Patent Application
20140287012
The present invention relates to an antibacterially-acting moulded article which is formed from a moulding compound which comprises at least one sort of a particular antibacterial material. The invention is distinguished by the moulded article having an essentially cylindrical, cuboid, spherical or ellipsoid basic body, the basic body having special dimensions which depend upon the average particle diameter of the particular antibacterial material which is used.
An antibacterial glass composition is known from EP 1 496 086 A1, which comprises an antibacterial glass and an inorganic filler which is dispersed in the antibacterial glass composition. This glass composition can be present for example as pellets or as a paste, likewise it is possible to provide the composition in the form of a film, a moulded article or a coating composition. For example, textiles or sheets can be produced herefrom.
However, it is problematic with such moulded articles that the antibacterial effect requires a relatively high content of the antibacterial glass since the antibacterial effect can be attributed to the fact that the antibacterial glass particles must be disposed on the surface of the composition in order to develop their antibacterial effect by contact with the respective bacteria.
Starting from this problem, it is the object of the present invention to indicate an antibacterially-acting moulded article which has an increased antibacterial effect due to the choice of its shape in the case of the same loading with an antibacterially-acting material.
This object is achieved by the moulded article having the features of patent claim 1. Patent claim 13 indicates a method for sterilisation of formulations by means of the moulded article according to the invention. Patent claim 14 describes a storage vessel which comprises a moulded article according to the invention. Finally, purposes of use of the storage vessel are described by patent claim 15. The respective dependent patent claims thereby represent advantageous developments.
According to the invention, an antibacterially-acting moulded article is hence indicated, which moulded article comprises a moulding compound or is formed from this and comprises at least one sort of a particular antibacterial material with an average particle diameter which is present dispersed in at least one synthetic resin, the basis of the moulded article being
The principle which underlies the present invention is hence that the maximum diameter of the basic body whether it is the maximum diameter of the base of a cylindrical, cuboid or conical basic body or the maximum diameter of an ellipsoid or spherical basic body—is determined in relation to the average particle diameter of the particular antibacterial material.
A cylindrical basic body, given by way of example, is thereby represented in
This cylinder with the circular base represents however only one possible embodiment of a cylindrical basic body. Likewise, the possibility can be given that the base of the cylindrical basic body is elliptical, n-angular, with 3≦n≦10, or is irregular. There are included herein for example also star-shaped bases.
A further basic shape, given by way of example, of the basic body underlying the moulded article is represented in
Likewise, the principle of the present invention is applicable to conical basic bodies. The base of the cone hereby also fulfils the conditions mentioned in claim 1. The base of the cone can thereby be formed to be circular, ellipsoid but also star-shaped or irregular. The cone can be straight or skewed. Likewise, it is possible that the basic body is configured as a truncated cone.
The principle of the present invention is hence based on the fact that a specific diameter of a basic body has a smaller dimension than 100 times the average particle diameter of the particular antibacterial material which is embedded in the moulding compound of which the basic body consists. This has the effect that merely a small part of the particular antibacterial material is surrounded completely by the moulding compound and a relatively large proportion of this material is disposed in the moulded article such that at least a part of the surface of the particular antibacterial material protrudes from the moulded article, i.e. is disposed on the surface of the moulded article. These particles made of antibacterial material are hence not surrounded completely by the moulding compound which forms the antibacterially-acting moulded article so that, relative to the total proportion of the particular antibacterial material, a relatively large proportion is disposed on the surface of the moulded article and hence can develop an antibacterial effect. A result of this relatively high proportion of the antibacterial material disposed on the surface of the basic body, the moulded article, compared with other moulding compounds in which a higher proportion of the antibacterial material is surrounded completely by the moulding compound, can develop a relatively high antibacterial effect.
As described above, the moulded article is essentially cylindrical or cuboid, essentially ellipsoid or spherical or conical. The feature should hereby be understood essentially such that certain deviations from the ideal geometric principle are permissible. For example, certain “indentations” or “bulges” can be present on the surface of the respective basic body, or certain rounded portions on the edges of the cylinder, which is represented for example in
Likewise, the expression “basic body” expresses that it need not hereby be a rigid or geometrically fixed basic body which meets the ideal geometric underlying principles, such as for example a cylinder, cuboid, sphere, ellipsoid or cone, which is hereby of concern.
In
If the basic body is present as cylinder or as cuboid, at best a comparison with a wire-shaped basic body can be made. In the case where the cylinder or cuboid has a linear course, a straight wire is present which can however likewise be present in a bent shape.
A preferred embodiment of the present invention provides that, starting with a cylindrical or cuboid basic body, the latter is coiled to form a spiral or is present in the shape of a randomly orientated ball. This embodiment has the effect that a more compact configuration of the moulded article according to the invention is present so that the antibacterial effect can be concentrated on the smallest spatial volumes.
A particularly preferred embodiment provides that the maximum diameter of the base of the cylindrical or cuboid basic body or the maximum diameter of the ellipsoid or spherical basic body is from 0.5 to 80 times, preferably from 1 to 60 times, particularly preferred from 2 to 30 times, the average particle diameter of the particular antibacterial material.
For the respective basic bodies, the following preferred absolute dimensionings are produced:
The length or height of the cylindrical or cuboid moulded article is preferably from 1 mm to 100 cm, further preferred from 5 mm to 80 cm, particularly preferred from 10 mm to 60 cm andor the maximum diameter of the base of the cylindrical or cuboid basic body or the maximum diameter of the ellipsoid or spherical basic body is less than 5 mm, preferably from 0.01 to 0.9 mm.
In a further preferred embodiment, the at least one sort of particular antibacterial material is a particular antibacterial glass, in particular a particular antibacterial glass selected from the group consisting of element glass, oxide glass, silicate glass, silica glass, alkalisilicate glass, soda-lime glass, lead (alkali) glass, barium glass, borosilicate glass, phosphate glass, borate glass, fluoride glass, chloride glass, sulphide glass, carbonate glass, nitrate glass, sulphate glass, water-soluble glass, crystallised glass and also mixtures hereof
Preferably, the surface of the particles of the at least one sort of particular antibacterial material is coated at least partially or entirely with an antibacterially-acting metal, in particular a metal selected from the group consisting of silver, copper, zinc andor mixtures or combinations hereof, andor comprises ions andor colloids of the previously mentioned metals.
Furthermore, it is advantageous if the average particle diameter of the particles of the particular antibacterial material is 0.05 to 50 μm, preferably 0.1 to 25 μm, particularly preferred 2 to 10 μm.
Preferred contents of the metal andor of the metal ions are thereby, relative to the total mass of particular antibacterial material, of 0.01% by weight or more, preferably from 0.01 to 50% by weight.
In addition, the moulding compound can comprise at least one particular inorganic filler which is selected preferably from the group consisting of barium andor barium salts, silver or silver salts, silica, zeolites, kaolin, talcum, zinc oxide and also mixtures hereof
These particular inorganic fillers which are possibly contained in addition thereby have preferably average particle diameters of 0.1 to 10 μm.
Preferred synthetic resins which can form the basis of the moulded article according to the invention are thereby selected from the group consisting of
Preferred contents of the at least one sort of particular antibacterial material are thereby, relative to the moulding compound, at least 0.01% by weight, preferably 0.01% by weight to 50% by weight and particularly preferred 0.1% by weight to 15% by weight.
Furthermore, it is possible, in the case where particular inorganic fillers are incorporated in addition, that these can comprise a content of 3 to 50% by weight, relative to the at least one sort of particular antibacterial material.
According to the invention, a method is likewise indicated for sterilisation of formulations selected from the group consisting of liquids, solutions, dispersions, suspensions, gels, organogels, microemulsion gels, pastes andor creams, in particular for pharmaceutical, cosmetic andor foodstuff applications, in which at least one moulded article according to the invention is brought in contact with the previously mentioned formulations.
In addition, the present invention relates to a storage vessel, in which at least one moulded article according to the invention is disposed in the interior of the storage vessel. The storage vessel is thereby suitable in particular for sterile storage of liquids, solutions, dispersions, suspensions, gels, organogels, microemulsion gels, pastes andor creams, in particular for pharmaceutical, cosmetic andor foodstuff applications, or can be used for this purpose. The previously mentioned components, i.e. liquids, solutions, dispersions, suspensions, gels, organogels, microemulsion gels, pastes andor creams, can be sterilised for example before introduction into the storage vessel and storage of these components by means of a method known from the state of the art. The moulded article then serves for maintaining sterility during storage.
However it is likewise possible and conceivable that the previously mentioned components are introduced unsterilised into the storage vessel, sterilisation being effected upon first contact with the antibacterially-acting moulded article according to the invention. In the case of both variants, maintaining sterility is ensured during the entire period of storage.
The present invention is described in more detail with reference to the subsequent Figures without restricting the invention to the special embodiments represented there.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10 2011 106 303.3 | May 2011 | DE | national |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/EP2012/058803 | 5/11/2012 | WO | 00 | 4/17/2014 |
