Claims
- 1. A compound of Formula I:
- 2. A compound according to claim 1, wherein R1 and R2 are, independently, hydrogen, halo, cyano, carboxamido, trifluoromethyl, amino, alkyl of one to six carbon atoms or alkoxy of one to six carbon atoms.
- 3. A compound according to claim 1, wherein R1 is alkoxy of one to six carbon atoms and is attached to position 8 of the benzodioxan moiety.
- 4. A compound according to claim 1, wherein R2 is hydrogen.
- 5. A compound according to claim 1, wherein R4, R5, R6 and R7 are independently hydrogen, halo, cyano, alkyl of one to six carbon atoms, or alkoxy of one to six carbon atoms.
- 6. A compound according to claim 1, wherein R4, R5, R6 and R7 are independently hydrogen, halo or cyano.
- 7. A compound according to claim 1, wherein m and n are, independently 1 or 2.
- 8. A compound according to claim 1, wherein m is 1 and n is 2.
- 9. A compound according to claim 1, wherein p is 0 or 1.
- 10. A compound according to claim 1, wherein p is 0.
- 11. A compound according to claim 1, wherein X is NR8 and R8 hydrogen or alkyl of 1 to 3 carbons.
- 12. A compound according to claim 1, wherein R3 is hydrogen or alkyl of 1 to 3 carbons.
- 13. A compound according to claim 1, wherein said compound is N-[(cis)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 14. A compound according to claim 1, wherein said compound is N-[(1R,3S)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 15. A compound according to claim 1, wherein said compound is N-[(1S,3R)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 16. A compound according to claim 1, wherein said compound is N-[(trans)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof
- 17. A compound according to claim 1, wherein said compound is N-[(1S,3S)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 18. A compound according to claim 1, wherein said compound is N-[(1R,3R)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 19. A compound according to claim 1, wherein said compound is N-[(cis)-3-(5-fluoro-1-methyl-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 20. A compound according to claim 1, wherein said compound is N-[(trans)-3-(5-fluoro-1-methyl-1H-indol-3-yl)cyclopentyl]-N-{[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amine or a pharmaceutically acceptable salt thereof.
- 21. A compound according to claim 1, wherein said compound is 3-[(cis)-3-({[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amino)cyclopentyl]-1H-indole-5-carbonitrile or a pharmaceutically acceptable salt thereof.
- 22. A compound according to claim 1, wherein said compound is 3-[(trans)-3-({[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amino)cyclopentyl]-1H-indole-5-carbonitrile or a pharmaceutically acceptable salt thereof.
- 23. A compound according to claim 1, wherein said compound is 3-[(cis)-3-({[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amino)cyclopentyl]-1-methyl-1H-indole-5-carbonitrile or a pharmaceutically acceptable salt thereof.
- 24. A compound according to claim 1, wherein said compound is 3-[(trans)-3-({[(2S)-8-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}amino)cyclopentyl]-1-methyl-1H-indole-5-carbonitrile or a pharmaceutically acceptable salt thereof.
- 25. A compound according to claim 1, wherein said compound is N-{[(2S)-8-ethoxy-2,3-dihydro-1,4-benzo-dioxin-2-yl]methyl}-N-[(cis)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]amine or a pharmaceutically acceptable salt thereof.
- 26. A compound according to claim 1, wherein said compound is N-{[(2S)-8-ethoxy-2,3-dihydro-1,4-benzo-dioxin-2-yl]methyl}-N-[(trans)-3-(5-fluoro-1H-indol-3-yl)cyclopentyl]amine or a pharmaceutically acceptable salt thereof.
- 27. A method of treating a subject suffering from a condition selected from depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating, vasomotor flushing, cocaine and alcohol addiction, and sexual dysfunction, comprising the step of:
administering to said subject suffering from said condition, a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.
- 28. A method according to claim 27, wherein the condition is depression.
- 29. A method according to claim 27, wherein the condition is selected from the group consisting of obsessive-compulsive disorder, panic attacks, generalized anxiety disorder, and social anxiety disorder.
- 30. A method of treating a subject suffering from a condition selected from depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders, vasomotor flushing, cocaine and alcohol addiction, and sexual dysfunction, comprising the step of:
administering to said subject suffering from said condition, a therapeutically effective amount of a compound according to claim 13.
- 31. A pharmaceutical composition, comprising:
an effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or excipient.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Application Serial No. 60/410,169, filed Sep. 12, 2002, the disclosure of which is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60410169 |
Sep 2002 |
US |