Claims
- 1. A compound having the formula ##STR7## wherein R is NH.sub.2, NH-alkyl having 1-7 carbon atoms, N(alkyl).sub.2 having 2-5 carbon atoms, 1-morpholinyl, 4-methyl-1-piperazinyl, or ##STR8## wherein Y is a straight or branched chain alkylene radical having 4-8 carbon atoms and forming with the nitrogen atom a 5-8 membered ring, optionally substituted by a hydroxy group;
- R' is H, O.sub.2 N, halogen, alkyl of 1-3 carbon atoms, alkoxy of 1-3 carbon atoms, HO or Z.dbd.NO.sub.2 S, where Z.dbd.N is amino, phenylamino, benzylamino, 4-methylbenzylamino, alkylamino or dialkylamino, alkyl having 1-3 carbon atoms;
- R" is H or alkyl of 1-3 carbon atoms; and
- R'" is H, 2-propenyl or alkyl of 1-3 carbon atoms; or a pharmaceutically acceptable acid-addition or quaternary ammonium salt thereof.
- 2. A compound according to claim 1 wherein R is ##STR9##
- 3. 1-[2-(4-Pyridinylamino)benzoyl]piperidine, according to claim 2.
- 4. Hexahydro-1-[2-(4-pyridinylamino)benzoyl]azepine, according to claim 2.
- 5. Octahydro-1-[2-(4-pyridinylamino)benzoyl]azocine, according to claim 2.
- 6. 1-[5-Nitro-2-(4-pyridinylamino)benzoyl]piperidine, according to claim 2.
- 7. 2-Methyl-1-[2-(4-pyridinylamino)benzoyl]piperidine, according to claim 2.
- 8. 1-[5-Hydroxy-2-(4-pyridinylamino)benzoyl]piperidine, according to claim 2.
- 9. 1-[5-(Benzylaminosulfonyl)-2-(4-pyridinylamino)benzoyl]piperidine, according to claim 2.
- 10. A compound according to claim 1 wherein R is NH-alkyl and R', R" and R'" are H.
- 11. N-Ethyl-2-(4-Pyridinylamino)benzamide, according to claim 10.
- 12. N-(n-Hexyl)-2-(4-pyridinylamino)benzamide, according to claim 10.
- 13. N-Isopropyl-2-(4-pyridinylamino)benzamide, according to claim 10.
- 14. A compound according to claim 1 wherein R is NH.sub.2, and R', R" and R'" are H.
- 15. 2-(4-Pyridinylamino)benzamide, according to claim 14.
- 16. 5-Bromo-2-(4-pyridinylamino)benzamide, according to claim 1.
- 17. 4-(4-Pyridinylamino)benzamide.
- 18. 1-[4-(4-Pyridinylamino)benzoyl]piperidine.
- 19. 3-(4-Pyridinylamino)benzamide.
- 20. 1-[3-(4-Pyridinylamino)benzoyl]piperidine.
- 21. A composition for lowering the blood pressure of a hypertensive mammal which comprises an antihypertensively effective amount of a compound according to claim 1 together with one or more pharmaceutically acceptable excipients.
- 22. A composition according to claim 21 wherein the compound is 1-[2-(4-pyridinylamino)benzoyl]piperidine or a pharmaceutically acceptable acid-addition salt thereof.
- 23. A process for lowering the blood pressure of a hypertensive mammal which comprises administering to said mammal a composition according to claim 21.
- 24. A process for lowering the blood pressure of a hypertensive mammal which comprises administering to said mammal a composition according to claim 22.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 485,923, filed Apr. 18, 1983, now abandoned, which is in turn a continuation-in-part of application Ser. No. 388,080, filed June 14, 1982, now abandoned.
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Entry |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
485923 |
Apr 1983 |
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Parent |
388080 |
Jun 1982 |
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