Claims
- 1. A compound represented by the formula I: ##STR7## wherein R.sub.1 and R.sub.2 are the same or different and are selected from any of hydrogen, alkyl (C.sub.1 to C.sub.6), cycloalkyl (C.sub.3 -C.sub.7), allyl, or benzyl;
- R.sub.3 and R.sub.4 are the same or different and selected from hydrogen or lower alkyl;
- X may be chosen from carbon (C) or sulfur (S), with the stipulation that when X is carbon R.sub.5 and R.sub.6 are the same or different and are selected from hydrogen or lower alkyl, whereas when X is sulfur one of R.sub.5 and R.sub.6 is oxygen and the other is a lone pair of electrons or both are oxygen; or
- the pharmaceutically acceptable salt, hydrate, anomer, diastereomer, or enanantiomer thereof.
- 2. The compound of claim 1, wherein R.sub.1 and R.sub.2 are each hydrogen.
- 3. The compound of claim 1, wherein X is carbon.
- 4. The compound of claim 1, wherein X is sulfur.
- 5. The compound of claim 4, wherein R.sub.5 and R.sub.6 are each oxygen.
- 6. The compound of claim 4, wherein R.sub.5 and R.sub.6 are a lone pair of electrons and oxygen.
- 7. The compound of claim 1, selected from any of
- (1R,2R,3S,4S)-(1,2:3,4-di-O-methylethylidenecyclohexan- 1,2,3,4-tetraol-4-yl)methyl sulfamate, i.e., where R.sub.1 and R.sub.2 are hydrogen, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are methyl and X is carbon in formula I.
- (1R,2S,3S,4S)-(3,4-O-methylethylidene-1,2-O-sulfinylcyclohexan 1,2,3,4-tetraol-4-yl)methyl sulfamate, i.e., where R.sub.1 and R.sub.2 are hydrogen, R.sub.3 and R.sub.4 are methyl, R.sub.5 is oxygen and R.sub.6 is an electron pair and X is sulfur in formula I.
- 8. A pharmaceutical composition for treating convulsions comprising the compound of claim 1, in combination with a pharmaceutically acceptable carrier, said compound being present in a therapeutically effective amount for treating convulsions.
- 9. A method of treating an animal suffering from convulsions comprising treating that animal with the compound of claim 1 in an amount sufficient to treat the convulsions.
Parent Case Info
This application is a Continuation of U.S. Ser. No. 08/173,39 which is filed Dec. 23, 1993, now abandoned.
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Number |
Name |
Date |
Kind |
4075351 |
Hirsch |
Feb 1978 |
|
4513006 |
Maryanoff et al. |
Apr 1985 |
|
4792569 |
Maryanoff et al. |
Dec 1988 |
|
Non-Patent Literature Citations (1)
Entry |
McComsey et al., J. Org. Chem. (1994) 59(9), 2652-4. |
Continuations (1)
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Number |
Date |
Country |
Parent |
173399 |
Dec 1993 |
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