Claims
- 1. A compound of the formula ##STR15## wherein R.sub.3 is hydrogen;
- R.sub.1 and R.sub.2 taken together are alkylene of 3 to 9 carbon atoms or phenylalkylene of 9 to 11 carbon atoms with the proviso that the ring system so formed is 5- to 8-membered;
- R.sub.1 and R.sub.2 taken separately are each hydrogen or lower alkyl of 1 to 5 carbon atoms, provided that when R.sub.2 is hydrogen, R.sub.1 is other than hydrogen or methyl and when R.sup.1 is hydrogen, R.sup.2 is other than methyl;
- and cationic salts thereof.
- 2. A compound of claim 1, wherein R.sub.1 and R.sub.2 taken together are alkylene of 3 to 6 carbon atoms.
- 3. A compound of claim 2, wherein R.sub.1 and R.sub.2 taken together are butylene.
- 4. A method of inhibiting allergic reactions in a mammal which comprises administering to said mammal a compound of the formula ##STR16## or a pharmaceutically-acceptable salt thereof, wherein R.sub.1 and R.sub.2 when taken together are alkylene of 4 to 9 carbon atoms or phenylalkylene of 9 to 11 carbons, with the proviso that the ring system so formed is 5- to 8-membered, or, when taken separately, R.sub.1 is alkyl or 2 to 5 carbon atoms, and R.sub.2 is hydrogen or alkyl of 1 to 5 carbon atoms, in an amount sufficient to inhibit said allergenic reactions.
- 5. A method of claim 4 wherein R.sub.1 and R.sub.2 are taken together and are alkylene of 4 to 6 carbon atoms.
- 6. A method of inhibiting gastric ulcers in a mammal which comprises administering to said mammal a compound of the formula ##STR17## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 when taken together are alkylene of 3 to 9 carbon atoms or phenylalkylene of 9 to 11 carbon atoms, with the proviso that the ring system so formed is 5- to 8-membered, and R.sub.1 and R.sub.2 when taken separately are each hydrogen or alkyl of 1 to 5 carbon atoms, with the proviso that when R.sub.2 is hydrogen, R.sub.1 is other than hydrogen or methyl, in an amount sufficient to inhibit said gastric ulcers.
- 7. A method of claim 6 wherein R.sub.1 and R.sub.2 are taken separately.
- 8. A method of claim 7 wherein R.sub.1 is ethyl.
- 9. A method of claim 8 wherein R.sub.2 is ethyl.
- 10. A method of claim 8 wherein R.sub.2 is hydrogen.
Parent Case Info
This application is a division of application Ser. No. 312,372 filed Oct. 19, 1981 now U.S. Pat. No. 4,423,048 which in turn is a division of application Ser. No. 096,631 filed Nov. 23, 1979 and now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1331059 |
Sep 1973 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Ohta et al., Chemical Abstracts, vol. 49, 10931g, (1955). |
Yamane et al., Chemical Abstracts, vol. 71, 61274e, (1969). |
Dunwell et al., J. Chem Soc., 1971, 2094-2097. |
Divisions (2)
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Number |
Date |
Country |
Parent |
312372 |
Oct 1981 |
|
Parent |
96631 |
Nov 1979 |
|