Claims
- 1. A compound of the formula ##STR36## wherein R is hydroxy, NH.sub.2 or lower alkoxy; R.sub.1 and R.sub.4 each is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl;
- R.sub.2 is hydrogen, lower alkyl, phenyl, substituted phenyl wherein the phenyl substituent is halo, lower alkyl or lower alkoxy, phenyl-lower alkyl, diphenyl-lower alkyl, triphenyl-lower alkyl, lower alkylthiomethyl, phenyl-lower alkylthiomethyl, lower alkanoylamidomethyl, ##STR37## R.sub.6 --S-- or R.sub.7 ; R.sub.3 is hydrogen, hydroxy or lower alkyl;
- R.sub.5 is lower alkyl, phenyl or phenyl-lower alkyl;
- R.sub.6 is lower alkyl, phenyl, substituted phenyl, wherein the phenyl substituent is halo, lower alkyl or lower alkoxy, hydroxy-lower alkyl or amino(carboxy)lower alkyl;
- R.sub.7 is ##STR38## M is O or S; m is 3;
- n and p each is 0, 1 or 2; and basic salts thereof, said lower alkoxy, lower alkyl and lower alkanoyl groups having up to seven carbon atoms.
- 2. A compound as in claim 1 wherein R is hydroxy or lower alkoxy; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen, R.sub.5 --CO, R.sub.6 --S--, or R.sub.7 ; R.sub.3 and R.sub.4 each is hydrogen; R.sub.5 is lower alkyl or phenyl; R.sub.6 is lower alkyl; R.sub.7 is ##STR39## wherein R, R.sub.1 and R.sub.4 have the same meaning as above; n is 0, 1 or 2; and p is 0.
- 3. A compound as in claim 1 wherein R.sub.3 and R.sub.4 each is hydrogen.
- 4. A compound as in claim 1 wherein R.sub.3 is hydrogen.
- 5. A compound of the formula ##STR40## wherein R is hydroxy or lower alkoxy; R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 is hydrogen or lower alkanoyl;
- n is 0, 1 or 2; and physiologically acceptable salts thereof, said lower alkoxy, lower alkyl and lower alkanoyl groups having up to seven carbon atoms.
- 6. A compound as in claim 5 wherein R is hydroxy.
- 7. A compound as in claim 5 wherein n is 1.
- 8. A compound as in claim 5 wherein R.sub.2 is hydrogen or lower alkanoyl.
- 9. A compound as in claim 5 wherein R.sub.2 is hydrogen.
- 10. A compound as in claim 5 wherein R.sub.2 is acetyl.
- 11. A compound as in claim 5 wherein R.sub.1 is hydrogen or lower alkyl.
- 12. A compound as in claim 5 wherein R.sub.1 is hydrogen or methyl.
- 13. A compound as in claim 5 wherein R is hydroxy and R.sub.1 is hydrogen or methyl.
- 14. A compound as in claim 5 wherein R is hydroxy, R.sub.1 is hydrogen or methyl, R.sub.2 is hydrogen or acetyl and n is 0, 1 or 2.
- 15. A compound as in claim 5 wherein R is hydroxy, R.sub.1 and R.sub.2 each is hydrogen and n is 0.
- 16. A compound as in claim 5 wherein R is hydroxy, R.sub.1 is hydrogen, R.sub.2 is acetyl and n is 1.
- 17. A compound as in claim 5 wherein R is hydroxy, R.sub.1 and R.sub.2 each is hydrogen and n is 1.
- 18. A compound as in claim 5 wherein R is hydroxy, R.sub.1 is methyl, R.sub.2 is hydrogen and n is 1.
- 19. The L-form of a compound of claim 5.
- 20. The compound of claim 18 in which the piperidine is in the L-form.
- 21. A compound as in claim 5 wherein R is hydroxy, R.sub.1 is hydrogen, R.sub.2 is lower alkylthio and n is 2.
- 22. A compound as in claim 1 wherein R.sub.2 is ##STR41## each R is hydroxy; each R.sub.1 is hydrogen or lower alkyl; and each n is 0 to 2.
- 23. A compound as in claim 22 wherein each R is hydroxy; each R.sub.1 is methyl and each n is 1.
- 24. The compound according to claim 1 having the name 1-(3-mercapto-2-methylpropanoyl)-L-pipecolic acid.
- 25. The compound according to claim 1 having the name 1,1'-[dithiobis(2-methyl-3-propanoyl)]-bis-L-pipecolic acid.
- 26. The compound of claim 17 in which the piperidine is in the L-form.
- 27. A composition for reducing blood pressure comprising about 10 to 500 mg. of a compound of claim 1 and a pharmaceutically acceptable vehicle therefor.
- 28. A composition for reducing blood pressure comprising about 10 to 500 mg. of a compound of claim 18 and a pharmaceutically acceptable vehicle therefor.
- 29. A composition for reducing blood pressure comprising about 10 to 500 mg. of a compound of claim 17 and a pharmaceutically acceptable vehicle therefor.
- 30. A composition for reducing blood pressure comprising about 10 to 500 mg. of the compound of claim 24 and a pharmaceutically acceptable vehicle therefor.
- 31. A composition for reducing blood pressure comprising about 10 to 500 mg. of the compound of claim 25 and a pharmaceutically acceptable vehicle therefor.
- 32. A method for reducing blood pressure in a hypertensive mammal which comprises administering to said mammal an effective hypotensive amount of a composition comprisng a compound having the formula in claim 1, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable vehicle therefor.
- 33. A method for reducing blood pressure in a hypertensive mammal which comprises administering to said mammal an effective hypotensive amount of a composition comprising a compound of claim 18 and a pharmaceutically acceptable vehicle therefor.
- 34. A method for reducing blood pressure in a hypertensive mammal which comprises administering to said mammal an effective hypotensive amount of a composition comprising a compound of claim 17 and a pharmaceutically acceptable vehicle therefor.
- 35. A method for reducing blood pressure in a hypertensive mammal which comprises administering to said mammal an effective hypotensive amount of a composition comprising the compound of claim 24 and a pharmaceutically acceptable vehicle therefor.
- 36. A method for reducing blood pressure in a hypertensive mammal which comprises administering to said mammal an effective hypotensive amount of a composition comprising the compound of claim 25 and a pharmaceutically acceptable vehicle therefor.
Parent Case Info
This application is a division of our application Ser. No. 751,851, filed Dec. 22, 1976, now U.S. Pat. No. 4,105,776, issued Aug. 8, 1978, which is a continuation-in-part of our application Ser. No. 698,432, filed June 21, 1976, now abandoned, which is a continuation-in-part of our application Ser. No. 657,792, filed Feb. 13, 1976, now U.S. Pat. No. 4,046,889, issued Sept. 6, 1977.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4091024 |
Ondetti et al. |
May 1978 |
|
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, 41:3208g (1947) [Thomson, J., et al., J. Pharmacol., 89, 1-13 (1947)]. |
Divisions (1)
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Number |
Date |
Country |
Parent |
751851 |
Dec 1976 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
698432 |
Jun 1976 |
|
Parent |
657792 |
Feb 1976 |
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