Claims
- 1. A compound of formula (I) ##STR25## wherein R.sup.1 is trifluoromethoxy or .beta.,.beta.,.beta.-trifluoroethoxy; R.sup.2 and R.sup.3 are joined together to form ##STR26## wherein R.sup.4 is selected from the group consisting of hydrogen, alkoxy containing 1 to 5 carbon atoms, amino or mono- or disubstituted alkyl amino wherein said alkyl groups contain 1 to 5 carbon atoms and the pharmaceutically acceptable salts and solvates thereof.
- 2. The compound designated 2-[2,2-dimethyl-6-(trifluoromethoxy)-2H-1-benzopyran-4-yl]-2,3-dihydro-1H-isoindol-1-one or the pharmaceutically acceptable salts thereof.
- 3. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier for use in the treatment of hypertension.
- 4. A method of treatment of hypertension in mammals which comprises administering to the mammal in need thereof an effective antihypertensive amount of a compound of claim 1.
Parent Case Info
This is a divisional application of copending application U.S. Ser. No. 07/773,186, filed Oct. 8, 1991, issued as U.S. Pat. No. 5,171,857 on Dec. 15, 1992 which in turn is a continuation-in-part application of copending application U.S. Ser. No. 07/753,256, filed Aug. 30, 1991, now abandoned, which in turn is a continuation application of copending application U.S. Ser. No. 07/502,084, filed Mar. 29, 1990, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4616021 |
Ashwood et al. |
Oct 1986 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0158923 |
Jul 1990 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
773186 |
Oct 1991 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
502084 |
Mar 1990 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
753256 |
Aug 1991 |
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