Claims
- 1. A method for treating or preventing convulsions in mammals in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula ##STR4## wherein R.sub.1 is hydroxy, C.sub.1 -C.sub.4 alkoxy, -S(O).sub.p -(C.sub.1 -C.sub.4 alkyl), trifluoromethyl, C.sub.1 -C.sub.4 alkyl, aminomethyl, aminocarboxy, 1-imidazolyl, or -NR.sub.3 R.sub.4, where R.sub.3 and R.sub.4 are independently C.sub.1 -C.sub.3 alkyl, P is 0, 1, or 2, and
- R.sub.2 is methyl, methoxy, trifluoromethyl, hydroxymethyl, or chloro, or a pharmaceutically acceptable acid addition salt thereof.
- 2. The method of claim 1 employing a compound wherein R.sub.2 is methyl.
- 3. The method of claim 2 employing a compound wherein, R.sub.1 is -NR.sub.3 R.sub.4.
- 4. The method of claim 3 employing the compound 4-(dimethylamino)-N-(2,6-dimethylphenyl)benzamide or a pharmaceutically acceptable acid addition salt thereof.
- 5. The method of claim 3 employing the compound N-(2,6-dimethylphenyl)-4-(ethylamino)benzamide or a pharmaceutically acceptable acid addition salt thereof.
- 6. The method of claim 3 employing the compound N-(2,6-dimethylphenyl)-4-(methylamino)benzamide or a pharmaceutically acceptable acid addition salt thereof.
Parent Case Info
This application is a division of application Ser. No. 07/335,393, filed Apr. 10, 1989, now U.S. Pat. No. 4,939,163 which is a division of application Ser. No. 07/016,047, filed Feb. 18, 1987, now U.S. Pat. No. 4,835,181.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1198019 |
Jul 1970 |
GBX |
Non-Patent Literature Citations (6)
Entry |
Hodd et al., British Polymer Journal, 15, 201 (1983). |
Stout et al., J. Med. Chem., 28, 295 (1985). |
Rodriguez-Salazar, J. Pharm. Sci., 63, 158 (1974). |
Goerdeler et al., Chem. Ber., 110, 2996 (1977). |
Grammaticakis, Bull. Soc. Chim. France, 924 (1964), (CA 61:5488a). |
Grammaticakis, Bull. Soc. Chem. France, 862 (1963), (CA 59:5945f). |
Divisions (2)
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Number |
Date |
Country |
Parent |
335393 |
Apr 1989 |
|
Parent |
16047 |
Feb 1987 |
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