Claims
- 1. A penem derivative of the formula I ##STR77## in which R is hydrogen or a carboxyl esterifying group
- R.sup.1 is phenyl or naphthyl, each which is unsubstituted or substituted by one, two or three substituents, which may be the same or different, selected from the group consisting of halogen, cycloalkyl having from 5 to 10 carbon atoms --NH.sub.2, --CONH.sub.2, --NO.sub.2, --CN, --R.sup.2, --OR.sup.2, --SR.sup.2, --SO--R.sup.2, --SO.sub.2 R.sup.2, --CO--R.sup.2, --CO--O--R.sup.2, --CH.sub.2 --CO--O--R.sup.2, --NHR.sup.2, --NR.sup.2 R.sup.2', --CO--NH--R.sup.2, --CO--NR.sup.2 R.sup.2', --NH--CO--R.sup.2, --NH--CO--NH.sub.2, --NH--CO--NH--R.sup.2, --NH--SO.sub.2 --R.sup.2, --CF.sub.3, --CO--OH, --CH.sub.2 --CO--OH, wherein R.sup.2 and R.sup.2' are the same or different and each represents alkyl of 1 to 4 carbon atoms
- or a physiologically acceptable salt thereof.
- 2. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which unsubstituted or substituted by --SO--R.sup.2 or --SO.sub.2 --R.sup.2.
- 3. A compound as claimed in claim 2 wherein R.sup.2 is methyl.
- 4. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which is substituted by fluorine.
- 5. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which is substituted by chlorine.
- 6. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which is substituted by cyano.
- 7. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which is substituted by acetyl.
- 8. A compound as claimed in claim 1 wherein R.sup.1 is phenyl which is substituted by methoxycarbonyl.
- 9. An antibacterial pharmaceutical preparation which comprises an effective amount of a compound as claimed in claim 1 together with a pharmaceutically suitable carrier.
- 10. A method for combating bacterial infection in a host which comprises orally or parenterally administering to said host a compound as claimed in claim 1.
- 11. A compound as claimed in claim 1 wherein R is hydrogen or a carboxyl esterifying group removable by hydrolysis, by photolysis, by reduction or by enzyme action to give the free acid.
- 12. The compound as claimed in claim 1, wherein R.sup.1 is phenyl, or phenyl substituted by fluorine, chlorine, --SOCH.sub.3 is --SO.sub.2 CH.sub.3.
- 13. The compound as claimed in claim 1, wherein R.sup.1 is phenyl which is unsubstituted or substituted by --SO--R.sup.2, SO.sub.2 --R.sup.2, fluorine or chlorine.
- 14. The compound as claimed in claim 1, wherein R.sup.1 is an unsubstituted or substituted naphthyl.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8121107 |
Jul 1981 |
GBX |
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Parent Case Info
This application is a continuation of application Ser. No. 395,641, filed July 6, 1982, now abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4272437 |
Menard et al. |
Jun 1981 |
|
4290948 |
Brain et al. |
Sep 1981 |
|
4331676 |
Gosteli et al. |
May 1982 |
|
4347183 |
Afonso et al. |
Aug 1982 |
|
4585767 |
Cooke et al. |
Apr 1986 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0002210 |
Jun 1979 |
EPX |
2042515 |
Sep 1980 |
GBX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
395641 |
Jul 1982 |
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