Claims
- 1. A para-[thienyl or furyl(alkyl or alkenyl)amino]-benzoic acid derivative of the formula: ##STR4## wherein R.sub.1 is selected from the group hydrogen, lower alkyl, benzyl, diloweralkylaminoethyl and loweralkoxyethyl; R.sub.2 is selected from the group halofuryl, dihalofuryl, alkylfuryl, dialkylfuryl, thienyl or furyl; A is selected from the group C.sub.n H.sub.2n, wherein n=1-16, with the provision that when n is 1, R.sub.2 is not thienyl C.sub.n H.sub.2n-2, wherein n=3-16; the pharmaceutically acceptable salts thereof; and when R.sub.1 is hydrogen, the alkali metal or organic base carboxylic acid salts thereof.
- 2. The compound according to claim 1, p-[(4-([2-thienyl]butyl)amino]benzoic acid.
- 3. The compound according to claim 1, p-[(4-[2-furyl]butyl)amino]benozic acid.
- 4. The compound according to claim 1, ethyl p-[(4-[2-thienyl]butyl)amino]benzoate.
- 5. The compound according to claim 1, p-([2-(2-thienyl)ethylamino]benzoic acid.
- 6. The compound according to claim 1, ethyl p-[2-(2-thienyl)ethylamino]benzoate.
- 7. A method of lowering serum-lipid levels in mammals which comprises orally administering to said mammals an effective amount of a para-[thienyl and furyl(alkyl or alkenyl)amino]benzoic acid derivative of the formula: ##STR5## wherein R.sub.1 is selected from the group hydrogen, lower alkyl, benzyl, diloweralkylaminoethyl and loweralkoxyethyl; R.sub.2 is selected from the group halofuryl, dihalofuryl, alkylfuryl, dialkylfuryl, thienyl or furyl; A is selected from the group C.sub.n H.sub.2n, wherein n=1-16, with the proviso that when n is 1, R.sub.2 is not thienyl and C.sub.n H.sub.2n-2, wherein n=3-16; the pharmaceutically acceptable salts thereof; and when R.sub.1 is hydrogen, the alkali metal or organic base carboxylic acid salts thereof.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of our copending application Ser. No. 557,550, filed Mar. 12, 1975, now U.S. Pat. No. 4,185,115.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4192884 |
Wagner et al. |
Mar 1980 |
|
Non-Patent Literature Citations (4)
Entry |
Fedorov et al., Chem. Abs., vol. 68 (1968) 104869k. |
Ferlux, Chemical Abstracts, vol. 78 (1973) 29,493j. |
Ferlux, Chemical Abstracts, vol. 81 (1974) 25,703s. |
Ferlux, Chemical Abstracts, vol. 83 (1975) 113,925n. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
557550 |
Mar 1975 |
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