Claims
- 1. A pharmaceutical composition for treating bacterial infections in humans and animals which comprises an antibacterially effective amount of a compound of the formula (II): ##STR30## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2 to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substittued by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety, in combination with a pharmaceutically acceptable carrier.
- 2. A composition according to claim 1 wherein R is methylphenyl.
- 3. A composition according to claim 1 wherein R is ##STR31##
- 4. A composition according to claim 1 wherein the double bond in the compound of the formula (II) is in the E configuration.
- 5. A composition according to claim 1 wherein the compound is 1R,S-methoxycarbonyl-1R,S-cyclohexylmethyl monate.
- 6. A method of treating bacterial infections in humans and animals which comprises administering to a human or animal in need of said treatment an antibacterially effective amount of a compound of the formula (II). ##STR32## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety.
- 7. A method according to claim 6 wherein R is methylphenyl.
- 8. A method according to claim 6 wherein R is ##STR33##
- 9. A method according to claim 6 wherein the double bond in the compound of the formula (II) is in the E configuration.
- 10. A method according to claim 6 wherein the compound 1R,S-methoxycarbonyl-1R,S-cyclohexylmethyl monate is administered.
Priority Claims (3)
Number |
Date |
Country |
Kind |
24712/76 |
Jun 1976 |
GBX |
|
40472/76 |
Sep 1976 |
GBX |
|
8647/77 |
Mar 1977 |
GBX |
|
CROSS-REFERENCE
This is a division of Ser. No. 931,385 filed Aug. 7, 1978, now U.S. Pat. No. 4,237,161 issued Dec. 2, 1980, which is a divisional of U.S. Ser. No. 873,394, filed Jan. 30, 1978, now U.S. Pat. No. 4,166,863 issued Sept. 4, 1979, which is a divisional of U.S. Ser. No. 803,466, filed June 6, 1977, now U.S. Pat. No. 4,102,901 issued July 25, 1978.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1395907 |
May 1975 |
GBX |
Divisions (3)
|
Number |
Date |
Country |
Parent |
931385 |
Aug 1978 |
|
Parent |
873394 |
Jan 1978 |
|
Parent |
803466 |
Jun 1977 |
|