Claims
- 1. An anti-cancer composition for delivering 5-fluorouracil to cancer tissues in a warm-blooded animal, wherein the cancer is a cancer sensitive to 5-fluorouracil, said composition comprising uracil or a pharmaceutically acceptable salt thereof and 1-n-hexylcarbamoyl-5-fluorouracil in a small amount of about 0.01 to less than 0.1 mole per mole of the uracil or salt thereof.
- 2. An anti-cancer composition as defined in claim 1 wherein the salt of uracil is an alkali metal salt.
- 3. An anti-cancer composition as defined in claim 2 wherein the alkali metal salt is sodium or potassium salt.
- 4. An anti-cancer composition as defined in claim 1 wherein 0.01 to 0.09 mole of the 5-fluorouracil is used per mole of the uracil or salt thereof.
- 5. An anti-cancer composition as defined in claim 1 which is an oral preparation.
- 6. An anti-cancer composition as defined in claim 1 which is an injection preparation.
- 7. An anti-cancer composition as defined in claim 1 which is a suppository.
- 8. A method of delivering 5-fluorouracil to a cancer sensitive to 5-fluooruracil in a warm-blooded animal, said method comprising administering to the animal the anti-cancer composition of claim 1 in the form of a single preparation in an amount which is effective to deliver an anti-cancer effective amount of 5-fluorouracil to the cancer.
- 9. A method of delivering 5-fluorouracil to a cancer sensitive to 5-fluorouracil in a warm blooded animal, the method comprising administering to said animal in separate doses uracil or a pharmaceutically acceptable salt thereof and 1-n-hexylcarbamoyl-5-fluorouracil wherein about 0.01 to less than 0.1 mole of 1-n-hexylcarbamoyl-5-fluorouracil is used per mole of the uracil or salt thereof, in an amount which is effective to deliver an anti-cancer amount of 5-fluorouracil to the cancer and the pharmaceutically acceptable salts thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
52-39341 |
Apr 1977 |
JPX |
|
53-14676 |
Feb 1978 |
JPX |
|
CROSS REFERENCE TO RELATED APPLICATIONS
This is a divisional application of Ser. No. 214,022, filed Dec. 8, 1980, now U.S. Pat. No. 4,507,301, issued Mar. 26, 1985, which was a continuation-in-part of application Ser. No. 15,161, filed Feb. 26, 1979, now U.S. Pat. No. 4,328,229, issued May 4, 1982, which was a continuation-in-part of application Ser. No. 891,343, filed Mar. 29, 1977, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4481203 |
Fujii et al. |
Nov 1984 |
|
Non-Patent Literature Citations (4)
Entry |
Burchewal et al., Cancer Chemotherapy Repts., 6, pp. 1-5 (1960). |
Chemical Abstracts 86:50590p (1976). |
Jato et al., J. of Pharm. Sciences 62, pp. 1975-1978, (Dec. 1978). |
Jato et al., J. of Pham. Sciences 64, pp. 943-946 (Jun. 1975). |
Divisions (1)
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Number |
Date |
Country |
Parent |
214022 |
Dec 1980 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
15161 |
Feb 1979 |
|
Parent |
891343 |
Mar 1977 |
|