Claims
- 1. A 17.alpha.-substituted steroid of the formula ##STR4## wherein R.sub.1 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl,
- R.sub.2 is C.sub.5-6 -alkyl,
- X is oxygen or H(OR.sub.3) wherein R.sub.3 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 alkenyl interrupted by an oxa atom, cyclopentyl or tetrahyropyranyl.
- 2. 17.beta.-Hydroxy-1.alpha.-methyl-17.alpha.-n-pentyl-5.alpha.-androstan-3-one, a compound of claim 1.
- 3. 17.alpha.-n-Hexyl-17.beta.-hydroxy-1.alpha.-methyl-5.alpha.-androstan-3-one, a compound of claim 1.
- 4. A 17.alpha.-substituted steroid of the formula ##STR5## wherein R.sub.1 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl,
- R.sub.2 is C.sub.3-6 -alkyl,
- X is H(OR.sub.3) and R.sub.3 is C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom.
- 5. 17.beta.-Acetoxy-3.beta.-methoxymethoxy-1.alpha.-methyl-17.alpha.-n-propyl-5.alpha.-androstane, a compound of claim 4.
- 6. A pharmaceutical composition comprising an antiandrogenically topically effective amount of a composition of claim 1 and a pharmaceutically acceptable carrier for topical formulations.
- 7. A method of achieving a topical antiandrogenic effect in a patient suffering from a disease treatable by topical administration of an antiandrogenically active agent, which comprises topically administering to the patient an antiandrogenically effective amount of a compound of the formula ##STR6## wherein R.sub.1 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl,
- R.sub.2 is C.sub.3-6 -alkyl,
- X is oxygen or H(OR.sub.3) wherein R.sub.3 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl.
- 8. A pharmaceutical composition comprising an antiandrogenically topically effective amount of a composition of claim 4 and a pharmaceutically acceptable carrier for topical formulations.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2943776 |
Oct 1979 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 380,328 filed May 20, 1982, now U.S. Pat. No. 4,456,600 which is a divisional of Ser. No. 198,383, filed Oct. 20, 1980 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3391168 |
Counsell et al. |
Jul 1968 |
|
3705180 |
Klimstra |
Dec 1972 |
|
Divisions (2)
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Number |
Date |
Country |
Parent |
380328 |
May 1982 |
|
Parent |
198383 |
Oct 1980 |
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