Claims
- 1. A compound, or a salt, prodrug, or a salt of a prodrug thereof, having formula (I)
- 2. A compound of claim 1, or a salt, prodrug, or a salt of a prodrug thereof, having formula (I)
- 3. A compound of claim 1, or a salt, prodrug, or a salt of a prodrug thereof, having formula (I)
- 4. A composition for prophylaxis or treatment of penicillin-resistant streptococcus pneumoniae in a fish or a mammal comprising a therapeutically effective amount of a compound of claim 1 and an excipient.
- 5. A method for prophylaxis or treatment of penicillin-resistant streptococcus pneumoniae in a fish or a mammal comprising administering to the fish of the mammal a therapeutically effective amount of a compound of claim 1.
- 6. A compound, or a therapeutically acceptable salt, prodrug, or salt of a prodrug thereof, which is
(3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((4-phenoxybenzyl)amino)propoxy)propyl)amino)ethyl)oxime); (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((1,1′-biphenyl-4-ylmethyl)amino)propoxy)propyl)amino)ethyl)oxime); (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((3-phenoxybenzyl)amino)propoxy)propyl)amino)ethyl)oxime); (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((3-(4-methylphenoxy)benzyl)amino)propoxy)propyl)amino)ethyl)oxime; (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((3-(benzyloxy)benzyl)amino)propoxy)propyl)amino)ethyl)oxime); (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-(((9-ethyl-9H-carbazol-3-yl)methyl)amino)propoxy)propyl)amino)ethyl)oxime); (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((3-(3-((3-(4-isopropylphenyl)-2-methylpropyl)amino)propoxy)propyl)amino)ethyl)oxime; (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(2-((6-((3-phenoxybenzyl)amino)hexyl)amino)ethyl)oxime); or (3R,5R,6R,7S,9R,10E,11S,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,4,10-trione 10-(O-(13-(4-phenoxyphenyl)-6,9-dioxa-3,12-diazatridec-1-yl)oxime).
Parent Case Info
[0001] This application claims benefit of co-pending U.S. Provisional Application Ser. No. 60/375,652, filed Apr. 26, 2002, the specification of which is hereby incorporated by reference into this application.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60375652 |
Apr 2002 |
US |