Patent Application
20220226219
The present invention relates to the area of preservation for personal care, in particular hair care compositions.
In the personal care and cosmetic industry there is a constant need for preservation chemicals, especially preservation chemicals that are from natural sources, that are abundant and readily available.
A large number of antimicrobial active compounds are already employed in the personal care industry, but alternatives nevertheless continue to be sought. Not all antimicrobial agents have adequate preservation properties and thus the need for new preservation solutions is particularly required. It is to be noted that the substances used in the personal care field must be:
The present application has found a combination of antimicrobial chemicals suitable for achieving preservation of personal care compositions.
A product named Lifebuoy Total 10 Germ Protection Bodywash, sold by Hindustan Lever is said to contain inter alia piroctone olamine, sodium benzoate and eugenol, but according to the order of the ingredients on the product label, the sodium benzoate component is present in the composition at a level less than the piroctone olamine. A further commercial product is Rituals Ancient Samurai Hydrating Body Moisturiser, said to from the label contain limonene, eugenol, sodium benzoate and piroctone olamine; however this is not a cleansing product but clearly a leave-on, moisturizing product.
The listing or discussion of an apparently prior published document in this specification should not necessarily be taken as an acknowledgement that the document is part of the state of the art or is common general knowledge.
The present invention relates to a personal care composition comprising:
The invention further relates to a method of preserving a composition by the use of a combination of:
The invention further relates to the use of a combination of:
In certain embodiments, the invention may relate to a personal care composition comprising:
In certain embodiments, the invention may further relate to a method of preserving a composition by the use of a combination of:
In certain further embodiments, the invention may further relate to the use of a combination of:
In other embodiments, the invention relates to a personal care composition comprising:
In other embodiments, the invention relates to a method of preserving a composition by the use of a combination of:
In further embodiments, the invention further relates to the use of a combination of:
Compositions of the invention comprise a piroctone compound. The forms of piroctone compound according to the present invention include piroctone acid, primary, secondary and tertiary olamine salts of piroctone acid (such as the diethanolamine and triethanolamine salts), and mixtures thereof, preferably piroctone acid, primary olamine salt of piroctone acid (i.e. piroctone olamine, also known as Octopirox®) and mixtures thereof, more preferably piroctone acid.
The piroctone compound useful in the present invention typically contains the structure defined by Formula (IV):
wherein R4 is selected from C1-C17 hydrocarbon radicals, R5 is selected from C1-4 alkyl, C2-4 alkenyl or alkynyl, hydrogen, phenyl or benzyl, and M1 is selected from hydrogen, monoethanolamine (MEA), diethanolamine (DEA), or triethanolamine (TEA). Preferred R4 group is (CH3)3CCH2CH(CH3)CH2— and preferred R5 is a methyl. More preferably, R4 is (CH3)3CCH2CH(CH3)CH2—, R5 is a methyl and M1 is a hydrogen or MEA. Most preferably, R4 is (CH3)3CCH2CH(CH3)CH2—, R5 is a methyl and M1 is hydrogen.
Typically, the piroctone compound comprises piroctone acid, piroctone olamine or mixtures thereof. The most preferred example is a piroctone acid.
The preferred level of the piroctone compound is from 0.01 to 5 wt % by weight of the total composition, more preferably from 0.05 to 2 wt %, most preferably from 0.1 to 1.5 wt %.
The composition according to the invention comprises sodium benzoate. The preferred level of the sodium benzoate is from 0.01 to 5 wt % by weight of the total composition, more preferably from 0.05 to 2 wt %, most preferably from 0.1 to 1.5 wt %.
Compositions according to the invention comprise a fragrance comprising as components benzyl acetate, hexyl acetate, phenethyl ether, ethyl butyrate, eucalyptol, limonene, undecalalactone and eugenol. In an embodiment, the undecalactone can be gamma undecalactone. The preferred level of fragrance is from 0.01 to 10 wt % by weight of the total composition, more preferably from 0.05 to 6 wt %, most preferably from 0.05 to 3 wt %.
Preferably the weight ratio of piroctone to sodium benzoate to the defined fragrance components iii) is from 1:1:1 to 1:130:130, further preferred more is from 1:1:1 to 1:100:100 more preferably from 1:1:1 to 1:75:75, most preferably from 1:1:1 to 1:50:50.
Preferably the composition comprises an aqueous base of at least 50 wt % water of the total composition.
In a preferred embodiment, the personal care composition comprises a cleansing phase comprising one or more cleansing surfactants.
The composition according to the invention preferably comprises a surfactant chosen from anionic, nonionic, zwitterionic or amphoteric surfactants or mixtures thereof.
Suitable anionic surfactants include the alkyl sulphates, alkyl ether sulphates, alkaryl sulphonates, alkanoyl isethionates, alkyl succinates, alkyl sulphosuccinates, N-alkoyl sarcosinates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, and alpha-olefin sulphonates, especially their sodium, magnesium ammonium and mono-, di- and triethanolamine salts. The alkyl and acyl groups generally contain from 8 to 18 carbon atoms and may be unsaturated. The alkyl ether sulphates, alkyl ether phosphates and alkyl ether carboxylates may contain from one to 10 ethylene oxide or propylene oxide units per molecule, and preferably contain 2 to 3 ethylene oxide units per molecule.
Examples of suitable anionic surfactants include sodium oleyl succinate, ammonium lauryl sulphosuccinate, ammonium lauryl sulphate, sodium dodecylbenzene sulphonate, triethanolamine dodecylbenzene sulphonate, sodium cocoyl isethionate, sodium lauroyl isethionate and sodium N-lauryl sarcosinate. The most preferred anionic surfactants are sodium lauryl sulphate, triethanolamine lauryl sulphate, triethanolamine monolauryl phosphate, sodium lauryl ether sulphate 1EO, 2EO and 3EO, ammonium lauryl sulphate and ammonium lauryl ether sulphate 1EO, 2EO and 3EO.
Nonionic surfactants suitable for use in compositions of the invention may include condensation products of aliphatic (C8-C18) primary or secondary linear or branched chain alcohols or phenols with alkylene oxides, usually ethylene oxide and generally having from 6 to 30 ethylene oxide groups. Other suitable nonionic surfactants include mono- or di-alkyl alkanolamides, glycolipids preferably selected from the group of rhamnolipids and sophorolipids.
Amphoteric and zwitterionic surfactants suitable for use in compositions of the invention may include alkyl amine oxides, alkyl betaines, alkyl amidopropyl betaines, alkyl sulphobetaines (sultaines), alkyl glycinates, alkyl carboxyglycinates, alkyl am phopropionates, alkylamphoglycinates alkyl amidopropyl hydroxysultaines, acyl taurates and acyl glutamates, wherein the alkyl and acyl groups have from 8 to 19 carbon atoms. Examples include lauryl amine oxide, cocodimethyl sulphopropyl betaine and preferably lauryl betaine, cocamidopropyl betaine, coco mono- or di-ethanolamide, coco mono-isopropanolamide and sodium cocamphopropionate.
Generally, the surfactants are present in shampoo compositions of the invention in an amount of from 0.1 to 50%, preferably from 5 to 30%, more preferably from 10% to 25% by weight.
Compositions of the invention are preferably personal care compositions, more preferably shampoo compositions.
The compositions of the invention may comprise silicone conditioning agent, preferably in the form of emulsified droplets for enhancing conditioning performance.
Suitable silicones include polydiorganosiloxanes, in particular polydimethylsiloxanes which have the CTFA designation dimethicone. Also suitable for use compositions of the invention (particularly shampoos and conditioners) are polydimethyl siloxanes having hydroxyl end groups, which have the CTFA designation dimethiconol. Also suitable for use in compositions of the invention are silicone gums having a slight degree of cross-linking, as are described for example in WO 96/31188.
The viscosity of the emulsified silicone itself (not the emulsion or the final hair conditioning composition) is typically at least 10,000 cst at 25° C.; the viscosity of the silicone itself is preferably at least 60,000 cst, most preferably at least 500,000 cst, ideally at least 1,000,000 cst. Preferably the viscosity does not exceed 109 cst for ease of formulation.
Emulsified silicones for use in the shampoo compositions of the invention will typically have a D90 silicone droplet size in the composition of less than 30, preferably less than 20, more preferably less than 10 microns, ideally from 0.01 to 1 micron. Silicone emulsions having an average silicone droplet size (D50) of 0.15 microns or less are generally termed microemulsions.
Silicone particle size may be measured by means of a laser light scattering technique, for example using a 2600D Particle Sizer from Malvern Instruments. Examples of suitable pre-formed emulsions include Xiameter MEM 1785 and microemulsion DC2-1865 available from Dow Corning. These are emulsions/microemulsions of dimethiconol. Cross-linked silicone gums are also available in a pre-emulsified form, which is advantageous for ease of formulation.
A further preferred class of silicones for inclusion in shampoos and conditioners of the invention are amino functional silicones. By “amino functional silicone” is meant a silicone containing at least one primary, secondary or tertiary amine group, or a quaternary ammonium group. Examples of suitable amino functional silicones include: polysiloxanes having the CTFA designation “amodimethicone”.
Specific examples of amino functional silicones suitable for use in the invention are the aminosilicone oils DC2-8220, DC2-8166 and DC2-8566 (all ex. Dow Corning).
Suitable quaternary silicone polymers are described in EP-A-0 530,974. A preferred quaternary silicone polymer is K3474, ex. Goldschmidt.
Also suitable are emulsions of amino functional silicone oils with nonionic and/or cationic surfactant. Pre-formed emulsions of amino functional silicone are also available from suppliers of silicone oils such as Dow Corning and General Electric. Specific examples include DC939 Cationic Emulsion and the non-ionic emulsions DC2-7224, DC2-8467, DC2-8177 and DC2-8154 (all ex. Dow Corning).
The total amount of silicone is preferably from 0.01 to 10 wt % of the total composition, more preferably from 0.1 to 5 wt %, most preferably 0.5 to 3 wt % is a suitable level. Preferably the weight ratio of silicone conditioning agent to short chain, unsaturated organic, acid is from 20:1 to 1:4.
Compositions of the invention may comprise further ingredients such as cationic deposition polymer preferably those selected from cationic cellulose and cationic guar derivatives.
Other examples of ingredients found in compositions according to the invention comprise fragrances and pH adjusting agents. Preferably the pH of the composition at 20° C. is from 3 to 7, more preferably from 4 to 6.
The invention will now be illustrated by the following non-limiting examples.
The differing behaviors of inhibitory antimicrobials in isolation and mixtures have been widely explored using the concept of the Fractional Concentration and Fractional Inhibitory Concentration (FIC). See for instance JRW Lambert and R Lambert, J. Appl. Microbiol 95, 734 (2003); T. Jadavji, C G Prober and R Cheung, Antimicrobial Agents and Chemotherapy 26, 91 (1984), and WO 2004/006876. These parameters can be defined as follows: FIC (component a)=MIC (component a tested in the mixture)/MIC (component a tested as a single active).
The interactions between antimicrobials can be additive, synergistic or possibly antagonistic depending on whether the efficacy of the combination is equivalent to, greater than or less than that obtained for the same total concentration of the individual components when tested alone.
These relationships can be expressed mathematically by summing the FIC values for all the components present in the mixture to give the “fractional inhibitory index”:
ΣFIC=FIC(component 1)+FIC(component 2)+FIC(component 3)
Such that:
ΣFIC≥1 corresponds to additive or antagonistic activity
ΣFIC<1 corresponds to synergistic activity
A comparable method is the calculation of the synergy index (SI) which is an industrial accepted method described by Kull, F. C.; Eisman, P. C.; Sylwestrowicz, H. D. and Mayer, R. L., in Applied Microbiology 9:538-541 (1961).
Liquid broth assays (MIC and checkerboard) were conducted to identify the minimum concentration(s) of individual and tertiary antimicrobial chemicals. A modified methodology to ISO 20776-1:2006 was utilized for the screening as follows. Stock solutions of antimicrobial chemicals and tryptic soy broth were inoculated with 1-5×106 microorganism mixture of Gram negative fermenting bacteria; Enterobacter gergoviae and Klebsiella species.
Samples were incubated at 30° C. for 24 hours, after which optical densities at OD600 nm were measured. MIC was defined as the concentration at which <25% growth was observed in comparison to a positive growth control containing no antimicrobial chemicals.
Tertiary combinations were evaluated at sub-MIC concentrations to identify if synergy was observed.
In the table above any FIC value of 1.00 or above is non-synergistic or merely additive. A value of 2.00 is antagonistic.
Table 2 demonstrates that the Examples according to the invention demonstrated a synergistic chemical combination against Gram negative fermenting bacteria.
Table 3 demonstrates further the benefits of compositions and methods according to the invention, tested under the same conditions as the compositions in Table 2, with different ingredient component ratios. The following are the tertiary ratio combinations and corresponding FIC scores observed when varied ratios are included.
A shampoo was prepared having the formulation according to Table 4.
| Number | Date | Country | Kind |
|---|---|---|---|
| 19170898.1 | Apr 2019 | EP | regional |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2020/061159 | 4/22/2020 | WO | 00 |
