Claims
- 1. A 10-aminoaliphatyl-dibenz�b,f!oxepine of formula I ##STR12## wherein alk is a divalent aliphatic radical,
- R is an amino group that is mono or di-substituted by monovalent aliphatic groups at least one monovalent radical being a substituted or unsubstituted lower alkynyl group, and
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl
- or a salt thereof.
- 2. A compound according to claim 1 being N-(Dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine or a salt thereof.
- 3. A compound according to claim 1 being
- N-(dibenz�b,f!oxepin-10-ylmethyl)-N-prop-2-ynylamine,
- N-(1-chloro-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(7-chloro-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(8-methoxy-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(8-tert-butyl-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(6-chloro-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(1-fluoro-dibenz�b,f!oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine,
- N-(7-chloro-dibenz�b,f!oxepin-10-methyl)-N-methyl-N-prop-2-ynylamine or a salt of any one thereof.
- 4. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof together with customary pharmaceutical excipients and carriers.
Priority Claims (1)
Number |
Date |
Country |
Kind |
367/95 |
Feb 1995 |
CHX |
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Parent Case Info
This is a Divisional of Ser. No. 08/594,215, filed Jan. 31, 1996 now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3100207 |
Zirkle et al. |
Aug 1963 |
|
3641056 |
Schindler et al. |
Feb 1972 |
|
3928383 |
Kaplan et al. |
Dec 1975 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
357126 |
Mar 1990 |
EPX |
436338 |
Nov 1967 |
CHX |
440318 |
Dec 1967 |
CHX |
1080979 |
Aug 1967 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Chemical Abstract, vol. 85, No. 11, Sep. 13, 1976, No. 77999v. |
Chemical Abstract, vol. 81, No. 19, Nov. 11, 1974, No. 120510k. |
Chemical Abstract, 85:78000z, (1976). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
594215 |
Jan 1996 |
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