Claims
- 1. An N-piperazinylalkanoylanilide having the formula I or a pharmaceutically acceptable non-toxic salt thereof: ##STR5## wherein n is 0, 1 or 2; R represents a hydrogen atom or an alkyl group; R.sub.1 represents a hydrogen atom; one of R.sub.2 and R.sub.3 represents a hydrogen atom and the other of R.sub.2 and R.sub.3 represents a hydroxyalkyl, alkylthio, alkylsulphonyl, alkylsulphonyl, alkanoyl, carbamoyl or guanidinosulphonyl group; or a group of the formula SO.sub.2 NR.sub.5 R.sub.6 in which each of R.sub.5 and R.sub.6 independently represents a hydrogen atom or an alkyl, phenyl or alkanoyl group; or one of R.sub.2 and R.sub.3 represents a halogen atom and the other of R.sub.2 and R.sub.3 represents a sulphamoyl group; and R.sub.4 is a hydrogen atom; said alkyl group having from 1 to 4 carbon atoms.
- 2. The N-piperazinylalkanoylanilide according to claim 1 wherein n is 1, each of R and R.sub.2 represents a hydrogen atom, and R.sub.3 represents a carbamoyl, acetyl, methylthio, 1-hydroxyethyl, acetylsulphamoyl, methylsulphamoyl, phenylsulphamoyl, guanidinosulphonyl or dimethylsulphamoyl group.
- 3. 4-Methylsulphonyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 4. 4-Sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 5. 4-Sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]butyrylanilide.
- 6. 4-Acetylsulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionyl anilide.
- 7. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 3-sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 8. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-(dimethylsulphamoyl)-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 9. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-methylthio-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 10. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-methylsulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl-propionylanilide.
- 11. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-chloro-3-sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 12. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-sulphamoyl-3-chloro-.beta.-[4-(2-methoxyphenyl-1-piperazinyl]-propionylanilide.
- 13. The N-piperazinylalkanoylanilide according to claim 1 wherein said N-piperazinylalkanoylanilide is 4-methylsulphonyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide.
- 14. A pharmaceutical composition comprising an antihypertensively effective amount of the N-piperazinylalkanoylanilide according to claim 1 or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.
- 15. A method of promoting an antihypertensive effect in a warm-blooded animal in need thereof comprising administering thereto an antihypertensively effective amount of the N-piperazinylalkanoylanilide according to claim 1.
- 16. The method according to claim 15 wherein said N-piperazinylalkanoylanilide is 4-methylsulphonyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]butyrylanilide, 4-acetylsulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 3-sulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-(dimethylsulphamoyl)-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-methylthio-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-methylsulphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide, 4-chloro-3-sylphamoyl-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide 4-sulphamoyl-3-chloro-.beta.-[4-(2-methoxyphenyl)-1-piperazinyl]-propionylanilide or 4-methylsulphonyl-.beta.-[4-(2-methoxyphenyl)-l-piperazinyl]-propionylanilide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8303946 |
Feb 1983 |
GBX |
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Parent Case Info
This application is a continuation of application Ser. No. 578,374, filed Feb. 8, 1984, now abandoned.
Foreign Referenced Citations (3)
Number |
Date |
Country |
120558 |
Mar 1984 |
EPX |
912788 |
Dec 1962 |
GBX |
1166595 |
Oct 1969 |
GBX |
Continuations (1)
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Number |
Date |
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Parent |
578374 |
Feb 1984 |
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