Claims
- 1. A compound represented by the following general structural formula (II.sup.') ##STR31## wherein: n is 0 to 1;
- R.sup.1 is C.sub.1-3 alkyl;
- R.sup.2 is hydrogen or C.sub.1-3 alkyl;
- R.sup.3 is hydrogen or C.sub.1-3 alkyl;
- R.sup.4 is hydrogen or C.sub.1-3 alkyl;
- R.sup.6 is hydrogen or C.sub.1-3 alkyl; ##STR32## and a, b, c and d represent single bonds, one of a, b, c or d represent a double bond, or both a and c or both b and d represent double bonds;
- Z is hydrogen, C.sub.1-5 alkyl, or C.sub.1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino or acetylamino; or a pharmaceutically acceptable salt of a compound of the formula (II.sup.40) in which Z is hydrogen.
- 2. A compound according to Claim 1 wherein R.sup.3 and R.sup.4 are C.sub.1-3 alkyl; and a, b, c and d represent single bonds or both b and d represent double bonds.
- 3. A compound according to claim 1 wherein
- R.sup.1 is methyl;
- R.sup.2 is methyl; and
- R.sup.3 and R.sup.4 are hydrogen.
- 4. A hypocholesterolemic, hypolipidemic pharmaceutical composition comprising a nontoxic therapeutically effective amount of a compound of claim 3 and a pharmaceutically acceptable carrier.
- 5. A composition according to claim 4 wherein R.sup.3 and R.sup.4 are C.sub.1-3 alkyl; and a, b, c and d represent single bonds or both b and d represent double bonds.
- 6. A composition according to claim 4 wherein
- R.sup.1 is methyl;
- R.sup.2 is methyl;
- R.sup.3 and R.sup.4 are hydrogen.
- 7. A method of inhibiting cholesterol biosynthesis comprising the administration to a subject in need of such treatment a nontoxic therapeutically effective amount of a compound of claim 1.
- 8. A method according to Claim 7 wherein R.sup.3 and R.sup.4 are C.sub.1-3 alkyl; and a, b, c and d represent single bonds or both b and d represent double bonds.
- 9. A method according to claim 7 wherein
- R.sup.1 is methyl;
- R.sup.2 is methyl;
- R.sup.3 and R.sup.4 are hydrogen.
- 10. A compound of Claim 3 which is 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-(2,2-dimethyl-3-methoxy-3-oxopropionyloxy-1(S)-naphthyl]-3(R),5(R)-dihydryoxyheptanoic acid.
- 11. A compound of Claim 3 which is 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-(2,2-dimethyl-3-methoxycarbonylpropionyloxy)-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid.
- 12. A composition according to claim 6 in which the therapeutically-active ingredient is selected from;
- 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-(2,2-dimethyl-3-methoxy-3-oxopropionyloxy)-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, or
- 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-.8(S)-(2,2-dimethyl-3-methoxycarbonylpropionyl-oxy)-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanioc acid.
- 13. A method according to claim 7 in which the therapeutically-active ingredient is selected from:
- 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-(2,2-dimethyl-3-methoxy-3-oxopropionyloxy)-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, or
- 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-.8(S)-(2,2-dimethyl-3-methoxycarbonylpropionyl-oxy)-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid.
Parent Case Info
This is a division of application Ser. No. 859,535 filed May 5, 1986; now U.S. Pat. No. 4,771,071.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4444784 |
Hoffman et al. |
Apr 1984 |
|
4668699 |
Hoffman et al. |
May 1987 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
859535 |
May 1986 |
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