Claims
- 1. A pharmaceutical composition for treating bacterial infections in humans and animals which comprises an antibacterially effective amount of a compound of the formula (II): ##STR34## wherein R is cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms; or aryl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms in the alkoxy moiety and alkoxycarbonylalkyl of 1 to 6 carbon atoms, in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety, in combination with a pharmaceutically acceptable carrier.
- 2. A composition according to claim 1 wherein R is cycloalkyl unsubstituted or substituted by alkyl of 1 to 6 carbon atoms.
- 3. A composition according to claim 1 wherein R is phenyl or naphthyl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms in the alkoxy moiety and alkoxycarbonylalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in alkyl moiety.
- 4. A composition according to claim 1 wherein R is phenyl, benzyl, methoxycarbonylphenyl ##STR35##
- 5. A composition according to claim 1 wherein the double bond in the compound of the formula (II) is in the E configuration.
- 6. A composition according to claim 1 wherein the compound is benzyl monate.
- 7. A composition according to claim 1 wherein the compound is phenyl monate.
- 8. A composition according to claim 1 wherein the compound is p-methoxycarbonylphenyl monate.
- 9. A composition according to claim 1 wherein the compound is .alpha.-R,S-methoxycarbonylbenzyl monate.
- 10. A method of treating bacterial infections in humans and animals which comprises administering to a human or animal in need of said treatment an antibacterially effective amount of a compound of the formula (II): ##STR36## wherein R is cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms; or aryl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms in the alkoxy moiety and alkoxycarbonylalkyl of 1 to 6 carbon atoms, in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety.
- 11. A method according to claim 10 wherein R is cycloalkyl unsubstituted or substituted by alkyl of 1 to 6 carbon atoms.
- 12. A method according to claim 10 wherein R is phenyl or naphthyl unsubstituted or substitured by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms in the alkoxy moiety and alkoxycarbonylalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in alkyl moiety.
- 13. A method according to claim 10 wherein R is phenyl, benzyl, methoxycarbonylphenyl ##STR37##
- 14. A method according to claim 10 wherein the double bond in the compound of the formula (II) is in the E configuration.
- 15. A method according to claim 10 wherein benzyl monate is administered.
- 16. A method according to claim 10 wherein phenyl monate is administered.
- 17. A method according to claim 10 wherein p-methoxycarbonylphenyl monate is administered.
- 18. A method according to claim 10 wherein .alpha.-R,S-methoxycarbonylbenzyl monate is administered.
Priority Claims (3)
Number |
Date |
Country |
Kind |
24712/76 |
Jun 1976 |
GBX |
|
40472/76 |
Sep 1976 |
GBX |
|
8647/77 |
Mar 1977 |
GBX |
|
Parent Case Info
This is a division of Ser. No. 931,385 filed Aug. 7, 1978, now U.S. Pat. No. 4,237,161 issued Dec. 2, 1980, which is a divisional of U.S. Ser. No. 873,394 filed Jan. 30, 1978, now U.S. Pat. No. B 4,166,863 issued Sept. 4, 1979, which is a divisional of U.S. Ser. No. 803,466 filed June 6, 1977, now U.S. Pat. No. 4,102,901, issued July 25, 1978.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1395907 |
May 1975 |
GBX |
Divisions (3)
|
Number |
Date |
Country |
Parent |
931385 |
Aug 1978 |
|
Parent |
873394 |
Jan 1978 |
|
Parent |
803466 |
Jun 1977 |
|