Claims
- 1. An antibacterial composition of Cefditoren pivoxyl for use in oral administration and having a reduced bitter taste and having an enhanced dispersibility of the composition in water and an enhanced rate of dissolution of Cefditoren pivoxyl component in water, characterised in that the composition comprises a mixture of Cefditoren pivoxyl with a proportion of a pharmaceutically acceptable and water-soluble casein salt.
- 2. The composition as claimed in claim 1, in which the casein salt is sodium caseinate or potassium caseinate.
- 3. The composition as claimed in claim 1, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.1 to 1:4.
- 4. The composition as claimed in claim 3, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.4 to 1:2.
- 5. The composition as claimed in claim 1, which further contains one or more additives chosen from pharmaceutically acceptable excipients and disintegrators.
- 6. The composition as claimed in claim 1, which is prepared in the form of granules, fine granules or tablets.
- 7. An antibacterial composition of Cefditoren pivoxyl for use in oral administration and having a reduced bitter taste and having an enhanced dispersibility of the composition and an enhanced rate of dissolution of the Cefditoren pivoxyl component in water and also capable of maintaining a high rate of disolution of the Cefditoren pivoxyl component into water after storage of the composition at an elevated temperature, characterized in that the composition comprises a mixture of Cefditoren pivoxyl with a proportion of a pharamceutically acceptable and water-soluble casein salt and a proportion of a pharmaceutically acceptable and water-soluble polyphosphoric acid salt.
- 8. The composition as claimed in claim 7, in which the casein salt is sodium caseinate or potassium caseinate and the polyphosphoric acid salt is sodium or potassium polyphosphate.
- 9. The composition as claimed in claim 8, in which the sodium or potassium polyphosphate is a pure sodium or potassium tri-polyphosphate, or a commercially available sodium or potassium polyphosphate.
- 10. The composition as claimed in claim 7, in which the ratio by weight of the casein salt to polyphosphoric acid salt is in a range of 1:0.02 to 1:0.06.
- 11. The composition as claimed in claim 7, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.1 to 1:4.
- 12. The composition as claimed in claim 7, which further contains one or more additives chosen from pharmaceutically acceptable excipients and disintegrators and is prepared in the form of granules, fine granuels or tablets.
- 13. The composition as claimed in claim 7, in which the ratio by weight of the casein salt to polyphosphoric acid salt is in a range of 1:0.02 to 1:0.05.
- 14. A method for reducing the bitter taste of Cefditoren pivoxyl and enhancing the rate of dissolution of Cefditoren pivoxyl into water, as well as the concentration of Cefditoren pivoxyl attainable by its dissolution into water for a predetermined period of time, which method comprises mixing Cefditoren pivoxyl with a proportion of a pharmaceutically acceptable and water-soluble casein salt at a ratio by weight of Cefditoren pivoxyl to the casein salt in a range of 1:0.1 to 1:4 and thereby forming a uniform mixture of Cefditoren pivoxyl with the casein salt.
- 15. The method as claimed in claim 14, in which the casein salt is sodium caseinate or potassium caseinate.
- 16. The method as claimed in claim 14, in which Cefditoren pivoxyl is mixed with the casein salt in a range of 1:0.4 to 1:2.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7-265847 |
Oct 1995 |
JPX |
|
Parent Case Info
This application is a 371 of PCT/JP96/02967, filed Oct. 14, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP96/02967 |
10/14/1996 |
|
|
4/8/1998 |
4/8/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/13516 |
4/17/1997 |
|
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2-225423 |
Sep 1990 |
JPX |