Claims
- 1. An anti-idiotypic antibody or antigen-binding fragment thereof which immunospecifically binds to an idiotype of a second antibody, wherein said idiotype of said second antibody specifically binds an epitope of FimH adhesin from uropathogenic Type I-fimbriated Escherichia coli which is not present in FimH adhesin from non-uropathogenic Type I-fimbriated Escherichia coli.
- 2. A hybridoma cell which produces an anti-idiotypic antibody according claim 1.
- 3. An immunizing composition for stimulating and enhancing, in a subject to which the composition is administered, production of antibodies, which recognize FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli but not FimH adhesin of non-uropathogenic Type I-fimbriated Escherichia coli, comprising an immunizing effective amount of an anti-idiotypic antibody or antigen-binding fragment thereof according to claim 1, and a pharmaceutically acceptable diluent, excipient, carrier or auxiliary agent.
- 4. A method for stimulating and enhancing production of antibodies, which recognize FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli but not FimH adhesin of non- uropathogenic Escherichia coli, comprising administering the immunizing composition according to claim 3 to a subject.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of priority from U.S. Provisional Application No. 60/204,572, filed May 16, 2000, the entire content of which is incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
|
60204572 |
May 2000 |
US |