Claims
- 1. A compound having the formula: Wherein:R1-R6 may be the same or different and are methyl, propyl, butyl, pentyl, benzyl or β,β,β,-trifluoro-ethyl; m is an integer from 3 to, 4, 5, or 6, inclusive ; and n is an integer from 3 to, 4, 5, or 6, inclusive,; or a salt thereof with an acid; with the proviso that if m is 3, and n is 3 or 4, then at least one of R1-R6 is β,β,β,-trifluoroethyl.
- 2. A compound according to claim 1 wherein R1 and R6 are propyl.
- 3. A compound according to claim 1 wherein R1 and R6 are benzyl.
- 4. A compound according to claim 1 wherein m is 3 and n is 4.
- 5. A compound according to claim 1 wherein m and n are 3.
- 6. A compound according to claim 1 wherein m and n are 4.
- 7. A compound having the formula:R1—N1H—(CH2)3—N2H—(CH2)3—N3H—(CH2)4—N4H—(CH2)3—N5H—(CH2)3—N6H—R6 (II) Wherein:R1 and R6 may be the same or different and are alkyl or aralkyl having from 1 to 12 carbon atoms, or a salt thereof with an acid.
- 8. A compound according to claim 7 wherein R1 and R6 are alkyl.
- 9. A compound according to claim 7 wherein R1 and R6 are aralkyl.
- 10. A compound according to claim 7 wherein R1 and R6 are methyl.
- 11. A compound according to claim 7 wherein R1 and R6 are ethyl.
- 12. A compound according to claim 7 wherein R1 and R6 are propyl.
- 13. A compound according to claim 7 wherein R1 and R6 are benzyl.
- 14. A compound having the formula:CH3CH2—NH—(CH2)4—NH—(CH2)4—NH—(CH2)4—NH—CH2CH3.
RELATED APPLICATIONS
This is a reissue of application Ser. No. 07/210,520, filed Jun. 23, 1988, now U.S. Pat. No. 5,091,576, which is a continuation-in-part of application Ser. No. 066,227, filed Jun. 25, 1987, now abandoned, which is a continuation-in-part application of application Ser. No. 936,835, filed Dec. 2, 1986, now abandoned.
BACKGROUND OF THE INVENTION
This invention was made with U.S. Government support under Grant NCDDG-CA37606, awarded by the National Cancer Institute. The U.S. Government has certain rights in this invention.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
SHO.52-118405 |
Oct 1977 |
JP |
Non-Patent Literature Citations (3)
Entry |
Glaser R and Gabbay E J, “Topography of Nucleic Acid Helices in Solutions. III. Interactions of Spermine and Spermine Derivatives with Polyadenylic-Polyuridylic and Polyinosinic-Polycytidylic Acid Helices,” Biopolymers 6:243-254 (1968). |
Clay R M et al., “Noncyclic Reference Ligands for Tetraaza Macrocycles. Synthesis and Therodynamic Properties of a Series of α, ω-Di-N-methylated Tetraaza Ligands and Their Copper (II) Complexes,” Inorganic Chemistry 24(21):3330-3336 (1985). |
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Divisions (1)
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Number |
Date |
Country |
Parent |
07/210520 |
Jun 1988 |
US |
Child |
10/212365 |
|
US |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
07/066227 |
Jun 1987 |
US |
Child |
07/210520 |
|
US |
Parent |
06/936835 |
Dec 1986 |
US |
Child |
07/066227 |
|
US |
Reissues (1)
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Number |
Date |
Country |
Parent |
07/210520 |
Jun 1988 |
US |
Child |
10/212365 |
|
US |