TREA

Antiatherosclerotic benzopyrans

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Information

  • Patent Grant
  • 4490547
  • Patent Number
    4,490,547
  • Date Filed
    Thursday, October 27, 1983
    40 years ago
  • Date Issued
    Tuesday, December 25, 1984
    39 years ago
Information
Abstract
The present invention provides certain novel benzopyrans which are useful for antiatherosclerotic purposes.
Description

BACKGROUND OF THE INVENTION
The present invention provides novel anti-atherosclerotic benzofurans, the use and preparation of which are described in U.S. Pat. No. 4,438,274 which is incorporated herein by reference.
PRIOR ART
Extensive pharmacological uses for khellin and related substances are known, as indicated in U.S. Pat. No. 4,438,274. Khellin analogs are also known in the art. See, e.g., U.S. Pat. No. 4,284,569 and the review by Mustafa, "Furopyrans and Furopyrones," John Wiley and Sons, Inc., N.Y., N.Y. (1976) pages 102-159 and U.S. Pat. No. 2,680,119 which describes 6 and/or 7-substituted furochromones, i.e., alkyl, alkoxyalkyl, and phenylalkyl substituted compounds.
SUMMARY OF THE INVENTION
The present invention provides:
a benzopyran of formula III
wherein R.sub.14 is
(1) hydrogen;
(2) alkyl of one to 8 carbon atoms, inclusive;
(3) alkoxymethyl of 2 to 8 carbon atoms, inclusive;
(4) alkylthioalkyl of 2 to 8 carbon atoms, inclusive;
(5) trifluoromethyl;
(6) phenoxymethyl;
(7) phenylthiomethyl;
(8) phenoxymethyl or phenylthiomethyl substituted by chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms or alkoxy of one to 8 carbon atoms; or
(9) cycloalkyl of 3 to 10 carbon atoms, inclusive; and wherein one of R.sub.5 and R.sub.6 is methoxy and the other is hydrogen or R.sub.5 and R.sub.6 are both methoxy.





DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention particularly provides 4,9-dimethoxy-7-methyl-7H-furo[3,2g][1]benzopyran.
Claims
  • 1. A benzopyran of formula III ##STR1## wherein R.sub.14 is
  • (1) hydrogen;
  • (2) alkyl of one to 8 carbon atoms, inclusive;
  • (3) alkoxymethyl of 2 to 8 carbon atoms, inclusive;
  • (4) alkylthioalkyl of 2 to 8 carbon atoms, inclusive;
  • (5) trifluoromethyl;
  • (6) phenoxymethyl;
  • (7) phenylthiomethyl;
  • (8) phenoxymethyl or phenylthiomethyl substituted by chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms or alkoxy of one to 8 carbon atoms; or
  • (9) cycloalkyl of 3 to 10 carbon atoms, inclusive; and wherein one of R.sub.5 and R.sub.6 is methoxy and the other is hydrogen or R.sub.5 and R.sub.6 are both methoxy.
  • 2. 4,9-Dimethoxy-7-methyl-7H-furo[3,2-g][1]benzopyran, a compound according to claim 1.
CROSS REFERENCE TO RELATED APPLICATIONS

This application is a divisional of co-pending application 378,700, filed May 17, 1982, now U.S. Pat. No. 4,438,274.

US Referenced Citations (2)
Number Name Date Kind
2680119 Robertson et al. Jun 1954
4284569 Gammill Aug 1981
Non-Patent Literature Citations (29)
Entry
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Divisions (1)
Number Date Country
Parent 378700 May 1982