:174, SEQ ID NO:175, SEQ ID NO:176, SEQ ID NO:177, SEQ ID NO:178, SEQ ID NO:179, SEQ ID NO:180, SEQ ID NO:181, SEQ ID NO:182, SEQ ID NO:183, SEQ ID NO:184, SEQ ID NO:185, SEQ ID NO:186, SEQ ID NO:187, SEQ ID NO:188, SEQ ID NO:189, SEQ ID NO:190, SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID NO:195, SEQ ID NO:196, SEQ ID NO:197, SEQ ID NO:198, SEQ ID NO:199, SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208, SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217, SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226, SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235, SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244, SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:973, SEQ ID NO:976, SEQ ID NO:980, SEQ ID NO:981, or SEQ ID NO:984. The heavy chain variable domain sequences may consist essentially of SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:110, SEQ ID NO:111, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:116, SEQ ID NO:117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID NO:123, SEQ ID NO:124, SEQ ID NO:125, SEQ ID NO:126, SEQ ID NO:127, SEQ ID NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID NO:141, SEQ ID NO:142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, SEQ ID NO:147, SEQ ID NO:148, SEQ ID NO:149, SEQ ID NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154, SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID NO:159, SEQ ID NO:160, SEQ ID NO:161, SEQ ID NO:162, SEQ ID NO:163, SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID NO:168, SEQ ID NO:169, SEQ ID NO:170, SEQ ID NO:171, SEQ ID NO:172, SEQ ID NO:173, SEQ ID NO:174, SEQ ID NO:175, SEQ ID NO:176, SEQ ID NO:177, SEQ ID NO:178, SEQ ID NO:179, SEQ ID NO:180, SEQ ID NO:181, SEQ ID NO:182, SEQ ID NO:183, SEQ ID NO:184, SEQ ID NO:185, SEQ ID NO:186, SEQ ID NO:187, SEQ ID NO:188, SEQ ID NO:189, SEQ ID NO:190, SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID NO:195, SEQ ID NO:196, SEQ ID NO:197, SEQ ID NO:198, SEQ ID NO:199, SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208, SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217, SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226, SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235, SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244, SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:973, SEQ ID NO:976, SEQ ID NO:980, SEQ ID NO:981, or SEQ ID NO:984.


The antibodies of the disclosure may comprise the light chain variable domain sequences of SEQ ID NO:247, SEQ ID NO:248, SEQ ID NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253, SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262, SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271, SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280, SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289, SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298, SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307, SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316, SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325, SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334, SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343, SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352, SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361, SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370, SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379, SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388, SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397, SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406, SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415, SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424, SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433, SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442, SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451, SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460, SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469, SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478, SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:977, SEQ ID NO:978, SEQ ID NO:979, SEQ ID NO:982, or SEQ ID NO:983. The light chain variable domain sequences may consist essentially of SEQ ID NO:247, SEQ ID NO:248, SEQ ID NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253, SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262, SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271, SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280, SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289, SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298, SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307, SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316, SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325, SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334, SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343, SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352, SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361, SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370, SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379, SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388, SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397, SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406, SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415, SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424, SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433, SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442, SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451, SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460, SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469, SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478, SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:977, SEQ ID NO:978, SEQ ID NO:979, SEQ ID NO:982, or SEQ ID NO:983.


The disclosure also provides a variable domain sequence comprising a sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to a sequence selected from SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO: 11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:110, SEQ ID NO:111, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:116, SEQ ID NO:117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID NO:123, SEQ ID NO:124, SEQ ID NO:125, SEQ ID NO:126, SEQ ID NO:127, SEQ ID NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID NO:141, SEQ ID NO:142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, SEQ ID NO:147, SEQ ID NO:148, SEQ ID NO:149, SEQ ID NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154, SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID NO:159, SEQ ID NO:160, SEQ ID NO:161, SEQ ID NO:162, SEQ ID NO:163, SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID NO:168, SEQ ID NO:169, SEQ ID NO:170, SEQ ID NO:171, SEQ ID NO:172, SEQ ID NO:173, SEQ ID NO:174, SEQ ID NO:175, SEQ ID NO:176, SEQ ID NO:177, SEQ ID NO:178, SEQ ID NO:179, SEQ ID NO:180, SEQ ID NO:181, SEQ ID NO:182, SEQ ID NO:183, SEQ ID NO:184, SEQ ID NO:185, SEQ ID NO:186, SEQ ID NO:187, SEQ ID NO:188, SEQ ID NO:189, SEQ ID NO:190, SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID NO:195, SEQ ID NO:196, SEQ ID NO:197, SEQ ID NO:198, SEQ ID NO:199, SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208, SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217, SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226, SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235, SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244, SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:973, SEQ ID NO:976, SEQ ID NO:980, SEQ ID NO:981, or SEQ ID NO:984. The disclosure also provides a variable domain sequence comprising a sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to a sequence selected from SEQ ID NO:247, SEQ ID NO:248, SEQ ID NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253, SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262, SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271, SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280, SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289, SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298, SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307, SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316, SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325, SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334, SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343, SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352, SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361, SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370, SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379, SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388, SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397, SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406, SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415, SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424, SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433, SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442, SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451, SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460, SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469, SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478, SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:977, SEQ ID NO:978, SEQ ID NO:979, SEQ ID NO:982, or SEQ ID NO:983. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:4 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:247. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:5 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:248. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:6 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:249. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:7 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:250. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:8 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:251. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:9 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:252. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:9 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:253. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:9 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:254. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:9 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:255. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:10 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:256. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:11 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:254. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:11 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:256. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:12 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:254. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:13 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:257. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:14 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:258. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:15 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:259. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:16 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:260. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:16 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:261. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:17 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:257. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:18 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:262. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:19 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:250. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:19 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:250. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:21 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:263. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:22 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:263. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:22 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:250. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:22 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:22 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:265. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:23 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:266. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:24 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:267. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:25 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:268. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:26 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:269. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:27 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:270. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:28 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:271. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:29 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:266. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:30 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:272. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:31 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:273. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:32 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:274. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:33 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:275. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:34 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:276. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:35 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:277. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:36 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:278. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:37 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:279. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:38 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:280. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:39 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:281. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:39 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:282. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:40 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:283. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:41 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:284. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:41 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:285. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:42 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:286. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:43 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:287. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:44 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:288. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:45 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:289. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:46 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:287. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:47 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:290. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:48 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:291. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:49 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:292. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:50 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:293. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:51 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:52 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:53 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:295. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:54 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:296. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:55 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:297. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:56 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:57 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:298. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:57 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:299. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:58 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:300. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:59 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:301. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:59 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:60 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:302. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:60 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:303. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:60 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:249. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:60 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:61 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:249. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:62 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:305. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:62 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:306. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:62 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:249. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:63 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:63 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:307. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:64 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:308. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:65 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:257. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:66 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:309. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:67 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:310. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:68 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:283. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:68 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:311. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:69 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:312. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:70 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:293. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:71 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:313. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:72 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:314. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:72 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:305. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:72 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:293. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:73 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:315. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:74 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:316. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:75 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:317. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:75 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:75 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:319. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:76 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:320. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:77 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:321. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:77 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:322. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:77 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:323. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:77 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:324. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:78 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:79 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:321. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:80 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:325. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:80 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:326. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:80 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:81 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:82 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:327. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:82 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:328. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:82 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:329. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:82 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:330. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:83 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:331. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:83 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:83 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:332. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:83 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:84 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:334. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:85 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:85 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:326. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:85 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:85 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:332. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:86 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:335. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:336. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:337. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:326. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:338. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:339. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:340. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:341. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:87 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:88 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:89 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:342. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:89 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:313. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:90 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:342. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:91 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:329. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:91 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:91 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:91 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:343. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:92 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:344. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:92 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:345. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:92 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:346. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:93 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:316. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:94 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:347. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:95 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:348. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:96 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:349. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:97 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:342. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:98 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:284. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:296. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:350. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:351. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:352. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:353. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:99 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:354. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:100 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:355. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:101 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:314. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:101 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:101 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:332. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:101 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:322. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:102 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:356. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:103 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:356. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:104 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:357. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:105 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:267. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:105 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:261. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:105 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:358. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:105 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:359. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:360. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:361. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:362. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:363. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:364. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:312. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:365. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:106 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:366. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:107 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:262. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:108 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:283. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:108 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:359. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:108 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:367. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:109 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:368. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:110 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:368. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:111 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:112 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:369. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:113 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:114 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:370. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:115 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:371. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:116 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:372. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:117 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:373. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:118 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:119 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:120 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:374. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:121 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:329. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:121 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:122 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:375. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:123 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:376. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:124 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:377. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:124 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:378. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:125 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:379. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:126 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:126 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:377. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:126 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:127 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:128 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:128 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:359. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:128 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:380. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:128 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:129 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:130 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:131 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:381. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:132 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:317. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:133 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:382. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:134 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:317. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:135 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:383. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:136 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:384. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:137 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:385. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:138 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:386. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:139 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:139 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:386. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:140 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:387. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:141 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:388. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:142 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:143 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:389. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:144 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:329. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:144 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:145 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:390. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:146 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:391. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:147 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:349. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:148 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:392. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:149 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:393. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:150 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:394. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:151 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:395. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:152 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:396. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:153 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:397. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:154 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:398. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:155 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:399. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:156 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:400. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:157 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:401. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:157 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:402. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:158 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:403. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:159 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:404. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:160 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:405. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:161 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:406. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:162 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:407. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:163 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:408. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:164 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:397. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:165 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:409. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:165 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:397. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:166 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:305. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:167 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:397. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:168 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:410. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:169 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:411. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:170 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:412. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:171 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:413. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:172 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:414. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:173 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:415. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:173 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:174 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:416. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:175 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:417. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:176 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:418. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:177 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:419. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:178 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:419. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:179 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:420. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:180 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:421. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:181 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:422. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:182 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:423. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:183 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:424. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:184 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:425. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:185 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:426. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:186 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:427. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:187 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:428. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:188 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:429. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:188 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:430. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:189 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:431. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:190 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:429. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:190 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:387. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:191 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:430. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:192 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:432. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:193 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:433. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:194 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:434. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:194 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:434. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:196 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:429. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:197 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:434. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:198 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:435. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:252. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:301. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:293. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:337. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:294. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:358. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:312. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:371. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:199 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:366. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:430. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:328. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:264. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:411. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:413. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:318. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:324. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:200 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:265. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:201 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:429. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:202 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:436. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:203 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:437. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:204 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:438. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:204 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:439. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:205 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:440. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:205 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:438. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:206 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:441. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:207 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:442. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:208 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:443. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:209 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:443. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:210 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:444. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:211 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:445. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:212 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:446. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:213 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:447. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:214 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:410. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:215 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:448. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:215 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:216 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:449. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:217 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:450. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:218 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:451. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:219 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:452. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:220 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:453. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:221 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:331. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:222 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:454. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:222 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:455. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:222 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:366. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:223 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:438. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:224 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:456. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:225 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:400. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:225 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:457. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:225 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:458. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:226 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:456. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:227 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:459. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:228 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:457. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:229 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:460. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:230 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:461. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:231 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:462. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:232 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:463. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:233 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:464. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:234 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:465. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:235 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:466. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:236 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:467. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:237 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:468. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:238 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:469. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:239 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:304. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:239 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:354. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:239 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:470. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:240 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:471. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:241 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:472. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:242 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:473. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:242 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:474. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:242 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:475. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:242 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:265. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:243 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:476. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:244 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:468. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:245 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:477. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:246 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:478. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:246 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:333. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:973 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:974. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:973 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:975. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:976 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:977. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:976 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:978. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:976 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:979. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:980 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:977. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:980 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:978. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:980 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:979. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:981 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:982. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:981 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:983. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:984 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:982. The disclosure also provides antibodies comprising a heavy chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:984 and a light chain variable domain sequence that is at least 80%, at least 85%, at least 90%, or at least 95% identical to SEQ ID NO:983.


Table 1 provides a summary of the B7-H3-specific antibodies described herein:


Pharmaceutical Compositions

Pharmaceutical compositions comprising the antibodies or antibody fragments of the present disclosure are also contemplated and can be used in the methods disclosed herein. Pharmaceutical compositions can comprise one or more of the antibodies or antibody fragments described herein and a pharmaceutically acceptable carrier or excipient. Although the carrier or excipient may facilitate administration, it should not itself induce the production of antibodies harmful to the subject or individual receiving the composition; nor should it be toxic. Suitable carriers may be large, slowly metabolized macromolecules such as proteins, polypeptides, liposomes, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers and inactive virus particles, and are known to one of skill in the art.


The antibodies or an antigen binding fragments described herein, or the pharmaceutical compositions disclosed herein, may be administered by any number of routes including, but not limited to, oral, intravenous, intramuscular, intra-arterial, intramedullary, intraperitoneal, intrathecal, intraventricular, transdermal, transcutaneous, topical, subcutaneous, intranasal, enteral, sublingual, intravaginal or rectal routes. Typically, the therapeutic compositions may be prepared as injectables, either as liquid solutions or suspensions. Solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared.


In one embodiment, the antibody, or an antigen binding fragment thereof, or pharmaceutical composition is administered intravenously. In another embodiment, the antibody, or an antigen binding fragment thereof, or pharmaceutical composition is administered by intravenous infusion.


Direct delivery of the compositions will generally be accomplished by injection, subcutaneously, intraperitoneally, intravenously or intramuscularly, or delivered to the interstitial space of a tissue. The compositions can also be administered into a lesion. Dosage treatment may be a single dose schedule or a multiple dose schedule. Known antibody-based pharmaceuticals provide guidance relating to frequency of administration e.g., whether a pharmaceutical should be delivered daily, weekly, monthly, etc. Frequency and dosage may also depend on the severity of symptoms.


It will be appreciated that the active ingredient in the composition will be an antibody molecule, an antibody fragment or variants and derivatives thereof. As such, it will be susceptible to degradation in the gastrointestinal tract. Thus, if the composition is to be administered by a route using the gastrointestinal tract, the composition will need to contain agents which protect the antibody from degradation, but which release the antibody once it has been absorbed from the gastrointestinal tract.


The methods of the present invention can use an antibody, or an antigen binding fragment thereof, as described above, alone or in combination with other pharmaceutically active compounds, to treat conditions such as those disclosed hereinabove. The additional pharmaceutically active compound(s) can be administered simultaneously (either in the same dosage form or in separate dosage forms) or sequentially. Accordingly, in one embodiment, the present invention comprises methods for treating a condition by administering to the subject a therapeutically effective amount of an antibody, or an antigen binding fragment thereof, of the present invention and one or more additional pharmaceutically active compounds.


In some embodiments, the antibody, or an antigen binding fragment thereof, of the present invention is used in combination with existing LAG-3-related disease therapies.


EXAMPLES

The following example is put forth so as to provide those of ordinary skill in the art with a complete description of how to make and use the present disclosure, and is not intended to limit the scope of what the inventors regard as their disclosure nor is it intended to represent that the experiment below is all or the only experiment that could be performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Centigrade, and pressure is at or near atmospheric.


Example 1: Isolation of Murine Anti-Human B7-113 Antibodies
Immunization, & Single Cell Suspension Generation

Recombinant human B7-H3 (4Ig) His tagged, catalog no: B7B-H52E7, ACROBiosystems, Beijing, China, SEQ ID NO:2) was used to immunize young C57/BL6 mice each with 80 μg of the protein in Sigma Adjuvant System® (Sigma-Aldrich, St. Louis, Mo.) over a period of 35 days using a rapid immunization protocol of Antibody Solutions (Sunnyvale, Calif.). The lymph nodes were harvested on day 35. Single cell suspension of the lymph node was generated, and the suspension was filtered through a 70 μm mesh (BD Bioscience) to remove clumps.


Plasma Cell Isolation, Antibody Capture, and Antigen Interrogation

The filtered lymphocyte suspension was enriched for plasma cells actively secreting IgGs using a kit based on cell surface expression of CD138 (Miltenyi, Auburn, Calif.). Using a method described in U.S. Pat. No. 9,328,172, freshly enriched plasma cells were deposited on a PDMS device to allow a single cell settled in the microwells on the device. Antibody secreted from each plasma cell was captured on a derivatized microscope slide. Antigen-specific antibody secreting cells were identified by interrogating the antibody capture slide with varying concentrations of fluorescently labeled B7-H3 (4Ig) protein tagged with human Fc (ACROBiosystems, Beijing, China, catalog no: B7B-H5258, SEQ ID NO:3). Labeling was done using a kit (AnaSpec, Fremont, Calif., AS-72046, AnaTag™ HiLyte™ Fluor 555 Microscale Protein Labeling Kit *Ultra Convenient*).


mRNA Capture


After antibody capture, the medium was removed, and replaced with lysis buffer followed by prompt closure of the top of the microwells with a custom oligonucleotide microarray (Agilent, Santa Clara, Calif.). This procedure was previously described in U.S. Pat. No. 9,328,172. The custom oligonucleotide microarray is prepared such that each feature contains not only a unique tag specifying its coordinate but also capture probes for all subclasses (1, 2a, 2b, and 3) of murine IgG heavy chain, murine Ig kappa light chain.


cDNA Synthesis, PCR Amplification, and Next Generation Sequencing


Captured mRNA on the custom microarray was further processed to synthesize cDNA of each mRNA incorporating the unique tag originally on each feature. The cDNA is then amplify using a Taq polymerase (Promega, Madison, Wis.) and appropriate set of primers to allow amplification of the following genes: variable domain of IgG heavy chain subclasses and variable domain of Ig kappa light chain. Though now released from cells, these fragments of each gene are now labeled with the unique tag from the custom oligonucleotide microarray manifesting their originating locations. The amplicons were further manipulated to have appropriate sequence attached at both ends to enable sequencing on an Illumina MiSeq instrument using 2×250 bp chemistry at SeqMatic LLC (Fremont, Calif.).


Bioinformatic Analysis of Images and DNA Sequences

Sequencing reads from MiSeq were processed and the embedded tag in each read was identified and converted into coordinates. The coordinates were plotted to yield a synthetic map of the mRNA recovered. Most of the coordinates form clusters that designate the location of the originating cell for the recovered mRNA sequences. Next, CDR3 motif present in each read with the coordinates was identified and collated according to the clusters that matched the location of an antibody spot visualized by an appropriate fluorescently labeled secondary antibody. Identical or nearly identical CDR3s for a given antibody spot were organized and form consistent pair of VH and VL sequences. The remaining part of VH or VL sequence containing the identified CDR3s was identified and the associated sequencing reads were assembled into full-length cDNA sequences for VH and VL. The pair of full-length cDNA was correlated with the affinity measurements associated with each of the antigen-specific antibody spot.


Example 2: Molecular Reconstruction and Recombinant Expression of Anti-B7-H3 Antibodies

The paired VH and VL anti-B7-H3 antibody sequences were used to synthesize corresponding gene fragments by a service provider according to the known art. The resulting gene fragments were cloned into an appropriate plasmid vector and transfected into an appropriate mammalian host, such as HEK293, for recombinant expression to produce an antibody preparation in full-IgG format. The antibody preparations were characterized by measurements at OD280 to assess the amount produced and by gel electrophoresis on PAGE to assess the size of the antibody chains produced.


Example 3: Characterization of Recombinant Anti-B7-H3 Antibodies

The recombinantly expressed antibodies were used to assess binding activity to B7-H3 by conventional ELISA according to the known art. Recombinant human B7-H3 and cyno B7-H3 were coated onto ELISA plates to detect binding at serially diluted concentrations of the anti-B7-H3 antibody preparations. The EC50s based on ELISA is shown in table 2. The binding affinity of select anti-B7-H3 antibodies were measured on a surface plasmon resonance (SPR) instrument, such as a Biacore T200™, against human B7-H3 (table 3) and cyno B7-H3 (table 4). Cell lines expressing B7-H3, A498 and SK-MES-1, were used to assess binding by anti-B7-H3 antibodies on the native protein on the cell surface by flow cytometry according to the known art. The EC50s for these binding to these 2 cell lines are displayed in table 2 under the heading “FACS” and FIGS. 1A and 1B. In addition, the antibody-dependent cellular cytotoxicity (ADCC) activity of select anti-B7-H3 antibodies were assessed using an engineered surrogate effector cell line, kit reagents, and a luminometer (Promega, Madison, Wis.) on A498 and SK-MES-1 as target cells in table 2 under the heading “ADCC (reporter) and FIGS. 1C and 1D. Finally, specificity of each of the antibodies examined thus far were assessed by interacting with proteins from the B7 family (human B7-1, B7-2, PD-L2, PD-L1, B7-H2, B7-H4, B7-H5, B7-H6, B7-H7) against B7-H3 using ELISA. The data were plotted for each antibody on FIGS. 3A through 3E.


Antibodies recovered from the antibody campaign described above are listed herein. The CDR sequences and the VH and VL sequences for the anti-B7-H3 antibodies described herein are depicted in Tables 5 and 6, respectively.














TABLE 2











ADCC




ELISA
FACS
(reporter)
ADCC
















Human
Cyno

SK-


SK-
(PBMC)



B7-H3
B7-H3
A498
MES-1
Raji
A498
MES-1
A549



EC50
EC50
EC50
EC50
EC50
EC50
EC50
EC50


Anti-B7-H3 mAb
(pM)
(pM)
(nM)
(nM)
(nM)
(nM)
(nM)
(nM)


















SCT-Da148
7.60
11.43
1.60
1.49
>100
3.6
4.2
0.75


SCT-Da182
10.46
8.82
3.70
4.09
>100
4.5
4.6
ND


SCT-Da192
10.86
17.64
2.62
2.32
>100
1.1
0.9
0.21


SCT-Da250
22.55
23.74
1.43
1.46
>100
2.4
2.4
0.20


SCT-Da333
8.33
3048.00
3.29
1.94
>100
23.3
32.8
ND


SCT-Da364
ND
ND
ND
ND
ND
ND
ND
0.18


SCT-Da369
ND
ND
ND
ND
ND
ND
ND
8.05





ND: Not determined.

















TABLE 3





Anti-B7-H3 mAb
Ka (1/Ms)
Kd (1/s)
KD (M)
Rmax (RU)



















SCT-Da148
3.66E+05
2.34E−03
6.41E−09
50.4


SCT-Da182
9.27E+04
1.01E−03
1.09E−08
39.2


SCT-Da192
8.51E+04
2.03E−03
2.38E−08
118.2


SCT-Da250
4.02E+05
1.10E−03
2.75E−09
71.3


SCT-Da333
1.35E+05
5.12E−02
3.80E−07
51.0




















TABLE 4





Anti-B7-H3 mAb
Ka (1/Ms)
Kd (1/s)
KD (M)
Rmax (RU)







SCT-Da148
7.31E+05
3.68E−04
5.03E−10
138.1


SCT-Da182
2.32E+05
2.83E−04
1.22E−09
206.1


SCT-Da192
3.07E+05
5.05E−04
1.64E−09
132.2


SCT-Da250
9.05E+05
3.61E−04
3.98E−10
171.0








SCT-Da333
No binding
















TABLE 5







CDR sequences of mAbs generated against human B7-H3


(SEQ ID Nos for each listed sequence are provided in parenthesis)













mAb AA ID
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3





SCT-Da001
GYSITSNYN
IHYSDDT
ARWSYYYGGPYYYSMDY
QDINSY
RAN
LQYDEFPPT



(479)
(480)
(481)
(763)
(764)
(765)





SCT-Da002
GYSITSGYN
IHYSGGT
GRWSYYYGSPYYYSMDY
QDINTY
RAN
LQYDEFPPT



(482)
(483)
(484)
(766)
(764)
(765)





SCT-Da003
GFSITSGYY
ISYDGSN
ARDYYGYPAWFTY
QSVDYDGDSY
AAS
QQSNEDPRT



(485)
(486)
(487)
(857)
(794)
(837)





SCT-Da004
GYSITDGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(488)
(489)
(490)
(773)
(771)
(807)





SCT-Da005
GYSITSAYF
INYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGKSLPWT



(491)
(492)
(490)
(773)
(771)
(814)





SCT-Da006
GYSITSAYF
INFDGSS
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(491)
(493)
(490)
(773)
(771)
(772)





SCT-Da007
GYSITSAYF
INFDGSS
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(491)
(493)
(490)
(773)
(771)
(772)





SCT-Da008
GYSITSAYF
INFDGSS
ARRKGWLYAMDY
QDINNY
YTS
QQGNTLPWT



(491)
(493)
(490)
(770)
(771)
(772)





SCT-Da009
GYSITSAYF
INFDGSS
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(491)
(493)
(490)
(773)
(771)
(772)





SCT-Da010
GYSITSAYF
INYDGTN
ARRKGWLYAMDY
QDISNY
YTS
QQGKSLPWT



(491)
(494)
(490)
(773)
(771)
(814)





SCT-Da011
GYSITSAYF
INYDGTN
ARRKGWLYAMDY
QDINNY
YTS
QQGNTLPWT



(491)
(494)
(490)
(770)
(771)
(772)





SCT-Da012
GYSITSAYF
INYDGTN
ARRKGWLYAMDY
QDISNY
YTS
QQGKSLPWT



(491)
(494)
(490)
(773)
(771)
(814)





SCT-Da013
GYSITSDSF
ISYDGSN
ARRKGWLYAMDY
QDINNY
YTS
QQGNTLPWT



(495)
(486)
(490)
(770)
(771)
(772)





SCT-Da014
GYSITSDYF
ISYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(496)
(486)
(490)
(773)
(771)
(772)





SCT-Da015
GYSITSDYF
ISYDGSN
ARRKGWLYAMDY
QDISNF
YTS
QQGKTLPWT



(496)
(486)
(490)
(812)
(771)
(813)





SCT-Da016
GYSITSGYF
INYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(497)
(492)
(490)
(773)
(771)
(772)





SCT-Da017
GYSITSGYF
INYDGSD
ARRKGWLYAMDS
QDINNY
YTS
QQGNTLPWT



(497)
(498)
(499)
(770)
(771)
(772)





SCT-Da018
GYSITSGYF
INYDGSD
ARRKGWLYAMDS
HDIHNY
YTS
QQGNTLPWT



(497)
(498)
(499)
(811)
(771)
(772)





SCT-Da019
GYSITSGYF
INYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(497)
(492)
(490)
(773)
(771)
(772)





SCT-Da020
GYSITSGYF
INYDGSS
ARRKGWLYAMDY
SSISSNY
RTS
QQGSSIPRT



(497)
(500)
(490)
(928)
(929)
(932)





SCT-Da021
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(497)
(489)
(490)
(773)
(771)
(807)





SCT-Da022
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(497)
(489)
(490)
(773)
(771)
(807)





SCT-Da023
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGIALPWT



(497)
(489)
(490)
(773)
(771)
(808)





SCT-Da024
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGIALPWT



(497)
(489)
(490)
(773)
(771)
(808)





SCT-Da025
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(497)
(489)
(490)
(773)
(771)
(807)





SCT-Da026
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
ESVDSYGNSF
IAS
QQSNEDPRT



(497)
(489)
(490)
(846)
(842)
(837)





SCT-Da027
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QSVTND
YAS
QQDYNSPYT



(497)
(489)
(490)
(970)
(818)
(962)





SCT-Da028
GYSITSGYF
LNYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(497)
(489)
(490)
(773)
(771)
(772)





SCT-Da029
GYSITSGYF
LNYDGSS
ARRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(497)
(501)
(490)
(773)
(771)
(807)





SCT-Da030
GYSITSGYF
INYDGSN
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(497)
(492)
(490)
(773)
(771)
(772)





SCT-Da031
GYSITSGYY
ISYDGSN
AREGDYGSY
QDVGTA
WAS
QQYSSYPYT



(502)
(486)
(503)
(879)
(866)
(881)





SCT-Da032
GYSITSGYY
ISYDGSN
TRRKGWLYAMDY
QDISNY
YTS
QQGNALPWT



(502)
(486)
(504)
(773)
(771)
(807)





SCT-Da033
GYSITSDYA
ISYSGST
ASGYYGIHYYAMDY
QDVNTA
SAS
QQHYSTPFT



(505)
(506)
(507)
(876)
(882)
(883)





SCT-Da034
GYSITSGYF
INYDGSS
ARRKGWLYAMDY
QDISNY
YTS
QQGNTLPWT



(497)
(500)
(490)
(773)
(771)
(772)





SCT-Da035
GYSFTAYI
INPYYGST
ARGPPYYYGSSRDYALDY
QSIVHTNGNTY
KVS
FQGSHVPYT



(508)
(509)
(510)
(906)
(907)
(908)





SCT-Da036
GYSFTDYI
INPYYDTT
ATYDGFAY
QSLVHSNGNTY
KVS
SQSTHGPWT



(511)
(512)
(513)
(919)
(907)
(921)





SCT-Da037
GYSFTDYI
INPYYGTT
ATYDGFAY
QSLVHSYGNTY
KVS
SQSTHGPWT



(511)
(514)
(513)
(923)
(907)
(921)





SCT-Da038
GYSFTDYI
INPYYYTT
ATYDGFAY
QSLVHSNGNTY
KVS
SQSTHGPWT



(511)
(515)
(513)
(919)
(907)
(921)





SCT-Da039
GFNIKDYY
IDPENGNT
TIGVRRDYFDY
SSISSNY
RTS
QQGSSLPRT



(516)
(517)
(518)
(928)
(929)
(930)





SCT-Da040
GFTFSNYW
IRLKFNNY
IKFGGMDY
SSVNY
STS
QQRSTYPRT



(519)
(520)
(521)
(949)
(877)
(950)





SCT-Da041
GFAFNSYD
ISDGGSFT
ARHQITTLRMDY
QGISSN
HGT
VQYAQFPYT



(522)
(523)
(524)
(767)
(768)
(769)





SCT-Da042
GFAFSSYD
ISDGGSYT
ARHRVTTVRMDY
QGISSN
HGT
VQYAQFPYT



(525)
(526)
(527)
(767)
(768)
(769)





SCT-Da043
GFAFSSYD
ISDGGSYT
ARHRVTTVRMDY
QGISSN
HGT
VQYAQFPYT



(525)
(526)
(527)
(767)
(768)
(769)





SCT-Da044
GFAFSDYD
ISDGGSYT
ARHLITTLRMDY
QGISSN
HGT
VQYAQFPYT



(528)
(526)
(529)
(767)
(768)
(769)





SCT-Da045
GFAFSDYD
ISDGGSYT
ARHLITTLRMDY
QGISSN
HGT
VQYAQFPYT



(528)
(526)
(529)
(767)
(768)
(769)





SCT-Da046
GFAFSDYD
ISDGGSYT
ARHLITTLRMDY
QGISSN
HGT
VQYAQFPYT



(528)
(526)
(529)
(767)
(768)
(769)





SCT-Da047
GFAFSDYD
ISNDGSYT
ARHLITTLRMDY
QGISSN
HGT
VQYAQFPYT



(528)
(530)
(529)
(767)
(768)
(769)





SCT-Da048
GFAFSDYD
ISNDGSYT
ARHLITTLRMDY
QGISSN
HGT
VQYAQFPYT



(528)
(530)
(529)
(767)
(768)
(769)





SCT-Da049
GFTFSSYT
IISGGGDI
ARWYSAGYFDV
KSVSTSAYSY
LAS
QHSRELLT



(531)
(532)
(533)
(852)
(829)
(853)





SCT-Da050
GFTFSSYT
ISGGGVTY
ARWYSVGYFDV
KSVSTSAYSY
LAS
QHSRELLT



(531)
(534)
(535)
(852)
(829)
(853)





SCT-Da051
GFTFSSYT
ITGGGDTY
ARWYSVGYFDV
KSVSTSAYSY
LAS
QHSRELLT



(531)
(536)
(535)
(852)
(829)
(853)





SCT-Da052
GFTFSSYT
ITSGGGDT
ARWYSAGYFDV
KSVSTSAYSY
LAS
QHSRELLT



(531)
(537)
(533)
(852)
(829)
(853)





SCT-Da053
GFTFSSYT
ISGGGVTY
ARWYSVGYFDV
KSVSTSAYSY
LAS
QHSRELLT



(531)
(534)
(535)
(852)
(829)
(853)





SCT-Da054
GFTFSSYA
IFFGSSVT
ARQGTSPWFAY
KSVSTSNYSY
LAS
QHSRELPT



(538)
(539)
(540)
(855)
(829)
(856)





SCT-Da055
GFTFSSYT
IISGGGNT
ARWYSAGYFDV
KSVSTSGYSY
LAS
QHSRELLT



(531)
(541)
(533)
(828)
(829)
(853)





SCT-Da056
GFTFSSYT
ISGGVGDT
ARQGGFPWFAY
KSVSTSGYSY
LAS
QHSRELPYT



(531)
(542)
(543)
(828)
(829)
(830)





SCT-Da057
GFNIEDTY
IDPANGNT
ARDGYYAPGY
QNVDTN
SGS
QQYNTYPYT



(544)
(545)
(546)
(873)
(874)
(875)





SCT-Da058
GFNIEDTY
IDPANGNT
ARDGYYAPGY
QNVDTN
SAS
QQYNSYPYT



(544)
(545)
(546)
(873)
(882)
(902)





SCT-Da059
GFNIEDTY
IDPANGYT
ARDGYYAPGY
QNVDTN
SAS
QQYNSYPYT



(544)
(547)
(546)
(873)
(882)
(902)





SCT-Da060
GYTFTDYN
INPNYDST
ARSGFDGYYYAMDY
ETVDSYGSSF
RAS
QQSNEDPFT



(548)
(549)
(550)
(864)
(844)
(845)





SCT-Da061
DYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
QGISNY
YTS
QQYSKLPLT



(551)
(552)
(553)
(815)
(771)
(816)





SCT-Da062
GYTFTDYN
INPNGDFT
ARRHYGNYFYAMDY
ESVDSYGNSF
IAS
QQSNEDPRT



(548)
(554)
(553)
(846)
(842)
(837)





SCT-Da063
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
ESVDSYGNSF
IAS
QQSNEDPRT



(548)
(552)
(553)
(846)
(842)
(837)





SCT-Da064
GYTFTDYN
INPNDDST
ARRHYGNYFYAMDY
DHINNW
GAT
QQYWSTPT



(548)
(555)
(553)
(799)
(800)
(804)





SCT-Da065
GYTFTDYN
INPNDDST
ARRHYGNYFYAMDY
ESVDSFGHSF
LAS
QQSNEDPRT



(548)
(555)
(553)
(841)
(829)
(837)





SCT-Da066
GYTFTDYN
INPNDDST
ARRHYGNYFYAMDY
ESVDSFGNSF
IAS
QQSNEDPRT



(548)
(555)
(553)
(836)
(842)
(837)





SCT-Da067
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
ESVDNFGNSF
LAS
QQSNEDPRT



(548)
(552)
(553)
(838)
(829)
(837)





SCT-Da068
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
ESVDSYGNSF
IAS
QQSNEDPRT



(548)
(552)
(553)
(846)
(842)
(837)





SCT-Da069
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
ESVDSFGNSF
LAS
QQSNEDPRT



(548)
(552)
(553)
(836)
(829)
(837)





SCT-Da070
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
ESVDSYGNSF
LAS
QQSNEDPRT



(548)
(552)
(553)
(846)
(829)
(837)





SCT-Da071
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
QSVDYDGDSY
AAS
QQSNEDPRT



(548)
(552)
(553)
(857)
(794)
(837)





SCT-Da072
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
QNVGTD
SAS
QQYNSYPYT



(548)
(552)
(553)
(904)
(882)
(902)





SCT-Da073
GYTFTDYN
INPNNGGT
ARRHYGNYFYAMDY
QSVDYDGDSY
AAS
QQSNEDPRT



(548)
(552)
(553)
(857)
(794)
(837)





SCT-Da074
GYTFTDYN
INPNYDST
ARRHYGNYFYAMDY
DHINNW
GAT
QQYWSIPYT



(548)
(549)
(553)
(799)
(800)
(802)





SCT-Da075
GYTFTDYN
INPNYDST
ARRHYGNYFYAMDY
ESVDSFGNSF
IAS
QQSNEDPRT



(548)
(549)
(553)
(836)
(842)
(837)





SCT-Da076
GYTFTDYN
INPNYDST
ARRHYGNYFYAMDY
QSVDYDGDSY
AAS
QQSNEDPRT



(548)
(549)
(553)
(857)
(794)
(837)





SCT-Da077
GYTFTDYN
ISPNYEST
ARRHYGNYFYAMDY
ESVDSYGNSF
IAS
QQSNEDPRT



(548)
(556)
(553)
(846)
(842)
(837)





SCT-Da078
GYTFTDYN
ISPNYEST
ARRHYGNYFYAMDY
ESVDSFGHSF
LAS
QQSNEDPRT



(548)
(556)
(553)
(841)
(829)
(837)





SCT-Da079
GYTFTDYN
INPNDDST
ARRHYGNYFYAMDY
ESVDSFGNSF
LAS
QQSNEDPRT



(548)
(555)
(553)
(836)
(829)
(837)





SCT-Da080
GYTFTDYN
INPNYDST
ARGGFYGNFFDY
QDISNY
YTS
QQGNTLPWT



(548)
(549)
(557)
(773)
(771)
(772)





SCT-Da081
GYTFTDYN
INPNYDST
ARGGFYGNFFDY
ESVDSSGNSF
RAS
QQSNEDPFT



(548)
(549)
(557)
(843)
(844)
(845)





SCT-Da082
GFNIKDYY
IDPENGNT
SIGVRRDYFAY
SSISSNY
RTS
QQGSSLPRT



(516)
(517)
(558)
(928)
(929)
(930)





SCT-Da083
GFNIKDYY
IDPENGNT
TIGVRRDYFDY
QGISSN
HGT
VQYAQFPYT



(516)
(517)
(518)
(767)
(768)
(769)





SCT-Da084
GFNIKDYY
IDPENGNT
TIGVRRDYFDY
SSISSNY
RTS
QQGSSIPRT



(516)
(517)
(518)
(928)
(929)
(932)





SCT-Da085
GFNIEDTY
IDPANGNP
ARDGYYAPGY
SSISSNY
RTS
QQGSSIPRT



(544)
(559)
(546)
(928)
(929)
(932)





SCT-Da086
GFNIEDTY
IDPANGNP
ARDGYYAPGY
QNVDTN
SGS
QQYNTYPYT



(544)
(559)
(546)
(873)
(874)
(875)





SCT-Da087
GFNIEDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(544)
(560)
(546)
(899)
(882)
(902)





SCT-Da088
GFNIEDTY
IDPANGNT
ARDGYYAPGY
QDINKY
YTS
LQYDNLRT



(544)
(545)
(546)
(796)
(771)
(797)





SCT-Da089
GFNIEDTY
IDPANGNT
ARDGYYAPGY
DHINNW
GAT
QQYWSIPYT



(544)
(545)
(546)
(799)
(800)
(802)





SCT-Da090
GFNIEDTY
IDPANGNT
ARDGYYAPGY
QNVDTN
SGS
QQYNTYPYT



(544)
(545)
(546)
(873)
(874)
(875)





SCT-Da091
GFNIEDTY
NDPANGNT
ASLWVDY
KSLLHSNGNTF
RMS
MQHLEFPYT



(544)
(561)
(562)
(868)
(869)
(870)





SCT-Da092
GFNIKDTY
IDPANANT
AHDGYYAPGY
QNVGTN
SAS
QQYNNYPYT



(563)
(564)
(565)
(899)
(882)
(900)





SCT-Da093
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNIYPYT



(563)
(545)
(565)
(904)
(882)
(903)





SCT-Da094
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(565)
(904)
(882)
(902)





SCT-Da095
GFNIKDTY
IDPANGNT
AHDGYYAPGY
TDIDDD
EGN
LQSDNLPFT



(563)
(545)
(565)
(939)
(940)
(941)





SCT-Da096
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(545)
(565)
(899)
(882)
(902)





SCT-Da097
GFNIKDTY
IDPANGNS
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(566)
(565)
(904)
(882)
(902)





SCT-Da098
GFNIKDTY
IDPANGNS
AHDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(566)
(565)
(899)
(882)
(902)





SCT-Da099
GFNIKDTY
IDPANGNS
AHDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(566)
(565)
(899)
(882)
(902)





SCT-Da100
GFNIKDTY
IDPANGNS
AHDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(566)
(565)
(899)
(882)
(902)





SCT-Da101
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(565)
(904)
(882)
(902)





SCT-Da102
GFNIKDTY
IDPANGNT
AHDGYYAPGN
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(567)
(904)
(882)
(902)





SCT-Da103
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QGISNY
YTS
QQYSKLPYT



(563)
(545)
(565)
(815)
(771)
(810)





SCT-Da104
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(565)
(904)
(882)
(902)





SCT-Da105
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(565)
(904)
(882)
(902)





SCT-Da106
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(545)
(565)
(904)
(882)
(902)





SCT-Da107
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QGISSN
HGT
VQYAQFPYT



(563)
(560)
(546)
(767)
(768)
(769)





SCT-Da108
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QSVDYDGDNY
AAS
QQSYEDPWT



(563)
(560)
(546)
(831)
(794)
(832)





SCT-Da109
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVDSN
SAS
QQYNSYPYT



(563)
(560)
(546)
(901)
(882)
(902)





SCT-Da110
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNTYPYT



(563)
(560)
(546)
(899)
(882)
(875)





SCT-Da111
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QSISDY
YVS
QNGHSFPFT



(563)
(560)
(546)
(888)
(897)
(889)





SCT-Da112
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da113
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da114
GFNIKDTY
IDPANGNR
ARDGYYAPGY
SSVSY
LTS
QQWSSNPLT



(563)
(560)
(546)
(944)
(957)
(947)





SCT-Da115
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(560)
(546)
(899)
(882)
(902)





SCT-Da116
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da117
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da118
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da119
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da120
GFNIKDTY
IDPANGNR
ARDGYSAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(569)
(904)
(882)
(902)





SCT-Da121
GFNIKDTY
IDPANGNR
ARDGYYAPGY
ESVESNGNSF
RAS
QQTDEDPFT



(563)
(560)
(546)
(848)
(844)
(849)





SCT-Da122
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QRISDY
YAS
QNGHSFPFT



(563)
(560)
(546)
(893)
(818)
(889)





SCT-Da123
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da124
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da125
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da126
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNTYPYT



(563)
(560)
(546)
(904)
(882)
(875)





SCT-Da127
GFNIKDTY
IDPANGNR
ARDGYYAPGY
KSISKY
SGS
QQHNEYPLT



(563)
(560)
(546)
(909)
(874)
(910)





SCT-Da128
GFNIKDTY
IDPANGNR
ARDGYYAPGY
SSVSY
LTS
QQWSSNPLT



(563)
(560)
(546)
(944)
(957)
(947)





SCT-Da129
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(546)
(904)
(882)
(902)





SCT-Da130
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(560)
(546)
(899)
(882)
(902)





SCT-Da131
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(560)
(546)
(899)
(882)
(902)





SCT-Da132
GFNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(563)
(560)
(546)
(899)
(882)
(902)





SCT-Da133
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVDSN
SAS
QQYNSYPYT



(563)
(545)
(565)
(901)
(882)
(902)





SCT-Da134
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVDTN
SAS
QQYNSYPYT



(563)
(545)
(565)
(873)
(882)
(902)





SCT-Da135
GFNIKDTY
IDPANGNT
AHDGYYAPGY
SSVSY
LTS
QQWSSNPLT



(563)
(545)
(565)
(944)
(957)
(947)





SCT-Da136
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QSVSND
YAS
QQDYSSPWT



(563)
(545)
(565)
(966)
(818)
(968)





SCT-Da137
GFNIKDTY
IDPANGNT
THDGYYAPGY
QNVDTN
SAS
QQYNIYPYT



(563)
(545)
(570)
(873)
(882)
(903)





SCT-Da138
GFNIKDTY
IDPANGNT
THDGYYAPGY
QNVDTN
SAS
QQYNSYPYT



(563)
(545)
(570)
(873)
(882)
(902)





SCT-Da139
GFNIKDTY
IDPANGNT
THDGYYAPGY
QSLVHSNGNTY
KVS
SQSTHAPWT



(563)
(545)
(570)
(919)
(907)
(920)





SCT-Da140
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTN
SAS
QQYNNYPYT



(563)
(545)
(565)
(899)
(882)
(900)





SCT-Da141
GFNIKDTY
IDPANGNT
AHDGYYAPGY
QNVGTN
SAS
QQYNNYPYT



(563)
(545)
(565)
(899)
(882)
(900)





SCT-Da142
GFNIKDTY
IDPANGNT
AHDGYYAPGF
QNVGTN
SAS
QQYNSYPFT



(563)
(545)
(571)
(899)
(882)
(905)





SCT-Da143
GFNIKDTY
IDPANGNT
APFSYGTLAY
SSIISNY
RTS
QQGSSLPRT



(563)
(545)
(572)
(935)
(929)
(930)





SCT-Da144
GLNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(573)
(560)
(546)
(899)
(882)
(902)





SCT-Da145
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da146
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QGISSN
HGT
VQYAQFPYT



(574)
(560)
(546)
(767)
(768)
(769)





SCT-Da147
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QGISNY
YTS
QQYSKLPLT



(574)
(560)
(546)
(815)
(771)
(816)





SCT-Da148
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da149
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da150
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da151
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da152
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(574)
(560)
(546)
(899)
(882)
(902)





SCT-Da153
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTN
SAS
QQYNSYPYT



(574)
(560)
(546)
(899)
(882)
(902)





SCT-Da154
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVDNY
YAS
QQDYSSPYT



(574)
(560)
(546)
(959)
(818)
(960)





SCT-Da155
GFNIKDTY
IDPANFNT
ASLWVDY
KSLLHSNGNTF
RMS
MQHLEYPYT



(563)
(575)
(562)
(868)
(869)
(871)





SCT-Da156
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QDINKY
YTS
LQYDNLRT



(563)
(560)
(568)
(796)
(771)
(797)





SCT-Da157
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da158
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTD
SAS
QQYNSYPYT



(563)
(560)
(568)
(904)
(882)
(902)





SCT-Da159
GFNIKDTY
IDPANGNR
ARDGYYAPGH
QNVGTN
SAS
QQYNSYPYT



(563)
(560)
(568)
(899)
(882)
(902)





SCT-Da160
GCNIKDYY
IDPENGNT
TIGVRRDYFAY
SSISSNY
RTS
QQGSSIPRT



(576)
(517)
(577)
(928)
(929)
(932)





SCT-Da161
GCNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISSNY
RTS
QQGSSIPRT



(576)
(517)
(578)
(928)
(929)
(932)





SCT-Da162
GFNIKDFY
IDPENGNT
AIGVRRDYFGY
SIISSNY
RTS
QQGSSIPRT



(579)
(517)
(580)
(934)
(929)
(932)





SCT-Da163
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
QDISNY
YTS
QQGNALPWT



(516)
(517)
(578)
(773)
(771)
(807)





SCT-Da164
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
HDIHNY
YTS
QQGNTLPWT



(516)
(517)
(578)
(811)
(771)
(772)





SCT-Da165
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISSNY
RTS
QQGSSLPRT



(516)
(517)
(578)
(928)
(929)
(930)





SCT-Da166
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SNISSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(931)
(929)
(932)





SCT-Da167
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
QDIKSY
YAT
LQHGESPFT



(516)
(517)
(578)
(760)
(761)
(762)





SCT-Da168
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
KSVSSSGYNY
LAS
QHSGELPLT



(516)
(517)
(578)
(850)
(829)
(851)





SCT-Da169
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
QSISDY
YAS
QNGHSFPPFT



(516)
(517)
(578)
(888)
(818)
(895)





SCT-Da170
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
QSLVHSDGNTY
KVS
SQSTHVPWT



(516)
(517)
(578)
(918)
(907)
(916)





SCT-Da171
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSINSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(933)
(929)
(932)





SCT-Da172
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(928)
(929)
(932)





SCT-Da173
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(928)
(929)
(932)





SCT-Da174
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISY
GTS
QQWSSYPLT



(516)
(517)
(578)
(954)
(955)
(956)





SCT-Da175
GFNIKDYY
IDPENGNT
AIGVRRDYFDY
SSISSNY
RTS
QQGSSIPRT



(516)
(517)
(581)
(928)
(929)
(932)





SCT-Da176
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
QGISSN
HGT
VQYAQFPYT



(516)
(517)
(578)
(767)
(768)
(769)





SCT-Da177
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SNISSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(931)
(929)
(932)





SCT-Da178
GFNIKDYY
IDPENGNT
AIGVRRDYFAY
SSISSNY
RTS
QQGSSIPRT



(516)
(517)
(578)
(928)
(929)
(932)





SCT-Da179
GFNIKDYY
IDPENGNT
AIGVRRDYFDY
SSISSNH
RTS
QQGSSIPRT



(516)
(517)
(581)
(936)
(929)
(932)





SCT-Da180
GFNIKDYY
IDPENGNT
AIGVRRDYFDY
SSISSNH
RTS
QQGSSIPRT



(516)
(517)
(581)
(936)
(929)
(932)





SCT-Da181
GYTFTEYT
INPNSGGT
TRPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(584)
(944)
(957)
(947)





SCT-Da182
GFSFTGYT
INTYNGGT
ARSPGRYSMDY
QSVDYNGYSY
PAS
QQSKEDPYT



(585)
(586)
(587)
(833)
(834)
(835)





SCT-Da183
GYTFTEYT
INPSTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(588)
(589)
(944)
(957)
(947)





SCT-Da184
GYTFAEYT
INPNNGGT
TRPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(590)
(552)
(584)
(944)
(957)
(947)





SCT-Da185
GYTFTEYP
INPNNGGT
ALYGNYWYFDV
SSVSY
DTS
QQWSSNPLT



(591)
(552)
(592)
(944)
(953)
(947)





SCT-Da186
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da187
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da188
GYTFTEYTM
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(593)
(552)
(589)
(944)
(957)
(947)





SCT-Da189
GYTFTEYT
VNPNTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(594)
(589)
(944)
(957)
(947)





SCT-Da190
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
HQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(958)





SCT-Da191
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
QNVDSN
SAS
QQYNSYPYT



(582)
(552)
(589)
(901)
(882)
(902)





SCT-Da192
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da193
GYTFTEYT
INPNNGGT
TRPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(584)
(944)
(957)
(947)





SCT-Da194
GYTFTEYT
INPNSGGT
TRPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(584)
(944)
(957)
(947)





SCT-Da195
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da196
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
HQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(958)





SCT-Da197
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da198
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
QNVDTN
SAS
QQYNSYPYT



(582)
(583)
(589)
(873)
(882)
(902)





SCT-Da199
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da200
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da201
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da202
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
QNVDTN
SAS
QQYNSYPYT



(582)
(583)
(589)
(873)
(882)
(902)





SCT-Da203
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SNISSNY
RTS
QQGSSIPRT



(582)
(583)
(589)
(931)
(929)
(932)





SCT-Da204
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
ATS
QQWSSNPLT



(582)
(583)
(589)
(944)
(945)
(947)





SCT-Da205
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da206
GYTFTEYT
INPNTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(595)
(589)
(944)
(957)
(947)





SCT-Da207
GYTFTEYT
INPNTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(595)
(589)
(944)
(957)
(947)





SCT-Da208
GYTFTEYT
VNLNTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(596)
(589)
(944)
(957)
(947)





SCT-Da209
GYTFTSYV
INPYHDGT
ARSRTVIGFDY
QNVGTD
SAS
QQYNIYPYT



(597)
(598)
(599)
(904)
(882)
(903)





SCT-Da210
GYTFTSYV
INPYHDGT
ARSRTVIGFDY
QSISDY
YAS
QSGHSFPLT



(597)
(598)
(599)
(888)
(818)
(896)





SCT-Da211
GYTFTSYV
INPYHDGT
ARSRTVIGFDY
QNVGTD
SAS
QQYNIYPYT



(597)
(598)
(599)
(904)
(882)
(903)





SCT-Da212
GYTFTSYV
INPYNDAT
ARGVRLLDY
ENIYSY
NAK
QHHYVIPPT



(597)
(600)
(601)
(774)
(775)
(785)





SCT-Da213
GYTFTSYV
INPYTDGT
AKSRTVIGFDY
QNISDY
YAS
QNGHSFPLT



(597)
(602)
(603)
(890)
(818)
(891)





SCT-Da214
GYTFTSYV
INPYNDGT
ARSRTVVGFDY
QNISDY
YAS
QNAHSFPLT



(597)
(604)
(605)
(890)
(818)
(892)





SCT-Da215
GYTFTTYV
INPYNDGS
ARWVYYDFGGSMDY
SSVSY
LTS
QQWSSNPLT



(606)
(607)
(608)
(944)
(957)
(947)





SCT-Da216
GYTFTTYV
INPYNDGS
ARWVYYDFGGSMDY
SSVSY
LTS
QQWSSNPLT



(606)
(607)
(608)
(944)
(957)
(947)





SCT-Da217
GYTFTTYV
INPYNDGS
ARWVYYDFGGSMDY
SSVSY
LTS
QQWSSNPLT



(606)
(607)
(608)
(944)
(957)
(947)





SCT-Da218
GYTFTEYT
VNPNTGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(594)
(589)
(944)
(957)
(947)





SCT-Da219
GYTFTSYV
INPYHDGT
ARSRTVIGFDY
QSISDY
YAS
QNGHSFPLT



(597)
(598)
(599)
(888)
(818)
(891)





SCT-Da220
GYTFTEYT
INPNSGGT
TRPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(584)
(944)
(957)
(947)





SCT-Da221
GYTFTEYT
INPNSGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(583)
(589)
(944)
(957)
(947)





SCT-Da222
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
QNVDSN
SAS
QQYNSYPYT



(582)
(552)
(589)
(901)
(882)
(902)





SCT-Da223
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da224
GFTLSRYG
SSGGGIYT
ARHDGVPMDY
ENIYSY
NAK
QHHYGIPPWT



(609)
(610)
(611)
(774)
(775)
(776)





SCT-Da225
GFTFSSYG
IFSGDSNT
SRQGHRSWFAY
KSVSTSGYSY
LAS
QHSRELPYT



(612)
(613)
(614)
(828)
(829)
(830)





SCT-Da226
GFTFSTYG
ISGGGIYT
VRMITTYFDH
SSIISNY
RTS
QQGSSLPRT



(615)
(616)
(617)
(935)
(929)
(930)





SCT-Da227
GFTFSSYG
IFSGDSYT
ARQGHRSWFAY
KSVSTSGYSY
LAS
QHSRELPST



(612)
(618)
(619)
(828)
(829)
(860)





SCT-Da228
GFTFSSYA
ISSGGSYT
ARHEDTTYYYAMDY
ENIYSY
YAK
QHHYGTPLT



(538)
(620)
(621)
(774)
(786)
(787)





SCT-Da229
GFTFNTYA
IRIKSNNY
VRQAYGNSYFFAMDY
SSVSSSH
STS
HQWSSYPYT



(622)
(623)
(624)
(951)
(877)
(952)





SCT-Da230
GFTFNTNA
IRSKSNNY
TAMDY
QSLVYSNGNTY
KVS
SQSTHVPYT



(625)
(626)
(627)
(924)
(907)
(925)





SCT-Da231
GYIFITYW
IFPASGST
ASYDGYYSWFAY
SSVSY
RTS
QQYHSFPRT



(628)
(629)
(630)
(944)
(929)
(948)





SCT-Da232
GFTFSHSY
IYAGTGGT
ARHETYGSSPDY
DHINNW
GAT
QQYWSIPYT



(631)
(632)
(633)
(799)
(800)
(802)





SCT-Da233
GFTFSSFY
IDAGTGGT
ARHVGRLRGYFDV
QDVNTA
STS
QQHYSSPWT



(634)
(635)
(636)
(876)
(877)
(878)





SCT-Da234
GFTFSSNY
IYAGTGST
ASHDGHDAMDY
QSISST
YAS
HQSYSWPHT



(637)
(638)
(639)
(826)
(818)
(827)





SCT-Da235
GFTFSSNY
IDAGTGGS
ARHVGRLRGYFDV
QDVSTA
SAS
QQHYSTPWT



(637)
(640)
(636)
(884)
(882)
(885)





SCT-Da236
GFTFSSRY
IYAGTGGT
ASHDGHDAMDY
QSISNT
YAS
QQSNDWPHT



(641)
(632)
(639)
(821)
(818)
(822)





SCT-Da237
GFTFSSRY
IYAGTGGT
ASHDGHDAMDY
QSISNT
YAS
QQSYDWPHT



(641)
(632)
(639)
(821)
(818)
(824)





SCT-Da238
GFTFSSRY
IYAGTGGS
ASHDGHDAMDY
QSISNT
YAS
QQSYNWPHT



(641)
(642)
(639)
(821)
(818)
(825)





SCT-Da239
GFTFSSSY
IYAGTGDT
ASPTGINWYFDV
ENIYSF
NAR
QHHYGPPFT



(643)
(644)
(645)
(782)
(783)
(784)





SCT-Da240
GFTFSSSY
IYAGTGDT
ASPTGVNWYFDV
ENIYSF
NAR
QHHYGPPFT



(643)
(644)
(646)
(782)
(783)
(784)





SCT-Da241
GFTFSSSY
IYAGTGGT
ARPNGYGYGMDY
DHISNW
GAT
QQYWSLPYT



(643)
(632)
(647)
(805)
(800)
(806)





SCT-Da242
GFTFSSSY
IYAGTGGT
ARQDSYGRGPDC
DHINNW
GAT
QQYWTIPYT



(643)
(632)
(648)
(799)
(800)
(803)





SCT-Da243
GFTFSSSY
IYAGTGGT
ARQDSYGRSPDY
DHINNW
GAT
QQYWSIPYT



(643)
(632)
(649)
(799)
(800)
(802)





SCT-Da244
GFTFSSSY
IYAGTGGT
ARHETYGSGPDY
DHINNW
GAT
QQYWSIPYT



(643)
(632)
(650)
(799)
(800)
(802)





SCT-Da245
GFTFSSSY
IYAGTGGT
ARHETYGSSPDY
GNIHNY
NAK
QHFWSTPWT



(643)
(632)
(633)
(788)
(775)
(789)





SCT-Da246
GFTFSSSY
IYAGTGGT
ARHETYGSSPDY
DHINNW
GAT
QQYWSIPYT



(643)
(632)
(633)
(799)
(800)
(802)





SCT-Da247
GFTFSSSY
IYAGTGGT
ARQDSYGRSPDY
DHINNW
GAT
QQYWSIPYT



(643)
(632)
(649)
(799)
(800)
(802)





SCT-Da248
GFTFSSSY
IYAGTGGT
ARQDSYGRSPDY
DHINNW
GAT
QQYWSIPYT



(643)
(632)
(649)
(799)
(800)
(802)





SCT-Da249
GFTFSSRY
IYAGTGGT
ASHDGLDAMDY
QSINNY
YAS
QQSNSWPLT



(641)
(632)
(651)
(820)
(818)
(819)





SCT-Da250
GFTFSSFY
IYAGPGYT
ARHVGRQRGYFDV
QDVSTA
SAS
QQHYSTPWT



(634)
(652)
(653)
(884)
(882)
(885)





SCT-Da251
GFTFSSSY
IYAGTGGT
GRHNGYGIGMDY
DHINNW
GAT
QQYWSLPYM



(643)
(632)
(654)
(799)
(800)
(801)





SCT-Da252
GLTFSSSY
IDAGTGGT
ARHVGRLRGYFDV
QDVTTA
SAS
QQHYSAPWT



(655)
(635)
(636)
(886)
(882)
(887)





SCT-Da253
GFTFSSNY
IYAGTGGT
ASHDGHDAMDY
QSISNT
YAS
QQSNSWPHT



(637)
(632)
(639)
(821)
(818)
(823)





SCT-Da254
GYTFTDYP
IITYYGDA
ASHRGKGYFDV
KSVSTSGYSY
LAS
QHSRELYT



(656)
(657)
(658)
(828)
(829)
(854)





SCT-Da255
GYTFTDYP
IITYYGDA
ASHRGKGYFDV
SSVSY
LTS
QQWSSNPLT



(656)
(657)
(658)
(944)
(957)
(947)





SCT-Da256
GYTFTDYF
IYPGNINT
AGGNYALDY
QSISNY
YAS
QQSNSWPLT



(659)
(660)
(661)
(863)
(818)
(819)





SCT-Da257
GYTFTDYY
IYPGNDNS
AGGNYAMDY
QSISNY
YAS
QQSNSWPLT



(662)
(663)
(664)
(863)
(818)
(819)





SCT-Da258
GYTFTAYY
IYPGNDNT
AGGNYAMDY
QSISNY
YAS
QQSNSWPLT



(665)
(666)
(664)
(863)
(818)
(819)





SCT-Da259
GYTFTNSG
INTYTGEP
APTIQVRRLFDY
SSVSY
ATS
QQWSSTPPT



(667)
(668)
(669)
(944)
(945)
(946)





SCT-Da260
GYTFTNSG
INTYTGEP
APTIQVRRLVDY
SSVSY
ATS
QQWSSTPPT



(667)
(668)
(670)
(944)
(945)
(946)





SCT-Da261
GYTFTNYG
INTNTGEP
ARRGYYGRGDY
ESVDSYGNSF
RAS
QQSNEDPYT



(671)
(672)
(673)
(846)
(844)
(847)





SCT-Da262
GFSLTSYD
IWTGGGT
VRWGDDYDWFAY
QSVSND
YAS
QQDYSSPPT



(674)
(675)
(676)
(966)
(818)
(967)





SCT-Da263
GFSLTTYG
IWRGGGTD
AIYSDHDTYALDY
LSLLYSSNQKNY
WAS
QQYYSYPLT



(677)
(678)
(679)
(865)
(866)
(867)





SCT-Da264
GYTFTDYA
ISNYNGDV
ARRHGNRAMDY
QDVGTA
RAS
QQYSTYYT



(680)
(681)
(682)
(879)
(844)
(880)





SCT-Da265
GYSFTSYY
INPSNGGT
TREGNYGYSWYAY
QDVSTA
SAS
QQHYSTPWT



(683)
(684)
(685)
(884)
(882)
(885)





SCT-Da266
GYTFTSYW
IDPSDSYT
AGGIHFDY
QSLLDSDGKTY
LVS
WQGTHFPFT



(686)
(687)
(688)
(926)
(912)
(927)





SCT-Da267
GYTFTSYN
IYPGKDDT
ARVYYGNYGGFDY
ESVDSYGYSF
LAS
QQNNEDPFT



(689)
(690)
(691)
(858)
(829)
(859)





SCT-Da268
GYTFTSYW
IYPGSGSV
TRGGIGVRSPFDV
QSLVHSNGNTY
KVS
SQSTHVWT



(686)
(692)
(693)
(919)
(907)
(922)





SCT-Da269
GYTFTSSW
IHPNSGNT
VRLGLFDF
DHINNW
GAT
QQYWSIPYT



(694)
(695)
(696)
(799)
(800)
(802)





SCT-Da270
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da271
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da272
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da273
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da274
GYTFTNYW
ISPRTGNT
TRGEAY
SSVSY
LTS
QQWSSNPLT



(697)
(698)
(699)
(944)
(957)
(947)





SCT-Da275
GYTFTNYW
ISPRTGNT
ARGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(700)
(780)
(778)
(781)





SCT-Da276
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da277
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAK
KQSYDVPYT



(697)
(698)
(699)
(780)
(775)
(781)





SCT-Da278
GYTFTNYW
ISPRTGNT
ARGEAY
ENIYYS
NAN
KQAYDVPYT



(697)
(698)
(700)
(780)
(778)
(779)





SCT-Da279
GYTFTNYW
ISPRTGNT
ARGEAY
ENIYYS
NAN
KQAYDVPYT



(697)
(698)
(700)
(780)
(778)
(779)





SCT-Da280
GYTFTNYW
ISPRTGNT
TRGEAY
ENIYYS
NAN
KQSYDVPYT



(697)
(698)
(699)
(780)
(778)
(781)





SCT-Da281
GYTFTNYW
ISPRTGNT
ARGEAY
ENIYYS
NAN
KQAYDVPYT



(697)
(698)
(700)
(780)
(778)
(779)





SCT-Da282
GYTFTNYW
ISPRTTYT
TRGEAY
ENIYYT
NAN
KQAYDVPYT



(697)
(701)
(699)
(777)
(778)
(779)





SCT-Da283
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
QDISNY
YTS
QQGNTLPWT



(702)
(703)
(704)
(773)
(771)
(772)





SCT-Da284
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
ESVDNFGNSF
LAS
QQSNEDPRT



(702)
(703)
(704)
(838)
(829)
(837)





SCT-Da285
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
ESVDSYGNSF
IAS
QQSNEDPRT



(702)
(703)
(704)
(846)
(842)
(837)





SCT-Da286
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
QNVDTN
SGS
QQYNTYPYT



(702)
(703)
(704)
(873)
(874)
(875)





SCT-Da287
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
QRISDY
YAS
QNGHSFPFT



(702)
(703)
(704)
(893)
(818)
(889)





SCT-Da288
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
QNVDTN
SAS
QQYNSYPYT



(702)
(703)
(704)
(873)
(882)
(902)





SCT-Da289
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
QNVGTD
SAS
QQYNSYPYT



(702)
(703)
(704)
(904)
(882)
(902)





SCT-Da290
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
SSISSNY
RTS
QQGSSLPRT



(702)
(703)
(704)
(928)
(929)
(930)





SCT-Da291
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
SSISSNY
RTS
QQGSSIPRT



(702)
(703)
(704)
(928)
(929)
(932)





SCT-Da292
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
SSVSY
DTS
QQWSSNPLT



(702)
(703)
(704)
(944)
(953)
(947)





SCT-Da293
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
SSISY
GTS
QQWSSYPLT



(702)
(703)
(704)
(954)
(955)
(956)





SCT-Da294
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
ENIYYS
NAN
KQSYDVPYT



(686)
(705)
(706)
(780)
(778)
(781)





SCT-Da295
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QSVDYDGDNY
AAS
QQSYEDPWT



(686)
(705)
(706)
(831)
(794)
(832)





SCT-Da296
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
ESVDSYGNSF
IAS
QQSNEDPRT



(686)
(705)
(706)
(846)
(842)
(837)





SCT-Da297
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QDVSTA
SAS
QQHYSTPWT



(686)
(705)
(706)
(884)
(882)
(885)





SCT-Da298
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QDVTTA
SAS
QQHYSAPWT



(686)
(705)
(706)
(886)
(882)
(887)





SCT-Da299
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QNVGTD
SAS
QQYNSYPYT



(686)
(705)
(706)
(904)
(882)
(902)





SCT-Da300
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QNVGTD
SAS
QQYNSYPYT



(686)
(705)
(706)
(904)
(882)
(902)





SCT-Da301
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QNVGTN
SAS
QQYNSYPYT



(686)
(705)
(706)
(899)
(882)
(902)





SCT-Da302
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
SSVSY
LTS
QQWSSNPLT



(686)
(705)
(706)
(944)
(957)
(947)





SCT-Da303
GYTFTSYW
IYPGDGDT
ARVEADDLWYFDV
QSVTND
YAS
QQDYNSPYT



(686)
(705)
(706)
(970)
(818)
(962)





SCT-Da304
GYTFTTYW
INPSTGYT
ASYYGTSQAWFAY
ENIYYS
NAN
KQSYDVPYT



(702)
(703)
(704)
(780)
(778)
(781)





SCT-Da305
GYAFTNYL
INPGSGGP
ASDNYGNYDVLDY
QEISGY
AAS
LQSASYPPT



(707)
(708)
(709)
(793)
(794)
(795)





SCT-Da306
GYAFTNYL
INPGSGGT
DREDAY
KSLLHSNGNTY
RMS
MQHLEYPYT



(707)
(710)
(711)
(872)
(869)
(871)





SCT-Da307
GYTFTDYA
INTYSSNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(712)
(713)
(888)
(818)
(889)





SCT-Da308
GYTFTDYA
INTYSSNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(712)
(713)
(888)
(818)
(889)





SCT-Da309
GYTFTDYA
INTYSSNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(712)
(713)
(888)
(818)
(889)





SCT-Da310
GYTFTDYA
INTYSSNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(712)
(713)
(888)
(818)
(889)





SCT-Da311
GYTFTDYV
IYPGGNRT
ARFNDWAMDH
QSLVHSNGITY
KVF
SQSTHVPWT



(714)
(715)
(716)
(914)
(915)
(916)





SCT-Da312
GYTFTDYV
IYPGGNST
ARFNDWSMDY
QSLVHSNGITY
KVS
SQSTHVPWT



(714)
(717)
(718)
(914)
(907)
(916)





SCT-Da313
GYTFTDYV
IYPGGSSI
ARFNDWAMDY
QSLVHSNGITY
KVS
SQSTHFPWT



(714)
(719)
(720)
(914)
(907)
(917)





SCT-Da314
GYTFTDYV
IYPGGSSI
ARFNDWAMDY
QSLVHSNGITY
KVS
SQSTHFPWT



(714)
(719)
(720)
(914)
(907)
(917)





SCT-Da315
GYTFTSYF
IYPGNVNT
ARDYAMDY
QSINNY
YAS
QQSSTWPLT



(721)
(722)
(723)
(820)
(818)
(862)





SCT-Da316
GYTFTTYF
IYPGNVNV
SRDYAMDY
QGINNY
YAS
QQSNSWPLT



(724)
(725)
(726)
(817)
(818)
(819)





SCT-Da317
GYTFTTYY
IYPGNVNT
TRDYAMDY
QSINNY
YAS
QQSNSWPLT



(727)
(722)
(728)
(820)
(818)
(819)





SCT-Da318
GYTFTTYY
IYPGNVNV
TRDYAMDY
QSINNY
YAS
QQSNSWPLT



(727)
(725)
(728)
(820)
(818)
(819)





SCT-Da319
GYTFTTYY
IYPGNVNV
TRDYAMDY
QSINNY
YAS
QQSNSWPLT



(727)
(725)
(728)
(820)
(818)
(819)





SCT-Da320
GYTFTTYY
IYPGNVNT
ARDYAMDY
QSINNY
YAS
QQSNSWPLT



(727)
(722)
(723)
(820)
(818)
(819)





SCT-Da321
GYTFTTYY
IYPGNVNT
ARDYAMDY
SSVSY
LTS
QQWSSNPLT



(727)
(722)
(723)
(944)
(957)
(947)





SCT-Da322
GYTFTTYY
IYPGNVNV
SRDYAMDY
QRINSY
YAS
QQSNSWPLT



(727)
(725)
(726)
(861)
(818)
(819)





SCT-Da323
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
SAS
QNGHSFPFT



(680)
(729)
(713)
(888)
(882)
(889)





SCT-Da324
GYTFTDYA
INTHSDNT
ARPNYDGHWYFDV
QSLLDSDGETY
LVS
WEGTHFWP



(680)
(730)
(731)
(911)
(912)
(913)





SCT-Da325
GYTFTDYA
INTYSGNT
ARRRGIHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(729)
(732)
(888)
(818)
(889)





SCT-Da326
GYTFTDYA
INSYSGNT
ARWAITTGVYYAMDY
SSVSSSY
STS
QQYSGYPLT



(680)
(733)
(734)
(937)
(877)
(938)





SCT-Da327
GYTFTDYA
INTYSANT
ARRRGSHRDAYFDY
QSISDY
YVS
QNGHSFPFT



(680)
(735)
(713)
(888)
(897)
(889)





SCT-Da328
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
ESVDNYGISF
AAS
QQSKEVPT



(680)
(729)
(713)
(839)
(794)
(840)





SCT-Da329
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(729)
(713)
(888)
(818)
(889)





SCT-Da330
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
SSISY
GTS
QQWSSYPLT



(680)
(729)
(713)
(954)
(955)
(956)





SCT-Da331
GYTFTDYA
INTYSGNT
ARRRGSHQDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(729)
(736)
(888)
(818)
(889)





SCT-Da332
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNSHSFPFT



(680)
(729)
(713)
(888)
(818)
(894)





SCT-Da333
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QDVSTA
SAS
QQHYSTPWT



(680)
(729)
(713)
(884)
(882)
(885)





SCT-Da334
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNSHSFPFT



(680)
(729)
(713)
(888)
(818)
(894)





SCT-Da335
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QTISDY
YAS
QNSHSFPFT



(680)
(729)
(713)
(898)
(818)
(894)





SCT-Da336
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNSHSFPFT



(680)
(729)
(713)
(888)
(818)
(894)





SCT-Da337
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNGHSFPFT



(680)
(729)
(713)
(888)
(818)
(889)





SCT-Da338
GYTFTDYA
INTYSGNT
ARRRGSHRDAYFDY
QSISDY
YAS
QNSHSFPFT



(680)
(729)
(713)
(888)
(818)
(894)





SCT-Da339
GYTFTDYV
IYPGGNR
ARFNDWAMDY
QSLVHSNGITY
KVS
SQSTHVPWT



(714)
(737)
(720)
(914)
(907)
(916)





SCT-Da340
GYTFTDYE
IDPETGAT
TARQLGLPFAY
QSVSND
YAS
QQDYTSPPT



(738)
(739)
(740)
(966)
(818)
(971)





SCT-Da341
GFSLNTSNL
AHIWWDDD
ARKNHYYGHWYFDV
QFVSNF
YAS
QQDYSSPYT



(741)
(742)
(743)
(963)
(818)
(960)





SCT-Da342
GFSLNTSNM
AHIWWDDD
ARKNHYYGHWYFDV
QFVSNF
YAS
QQDYSSPYT



(744)
(742)
(743)
(963)
(818)
(960)





SCT-Da343
GFSLSTPGL
AHIWWDDD
ARKNHYYGHWYFDV
QSVNND
YAS
QQDYNSPYA



(745)
(742)
(743)
(964)
(818)
(965)





SCT-Da344
GFSLSTPNM
AHIWWDDD
ARKIHYYGHWYFDV
QSVIND
YAS
QQDYSSPYT



(746)
(742)
(747)
(961)
(818)
(960)





SCT-Da345
GFSLSTPSM
AHIWWDDD
ARKNHYSGHWFFDV
QSVIND
YAS
QQDYSSPYT



(748)
(742)
(749)
(961)
(818)
(960)





SCT-Da346
GFSLSTSGM
AHIWWDDD
ARKNHYYGHWYFDV
QSVSNY
YAS
QQDYSSPYT



(750)
(742)
(743)
(969)
(818)
(960)





SCT-Da347
GFSLSTSNL
AHIWWDDD
ARKSHYYGHWYFDV
QSVIND
YAS
QQDYSSPYT



(751)
(742)
(752)
(961)
(818)
(960)





SCT-Da348
GFSLSTSNM
AHIWWDDD
ARKSHYYGHWYFDF
QSVIND
YAS
QQDYNSPFT



(753)
(742)
(754)
(961)
(818)
(972)





SCT-Da349
GFSLSTSNM
AHIWWDDD
GRKSHYYGHWYFDV
QNVGTD
SAS
QQYNSYPYT



(753)
(742)
(755)
(904)
(882)
(902)





SCT-Da350
GFSLSTSNM
AHIWWDDD
GRKSHYYGHWYFDV
QNVDNY
YAS
QQDYSSPYT



(753)
(742)
(755)
(959)
(818)
(960)





SCT-Da351
GFSLSTSNM
AHIWWDDD
GRKSHYYGHWYFDV
QNVDNY
YAS
QQDYSSPYT



(753)
(742)
(755)
(959)
(818)
(960)





SCT-Da352
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDF
QSVIND
YAS
QQDYNSPYT



(753)
(742)
(756)
(961)
(818)
(962)





SCT-Da353
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDF
QSVIND
YAS
QQDYNSPYT



(753)
(742)
(756)
(961)
(818)
(962)





SCT-Da354
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDV
ENIYSN
AAT
QHFWGTPFT



(753)
(742)
(743)
(790)
(791)
(792)





SCT-Da355
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDV
QDINKY
YTS
LQYDNLWT



(753)
(742)
(743)
(796)
(771)
(798)





SCT-Da356
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDV
QSVIND
YAS
QQDYSSPYT



(753)
(742)
(743)
(961)
(818)
(960)





SCT-Da357
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDV
QSVTND
YAS
QQDYNSPYT



(753)
(742)
(743)
(970)
(818)
(962)





SCT-Da358
GFSLSTSNM
AHIWWDDD
ARKSHYYGHWYFDV
QSVSND
YAS
QQDYNSPYT



(753)
(742)
(752)
(966)
(818)
(962)





SCT-Da359
GFSLSTSNM
AHIWWDDD
GRKSHYYGHWYFDV
QSVIND
YAS
QQDYSSPYT



(753)
(742)
(755)
(961)
(818)
(960)





SCT-Da360
GFSLSTSNM
AHIWWDDD
ARKNHYYGHWYFDV
QTVTND
YAS
QQDYISPYT



(753)
(742)
(743)
(942)
(818)
(943)





SCT-Da361
GFSLSTYGI
AHIWWNDN
ARIDYWFAY
QGIINY
YTS
QQYSKLPYT



(757)
(758)
(759)
(809)
(771)
(810)





SCT-Da362
GFSLSTYGI
AHIWWNDN
ARIDYWFAY
SSVSY
LTS
QQWSSNPLT



(757)
(758)
(759)
(944)
(957)
(947)





SCT-Da363
GFTFSSFY
IYAGPGYT
ARHVGRQRGYFDV
QDVSTA
SAS
QQHYSTPWT



(634)
(652)
(653)
(884)
(882)
(885)





SCT-Da364
GFTFSSFY
IYAGPGYT
ARHVGRQRGYFDV
QDVSTA
SAS
QQHYSTPWT



(634)
(652)
(653)
(884)
(882)
(885)





SCT-Da365
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da366
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da367
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da368
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da369
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da370
GYTFTEYT
INPNNGGT
ARPHSLLRLRREFDY
SSVSY
LTS
QQWSSNPLT



(582)
(552)
(589)
(944)
(957)
(947)





SCT-Da371
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da372
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da373
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)





SCT-Da374
GVNIKDTY
IDPANGNR
ARDGYYAPGY
QNVGTD
SAS
QQYNSYPYT



(574)
(560)
(546)
(904)
(882)
(902)




















TABLE 6







SEQ

SEQ


mAb

ID

ID


AA ID
VH Amino Acid Sequence
NO:
VL Amino Acid Sequence
NO:







SCT-Da001
AVQLQESGPDLVKPSQSLSLTCTVTGYSITSNY
  4
DIKMTQSPSSMYASLGERVTITCKASQDINSYL
247



NWHWIRQFPGNKLEWMGYIHYSDDTNYNPSLKS

SWFQQKTGKSPKTLIYRANRLVDGVPSRFSGSG




RISITRDPSKNQFFLQLNSVTTEDTATYYCARW

SGQDYSLTISSLEYEDMGIYYCLQYDEFPPTFG




SYYYGGPYYYSMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da002
DVQLQESGPDLVKPSQSLSLTCTVTGYSITSGY
  5
DIKMTQSPSSMYASLGERVTITCKASQDINTYL
248



NWHWIRQFPGNKLEWMGYIHYSGGTNYNPSLKS

SWFQQKPGKSPKTLIYRANILVDGVPSRFSGSG




RISITRDASKNQFFLQLNSVTTEDTATYYCGRW

SGQDYSLTISSLEYEDMGIYYCLQYDEFPPTFG




SYYYGSPYYYSMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da003
DVQLQESGPGLVKPSQSLSLTCSVTGFSITSGY
  6
DIVLTQSPASLAVSLGQRVTISCKASQSVDYDG
249



YWNWIRQFPGNKLEWMGYISYDGSNNYNPSLKN

DSYMNWYQQKPGQPPKVLIYAASNLESGIPARF




RISITRDTSKNQFFLNLNSVTTEDTATYYCARD

SGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDP




YYGYPAWFTYWGQGTLVTVSA

RTFGGGTKLEIK






SCT-Da004
DVQLQESGPGLVKPSQSLSLTCSVTGYSITDGY
  7
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
250



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RLSITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da005
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
  8
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
251



FWNWFRQFPGNKLEWLGFINYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTTEDTATYYCARR

SGTAYSLTISNLEEEDIATYFCQQGKSLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da006
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
  9
DIQMTQPTSSLSASLGDRVTISCRASQDISNYL
252



FWNWFRQFPGNKLEWMGYINFDGSSNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTSEDTATYFCARR

SGTDYSLTISNLDQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSITVSS

GGTKLEIK






SCT-Da007
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
  9
DIQMTQPTSSLSASLGDRVTISCRASQDISNYL
253



FWNWFRQFPGNKLEWMGYINFDGSSNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTSEDTATYFCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSITVSS

GGTKLEIK






SCT-Da008
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
  9
DIQMTQTTSSLSASLGDRVTISCRASQDINNYL
254



FWNWFRQFPGNKLEWMGYINFDGSSNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTSEDTATYFCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSITVSS

GGTKLEIK






SCT-Da009
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
  9
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
255



FWNWFRQFPGNKLEWMGYINFDGSSNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTSEDTATYFCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSITVSS

GGTKLEIK






SCT-Da010
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
 10
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
256



FWNWFRQFPGNRLEWLGFINYDGTNTYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTTEDTATYYCARR

SGTAYSLTISNLEEADIATYFCQQGKSLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da011
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
 11
DIQMTQTTSSLSASLGDRVTISCRASQDINNYL
254



FWNWFRQFPGNRLEWMGFINYDGTNTYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da012
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSAY
 11
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
256



FWNWFRQFPGNRLEWMGFINYDGTNTYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTTEDTATYYCARR

SGTAYSLTISNLEEADIATYFCQQGKSLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da013
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSDS
 12
DIQMTQTTSSLSASLGDRVTISCRASQDINNYL
254



FWNWIRQVPGNKLEWMGFISYDGSNNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLKLNSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da014
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSDY
 13
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
257



FWNWIRQFPGNKLEWMGFISYDGSNNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLKLNSVTSEDTATYFCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da015
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSDY
 14
DIQMTQTTSSLSASLGDRVTISCRASQDISNFL
258



FWNWIRQFPGNKLEWMGFISYDGSNYCNPSLKN

NWFQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLKLNSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIASYFCQQGKTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da016
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 15
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
259



FWNWFRQFPGDKLEWMGYINYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RVSISRDTSKNQFFLRLSSVTAEDTATYYCARR

SGTDYSLTISNLEQEDLATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da017
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 16
DIQMTQPTSSLSASLGDRVTISCRASQDINNYL
260



FWNWFRQFPGNKLEWMGFINYDGSDNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDSWGQGTSVTVSS

GGTKLEIK






SCT-Da018
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 16
DIQMTQTTSSLSASLGDRVTISCRASHDIHNYL
261



FWNWFRQFPGNKLEWMGFINYDGSDNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDSWGQGTSVTVSS

GGTKLEIK






SCT-Da019
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 17
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
257



FWNWFRQFPGNKLEWMGFINYDGSNNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTSEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da020
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 18
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
262



FWNWFRQFPGNKLEWMGFINYDGSSNYNPSLKN

LHWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




KGWLYAMDYWGQGTSVTVSS

GSGTKLEIK






SCT-Da021
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 19
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
250



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRFNSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da022
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 19
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
250



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRFNSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da023
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 21
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
263



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYFCARR

SGTDYSLTISSLEQEDIATYFCQQGIALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da024
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 22
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
263



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGIALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da025
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 22
DIQMTQSTSSLSASLGDRVTISCRASQDISNYL
250



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da026
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 22
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




KGWLYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da027
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 22
SIVMTQTPKFLLVSAGDRVTITCRASQSVTNDV
265



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

YGTDFTFTISTVQAEDLAVYFCQQDYNSPYTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da028
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 23
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
266



FWNWFRQFPGNKLEWMGFLNYDGSNNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLESK






SCT-Da029
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 24
DIQMTQSTSSLSASLGDRVSISCRASQDISNYL
267



FWNWFRQFPGNKLEWMGFLNYDGSSNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSENQFFLRLSSVTTEDTATYYCARR

SGTDYSLTISSLEQEDVATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da030
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 25
DIQMTQTTSSLSASLGDRVTISCRTSQDISNYL
268



FWNWIRQFPGNKLEWMGFINYDGSNNYNPSLKN

NWYQQKPDGWKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLKLNSVTTEDTATYYCARR

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da031
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 26
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTAV
269



YWNWIRQFPGNKLEWMGYISYDGSNNYNPSLKN

AWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSG




RISITRDTSKNQFFLKLNSVTTEDTATYYCARE

SGTDFTLTISNVQSEDLADYFCQQYSSYPYTFG




GDYGSYWGQGTLVTVSA

GGTKLEIK






SCT-Da032
DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGY
 27
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
270



YWNWIRQFPGNKLEWMGYISYDGSNNYNPSLKN

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




RISITRDTSKNQFFLKLTSVTTEDTATYYCTRR

SGTDYSLTISNLEQEDIATYFCQQGNALPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da033
DVQLQESGPGLVKPSQSLSLTCTVTGYSITSDY
 28
DIVMTQSHKFMSTSVGDRVSITCKASQDVNTAV
271



AWNWIRQFPGNKLEWMGYISYSGSTNYNPSLKS

AWYQQRPGQSPKLLIYSASYRFIGVPDRFTGSG




RISITRDTSKNQFFLQLNSVTTEDTATYYCASG

SGTDFTFTISTVQAEDLAVYYCQQHYSTPFTFG




YYGIHYYAMDYWGQGTSVTVSS

SGTKLEIK






SCT-Da034
DVQLQESGPGLVKSSQSLSLTCSVTGYSITSGY
 29
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
266



FWNWIRQFPGNKLEWMGFINYDGSSNYNPSLKN

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




RISITRDTSKNQFFLKLNSVTTEDTATYYCARR

SGTDYSLTISSLEQEDIATYFCQQGNTLPWTFG




KGWLYAMDYWGQGTSVTVSS

GGTKLESK






SCT-Da035
EIHLQQTGPELVKPGASVKISCKASGYSFTAYI
 30
DVLMTQTPLSLPVSLGDHASISCRSSQSIVHTN
272



MLWVKQSHGKSLEWIGNINPYYGSTSYNLKFKG

GNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTVDQSSSTAYMQLNSLTSDDSAVYYCARG

FSGSGSGTDFTLKISRVEAEDLGLYYCFQGSHV




PPYYYGSSRDYALDYWGQGTSVTVSS

PYTFGGGTKLEIK






SCT-Da036
EIQLQQTGPELVKPGASVKISCKASGYSFTDYI
 31
DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSN
273



MLWVKQSHGKSLEWIGNINPYYDTTAYNLKFKG

GNTYLHWYLQKPGQSPNLLIYKVSNRFSGVPDR




KATLTVDKSSSTAYMLLNSLTSEDSAVYYCATY

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHG




DGFAYWGQGTLVTVSA

PWTFGGGTKLEIK






SCT-Da037
EIQLQQTGPELVKPGASVKISCKASGYSFTDYI
 32
DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSY
274



MLWVKQSHGKSLEWIGNINPYYGTTSYNLKFKG

GNTYLHWHLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTVDKSSSTAYMQLNSLTSEDSAVYYCATY

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHG




DGFAYWGQGTLVTVSA

PWTFGGGTKLEIK






SCT-Da038
EIQLQQTGPELVKPGASVKISCKASGYSFTDYI
 33
DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSN
275



MLWVKQSHGKSLEWIGNINPYYYTTSYNLKFKG

GNTYLHWHLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTVDKSSSTAYMQLNSLTSEDSAVYYCATY

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHG




DGFAYWGQGTLVTVSA

PWTFGGGTKLEIK






SCT-Da039
EVHLQQSGAELVRPGALVKLSCKASGFNIKDYY
 34
EIVLTQSPTPMAASPGEKITITCSASSSISSNY
276



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LHWYRQKPGFSPKLLIYRTSNLASGVPPRFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCTIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSLPRTF




VRRDYFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da040
EVKLEESGGGLVQPGGSMRLSCVASGFTFSNYW
 35
QIVLTQSPAIMSASPGEKVTITCSASSSVNYMH
277



MNWVRQSPEKGLEWVAEIRLKFNNYTTHYAESV

WFQQKPGTSPKLWIYSTSNLASGVPARFSGSGS




KGRFTISRDDSKSSVYLQMNNLRTEDTGIYYCI

GTSYSLTISRMEAEDAATYYCQQRSTYPRTFGG




KFGGMDYWGPGTSVTVSS

GTKLEIK






SCT-Da041
EVKLVESGGGLVKPGGSLKLSCAASGFAFNSYD
 36
DILMTQSPSSMSVSLGDTVSITCHASQGISSNI
278



MSWVRQTPEKRLEWVATISDGGSFTYYPDSVKG

GWLQRKPGKSFKGLIYHGTNLEDGLPSRFSGSG




RFTISRDNARNTLYLHMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




QITTLRMDYWGQGTSVTVSS

GGTKLELK






SCT-Da042
EVKLVESGGGLVKPGGSLKLSCAASGFAFSSYD
 37
DILMTQSPSSMSVSLGDTVSITCHASQGISSNI
279



MSWVRQTPEKRLEWVAAISDGGSYTYYPDSVKG

GWLQQKPGKSFKGLIYHGTNLEDGLPSRFSGSG




RFTISRDNAGNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




RVTTVRMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da043
EVKLVESGGGLVKPGGSLKLSCAASGFAFSSYD
 38
DILMTQSPSSMSVSLGDTVSITCHASQGISSNI
280



MSWVRQTPEKRLEWVATISDGGSYTYYPDSVKG

GWLQQKPGKSFKGLIYHGTNLEDGLPSRFSGSG




RFTISRDNAGKTLYLQMSSLRPEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




RVTTVRMDYWGQGTSVTVSS

GGTKLEIL






SCT-Da044
EVKLVESGGGLVKPGGTLKLSCAASGFAFSDYD
 39
DILMTQSPSSMSVSLGDSVSITCHASQGISSNI
281



MSWVRQTPEKRLEWVATISDGGSYTYYPDSVKG

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




RFTISRDNARNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




LITTLRMDYWGQGASVTVSS

GGTKVEIK






SCT-Da045
EVKLVESGGGLVKPGGTLKLSCAASGFAFSDYD
 39
DILMTQSPSSMSVSLGDTVTITCHASQGISSNI
282



MSWVRQTPEKRLEWVATISDGGSYTYYPDSVKG

GWLQQKPGKSFKGLIYHGTNLEDGVPSKFGGSG




RFTISRDNARNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




LITTLRMDYWGQGASVTVSS

GGTKLEIK






SCT-Da046
EVKLVESGGGLVKPGGTLKLSCAASGFAFSDYD
 40
DILMTQSPSSMSVSLGDSVSITCHASQGISSNI
283



MSWVRQTPEKRLEWVATISDGGSYTYYPDSVKG

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




RFTVSRDNARNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




LITTLRMDYWGQGASVTVSS

GGTTLEIK






SCT-Da047
EVKLVESGGGLVKPGGTLKLSCAASGFAFSDYD
 41
DILMTQSPSSMSVSLGDSVSITCHASQGISSNM
284



MSWVRQTPEKRLEWVATISNDGSYTYYPDSVKG

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




RFTISRDNARNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




LITTLRMDYWGQGASVTVSS

GGTKLEIK






SCT-Da048
EVKLVESGGGLVKPGGTLKLSCAASGFAFSDYD
 41
DILMTQSPSSMSVSLGDSVSITCHASQGISSNM
285



MSWVRQTPEKRLEWVATISNDGSYTYYPDSVKG

GWLQQKTGKSFKGLIYHGTNLEDGVPSRFSGSG




RFTISRDNARNTLYLQMSSLRSEDTALYYCARH

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




LITTLRMDYWGQGASVTVSS

GGTKLEIK






SCT-Da049
EVMLVASGGGLVKPGGSLKLSCAASGFTFSSYT
 42
DIVLTQSPASLTVSLGQRATISCRASKSVSTSA
286



VSWVRQTPEKRLEWVASIISGGGDIYYPDSVRG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFTISRDNARNNLYLQMSSLRSEDTALYYCARW

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




YSAGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da050
EVMLVASGGGLVKPGGSLKLSCAASGFTFSSYT
 43
DIVLTQSPPSLAVSLGQRATISCRASKSVSTSA
287



VSWVRQTPEKRLEWVATISGGGVTYYPDSVRGR

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




FTISRDNAKNNLYLQMRSLRSEDTALYYCARWY

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




SVGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da051
EVMLVASGGGLVKPGGSLKLSCAASGFTFSSYT
 44
DIVLTQSPASLTVSLGQRATISCRASKSVSTSA
288



VSWVRQTPEKRLEWVATITGGGDTYYPDSVRGR

YSYMHWYQQKLGQPPKLLIYLASNLESGVPARF




FTISRDNAKNNLYLQMSSLRSEDTALYYCARWY

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




SVGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da052
EVMLVASGGGLVKPGGSLKLSCAASGFTFSSYT
 45
DIVLTQSPASLAVSLGQRATISCRASKSVSTSA
289



VSWVRQTPEKRLEWVATITSGGGDTYYPDSVRG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFTISRDNAKNNLYLEMSSLRSEDTALYYCARW

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




YSAGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da053
EVMLVASGGGLVKPGGSLNLSCAASGFTFSSYT
 46
DIVLTQSPPSLAVSLGQRATISCRASKSVSTSA
287



VSWVRQTPEKRLEWVATISGGGVTYYPDTVRGR

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




FTISRDNAKNNLYLQMRSLRSEDTALYYCARWY

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




SVGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da054
EVMLVESGGGLVKPGGSLKLSCAASGFTFSSYA
 47
DIVLTQSPASLAVSLGQRATISCRASKSVSTSN
290



MSWVRQTPEKRLEWVATIFFGSSVTYFPASVKG

YSYMHWYQQKPGQPPKLLLYLASNLESGVPARF




RFTISRDNANNTLFLQLSSLRSEDTAMYYCARQ

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELP




GTSPWFAYWGQGTLVTVSA

TFGGGTKLEIK






SCT-Da055
EVMLVESGGGLVKPGGSLKLSCAASGFTFSSYT
 48
DIVLTQSPASLAVSLGQRATISCRASKSVSTSG
291



MSWVRQTPEKRLEWVATIISGGGNTYYPDSVKG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFTISRDNAKNNLYLQMSSLRSEDTALYYCARW

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELL




YSAGYFDVWGAGTTVTVSS

TFGSGTKLEIK






SCT-Da056
EVMLVESGGGLVKPGGSLKLSCAASGFTFSSYT
 49
DIVLTQSPASLAVSLGQRATISCRASKSVSTSG
292



MSWVRQTPEKRLEWVATISGGVGDTYYPDSVKG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFTISRDNAKNNLYLQMSSLRSEDTALYYCARQ

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELP




GGFPWFAYWGQGTLVTVSA

YTFGGGTKLEIK






SCT-Da057
EVQLQPSGAELVKPGASVKLSCTASGFNIEDTY
 50
DIVMTQFQKFMSTSVGDRVSVTCKASQNVDTNV
293



IHWMKQRPEQGLEWIGRIDPANGNTISDPKFQG

AWYQQKPGQSPKLLIYSGSYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNTYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da058
EVQLQPSGAELVKPGASVKLSCTASGFNIEDTY
 51
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



IHWMKQRPEQGLEWIGRIDPANGNTISDPKFRG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da059
EVQLQPSGSELVKPGASVKLSCTASGFNIEDTY
 52
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



IHWMKQRPEQGLEWIGRIDPANGYTTYDPKFQD

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da060
EVQLQQFGAELVKPGASMKISCKASGYTFTDYN
 53
DIVLTQSPVSLVVSLGQRATISCRANETVDSYG
295



MAWVKQSHGKSLEWIGDINPNYDSTSYNQKFKG

SSFMHWYQQKPGHPPKLLIYRASNLESGIPARF




KATLTVDKSSSTAYMELRSLTSEDAALYYCARS

SGSGSRTDFTLTINPVEADDVATYFCQQSNEDP




GFDGYYYAMDYWGQGTSVTVSS

FTFGSGTKLEIK






SCT-Da061
EVQLQQFGAELVKPGASVKISCKASDYTFTDYN
 54
DIQMTQTTSSLSASLGDRVTISCSASQGISNYL
296



MDWVKQSHGKSLEWIGDINPNNGGTIYNLKFKG

NWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSG




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGTDYSLTISNLEPEDIATYYCQQYSKLPLTFG




HYGNYFYAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da062
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 55
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
297



IDWVKQSHGKSLEWIGDINPNGDFTTYNLKFKG

NSFMHWYQQKPGQPPKLLVYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAAAYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da063
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 56
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



MDWVKQNHGKSLEWIGDINPNNGGTIYNLKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da064
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 57
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
298



MDWVKQSHGKSLEWIGDINPNDDSTKYNLKFKG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGKDYTLSITSLQTEDVATYYCQQYWSTPTFGG




HYGNYFYAMDYWGQGTSVTVSS

GTKLEIK






SCT-Da065
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 57
DIVLTQSPASLAVSLGQRATISCRASESVDSFG
299



MDWVKQSHGKSLEWIGDINPNDDSTKYNLKFKG

HSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDGATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da066
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 58
DIVLTQSPASLAVSLGQRATISCRASESVDSFG
300



MDWVKQSHGKSLEWIGDINPNDDSTSYNLKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIGPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEII






SCT-Da067
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 59
DIVLTQSPASLAVSLGQRATISCRASESVDNFG
301



MDWVKQSHGKSLEWIGDINPNNGGTIYNLKFKG

NSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da068
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 59
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



MDWVKQSHGKSLEWIGDINPNNGGTIYNLKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da069
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 60
DIVLTQSPASLAVSLGQRATISCRASESVDSFG
302



MDWVKQSHGKSLEWIGDINPNNGGTIYNQKFKG

NSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da070
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 60
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
303



MDWVKQSHGKSLEWIGDINPNNGGTIYNQKFKG

NSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da071
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 60
DIVLTQSPASLAVSLGQRVTISCKASQSVDYDG
249



MDWVKQSHGKSLEWIGDINPNNGGTIYNQKFKG

DSYMNWYQQKPGQPPKVLIYAASNLESGIPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da072
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 60
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



MDWVKQSHGKSLEWIGDINPNNGGTIYNQKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




HYGNYFYAMDYWGQGTSVTVSS

GGAKLEIK






SCT-Da073
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 61
DIVLTQSPASLAVSLGQRVTISCKASQSVDYDG
249



MDWVKQSHGKSLEWIGDINPNNGGTLYNLKFKG

DSYMNWYQQKPGQPPKVLIYAASNLESGIPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da074
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 62
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
305



MDWVKQSHGKSLEWIGDINPNYDSTNYNLKFKG

GWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGKDYTLSITSLQTEDVATYYCQQYWSIPYTFG




HYGNYFYAMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da075
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 62
DIVLTQSPASLAVSLGQRATISCRASESVDSFG
306



MDWVKQSHGKSLEWIGDINPNYDSTNYNLKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTRLEIK






SCT-Da076
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 62
DIVLTQSPASLAVSLGQRVTISCKASQSVDYDG
249



MDWVKQSHGKSLEWIGDINPNYDSTNYNLKFKG

DSYMNWYQQKPGQPPKVLIYAASNLESGIPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da077
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 63
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



MDWVKQSHGKSLEWIGDISPNYESTNYSLKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da078
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 63
DIVLTQSPDSLAVSLGQRATISCRASESVDSFG
307



MDWVKQSHGKSLEWIGDISPNYESTNYSLKFKG

HSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da079
EVQLQQFGAELVKPGASVKISCKASGYTFTDYN
 64
DIVLTQSPASLAVSLGQRATISCRAGESVDSFG
308



VDWVKQSHGKSLEWIGDINPNDDSTSYNLKFKG

NSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTVDKSSSTAYMELRSLTSEDTAVYYCARR

SGSGSRTDFTLTIDPVEADDAAAYYCQQSNEDP




HYGNYFYAMDYWGQGTSVTVSS

RTFGGGTKLEIK






SCT-Da080
EVQLQQFGTELVKPGASVKISCKASGYTFTDYN
 65
DIQMTQTTSSLSASLGDRVTISCRASQDISNYL
257



INWVKQSHGRSLEWIGDINPNYDSTSYNQNFKG

NWYQQKPDGIVKLLIYYTSRLNSGVPSRFSGSG




KATLTVDKSSSTSYMELRSLTSEDTAVYYCARG

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




GFYGNFFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da081
EVQLQQFGTELVKPGASVKISCKASGYTFTDYN
 66
DIVLTQSPASLAVSLGQRATISCRASESVDSSG
309



INWVKQSHGRSLEWIGDINPNYDSTSYNQNFKG

NSFMHWYQQKPGQPPKLLIYRASNLESGIPARF




KATLTVDKSSSTSYMELRSLTSEDTAVYYGARG

SGSGSRTDFTLTINPVEADDVATYYCQQSNEDP




GFYGNFFDYWGQGTTLTVSS

FTFGSGTKLEIK






SCT-Da082
EVQLQQSGADLVRPGALVKLSCKTSGFNIKDYY
 67
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
310



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSSTAYLQLSSLTSEDTAVYYCSIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSLPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da083
EVQLQQSGAEFVRPGALVKLSCKTSGFNIKDYY
 68
DILMTQSPSSMSVSLGDSVSITCHASQGISSNI
283



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




KASITADTSSNTAYLQLSSLTSEDTAVYYCTIG

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




VRRDYFDYWGQGTTLTVSS

GGTTLEIK






SCT-Da084
EVQLQQSGAEFVRPGALVKLSCKTSGFNIKDYY
 68
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
311



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LHWYQQKPGFSPKLFIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCTIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da085
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 69
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
312



IHWMKQRPEQGLEWIGRIDPANGNPIYDPKFQG

LNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




GYYAPGYWGQGTTLTVSS

GSGTKLEIK






SCT-Da086
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 70
DIVMTQFQKFMSTSVGDRVSVTCKASQNVDTNV
293



IHWMKQRPEQGLEWIGRIDPANGNPKSDPRFQG

AWYQQKPGQSPKLLIYSGSYRFSGVPDRFTGSG




KATITADSSSNTAYLQFSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNTYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da087
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 71
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
313



IHWMKQRPEQGLEWIGRIDPANGNRKYDPRFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da088
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 72
DIQMTQSPSSLSASLGGKVTITCKASQDINKYI
314



IHWMKQRPEQGLEWIGRIDPANGNTISDPRFRG

AWYQHKPVKGPRLLIHYTSTLQPGIPSRFSGSG




KATITADTSSNTAYLQFSSLTSEDTAVYYCARD

SGRDYSFSISNLEPEDIATYYCLQYDNLRTFGG




GYYAPGYWGQGTTLTVSS

GTKLEIK






SCT-Da089
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 72
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
305



IHWMKQRPEQGLEWIGRIDPANGNTISDPRFRG

GWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KATITADTSSNTAYLQFSSLTSEDTAVYYCARD

SGKDYTLSITSLQTEDVATYYCQQYWSIPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da090
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 72
DIVMTQFQKFMSTSVGDRVSVTCKASQNVDTNV
293



IHWMKQRPEQGLEWIGRIDPANGNTISDPRFRG

AWYQQKPGQSPKLLIYSGSYRFSGVPDRFTGSG




KATITADTSSNTAYLQFSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNTYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da091
EVQLQQSGAELVKPGASVKLSCTASGFNIEDTY
 73
DIVMTQAAPSIPVTPGESVSISCRSSKSLLHSN
315



MHWVKERPEQGLEWIGRNDPANGNTEYDPKFQG

GNTFLYWFLLRPGQSPHLLIYRMSNLASGVPDR




KATITSDTSSNTAYLQLSTLTSEDTAVYYCASL

FSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEF




WVDYWGQGTSVTVSS

PYTFGGGTKLEIK






SCT-Da092
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 74
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
316



IHWMKQRPEQGLEWIGRIDPANANTQYDPKFQG

AWYQQRPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNNYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da093
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 75
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
317



IHWMKQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNIYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da094
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 75
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWMKQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da095
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 75
ETTVTQSPASLSMAIGEKVTIRCITSTDIDDDM
319



IHWMKQRPEQGLEWIGRIDPANGNTIYDPKFQG

NWYQQKPGEPPKLLISEGNTLRPGVPSRFSSSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

YGTDFVFTIENMLSEDVADYYCLQSDNLPFTFG




GYYAPGYWGQGTTLTVSS

SGTKLEIK






SCT-Da096
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 76
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
320



IHWMKQRPEQGLEWIGRIDPANGNTKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da097
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 77
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
321



IHWMKQRPIQGLEWIGRIDPANGNSHYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYSCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da098
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 77
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
322



IHWMKQRPIQGLEWIGRIDPANGNSHYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da099
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 77
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
323



IHWMKQRPIQGLEWIGRIDPANGNSHYDPKFQG

AWYQQKSGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da100
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 77
DNVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
324



IHWMKQRPIQGLEWIGRIDPANGMSHYDPKFQG

AWYQQKSGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da101
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 78
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWMMQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLHLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da102
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 79
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
321



IHWMMQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYSCQQYNSYPYTFG




GYYAPGNWGQGTTLTVSS

GGTKLEIK






SCT-Da103
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 80
DIQMTQTTSSLSASLGDRVTISCSASQGISNYL
325



IHWMMQRPEQGLEWIGRIDPANGNTIYDPKFQG

NWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDYSLTISNLEPEDIATYYCQQYSKLPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da104
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 80
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
326



IHWMMQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da105
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 80
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWMMQRPEQGLEWIGRIDPANGNTIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da106
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 81
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWMMQRPEQGLEWIGRIDPANGNTNYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da107
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 82
DILMTQSPSSMSVSLGDTVSITCHASQGISSNI
327



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

GWLQRKPGKSFKGLIYHGTNLEDGLPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYFCARD

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da108
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 82
DIVLTQSPASLAVSLGQRATISCKASQSVDYDG
328



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

DNYMNWYQQKPGQPPKLLIYAASNLESGIPARF




KATITADSSSNTAYLQLSSLTSEDTAVYFCARD

SGSGSGTDFTLNIHPVEEEDAATYYCQQSYEDP




GYYAPGYWGQGTTLTVSS

WTFGGGTKLEIK






SCT-Da109
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 82
DIVMTQSQKFMSTSVGDGVSVTCKASQNVDSNV
329



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

AWYHQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYFCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEVK






SCT-Da110
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 82
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNI
330



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYFCARD

SGTDFTLAISNVQSEDLAEYFCQQYNTYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da111
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 83
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
331



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

HWYQQKSHESPRLLIKYVSQSISGIPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




GYYAPGYWGQGTTLTVSS

SGTKLEIK






SCT-Da112
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 83
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da113
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 83
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
332



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da114
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 83
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



IHWVKQRPEQGLEWIGRIDPANGNRIYDPKFQG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




GYYAPGYWGQGTTLTVSS

GTKLELK






SCT-Da115
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 84
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
334



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQA

AWYQQKPGQSPKLLIYSASYRFSGVPDRFAGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLADYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEMK






SCT-Da116
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 85
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLTVSS

GGAKLEIK






SCT-Da117
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 85
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
326



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLTVSS

GGTKLEIK






SCT-Da118
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 85
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLTVSS

GGTKLEIK






SCT-Da119
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 85
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
332



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLTVSS

GGTKLEIK






SCT-Da120
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 86
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
335



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYWFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLASEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYSAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da121
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVLTQSPASLAVSLGQRATISCRASESVESNG
336



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

NSFMHWYQQKPGQSPKLLIYRASNLESGIPARF




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGSGSRTDFTLTIYPVEADDVATYYCQQTDEDP




GYYAPGYWGQGTTLTVSS

FTFGSGTKLGIK






SCT-Da122
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVMTQSPATLSVTPGDRVSLSCRASQRISDYL
337



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGSDFTLSINSVEPEDVGMYYCQNGHSFPFTFG




GYYAPGYWGQGTTLTVSS

SGTKLEIK






SCT-Da123
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
326



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da124
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
338



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKVEIK






SCT-Da125
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
339



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYNGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da126
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
340



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYNGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNTYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da127
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
DVQITQSPSYLAASPGETITINCRASKSISKYL
341



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQEKPGKTNKLLIYSGSTLQSGIPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISSLEPEDFAMYYCQQHNEYPLTFG




GYYAPGYWGQGTTLTVSS

AGTKLELK






SCT-Da128
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 87
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




GYYAPGYWGQGTTLTVSS

GTKLELK






SCT-Da129
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 88
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




TATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da130
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 89
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
342



MHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTQLEIK






SCT-Da131
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 89
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
313



MHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da132
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 90
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
342



MHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYWARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTQLEIK






SCT-Da133
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 91
DIVMTQSQKFMSTSVGDGVSVTCKASQNVDSNV
329



MHWVKQRPEQGLEWIGRIDPANGNTGYDPKFQG

AWYHQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEVK






SCT-Da134
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 91
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



MHWVKQRPEQGLEWIGRIDPANGNTGYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da135
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 91
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQRPEQGLEWIGRIDPANGNTGYDPKFQG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




GYYAPGYWGQGTTLTVSS

GTKLELK






SCT-Da136
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 91
SIVMTQTPKFLLVSAGDRVTITCKASQSVSNDV
343



MHWVKQRPEQGLEWIGRIDPANGNTGYDPKFQG

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

YGTDFTFTISTVQAEDLAVYFCQQDYSSPWTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da137
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 92
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
344



MHWVKQRPEQGLEWIGRIDPANGNTHYDPKFQV

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCTHD

SGTDFTLTISNVQSEDLAEYFCQQYNIYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da138
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 92
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
345



MHWVKQRPEQGLEWIGRIDPANGNTHYDPKFQV

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCTHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da139
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 92
DIVMTQTPLSLPVSLGDQASISCRSSQSLVHSN
346



MHWVKQRPEQGLEWIGRIDPANGNTHYDPKFQV

GNTYLHWHLQKPGQSPKLLIYKVSNRFSGVPDR




KATITADTSSNTAYLQLSSLTSEDTAVYYCTHD

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHA




GYYAPGYWGQGTTLTVSS

PWTFGGGTKLEIK






SCT-Da140
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 93
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
316



MHWVKQRPEQGLEWIGRIDPANGNTIYDPKFQA

AWYQQRPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNNYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da141
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 94
DIVMTQSQEFMSTSVGDRVSVTCKASQNVGTNV
347



MHWVKQRPEQGLEWIGRIDPANGNTIYDPNFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNNYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da142
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 95
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
348



MHWVKQRPEQGLEWIGRIDPANGNTNYDPKFQG

AWYQQKPGQSPELLIYSASYRYSGVPDRFTGSG




KATITTDTSSNTAYLQLSSLTSEDTAVYYCAHD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPFTFG




GYYAPGFWGQGTTLTVSS

GGTKLEIK






SCT-Da143
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTY
 96
EIVLTQSPTTMATSPGEKITITCSASSSIISNY
349



MNWVKQRPEQGLEWIGRIDPANGNTKYDPKFQG

LHWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




KATITADTSSNTAYLQLSSLTSEDTAVYYCAPF

GSGTSYSLTIGTMETEDVATYYCQQGSSLPRTF




SYGTLAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da144
EVQLQQSGAELVKPGASVKLSCTASGLNIKDTY
 97
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
342



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTQLEIK






SCT-Da145
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 98
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



IHWVKQRPEQGLEWIGRIDPANGNRKSDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGAKLEIK






SCT-Da146
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DILMTQSPSSMSVSLGDSVSITCHASQGISSNM
284



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da147
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIQMTQTTSSLSASLGDRVTISCSASQGISNYL
296



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

NWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDYSLTISNLEPEDIATYYCQQYSKLPLTFG




GYYAPGYWGQGTTLTVSS

AGTKLELK






SCT-Da148
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGAKLEIK






SCT-Da149
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
350



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da150
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
351



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGAKLEIK






SCT-Da151
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da152
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
352



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da153
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
353



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da154
EVQLQQSGAELVKPGASVKLSCTASGVNIKDTY
 99
SIVMTQTPKFLLVSAGDRFTITCKASQNVDNYV
354



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




KATITADSSSNTAYLQLSSLTSEDTAVYYCARD

YGTDFTFTITTVQAEDLAVYFCQQDYSSPYTFG




GYYAPGYWGQGTTLTVSS

GGTKLEIK






SCT-Da155
EVQLQQSGAELVKPGASVKLSCTVSGFNIKDTY
100
DIVMTQAAPSVPVTPGESVSISCRSNKSLLHSN
355



MHWVKQRPEQGLEWIGMIDPANFNTKYDPKFQG

GNTFLYWFLQRPGQSPQVLIYRHSNLASGVPDR




KATVTADTSSNTAYLQLSSLTSEDTAVYYCASL

FSGSGSGTAFTLRISRVESEDVGVYYCMQHLEY




WVDYWGQGTSVTVSS

PYTFGGGTKLEIK






SCT-Da156
EVQLQQSGAELVKPGASVKVSCTASGFNIKDTY
101
DIQMTQSPSSLSASLGGKVTITCKASQDINKYI
314



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQHKPVKGPRLLIHYTSTLQPGIPSRFSGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGRDYSFSISNLEPEDIATYYCLQYDNLRTFGG




GYYAPGHWGQGTTLSVSS

GTKLEIK






SCT-Da157
EVQLQQSGAELVKPGASVKVSCTASGFNIKDTY
101
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLSVSS

GGAKLEIK






SCT-Da158
EVQLQQSGAELVKPGASVKVSCTASGFNIKDTY
101
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
332



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLAISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLSVSS

GGTKLEIK






SCT-Da159
EVQLQQSGAELVKPGASVKVSCTASGFNIKDTY
101
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
322



IHWVKQRPEQGLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYSGVPDRFTGSG




KATITADSLSNTAYLQLSSLTSEDTAVYYCARD

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




GYYAPGHWGQGTTLSVSS

GGTKLEIK






SCT-Da160
EVQLQQSGAELVRPGALVKLSCKASGCNIKDYY
102
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
356



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQA

LNWYQQKPEFSPKLLIYRTSYLASGVPARFSGS




KASITADTSSNTAYLQFSSLTSEDTAVYYCTIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da161
EVQLQQSGAELVRPGALVKLSCKASGCNIKDYY
103
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
356



MHWVKQRPEQGLEWIGWIDPENGNTIYDSKFQA

LNWYQQKPEFSPKLLIYRTSYLASGVPARFSGS




KASITADTSSNTAYLQFSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da162
EVQLQQSGAELVRPGALVKLSCKASGFNIKDFY
104
EIVLTQSPTTMAASPGEKITITCSATSIISSNY
357



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LHWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFGYWGQGTTLTVSS

GSGTKLDIK






SCT-Da163
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
105
DIQMTQSTSSLSASLGDRVSISCRASQDISNYL
267



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




KARITADTSSNTAYLQLSSLTSEDTAVYYCAIG

SGTDYSLTISSLEQEDVATYFCQQGNALPWTFG




VRRDYFAYWGQGTTLTVSS

GGTKLEIK






SCT-Da164
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
105
DIQMTQTTSSLSASLGDRVTISCRASHDIHNYL
261



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




KARITADTSSNTAYLQLSSLTSEDTAVYYCAIG

SGTDYSLTISNLEQEDIATYFCQQGNTLPWTFG




VRRDYFAYWGQGTTLTVSS

GGTKLEIK






SCT-Da165
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
105
EIVLTQSPTTMAASPGEKITIICNASSSISSNY
358



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

FNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KARITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSLPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da166
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
105
EIVLTQSPTTMAASPGEKITITCSANSNISSNY
359



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPVFSPKLLIYRTSNLASGVPTRFSGS




KARITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da167
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
DIKMTQSPSSMYASLGERVTITCKASQDIKSYL
360



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

SWYQQKPWKSPKTLIYYATSLADGVPSRFSGSG




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

SGQDYSLTISSLESDDTATYYCLQHGESPFTFG




VRRDYFAYWGQGTTLTVSS

SGTKLEIK






SCT-Da168
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
DIVLTQSPASLAVSLGQRATISCRASKSVSSSG
361



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

YNYLHWYQQKPGQPPKLLIYLASNLESGVPARF




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

SGSGSGTDFTLNIHPVEEEDAATYYCQHSGELP




VRRDYFAYWGQGTTLTVSS

LTFGAGTKLELK






SCT-Da169
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
362



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

SGSDFTLSINSVEPEDVGVYYCQNGHSFPPFTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da170
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
DIVMTQTPLSLPVSLGDQASISCRSSQSLVHSD
363



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

GNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

FSGSGSGTDFTLMISRVEAEDLGVYFCSQSTHV




VRRDYFAYWGQGTTLTVSS

PWTFGGGTKLEIK






SCT-Da171
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
EIVLTQSPTTMAASPGEKITITCSASSSINSNY
364



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPEFSPKLLIYRTSNLASGVPTRFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da172
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
312



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da173
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
365



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPEFSPKLLIYRTSNLASGVPGRFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da174
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
106
QIVLTQSPALMAASPGEKVTITCSVSSSISYMY
366



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

WYQQKSETSPKPWIYGTSNLASGVPVRFSGSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GTSYSLTISSMEAEDAATYYCQQWSSYPLTFGA




VRRDYFAYWGQGTTLTVSS

GTKLELK






SCT-Da175
EVQLQQSGAELVRPGALVKLSCKASGFNIKDYY
107
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
262



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LHWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da176
EVQLQQSGAELVRPGALVKLSCKTSGFNIKDYY
108
DILMTQSPSSMSVSLGDSVSITCHASQGISSNI
283



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQD

GWLQQKAGKSFKGLIYHGTNLEDGVPSRFSGSG




KAGITADTSSNTAYLQLSSLTSEDSAVYYCAIG

SGADYSLTISSLESEDFADYYCVQYAQFPYTFG




VRRDYFAYWGQGTTLTVSS

GGTTLEIK






SCT-Da177
EVQLQQSGAELVRPGALVKLSCKTSGFNIKDYY
108
EIVLTQSPTTMAASPGEKITITCSANSNISSNY
359



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQD

LNWYQQKPVFSPKLLIYRTSNLASGVPTRFSGS




KAGITADTSSNTAYLQLSSLTSEDSAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da178
EVQLQQSGAELVRPGALVKLSCKTSGFNIKDYY
108
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
367



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQD

LNWYQQKPVFSPKLLIYRTSNLASGVPTRFSGS




KAGITADTSSNTAYLQLSSLTSEDSAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFAYWGQGTTLTVSS

GSGTKLEIK






SCT-Da179
EVQLQQSGAELVRPGALVKLSCKTSGFNIKDYY
109
EIVLTQSPTTVAASPGEKITITCSASSSISSNH
368



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLNSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da180
EVQLQQSGAELVRPGALVKLSCKTSGFNIKDYY
110
EIVLTQSPTTVAASPGEKITITCSASSSISSNH
368



MHWVKQRPEQGLEWIGWIDPENGNTIYDPKFQG

LNWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




KASITADTSSNTAYLQLSSLTSEDTAVYYCAIG

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




VRRDYFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da181
EVQLQQSGPELLKPGASVKISCKTSGYTFTEYT
111
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



LHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKD

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSSAYMELRSLTSEDSAVYYCTRP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da182
EVQLQQSGPELVKPGASMKISCKVSGFSFTGYT
112
DIVLTQSPASLAVSLGQRATISCKASQSVDYNG
369



MNWVKQSHGKNLEWIGLINTYNGGTFYNQKFKA

YSYLNWYQQKPGQPPKLLIYPASNLESGIPARF




KATLTVDKSSSTAHMELLSLTSEDSAVYYCARS

SGSGSGTDFTLNIHPVEEEDAATYYCQQSKEDP




PGRYSMDYWGQGTSVTVSS

YTFGGGTKLEIK






SCT-Da183
EVQLQQSGPELVKPGASMQISCKTSGYTFTEYT
113
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



VHWVKQSHGKSLEWIGVINPSTGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da184
EVQLQQSGPELVKPGASVKISCKTSGYTFAEYT
114
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
370



MHWVKQSHGKSLEWIGVINPNNGGTTYNQQFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCTRP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGT




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da185
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYP
115
QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMH
371



MHWVKQSHGKSLEWIGGINPNNGGTTYNQKFKG

WYQQKSGTSPKRWIYDTSKLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCALY

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




GNYWYFDVWGAGTTVTVSS

GTKLELK






SCT-Da186
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
116
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
372



IHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDHSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISTMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da187
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
117
QIVLTQSPALMSASPGEKVTMTCSATSSVSYMY
373



IHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da188
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
118
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHLVKQSHGKSLEWIGVINPNNGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da189
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
119
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGAVNPNTGGTTYNQKFKD

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTIDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da190
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
120
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
374



MHWVKQSHGKSLEWIGGINPNNGGTSYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCHQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da191
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
121
DIVMTQSQKFMSTSVGDGVSVTCKASQNVDSNV
329



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFKG

AWYHQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




HSLLRLRREFDYWGQGTTLTVSS

GGTKLEVK






SCT-Da192
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
121
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da193
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
122
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
375



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFNGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCTRP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da194
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
123
QIVLTQSPALMSVSPGEKVTMTCSASSSVSYMY
376



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKD

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCTRP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da195
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
124
QIVLTQSPALMSASPGEKVTMTCSASSSVSYIY
377



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da196
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
124
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
378



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSSLASGVPARFSGSGS




KATLTVDKSSSTAYMELRSLTSEDSAVYYCARP

GTSFSLTISNMEAEDAATYYCHQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da197
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
125
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
379



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELLSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELN






SCT-Da198
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
126
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTVDQSSSTAYMELRSLTSEDSAVYYCARP

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




HSLLRLRREFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da199
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
126
QIVLTQSPALMSASPGEKVTMTCSASSSVSYIY
377



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da200
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
126
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da201
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
127
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTYEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da202
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
128
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTVDQSSTTAYMELRSLTSEDSAVYYCARP

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




HSLLRLRREFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da203
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
128
EIVLTQSPTTMAASPGEKITITCSANSNISSNY
359



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

LNWYQQKPVFSPKLLIYRTSNLASGVPTRFSGS




KATLTVDQSSTTAYMELRSLTSEDSAVYYCARP

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




HSLLRLRREFDYWGQGTTLTVSS

GSGTKLEIK






SCT-Da204
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
128
QIVLSQSPAILSASPGEKVTMTCRASSSVSYMH
380



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPGSSPKPWIYATSNLASGVPARFSGSGS




KATLTVDQSSTTAYMELRSLTSEDSAVYYCARP

GTSYSLTISRVEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da205
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
128
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSTTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da206
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
129
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNTGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSTTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da207
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
130
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNTGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSTTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da208
EVQLQQSGPELVKPGASVKISCKTSGYTFTEYT
131
QIVLTQSPALMSASPGEKVTMTCSASSSVSYIY
381



MHWVKQSQGKSLEWIGAVNLNTGGTTYNQKFKD

WYQQKPGSSPKPWIYLTSNLASGVPPRFSGSGS




KATLTIDKSSSTAYMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAASYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da209
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
132
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
317



IHWVKQKPGQGLEWIGYINPYHDGTKYNEKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTSDKSSSTAYMELSSLTSEDSAVYYCARS

SGTDFTLTISNVQSEDLAEYFCQQYNIYPYTFG




RTVIGFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da210
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
133
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
382



MHWVKQKPGQGLEWIGYINPYHDGTKYNEKFIG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATLTSDKSSSTAYMELSSLTSEDSAVYYCARS

SGTDFTLSINSVEPEDVGVYYCQSGHSFPLTFG




RTVIGFDYWGQGTTLTVSS

AGTKLEVK






SCT-Da211
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
134
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
317



MHWVKQKPGQGLEWIGYINPYHDGTKYNEKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTSDKSSSTAYMELSSLTSEDSAVYYCARS

SGTDFTLTISNVQSEDLAEYFCQQYNIYPYTFG




RTVIGFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da212
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
135
DIQMTQSPASLSASVGETVTITCRASENIYSYL
383



MHWVKQKPGQGLEWIGYINPYNDATKNNEKFKV

AWHKQKQGKSPQFLVYNAKTLAEGVPSRFSGSG




KATLTSDKSSNTAYMELSSLTSEDSAVYYCARG

SGTQFSLKINGLQPEDFGSYYCQHHYVIPPTFG




VRLLDYWGQGTTLTVSS

GGTKLEIK






SCT-Da213
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
136
DIVMTQSPATLSVTPGDRVSLSCRASQNISDYL
384



MHWVKQKPGQGLEWIGYINPYTDGTKYNEKFKG

HWYQQRSHESPRLLIKYASLSISGIPSRFSGSG




KATLTSDKSSSTAYMELSSLTSEDSAVYYCAKS

SGSDFTLSINSVEPEDVGLYYCQNGHSFPLTFG




RTVIGFDYWGQGTTLTVSS

AGTKLELK






SCT-Da214
EVQLQQSGPELVKPGASVKMSCKASGYTFTSYV
137
DIVMTQSPATLSVTPGDRVSLSCRASQNISDYL
385



MHWVRQKPGQGLEWIGYINPYNDGTKYNEKFKG

HWYQQRSHESPRLLIKYASLSISGIPSRFSGSG




KATLTSDKSSSTANMELSSLTSEDSAVYYCARS

SGSDFTLSINSVEPEDVGVYYCQNAHSFPLTFG




RTVVGFDYWGQGTTLTVSS

AGTKLELK






SCT-Da215
EVQLQQSGPELVKPGASVKMSCKASGYTFTTYV
138
QNVLTQSPALMSASPGEKVTMTCSASSSVSYMY
386



MHWVKQKPGQGLEWICYINPYNDGSNYNEKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTSDKSSTTAYMELSSLTSEDSAVYYCARW

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




VYYDFGGSMDYWGQGTSVTVSS

GTKLELK






SCT-Da216
EVQLQQSGPELVKPGASVKMSCKASGYTFTTYV
139
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQKPGQGLEWIGYINPYNDGSNYNEKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTSDKSSTTAYMELSSLTSEDSAVYYCARW

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




VYYDFGGSMDYWGQGTSVTVSS

GTKLELK






SCT-Da217
EVQLQQSGPELVKPGASVKMSCKASGYTFTTYV
139
QNVLTQSPALMSASPGEKVTMTCSASSSVSYMY
386



MHWVKQKPGQGLEWIGYINPYNDGSNYNEKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTSDKSSTTAYMELSSLTSEDSAVYYCARW

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




VYYDFGGSMDYWGQGTSVTVSS

GTKLELK






SCT-Da218
EVQLQQSGPELVKPGTSVKISCKTSGYTFTEYT
140
QIVLTQSPALMSASPGEKVTMTCSASSSVSYIY
387



MHWVKQSHGKSLEWIGAVNPNTGGTTYNQKFKD

WYQQKPRSSPKPLIYLTSNLASGVPARFSGSGS




KATLTIDKSSSTAYMQLRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAASYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da219
EVQLQQSGPELVKPGTSVKMSCKASGYTFTSYV
141
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
388



MHWVKQKPGQGLEWIGYINPYHDGTQYNEKFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATLTSDKSSSTAYMELSSLTSEDSAVYYCARS

SGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFG




RTVIGFDYWGQGTTLTVSS

AGTKLELK






SCT-Da220
EVQLQQSGPELVKSGASVKISCKTSGYTFTEYT
142
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVKQSHGKSLEWIGVINPNSGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDQSSSTAYMELRSLTSEESAVYYCTRP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da221
EVQLQQSGPELVTPGASVNISCKTSGYTFTEYT
143
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
389



MHWVRQSHGKSLEWIGVINPNSGGTTYNQKFKD

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSTTAFMELRSLTSEDSAVYYCARP

GTSYSLTISNMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da222
EVQLQQYGPELVKPGASVKISCKTSGYTFTEYT
144
DIVMTQSQKFMSTSVGDGVSVTCKASQNVDSNV
329



MHWVRQSHGKSLEWIGVINPNNGGTTYNQKFKG

AWYHQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTVDKSSTTAFMELRSLTSEDSAVYYCARP

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




HSLLRLRREFDYWGQGTTLTVSS

GGTKLEVK






SCT-Da223
EVQLQQYGPELVKPGASVKISCKTSGYTFTEYT
144
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MHWVRQSHGKSLEWIGVINPNNGGTTYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTVDKSSTTAFMELRSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




HSLLRLRREFDYWGQGTTLTVSS

GTKLELK






SCT-Da224
EVQLVESGGDLAKPGGSLKLSCAASGFTLSRYG
145
DIQMTQSPAFLSASVGESVTITCRASENIYSYL
390



MSWVRQTPDKRLEWVATSSGGGIYTYYPDSVKG

AWYQQKQGKSPQLLVYNAKTLAEGVPSRFSGSG




RFTISRDNAKNTLYLQMSSLKSEDTAMYYCARH

SGTHFSLKINSLQPEDFGGYYCQHHYGIPPWTF




DGVPMDYWGQGTSVTVSS

GGGTKLEIK






SCT-Da225
EVQLVESGGDLVKPGGSLKLSCAASGFTFSSYG
146
DIVLTQSPASLAVSLGQRATFSCRASKSVSTSG
391



MSWVRQTPDKRLEWVATIFSGDSNTYYLDSVKG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFIISRDNAKNTLYLQMSSLKSEDTAMYYCSRQ

SGSGSGTDFTLNIHPVEEEDAAAYYCQHSRELP




GHRSWFAYWGQGTLVTVSA

YTFGGGTKLEIK






SCT-Da226
EVQLVESGGDLVKPGGSLKLSCAASGFTFSTYG
147
EIVLTQSPTTMATSPGEKITITCSASSSIISNY
349



MSWVRQTPDKRLEWVATISGGGIYTYYPDSVKG

LHWYQQKPGFSPKLLIYRTSNLASGVPARFSGS




RFTISSDNAKNTLYLQMSSLKSEDTAMYYCVRM

GSGTSYSLTIGTMETEDVATYYCQQGSSLPRTF




ITTYFDHWGQGTTLTVSS

GSGTKLEIK






SCT-Da227
EVQLVESGGDLVKPGGSLKVSCAASGFTFSSYG
148
DIVLTQSPASLVVSLGQRATISCRASKSVSTSG
392



MSWVRQTPDKRLEWVATIFSGDSYTYYSDSVKG

YSYMHWYQQKPGQPPKLLIYLASNLESGVPARF




RFTISRDNAKNTLYLQMSSLKSEDTAMYYCARQ

SGSGSGTDFTLNIHPVEEEDAATYYCQHSRELP




GHRSWFAYWGQGTLVTVSA

STFGGGTKLEIK






SCT-Da228
EVQLVESGGGLVKPGGSLKLSCAASGFTFSSYA
149
DIQMTQSPASLSASVGETVTITCRASENIYSYL
393



MSWVRQTPEKRLEWVATISSGGSYTYYPDSVKG

VWYQQKQGKSPQLLVYYAKTLAEGVPSRFSGSG




RFTISRDIAENTLFLQMSSLRSEDTAMYYCARH

SGTQFSLKINSMQPEDFGSYYCQHHYGTPLTFG




EDTTYYYAMDYWGQGTSVTVSS

VGTKVELK






SCT-Da229
EVQLVESGGGLVLPKGSLKLSCAASGFTFNTYA
150
QIVLTQSPAIMSASPGEKVTLTCSASSSVSSSH
394



MNWVRQAPGKGLEWVARIRIKSNNYATSYADSV

MYWYQQKPGSSPKLWIYSTSNLASGVPARFSGS




KDRFTISRDDSQSMLYLQMNNLKTEDTAVYYCV

GSGTSYSLTISSMEAEDAASYFCHQWSSYPYTF




RQAYGNSYFFAMDYWGQGTSVTVSS

GGGTKLEIK






SCT-Da230
EVQLVETGGGLVQPKGSLKLSCAASGFTFNTNA
151
DVVMTQTPLSLPVSLGDQASISCSSSQSLVYSN
395



MNWVRQAPGKGLEWVARIRSKSNNYATNYVDSV

GNTYLHWYLQKPGQSPKLLIYKVSNRFPGVPDR




KDRFTISRDDSQSILYLQMNNLKTEDTAMYYCT

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHV




AMDYWGQGTSVTVSS

PYTFGGGTKLEIK






SCT-Da231
HVQLQQSGPELVRPGASVKLSCKASGYIFITYW
152
QIVLTQSPAIMSASPGEKVTISCSASSSVSYMY
396



MTWVKQRPGQGLEWIGQIFPASGSTTYNEMFEG

WYQQKPGSSPKPWIYRTSNLASGVPARFSGSGS




KATLTVDTSSSTAYMQLSSLTSEDSAVYYCASY

GTSYSLTISSMEAEDAATYYCQQYHSFPRTFGG




DGYYSWFAYWGQGTLVTVSA

GTKLEIK






SCT-Da232
QGQMQQSGAELVKPGASVKLSCKTSGFTFSHSY
153
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
397



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGKDYTLSITSLQIEDVATYSCQQYWSIPYTFG




ETYGSSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da233
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSFY
154
DIVMTQSHKFMSTSVGDRVNITCKASQDVNTAV
398



ISWLKQKPGQSLEWIAWIDAGTGGTSYNQKFTG

AWYQQKPGQSPKLLFYSTSYRYTGVPDRFTGSG




KAQLTVDTFSSTAYMQFSSLTTEDSAIYYCARH

SGTDFTFTISSVQAEDLAVYYCQQHYSSPWTFG




VGRLRGYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da234
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSNY
155
DIVLTQSPAALSVTPGDSVSLSCRASQSISSTL
399



ISWLKQKPGQSLEWIAWIYAGTGSTGYNQKFTG

HWYQQKSHESPRLLIRYASQSISGIPSRFSGSG




KAQLTVDTFSSTAYMQFSSLTTEDSAIYYCASH

SGTDFTLSINSVETEDFGMYFCHQSYSWPHTFG




DGHDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da235
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSNY
156
DIVMTQSHKFMSTSVGDRVSITCRASQDVSTAV
400



ISWLNQKPGQSLEWIAWIDAGTGGSSYNQKFTG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTVSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGTDFTFTISSVQAEDLAVYYCQQHYSTPWTFG




VGRLRGYFDVWGAGTRVTVSS

GGTKLEIK






SCT-Da236
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSRY
157
DIVLTQSPAALSVTPGDSVSLSCRASQSISNTL
401



ISWLKQKPGQSLEWIAWIYAGTGGTGYNQKFTG

HWYQQKSHESPRLLIRYASQSISGIPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAMYYCASH

SGTDFTLSINSVETEDFGMYFCQQSNDWPHTFG




DGHDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da237
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSRY
157
DIVLTQSPAALSVTPGDSVSLSCRASQSISNTL
402



ISWLKQKPGQSLEWIAWIYAGTGGTGYNQKFTG

HWYQQKSHESPRLLIRYASQSISGIPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAMYYCASH

SGTDFTLSINSVETEDFGMYFCQQSYDWPHTFG




DGHDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da238
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSRY
158
DIVLTQSPAALSVTPGDSVSLSCRASQSISNTL
403



ISWLKQYPGQSLEWIAWIYAGTGGSGYNQKFTG

HWYQQKSHESPRLLIRYASQSISGIPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAMYYCASH

SGTDFTLSINSVETEDFGMYFCQQSYNWPHTFG




DGHDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da239
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
159
DIQMTQSPASLSGSVGETVTITCRASENIYSFL
404



ISWLKQKPGQSLEWIAWIYAGTGDTSYNQKFTG

AWYQQKQGKSPQLLIYNARTLAGGVPSRFSGSR




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCASP

SGTQFSLRINSLQPEDFGTYFCQHHYGPPFTFG




TGINWYFDVWGAGTTVTVSS

GGTNLEIK






SCT-Da240
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
160
DIQMTQSPASLSASVGETVTITCRASENIYSFL
405



ISWLKQKPGQSLEWIAWIYAGTGDTSYNQKFTG

AWYQQKQGKSPQLLIYNARALAEGVTSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCASP

SGTQFSLRINSLQPEDFGTYFCQHHYGPPFTFG




TGVNWYFDVWGAGTTVTVSS

GGTNLEIK






SCT-Da241
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
161
DIQMTQSSSYLSVSLGGRVTITCKASDHISNWL
406



ISWLKQKPGQSLEWIAWIYAGTGGTSYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARP

SGKDYTLSITSLQTEDVATYYCQQYWSLPYTFG




NGYGYGMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da242
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
162
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
407



ISWLKQKPGQSLEWIAWIYAGTGGTSYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARQ

SGKDYTLSITSLQTEDVATYFCQQYWTIPYTFG




DSYGRGPDCWGQGTTLTVSS

GGTKLEIK






SCT-Da243
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
163
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
408



ISWLKQKPGQSLEWIAWIYAGTGGTSYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARQ

SGKDYTLSITSLQTEDVATYYCQQYWSIPYTFG




DSYGRSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da244
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
164
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
397



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGKDYTLSITSLQIEDVATYSCQQYWSIPYTFG




ETYGSGPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da245
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
165
DIQMTQSPASLSASVGETVTITCRASGNIHNYL
409



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

AWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGTQYSLKINSLQPEDFGSYYCQHFWSTPWTFG




ETYGSSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da246
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
165
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
397



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGKDYTLSITSLQIEDVATYSCQQYWSIPYTFG




ETYGSSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da247
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
166
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
305



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

GWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARQ

SGKDYTLSITSLQTEDVATYYCQQYWSIPYTFG




DSYGRSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da248
QGQMQQSGAELVKPGASVKLSCKTSGFTFSSSY
167
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
397



ISWLKQKPGQSLEWIAWIYAGTGGTTYNQKFTG

AWYQQKPGNAPRLLISGATSLETGVPSRFSGSG




RAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARQ

SGKDYTLSITSLQIEDVATYSCQQYWSIPYTFG




DSYGRSPDYWGQGTTLTVSS

GGTKLEIK






SCT-Da249
QGQMQQSGAELVKPGASVKLSCRTSGFTFSSRY
168
DIVLTQSPATLSVTPGDRVSLSCRASQSINNYL
410



ISWLKQKPGQSLEWIAWIYAGTGGTSYNQKFTG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCASH

SGTDFTLSINSVETEDFGVYFCQQSNSWPLTFG




DGLDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da250
QGQMQQSGAELVKPGASVRLSCKTSGFTFSSFY
169
DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAV
411



ISWLKQKPGQSLEWIAWIYAGPGYTSYNQKFTG

AWYQQKPGQSPKLLIYSASYRYTGVPDHFTVSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGTDFTFTISSVQAEDLAVYYCQQHYSTPWTFG




VGRQRGYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da251
QGQMQQSGAELVKSGASVKLSCKTSGFTFSSSY
170
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
412



ISWLKQKPGQSLEWIAWIYAGTGGTTYNEKFTG

AWYQQKPGNAPRLLISGATSLEPGVPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCGRH

SGKDYTLTITSLQTEDVATYYCQQYWSLPYMFG




NGYGIGMDYWGQGTSVTVSS

GGTKLEIK






SCT-Da252
QGQMQQSGGELVKPGASVKLSCKTSGLTFSSSY
171
DIVMTQSHKFMSTSVGDRVSITCKASQDVTTAV
413



ISWLKQKPGQSLEWIAWIDAGTGGTSYNQKFTG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTVSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCARH

SGTDFTLTISSVQAEDLAVYYCQQHYSAPWTFG




VGRLRGYFDVWGAGTTVTVSS

GGTKLKIT






SCT-Da253
QGQMQQSGPELVKPGASVKLSCKTSGFTFSSNY
172
DIVLTQSPAALSVTPGDSVSLSCRASQSISNTL
414



ISWLKQKPGQSLEWIAWIYAGTGGTGYNQKFTG

HWYQQKSHESPRLLIRYASQSISGIPSRFSGSG




KAQLTVDTSSSTAYMQFSSLTTEDSAIYYCASH

SGTDFTLSINSVETEDFGMYFCQQSNSWPHTFG




DGHDAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da254
QIQLQQSGAELVRPGVSVKISCKGSGYTFTDYP
173
DIVLTQSPASLAVSLGQRATISCRASKSVSTSG
415



IHWVKQSHTTSLEWIGVIITYYGDATYNQKFKG

YSYMHWYQQKPGQAPKLLIYLASNLESGVPARF




KATMTVDKSSSTAYMELARLTSDDSAIYYCASH

SGSGSGTDFTLNIQPVEEEDAATYYCQHSRELY




RGKGYFDVWGAGTTVTVSS

TFGGGTKLEIK






SCT-Da255
QIQLQQSGAELVRPGVSVKISCKGSGYTFTDYP
173
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



IHWVKQSHTTSLEWIGVIITYYGDATYNQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATMTVDKSSSTAYMELARLTSDDSAIYYCASH

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




RGKGYFDVWGAGTTVTVSS

GTKLELK






SCT-Da256
QIQLQQSGPELVKPGASVKISCKASGYTFTDYF
174
DIVLTQSPATLSVTPGDRVSLSCRASQSISNYL
416



INWVKQKPGQGLEWIGWIYPGNINTNYNENFKG

HWYQQKSRESPRLLIKYASQSISGIPSRFSGSG




KATLTVDTSSSTAYMQLSSLTSEDTAVYFCAGG

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




NYALDYWGQGTSVTVSS

AGTKLELK






SCT-Da257
QIQLQQSGPELVKPGASVKISCKASGYTFTDYY
175
DIVLTQSPATLSVTPGDRVSLSCRASQSISNYL
417



INWVKQKPGQGLEWIGCIYPGNDNSNYNEKFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATLTVDTSSSTAYMQLSSLTSEDTAVYFCAGG

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




NYAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da258
QIQLQQSGPELVNPGASVMISCKASGYTFTAYY
176
DIVLTQSPATLSVTPGDRVSLSCRASQSISNYL
418



MNWVKQKPGQGLEWIGWIYPGNDNTNYNEKFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATLTVDTSSSTAFMQLSSLTSEDTAVYFCAGG

SGTDFTLSISSVETEDFGMYFCQQSNSWPLTFG




NYAMDYWGLGTSVTVSS

AGTKLELK






SCT-Da259
QIQLVQSGPELKKPGETVKISCKASGYTFTNSG
177
QIVLSQSPAILSASPGEKVTMTCRASSSVSYMH
419



MNWVKQAPGKGLKWMGWINTYTGEPTYVDDFKG

WYQQKPGSSPKPWIFATSNLAYGVPDRFSGSGS




RFAFSLETSASTAYLQINNLKNEDTATYFCAPT

GTSYSLTISRMEAEDAATYYCQQWSSTPPTFGG




IQVRRLFDYWGQGTTLTVSS

GTKLEIK






SCT-Da260
QIQLVQSGPELKKPGETVKISCKASGYTFTNSG
178
QIVLSQSPAILSASPGEKVTMTCRASSSVSYMH
419



MNWVKQAPGKGLKWMGWINTYTGEPTYVDDFKG

WYQQKPGSSPKPWIFATSNLAYGVPDRFSGSGS




RFAFSLETSASTAYLQINNLKNEDTATYFCAPT

GTSYSLTISRMEAEDAATYYCQQWSSTPPTFGG




IQVRRLVDYWGQGTTLTVSS

GTKLEIK






SCT-Da261
QIQLVQSGPELKKPGETVKISCKASGYTFTNYG
179
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
420



MNWVKQAPGKGLKWMGWINTNTGEPTYAEEFKG

NSFMHWYQQKPGQPPKLLIYRASNLESGIPARF




RFAFSLETSASTAYLQINNLKNEDTATYFCARR

SGSGSRTDFTLTINPVEADDVATYYCQQSNEDP




GYYGRGDYWGQGTTLTVSS

YTFGGGTKLEIK






SCT-Da262
QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYD
180
SIVMTQTPKFLLVSAGDRVTITCKASQSVSNDV
421



ISWIRQPPGKGLEWLGVIWTGGGTNYNSAFMSR

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




LSISKDNSKSQVFLKMNSLQTDDTAIYYCVRWG

YGTDFTFTISTVQAEDLAVYFCQQDYSSPPTFG




DDYDWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da263
QVQLKQSGPSLVQPAQSLSITCTVSGFSLTTYG
181
DIVMSQSPSSLAVSVGEKVTMSCKSSLSLLYSS
422



VHWLRQSPGKGLEWLGVIWRGGGTDYNAPFMSR

NQKNYLAWYQQKPGQSPKLLIYWASTRESGVPD




LSITKDDSKSQLFFKMNSLHADDTAIYYCAIYS

RFTGSGSGTGFTLTISSVKAEDLAVYYCQQYYS




DHDTYALDYWGQGTSVTVSS

YPLTFGAGTKLELK






SCT-Da264
QVQLQHSGAELVRPGVSVKISCKGSGYTFTDYA
182
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTAV
423



MHWVKQSHAKSLEWIGVISNYNGDVTYNQKFKG

AWYQQKPGQSPKLLIYRASTRHTGVPDRFTGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGTDFILTISNVQSEDLADYFCQQYSTYYTFGG




HGNRAMDYWGQGTSVTVSS

GTKLEIK






SCT-Da265
QVQLQQPGAELVKPGASVKLSCKASGYSFTSYY
183
DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAV
424



MYWVKQRPGHGLEWIGEINPSNGGTYFNVKFQS

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSG




KATLTVDKSSTTAYMQLSSLTSEDSAVYFCTRE

SGTDFTFTISSVQAEDLAVYYCQQHYSTPWTFG




GNYGYSWYAYWGQGTLVTVSA

GGTKLEIK






SCT-Da266
QVQLQQPGAELVKPGASVKLSCKASGYTFTSYW
184
DVVMTQTPLTLSVTIGQPASISCKSSQSLLDSD
425



MHWVKQRPGQGLEWIGEIDPSDSYTNYNQKFKG

GKTYLNWLLQRPGQSPKRLIYLVSKLDSGVPDR




KATLTVDKSSSTAYMQLSSLTSEDSAVYYCAGG

FTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHF




IHFDYWGQGTTLTVSS

PFTFGSGTKLEIK






SCT-Da267
QVQLQQPGAELVKPGASVKMSCKASGYTFTSYN
185
DIVLTQSPASLAVSQGQRATISCRASESVDSYG
426



LHWLKLTPGQGLEWIGIIYPGKDDTSYNQKFKG

YSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTADTSSSTAYMQLSSLTSEDSAVYYCARV

SGSGSRTDFTLTIDPVEADDAATYYCQQNNEDP




YYGNYGGFDYWGQGTLVTVSA

FTFGSGTKLEIK






SCT-Da268
QVQLQQPGSELVRPGASVKLSCKASGYTFTSYW
186
DIVMTQTPLSLPVSLGDQASISCRSSQSLVHSN
427



MYWVKQRPGQGLEWIGNIYPGSGSVNYDEKFKS

GNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTVDTSSSTAYMQLSSLTSEDSAVYYCTRG

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHV




GIGVRSPFDVWGAGTTVTVSS

WTFGGGTKLEIK






SCT-Da269
QVQLQQPGSVLVRPGASVKLSCKASGYTFTSSW
187
DIQMTQSSSYLSVSLGGRVTITCKASDHINNWL
428



MHWAKQRPGQGLEWIGEIHPNSGNTNYNEKFKG

AWYQQKPGNAPRLLISGATSLETGIPSRFSGSG




KATLTIDTSSSTAYVDLSSLASEDSAVYYCVRL

SGKDYSLSITSLQIEDVATYSCQQYWSIPYTFG




GLFDFWGQGTTLTVSS

GGTKLEIK






SCT-Da270
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
188
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
429



MHWIKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSASG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da271
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
188
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
430



MHWIKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da272
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
189
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
431



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQLKQGKSPQLLIYNANTLEDGVPSRFSASG




KATLTADKSSSIVYIQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da273
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
190
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
429



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSASG




KATLTADKSSSIVYMQLSSLTSEDSALYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da274
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
190
QIVLTQSPALMSASPGEKVTMTCSASSSVSYIY
387



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

WYQQKPRSSPKPLIYLTSNLASGVPARFSGSGS




KATLTADKSSSIVYMQLSSLTSEDSALYYCTRG

GTSYSLTISSMEAEDAASYYCQQWSSNPLTFGA




EAYWGQGTLVTVSA

GTKLELK






SCT-Da275
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
191
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
430



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCARG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da276
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
192
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
432



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQLKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDSATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da277
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
193
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
433



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKD

AWFQQKQGKSPQLLIYNAKSLEDGVPSRFSASG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da278
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
194
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
434



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKG

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMHLSSLTSEDSAVYYCARG

SGTQFSMKIKSMQPEDTATYFCKQAYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da279
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
194
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
434



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFKG

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMHLSSLTSEDSAVYYCARG

SGTQFSMKIKSMQPEDTATYFCKQAYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da280
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
196
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
429



MHWVKQRPGQGLEWIGYISPRTGNTEYNQKFRD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSASG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCTRG

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da281
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
197
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
434



MHWVKQRPGQGLEWIGYISPRTGNTNYNQRFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSIVYMQLSSLTSEDSAVYYCARG

SGTQFSMKIKSMQPEDTATYFCKQAYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da282
QVQLQQSGAELAKPGASVKMSCKASGYTFTNYW
198
DIQMTQSPASLAASVGETVTITCRASENIYYTL
435



MHWVKQRPGQGLEWIGYISPRTTYTEYNQKFKD

AWFQQKQGNSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSTAFLQLSSLTSEDSAVYYCTRG

SGTQYSMKINSMQPEDTATYFCKQAYDVPYTFG




EAYWGQGTLVTVSA

GGTKLEIK






SCT-Da283
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIQMTQPTSSLSASLGDRVTISCRASQDISNYL
252



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

NWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGTDYSLTISNLDQEDIATYFCQQGNTLPWTFG




YGTSQAWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da284
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVLTQSPASLAVSLGQRATISCRASESVDNFG
301



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

NSFMHWYQQKPGQPPKLLIYLASNLESGVPARF




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




YGTSQAWFAYWGQGTLVTVSA

RTFGGGTKLEIK






SCT-Da285
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




YGTSQAWFAYWGQGTLVTVSA

RTFGGGTKLEIK






SCT-Da286
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVMTQFQKFMSTSVGDRVSVTCKASQNVDTNV
293



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

AWYQQKPGQSPKLLIYSGSYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGTDFTLTISNVQSEDLAEYFCQQYNTYPYTFG




YGTSQAWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da287
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVMTQSPATLSVTPGDRVSLSCRASQRISDYL
337



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGSDFTLSINSVEPEDVGMYYCQNGHSFPFTFG




YGTSQAWFAYWGQGTLVTVSA

SGTKLEIK






SCT-Da288
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNV
294



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




YGTSQAWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da289
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




YGTSQAWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da290
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
EIVLTQSPTTMAASPGEKITIICNASSSISSNY
358



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

FNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

GSGTSYSLTIGTMEAEDVATYYCQQGSSLPRTF




YGTSQAWFAYWGQGTLVTVSA

GSGTKLEIK






SCT-Da291
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
EIVLTQSPTTMAASPGEKITITCSASSSISSNY
312



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

LNWYQQKPEFSPKLLIYRTSNLASGVPARFSGS




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

GSGTSYSLTIGTMEAEDVATYYCQQGSSIPRTF




YGTSQAWFAYWGQGTLVTVSA

GSGTKLEIK






SCT-Da292
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMH
371



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

WYQQKSGTSPKRWIYDTSKLASGVPARFSGSGS




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




YGTSQAWFAYWGQGTLVTVSA

GTKLELK






SCT-Da293
QVQLQQSGAELAKPGASVKMSCKASGYTFTTYW
199
QIVLTQSPALMAASPGEKVTITCSVSSSISYMY
366



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

WYQQKSETSPKPWIYGTSNLASGVPVRFSGSGS




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

GTSYSLTISSMEAEDAATYYCQQWSSYPLTFGA




YGTSQAWFAYWGQGTLVTVSA

GTKLELK






SCT-Da294
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
430



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSGSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da295
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVLTQSPASLAVSLGQRATISCKASQSVDYDG
328



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

DNYMNWYQQKPGQPPKLLIYAASNLESGIPARF




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGSGSGTDFTLNIHPVEEEDAATYYCQQSYEDP




EADDLWYFDVWGAGTTVTVSS

WTFGGGTKLEIK






SCT-Da296
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVLTQSPASLAVSLGQRATISCRASESVDSYG
264



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

NSFMHWYQQKPGQPPKLLIYIASNLESGVPARF




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGSGSRTDFTLTIDPVEADDAATYYCQQSNEDP




EADDLWYFDVWGAGTTVTVSS

RTFGGGTKLEIK






SCT-Da297
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAV
411



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKPGQSPKLLIYSASYRYTGVPDHFTVSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTDFTFTISSVQAEDLAVYYCQQHYSTPWTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da298
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVMTQSHKFMSTSVGDRVSITCKASQDVTTAV
413



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTVSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTDFTLTISSVQAEDLAVYYCQQHYSAPWTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLKIT






SCT-Da299
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




EADDLWYFDVWGAGTTVTVSS

GGAKLEIK






SCT-Da300
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
318



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da301
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
DNVMTQSQKFMSTSVGDRVSVTCKASQNVGTNV
324



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKSGQSPKLLIYSASYRFSGVPDRFTGSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

SGTDFTLTISNVQSEDLAEYFCQQYNSYPYTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da302
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




EADDLWYFDVWGAGTTVTVSS

GTKLELK






SCT-Da303
QVQLQQSGAELARPGASVKLSCKASGYTFTSYW
200
SIVMTQTPKFLLVSAGDRVTITCRASQSVTNDV
265



MQWIKQRPGQGLEWIGAIYPGDGDTRYTQKFKG

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




KATLTADKSSSTAYMQLSSLASEDSAVYYCARV

YGTDFTFTISTVQAEDLAVYFCQQDYNSPYTFG




EADDLWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da304
QVQLQQSGAELSKPGASVKMSCKASGYTFTTYW
201
DIQMTQSPASLAASVGETVTITCRTSENIYYSL
429



MHWVKQRPGQGLEWIGYINPSTGYTYYNQKFKD

AWFQQKQGKSPQLLIYNANSLEDGVPSRFSASG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCASY

SGTQFSMKIKSMQPEDTATYFCKQSYDVPYTFG




YGTSQAWFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da305
QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYL
202
DIQMTQSPSSLSASLGERVSLTCRASQEISGYL
436



IEWVKQRPGQGLEWIGVINPGSGGPNYNEKFKG

TWLQQKPDGTIKRLIYAASTLDSGVPKRFSGSR




KATLTADKSSSTAYMQLSSLTSDDSAVYFCASD

SESDYSLTISSLESEDFADYYCLQSASYPPTFG




NYGNYDVLDYWGQGTSVTVSS

GGTKLEIK






SCT-Da306
QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYL
203
DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSN
437



IEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKG

GNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDR




KATLTADKSSSTAYMQLSSLTSDDSAVYFCDRE

FSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEY




DAYWGQGTLVTVSA

PYTFGGGTKLEIK






SCT-Da307
QVQLQQSGPDLVRPGVSVKISCKGSGYTFTDYA
204
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
438



LHWVKQSHAKSLEWIGVINTYSSNTYYNQNFEG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSNTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da308
QVQLQQSGPDLVRPGVSVKISCKGSGYTFTDYA
204
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
439



LHWVKQSHAKSLEWIGVINTYSSNTYYNQNFEG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSNTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTRLEIK






SCT-Da309
QVQLQQSGPDLVRPGVSVKISCKGSGYTFTDYA
205
DIVMTQSPATLSVTLGDRVSLSCRASQSISDYL
440



LHWVKQSHAKSLEWIGVINTYSSNTYYNQNFEG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da310
QVQLQQSGPDLVRPGVSVKISCKGSGYTFTDYA
205
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
438



LHWVKQSHAKSLEWIGVINTYSSNTYYNQNFEG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da311
QVQLQQSGPELVKPGASVKMSCKASGYTFTDYV
206
DVVMTQTPLSLPVSLGDQASISCRSRQSLVHSN
441



MSWVKQRTGQGLEWIGEIYPGGNRTYYSEKFKG

GITYLHWYLQKPGQSPKLLIDKVFNRFSGVPDR




KATLTADKSSNTAYMQVSSLTAEDSAVYFCARF

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHV




NDWAMDHWGQGTSVTVSS

PWTFGGGTKLEIK






SCT-Da312
QVQLQQSGPELVKPGASVKMSCKASGYTFTDYV
207
DVVMTQTPLSLPVSLGDQASISCRSRQSLVHSN
442



MSWVKQRTGQGLEWIGEIYPGGNSTYYNEKFKG

GITYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTADKSSNTAYMQLSSLTSEDSAVYFCARF

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHV




NDWSMDYWGQGTSVTVSS

PWTFGGGTKLEIK






SCT-Da313
QVQLQQSGPELVKPGASVKMSCKASGYTFTDYV
208
DVVMTQTPLSLPVSLGDQASISCRSRQSLVHSN
443



MSWVTQRTGQGLEWIGEIYPGGSSIHYNEKFKD

GITYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTADKSSNTAYMQLSSLTSEDSAVYFCARF

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHF




NDWAMDYWGQGTSVTVSS

PWTFGGGTKLEIK






SCT-Da314
QVQLQQSGPELVKPGASVKMSCKASGYTFTDYV
209
DVVMTQTPLSLPVSLGDQASISCRSRQSLVHSN
443



MSWVTQRTGQGLEWIGEIYPGGSSIYYNEKFKD

GITYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR




KATLTADKSSNTAYMQLSSLTSEDSAVYFCARF

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHF




NDWAMDYWGQGTSVTVSS

PWTFGGGTKLEIK






SCT-Da315
QVQLQQSGPELVKPGASVRISCKASGYTFTSYF
210
DIVLTQSPATLSVTPGDRVSLSCRASQSINNYL
444



IHWVKQRPGQGLEWIGWIYPGNVNTNYNERFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCARD

SGTDFTLSINSVETEDFGMYFCQQSSTWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da316
QVQLQQSGPELVKPGASVRISCKASGYTFTTYF
211
DIVLIQSPATLSVTPGDRVSLSCRASQGINNYL
445



IHWVKQRPGQGLEWIGWIYPGNVNVNYNEKFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMHLSSLTSEDSAVYFCSRD

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da317
QVQLQQSGPELVKPGASVRISCKASGYTFTTYY
212
DIVLTQSPATLSVTPGDRVSLSCRASQSINNYL
446



IHWVKQRPGQGLEWIGWIYPGNVNTNYNEKFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCTRD

SGTDFTLSINSVESEDFGKYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTQLELK






SCT-Da318
QVQLQQSGPELVKPGASVRISCKASGYTFTTYY
213
DIVLIQSPATLSVTPGDRVSLSCRASQSINNYL
447



IHWVKQRPGQGLEWIGWIYPGNVNVNYNEKFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCTRD

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da319
QVQLQQSGPELVKPGASVRISCKASGYTFTTYY
214
DIVLTQSPATLSVTPGDRVSLSCRASQSINNYL
410



IHWVKQRPGQGLEWIGWIYPGNVNVNYNERFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCTRD

SGTDFTLSINSVETEDFGVYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da320
QVQLQQSGPELVKPGASVRISCTASGYTFTTYY
215
DIVLTQSPATLSVTPGDRVSLSCRASQSINNYL
448



IHWVKQRPGQGLEWIGWIYPGNVNTNYNEKFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYFCARD

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da321
QVQLQQSGPELVKPGASVRISCTASGYTFTTYY
215
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



IHWVKQRPGQGLEWIGWIYPGNVNTNYNEKFKG

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




KATLTADKSSSTAYMQLSSLTSEDSAVYFCARD

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




YAMDYWGQGTSVTVSS

GTKLELK






SCT-Da322
QVQLQQSGPELVKPWASVRISCKASGYTFTTYY
216
DIVLTQSPATLSVTPGDRVSLSCRASQRINSYL
449



IHWVKQRPGQGLEWIGWIYPGNVNVNYNERFKG

HWYQQKSHESPRLLIKYASHSISGIPSRFSGSG




KATLTADKPSSTAYMQLSSLTSEDSAVYFCSRD

SGTDFTLSINSVETEDFGMYFCQQSNSWPLTFG




YAMDYWGQGTSVTVSS

AGTKLELK






SCT-Da323
QVQLQQSGPELVRPGVSVKISCKGFGYTFTDYA
217
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
450



MHWVKQSHAKSLEWIGVINTYSGNTYYNQKFKD

HWYQQKSHESPRLLIKSASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTPLTVSS

SGTKLEIE






SCT-Da324
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
218
DVVMAPTPLTLSVTIGQPASISCKSSQSLLDSD
451



IHWVKQSHAKSLEWIGVINTHSDNTNYFQRFKG

GETYLNWLLQRPGQSPKRLIYLVSKLDSGVPDR




KATMTVDKSSSTAYMELARLTSEDSAIYYCARP

FTGSGSGTDFTLKISRVEAEDLGVYYCWEGTHF




NYDGHWYFDVWGAGTTVTVSS

WPFGGGTKLEIK






SCT-Da325
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
219
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
452



IHWVKQSHAKSLEWIGVINTYSGNTNYNQNFKV

YWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSNTAYMELARLTSEDSAIYYCARR

SGSDFTLSISSVEPEDVGVYYCQNGHSFPFTFG




RGIHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da326
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
220
ENVLTQSPVIMSASPGEKVTMTCRASSSVSSSY
453



MHWVKQSHAKSLEWIGIINSYSGNTNYNQKFKG

LHWYQQKSGASPKLWIYSTSNLASGVPARFSGS




KATMTVDKSSSTAYMELARLTSEDSAIYYCARW

GSGTSYSLTISSVEAEDAATYYCQQYSGYPLTF




AITTGVYYAMDYWGQGTSVTVSS

GSGTKLEIK






SCT-Da327
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
221
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
331



MHWVKQSHAKSLEWIGVINTYSANTNYNQKFKG

HWYQQKSHESPRLLIKYVSQSISGIPSRFSGSG




KATMTVDKSSSTAYLELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da328
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
222
DIVLTQSPASLAVSLGQRATISCRASESVDNYG
454



MHWVKQSHAKSLEWIGVINTYSGNTNYNQNFKV

ISFMNWFQQKPGQPPKLLIYAASNQGSGVPARF




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVP




RGSHRDAYFDYWGQGTTLTVSS

TFGGGTKLEIK






SCT-Da329
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
222
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
455



MHWVKQSHAKSLEWIGVINTYSGNTNYNQNFKV

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSISSVEPEDVGVYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da330
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
222
QIVLTQSPALMAASPGEKVTITCSVSSSISYMY
366



MHWVKQSHAKSLEWIGVTNTYSGNTNYNQNFKV

WYQQKSETSPKPWIYGTSNLASGVPVRFSGSGS




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

GTSYSLTISSMEAEDAATYYCQQWSSYPLTFGA




RGSHRDAYFDYWGQGTTLTVSS

GTKLELK






SCT-Da331
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
223
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
438



MHWVKQSHVKSLEWIGVINTYSGNTNYNQKFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFG




RGSHQDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da332
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
224
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
456



VHWMKQSHAKSLEWIGVINTYSGNTYYNLHFKD

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELATLTSEDSAIYYCARR

SGSDFTLSIMMVEPEDVGVYYCQNSHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da333
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
225
DIVMTQSHKFMSTSVGDRVSITCRASQDVSTAV
400



VHWVKQSHAKSLEWIGVINTYSGNTYYNLHFKG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTVSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGTDFTFTISSVQAEDLAVYYCQQHYSTPWTFG




RGSHRDAYFDYWGQGTTLTVSS

GGTKLEIK






SCT-Da334
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
225
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
457



VHWVKQSHAKSLEWIGVINTYSGNTYYMLHFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVDPEDVGMYYCQNSHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da335
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
225
DIVMTQSPATLSVTPGDSVSLSCRASQTISDYL
458



VHWVKQSHAKSLEWIGVINTYSGNTYYNLHFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLSINSVEPEDVGVYYCQNSHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da336
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
226
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
456



VHWVKQSHAKSLEWIGVINTYSGNTYYNLHFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELATLTSEDSAIYYCARR

SGSDFTLSINNVEPEDVGVYYCQNSHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da337
QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYA
227
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
459



VHWVKQSHAKSLEWIGVINTYSGNTYYNLNFTG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELARLTSEDSAIYYCARR

SGSDFTLTINSVEPEDIGLYYCQNGHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da338
QVQLQQSGPELVSPGVSVKISCKGSGYTFTDYA
228
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYL
457



VHWVKQSHAKSLEWIGVINTYSGNTYFNLHFKG

HWYQQKSHESPRLLIKYASQSISGIPSRFSGSG




KATMTVDKSSSTAYMELASLTSEDSAIYYCARR

SGSDFTLSINSVDPEDVGMYYCQNSHSFPFTFG




RGSHRDAYFDYWGQGTTLTVSS

SGTKLEIK






SCT-Da339
QVQLQQSGPEVVKPGASVKMSCKASGYTFTDYV
229
DVVMTQTPLSLPVSLGDQASISCRSRQSLVHSN
460



MTWVKQRTGQGLEWIGEIYPGGNRTYYKEKFKG

GITYLHWYLQKPGQSPKLLIFKVSNRFSGVPDR




KATLTADKSSNTAYMQLSSLTSEDSAVYFGARF

FSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHV




NDWAMDYWGQGTSVTVSS

PWTFGGGTKLEIK






SCT-Da340
QVQLQQSGTELVRPGASVTLSCKTSGYTFTDYE
230
SIVVTQTPKFLLVSAGDRVTITCKASQSVSNDV
461



MHWVKQTPVHGLEWIGGIDPETGATAYNQKFKG

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




KATLTADKSSSTAYMELRSLTSEDSAVYYCTAR

YGTDFTFTISTVQAEDLAVYFCQQDYTSPPTFG




QLGLPFAYWGQGTLVTVSA

GGTKLEIK






SCT-Da341
QVTLKESGPGILQPSQTLSLTCSFSGFSLNTSN
231
SIVMTQTPKFLLVSAGDRVTITCKANQFVSNFV
462



LGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDSSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTITAVQAEDLAVYFCQQDYSSPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da342
QVTLKESGPGILQPSQTLSLTCSFSGFSLNTSN
232
SIVMTQTPKFLLVSAGDRVTITCKASQFVSNFV
463



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDSSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTITTVQAEDLAVYFCQQDYSSPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da343
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTPG
233
SIVMTQTPKFLLVSAGDRVTITCKASQSVNNDV
464



LGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYNSPYAFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da344
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTPN
234
SIVMTQTPKFLLVSAGDRVTITCKASQSVINDV
465



MGVGWIRQPSGKGLEWLAHIWWDDDKRQNAALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKETSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISSVQAEDLAVYFCQQDYSSPYTFG




KIHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da345
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTPS
235
SIVMTQTPKFLLVSAGDRVTITCKASQSVINDV
466



MGVGWIRQPSGKGLEWLAHIWWDDDKRSDPALK

AWFQQKPGQSPNLLIYYASNRYTGVPARFTGSG




SRLTISKDTSSNQVFLKIASVDTADTGTYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYSSPYTFG




KNHYSGHWFFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da346
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSG
236
SIVMTQTPKFLLVSAGDRVTITCKASQSVSNYV
467



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDSSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTITTVQAEDLAVYFCQQDYSSPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da347
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
237
SIVMTQTPKFLLVSAGDRVTITCKASQSVINDV
468



LGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLE

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYSSPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da348
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
238
SVVMTQTPKFLLVSAGDRITITCKASQSVINDV
469



MGVGWIRQPSGKGLEWLAHIWWDDDKRYHPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYNSPFTFG




KSHYYGHWYFDFWGAGTTVTVSS

GGTKLEIK






SCT-Da349
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
239
DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTDV
304



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYSASYRFSGVPDRFTGSG




SRLTISKDSSNNQVFLKIASVDTSDTAIYYCGR

SGTDFSLAISNVQSEDLAEYFCQQYNSYPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGAKLEIK






SCT-Da350
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
239
SIVMTQTPKFLLVSAGDRFTITCKASQNVDNYV
354



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDSSNNQVFLKIASVDTSDTAIYYCGR

YGTDFTFTITTVQAEDLAVYFCQQDYSSPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da351
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
239
SIVMTQTPKFLLVSTGDRFTITCKASQNVDNYV
470



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDSSNNQVFLKIASVDTSDTAIYYCGR

YGTDFTFTITTVQAEDLAVYFCQQDYSSPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da352
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
240
SLVMTQTPKFLLVSPGDRITITCKASQSVINDV
471



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLIYYASNRNTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADSATYYCAR

YGTDFTLTISTVQAEDLAVYFCQQDYNSPYTFG




KNHYYGHWYFDFWGAGTTVTVSS

GGTKLEIK






SCT-Da353
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
241
SIVMTQTPKFLLVSAGDRITITCKASQSVINDV
472



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPALK

AWYQQKPGQSPKLLMYYASNRNTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTLTISTVQAEDLAVYFCQQDYNSPYTFG




KNHYYGHWYFDFWGAGTTVTVSS

GGTKLEIK






SCT-Da354
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
242
DIQMTQSPASLSVSVGETVTITCRASENIYSNL
473



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

AWYQQKQGKSPQLLVYAATNLADGVPSRFSGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

SGTQYSLKINSLQSEDFGSYYCQHFWGTPFTFG




KNHYYGHWYFDVWGAGTTVTVSS

SGTKLEIK






SCT-Da355
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
242
DIQMTQSPSSLSASLGGKVTITCKASQDINKYI
474



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

SWYQHKPGKGPRLLIHYTSTLQPGIPSRFSGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

SGRDYSFSISNLEPEDIATYYCLQYDNLWTFGG




KNHYYGHWYFDVWGAGTTVTVSS

GTKLEIK






SCT-Da356
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
242
SIVMTQTPKFLLVSAGDRVTITCKASQSVINDV
475



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

AWFQQQPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYSSPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da357
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
242
SIVMTQTPKFLLVSAGDRVTITCRASQSVTNDV
265



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYNSPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da358
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
243
SIVMTQTPKFLLVSAGDRVTITCKASQSVSNDV
476



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCAR

YGTDFTFTISTVQAEDLAVYFCQQDYNSPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da359
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
244
SIVMTQTPKFLLVSAGDRVTITCKASQSVINDV
468



MGVGWIRQPSGKGLEWLAHIWWDDDKRYNPDLK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYYCGR

YGTDFTFTISTVQAEDLAVYFCQQDYSSPYTFG




KSHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da360
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSN
245
NIVMTQTPRFLLVSAGDRVTITCKASQTVTNDV
477



MGVGWIRQPSGKGLEWLAHIWWDDDTRYKPALK

AWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSG




SRLTISKDTSSNQVFLKIASVDTADTATYFCAR

YGTDFTFTISTVQAEDLAVYFCQQDYISPYTFG




KNHYYGHWYFDVWGAGTTVTVSS

GGTKLEIK






SCT-Da361
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTYG
246
DIQMTQTTSSLSASLGDRVTINCSASQGIINYL
478



IGVGWIRQPSGKGLEWLAHIWWNDNKYYNTALK

NWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSG




SRLTISKDTSNNQVFLKIASVDTADTATYYCAR

SGTDYSLTISNLEPEDIASYYCQQYSKLPYTFG




IDYWFAYWGQGTLVTVSA

GGTKVEIK






SCT-Da362
QVTLKESGPGILQPSQTLSLTCSFSGFSLSTYG
246
QIVLTQSPALMSASPGEKVTMTCSASSSVSYMY
333



IGVGWIRQPSGKGLEWLAHIWWNDNKYYNTALK

WYQQKPRSSPKPWIYLTSNLASGVPARFSGSGS




SRLTISKDTSNNQVFLKIASVDTADTATYYCAR

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGA




IDYWFAYWGQGTLVTVSA

GTKLELK






SCT-Da363
EVQLVESGGDLVQPGGSLRLSCKTSGFTFSSFY
973
DIQMTQSPSSLSASVGDRVTITCRASQDVSTAV
974



ISWVRQAPGKGLEWIAWIYAGPGYTSYADSVKG

AWYQQKPGKAPKLLIYSASYRYSGVPSRFSGSG




RFTISRDNSRNTLYLQMNSLRAEDTAVYYCARH

SGTDFTLTISSLQPEDFATYYCQQHYSTPWTFG




VGRQRGYFDVWGQGTLVTVSS

QGTKVEIK






SCT-Da364
EVQLVESGGDLVQPGGSLRLSCKTSGFTFSSFY
973
DIVMTQSQRFMSTTVGDRVSITCKASQDVSTAV
975



ISWVRQAPGKGLEWIAWIYAGPGYTSYADSVKG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSG




RFTISRDNSRNTLYLQMNSLRAEDTAVYYCARH

SGTDFTLTISNMQSEDLADFFCQQHYSTPWTFG




VGRQRGYFDVWGQGTLVTVSS

GGTKLEIK






SCT-Da365
EVQLQQSGPELEKPGASVKLSCKASGYTFTEYT
976
DIQLTQSPSSLSASVGDRVTMTCRASSSVSYIH
977



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFRG

WFQQKPGKAPKPWIYLTSNLASGVPVRFSGSGS




KATLTVDKSSSTAYMQLKSLTSEDSAVYYCARP

GTDYTFTISSLQPEDIATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGAGTTVTVSS

GTKLEIK






SCT-Da366
EVQLQQSGPELEKPGASVKLSCKASGYTFTEYT
976
QIVLIQSPAIMSASPGEKVTMTCSASSSVSYMY
978



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFRG

WYQQKPGSSPRLLIYLTSNLASGVPVRFSGSGS




KATLTVDKSSSTAYMQLKSLTSEDSAVYYCARP

GTSYSLTISRMEAEDAATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGAGTTVTVSS

GTKLEIK






SCT-Da367
EVQLQQSGPELEKPGASVKLSCKASGYTFTEYT
976
QIVSTQSPAIMSASPGEKVTMTCSASSSVSYMQ
979



MHWVKQSHGKSLEWIGVINPNNGGTTYNQKFRG

WYQQKPGTSPKRWIYLTSKLASGVPARFSGSGS




KATLTVDKSSSTAYMQLKSLTSEDSAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGAGTTVTVSS

GTKLEIK






SCT-Da368
EVQLVQSGAEVKKPGASVKVSCKTSGYTFTEYT
980
DIQLTQSPSSLSASVGDRVTMTCRASSSVSYIH
977



MHWVKQAPGQGLEWIGVINPNNGGTTYNQKFQG

WFQQKPGKAPKPWIYLTSNLASGVPVRFSGSGS




RVTMTRDTSISTAYMELGSLRSDDTAVYYCARP

GTDYTFTISSLQPEDIATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGQGTMVTVSS

GTKLEIK






SCT-Da369
EVQLVQSGAEVKKPGASVKVSCKTSGYTFTEYT
980
QIVLIQSPAIMSASPGEKVTMTCSASSSVSYMY
978



MHWVKQAPGQGLEWIGVINPNNGGTTYNQKFQG

WYQQKPGSSPRLLIYLTSNLASGVPVRFSGSGS




RVTMTRDTSISTAYMELGSLRSDDTAVYYCARP

GTSYSLTISRMEAEDAATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGQGTMVTVSS

GTKLEIK






SCT-Da370
EVQLVQSGAEVKKPGASVKVSCKTSGYTFTEYT
980
QIVSTQSPAIMSASPGEKVTMTCSASSSVSYMQ
979



MHWVKQAPGQGLEWIGVINPNNGGTTYNQKFQG

WYQQKPGTSPKRWIYLTSKLASGVPARFSGSGS




RVTMTRDTSISTAYMELGSLRSDDTAVYYCARP

GTSYSLTISSMEAEDAATYYCQQWSSNPLTFGG




HSLLRLRREFDYWGQGTMVTVSS

GTKLEIK






SCT-Da371
QVQLQQPGAELVKPGASVKMSCKASGVNIKDTY
981
DIQMTQSPSSLSASVGDRVTITCKASQNVGTDV
982



IHWVKQTPGRGLEWIGRIDPANGNRKYNQKFKG

AWYQQKPGKAPKALIYSASYRFSGVPYRFSGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYYCARD

SGTDFTLTISSLQPEDFATYFCQQYNSYPYTFG




GYYAPGYWGAGTTVTVSA

QGTKVEIK






SCT-Da372
QVQLQQPGAELVKPGASVKMSCKASGVNIKDTY
981
DIVMTQSQRFMSTTVGDRVSITCKASQNVGTDV
983



IHWVKQTPGRGLEWIGRIDPANGNRKYNQKFKG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSG




KATLTADKSSSTAYMQLSSLTSEDSAVYYCARD

SGTDFTLTISNMQSEDLADFFCQQYNSYPYTFG




GYYAPGYWGAGTTVTVSA

GGTKLEIK






SCT-Da373
EVQLVQSGAEVKKPGASVKVSCKASGVNIKDTY
984
DIQMTQSPSSLSASVGDRVTITCKASQNVGTDV
982



IHWVRQAPGQRLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGKAPKALIYSASYRFSGVPYRFSGSG




RVTITADTSASTAYMELSSLRSEDTAVYYCARD

SGTDFTLTISSLQPEDFATYFCQQYNSYPYTFG




GYYAPGYWGQGTLVTVSS

QGTKVEIK






SCT-Da374
EVQLVQSGAEVKKPGASVKVSCKASGVNIKDTY
984
DIVMTQSQRFMSTTVGDRVSITCKASQNVGTDV
983



IHWVRQAPGQRLEWIGRIDPANGNRKYDPKFQG

AWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSG




RVTITADTSASTAYMELSSLRSEDTAVYYCARD

SGTDFTLTISNMQSEDLADFFCQQYNSYPYTFG




GYYAPGYWGQGTLVTVSS

GGTKLEIK









The preceding merely illustrates the principles of the disclosure. It will be appreciated that those skilled in the art will be able to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the disclosure and are included within its spirit and scope. Furthermore, all examples and conditional language recited herein are principally intended to aid the reader in understanding the principles of the disclosure and the concepts contributed by the inventors to furthering the art and are to be construed as being without limitation to such specifically recited examples and conditions. Moreover, all statements herein reciting principles, aspects, and embodiments of the disclosure as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents and equivalents developed in the future, i.e., any elements developed that perform the same function, regardless of structure. The scope of the present disclosure, therefore, is not intended to be limited to the exemplary embodiments shown and described herein. Rather, the scope and spirit of present disclosure is embodied by the appended claims.


REFERENCES CITED
Other References



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Claims
  • 1. An antibody that binds human B7-H3 (SEQ ID NO:1) comprising: a) a HCDR1 having the amino acid sequence of SEQ ID NO:574, a HCDR2 having the amino acid sequence of SEQ ID NO:560, a HCDR3 having the amino acid sequence of SEQ ID NO:546, a LCDR1 having the amino acid sequence of SEQ ID NO:904, a LCDR2 having the amino acid sequence of SEQ ID NO:882, and a LCDR3 having the amino acid sequence of SEQ ID NO:902; orb) a HCDR1 having the amino acid sequence of SEQ ID NO:585, a HCDR2 having the amino acid sequence of SEQ ID NO:586, a HCDR3 having the amino acid sequence of SEQ ID NO:587, a LCDR1 having the amino acid sequence of SEQ ID NO:833, a LCDR2 having the amino acid sequence of SEQ ID NO:834, and a LCDR3 having the amino acid sequence of SEQ ID NO:835; orc) a HCDR1 having the amino acid sequence of SEQ ID NO:582, a HCDR2 having the amino acid sequence of SEQ ID NO:552, a HCDR3 having the amino acid sequence of SEQ ID NO:589, a LCDR1 having the amino acid sequence of SEQ ID NO:944, a LCDR2 having the amino acid sequence of SEQ ID NO:957, and a LCDR3 having the amino acid sequence of SEQ ID NO:947; ord) a HCDR1 having the amino acid sequence of SEQ ID NO:634, a HCDR2 having the amino acid sequence of SEQ ID NO:652, a HCDR3 having the amino acid sequence of SEQ ID NO:653, a LCDR1 having the amino acid sequence of SEQ ID NO:884, a LCDR2 having the amino acid sequence of SEQ ID NO:882, and a LCDR3 having the amino acid sequence of SEQ ID NO:885; ore) a HCDR1 having the amino acid sequence of SEQ ID NO:634, a HCDR2 having the amino acid sequence of SEQ ID NO:652, a HCDR3 having the amino acid sequence of SEQ ID NO:653, a LCDR1 having the amino acid sequence of SEQ ID NO:884, a LCDR2 having the amino acid sequence of SEQ ID NO:882, and a LCDR3 having the amino acid sequence of SEQ ID NO:885; orf) a HCDR1 having the amino acid sequence of SEQ ID NO:582, a HCDR2 having the amino acid sequence of SEQ ID NO:552, a HCDR3 having the amino acid sequence of SEQ ID NO:589, a LCDR1 having the amino acid sequence of SEQ ID NO:944, a LCDR2 having the amino acid sequence of SEQ ID NO:957, and a LCDR3 having the amino acid sequence of SEQ ID NO:947.
  • 2. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:574, the HCDR2 has the amino acid sequence of SEQ ID NO:560, the HCDR3 has the amino acid sequence of SEQ ID NO:546, the LCDR1 has the amino acid sequence of SEQ ID NO:904, the LCDR2 has the amino acid sequence of SEQ ID NO:882, and the LCDR3 has the amino acid sequence of SEQ ID NO:902.
  • 3. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:585, the HCDR2 has the amino acid sequence of SEQ ID NO:586, the HCDR3 has the amino acid sequence of SEQ ID NO:587, the LCDR1 has the amino acid sequence of SEQ ID NO:833, the LCDR2 has the amino acid sequence of SEQ ID NO:834, and the LCDR3 has the amino acid sequence of SEQ ID NO:835.
  • 4. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:582, the HCDR2 has the amino acid sequence of SEQ ID NO:552, the HCDR3 has the amino acid sequence of SEQ ID NO:589, the LCDR1 has the amino acid sequence of SEQ ID NO:944, the LCDR2 has the amino acid sequence of SEQ ID NO:957, and the LCDR3 has the amino acid sequence of SEQ ID NO:947.
  • 5. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:634, the HCDR2 has the amino acid sequence of SEQ ID NO:652, the HCDR3 has the amino acid sequence of SEQ ID NO:653, the LCDR1 has the amino acid sequence of SEQ ID NO:884, the LCDR2 has the amino acid sequence of SEQ ID NO:882, and the LCDR3 has the amino acid sequence of SEQ ID NO:885.
  • 6. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:634, the HCDR2 has the amino acid sequence of SEQ ID NO:652, the HCDR3 has the amino acid sequence of SEQ ID NO:653, the LCDR1 has the amino acid sequence of SEQ ID NO:884, the LCDR2 has the amino acid sequence of SEQ ID NO:882, and the LCDR3 has the amino acid sequence of SEQ ID NO:885.
  • 7. The antibody of claim 1, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:582, the HCDR2 has the amino acid sequence of SEQ ID NO:552, the HCDR3 has the amino acid sequence of SEQ ID NO:589, the LCDR1 has the amino acid sequence of SEQ ID NO:944, the LCDR2 has the amino acid sequence of SEQ ID NO:957, and the LCDR3 has the amino acid sequence of SEQ ID NO:947.
  • 8. An antibody that binds human B7-H3 (SEQ ID NO:1) comprising: a) a VH having the amino acid sequence of SEQ ID NO:99, and a VL having the amino acid sequence of SEQ ID NO:304; orb) a VH having the amino acid sequence of SEQ ID NO:112, and a VL having the amino acid sequence of SEQ ID NO:369; orc) a VH having the amino acid sequence of SEQ ID NO:121, and a VL having the amino acid sequence of SEQ ID NO:333; ord) a VH having the amino acid sequence of SEQ ID NO:169, and a VL having the amino acid sequence of SEQ ID NO:411; ore) a VH having the amino acid sequence of SEQ ID NO:973, and a VL having the amino acid sequence of SEQ ID NO:975; orf) a VH having the amino acid sequence of SEQ ID NO:980, and a VL having the amino acid sequence of SEQ ID NO:978.
  • 9. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:99, and the VL has the amino acid sequence of SEQ ID NO:304.
  • 10. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:112, and the VL has the amino acid sequence of SEQ ID NO:369.
  • 11. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:121, and the VL has the amino acid sequence of SEQ ID NO:333.
  • 12. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:169, and the VL has the amino acid sequence of SEQ ID NO:411.
  • 13. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:973, and the VL has the amino acid sequence of SEQ ID NO:975.
  • 14. The antibody of claim 8, wherein the VH has the amino acid sequence of SEQ ID NO:980, and the VL has the amino acid sequence of SEQ ID NO:978.
  • 15. An antibody that binds human B7-H3 (SEQ ID NO:1) comprising: a) a heavy-chain comprising the amino acid sequence of SEQ ID NO:99 and a light-chain comprising the amino acid sequence of SEQ ID NO:304; orb) a heavy-chain comprising the amino acid sequence of SEQ ID NO: 112 and a light-chain comprising the amino acid sequence of SEQ ID NO:369; orc) a heavy-chain comprising the amino acid sequence of SEQ ID NO:121 and a light-chain comprising the amino acid sequence of SEQ ID NO:333; ord) a heavy-chain comprising the amino acid sequence of SEQ ID NO:169 and a light-chain comprising the amino acid sequence of SEQ ID NO:411; ore) a heavy-chain comprising the amino acid sequence of SEQ ID NO:973 and a light-chain comprising the amino acid sequence of SEQ ID NO:975; orf) a heavy-chain comprising the amino acid sequence of SEQ ID NO:980 and a light-chain comprising the amino acid sequence of SEQ ID NO:978.
  • 16. The antibody of claim 15, wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:99 and the light-chain comprises the amino acid sequence of SEQ ID NO:304.
  • 17. The antibody of claim 15, wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:112 and the light-chain comprises the amino acid sequence of SEQ ID NO:369.
  • 18. The antibody of claim 15, wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:121 and the light-chain comprises the amino acid sequence of SEQ ID NO:333; or wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:169 and the light-chain comprises the amino acid sequence of SEQ ID NO:411; or wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:973 and the light-chain comprises the amino acid sequence of SEQ ID NO:975; or wherein the heavy-chain comprises the amino acid sequence of SEQ ID NO:980 and the light-chain comprises the amino acid sequence of SEQ ID NO:978.
  • 19.-21. (canceled)
  • 22. A pharmaceutical composition comprising the antibody of claim 1.
  • 23. A kit comprising the antibody of claim 1.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Application No. 62/853,454 filed 28 May 2019, which is incorporated herein by reference in its entirety for all purposes.

PCT Information
Filing Document Filing Date Country Kind
PCT/CN2020/092472 5/27/2020 WO 00
Provisional Applications (1)
Number Date Country
62853454 May 2019 US