Claims
- 1. A method of producing an antimicrobial lens without an antimicrobial host comprising placing a lens in an antimicrobial containing solution.
- 2. The method of claim 1 wherein the lens is contacted with the antimicrobial containing solution under conditions sufficient to incorporate an effective amount of an antimicrobial component on and/or in the lens.
- 3. The method of claim 2 wherein the antimicrobial component is present in the lens.
- 4. The method of claim 2 wherein the antimicrobial component is present on the lens.
- 5. The method of claim 2 wherein the antimicrobial component is present in and on the lens.
- 6. The method of claim 5 wherein the antimicrobial containing solution comprises at least one antimicrobial component in an amount up to about 200,000 μg/gm.
- 7. The method of claim 5 wherein the antimicrobial containing solution comprises at least one antimicrobial component in an amount between about 0.01 μg/gm to about 10,000 μg/gm.
- 8. The method of claim 5 wherein the antimicrobial containing solution comprises at least one antimicrobial component in an amount between about 0.1 μg/gm to about 100 μg/gm.
- 9. The method of claim 2 wherein the antimicrobial containing solution comprises silver nitrate and a buffering solution.
- 10. The method of claim 2 wherein the antimicrobial containing solution comprises silver nitrate.
- 11. The method of claim 10 wherein silver is present in the lens at about 0.1 μg/gm to about 500 μg/gm.
- 12. The method of claim 10 wherein silver is present in the lens at about 0.1 μg/gm to about 100 μg/gm.
- 13. The method of claim 10 wherein silver is present in the lens at about 20 μg/gm to about 70 μg/gm.
- 14.The method of claim 5 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 0.01 μg/ml to about 500,000 μg/ml.
- 15. The method of claim 5 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 0.1 μg/ml to about 100 μg/ml.
- 16. The method of claim 5 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 1 to about 70 μg/ml
- 17. The method of claim 5 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 20 μg/ml.
- 18. The method of claim 5 wherein the antimicrobial containing solution comprises at least one metal ion selected from the group consisting of silver ions, cadmium ions, zinc ions, copper ions, gold ions, platinum ions, palladium ions, bismuth ions, tin ions, cobalt ions, nickel ions and combinations thereof.
- 19. The method of claim 5 wherein the antimicrobial containing solution comprises at least one metal salt selected from the group consisting of silver nitrate, silver acetate, silver citrate, silver iodide, silver lactate, silver sulfate and combinations thereof.
- 20. The method of claim 2 wherein the conditions comprise a temperature of about 20° C. for a time of at least about 15 minutes to about 130° C. for a time of at least about 5 minutes.
- 21. The method of claim 20 wherein the conditions comprise a temperature of about 120° C. for a time of at least about 15 minutes.
- 22. The method of claim 5 wherein the antimicrobial containing solution comprises at least one metal ion and at least one counterion.
- 23. The method of claim 22 wherein the counterion is selected from the group consisting of acetate, citrate, iodide, lactate, sulfate, and combinations thereof.
- 24. The method of claim 9 wherein the buffering solution buffers the antimicrobial containing solution and to a pH of about 7.
- 25. The method of claim 9 wherein the buffering solution is a borate solution.
- 26. The method of claim 2 wherein the conditions are sufficient to sterilize the lens concurrently with the incorporation of the antimicrobial component.
- 27. An antimicrobial lens comprising a contact lens with an antimicrobial component, in the absence of an antimicrobial host, incorporated on and/or in the lens by exposure to an antimicrobial containing solution.
- 28. The lens of claim 27 wherein the antimicrobial component is present in and on the lens at up to about 200,000 ppm.
- 29. The lens of claim 27 wherein the antimicrobial component is present in and on the lens at least about 0.1 ppm to about 10,000 ppm.
- 30. The lens of claim 27 wherein the antimicrobial component is present in and on the lens at least about 10 ppm to about 100 ppm.
- 31. The lens of claim 27 wherein the antimicrobial containing solution comprises silver nitrate and a buffering solution.
- 32. The lens of claim 27 wherein the antimicrobial containing solution comprises silver nitrate.
- 33. The lens of claim 31 wherein the silver is present in the lens at about 0.1 ppm to about 500 ppm.
- 34. The lens of claim 31 wherein the silver is present in the lens at about 0.1 ppm to about 100 ppm.
- 35. The lens of claim 31 wherein the silver is present in the lens at about 20 ppm to about 70 ppm.
- 36. The lens of claim 31 wherein the silver is present in the lens at about 40 ppm to about 50 ppm.
- 37. The lens of claim 27 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 0.1 μg/ml to about 500,000 μg/ml.
- 38. The lens of claim 27 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 1.0 μg/ml to about 100 μg/ml.
- 39. The lens of claim 27 wherein the antimicrobial containing solution has a concentration of the antimicrobial component of about 20 μg/ml.
- 40. The lens of claim 27 wherein the antimicrobial containing solution comprises at least one metal ion selected from the group consisting of silver ions, cadmium ions, zinc ions, copper ions, gold ions, platinum ions, palladium ions, bismuth ions, tin ions, cobalt ions, nickel ions and combinations thereof.
- 41. The lens of claim 27 wherein the antimicrobial containing solution comprises at least one metal salt selected from the group consisting of silver nitrate, silver acetate, silver citrate, silver lactate, silver sulfate and combinations thereof.
- 42. The lens of claim 27 wherein the antimicrobial containing solution comprises at least one metal ion and at least one counterion.
- 43. The lens of claim 42 wherein the counterion is selected from the group consisting of acetate, citrate, iodide, lactate, sulfate, and combinations thereof.
- 44. The lens of claim 31 wherein the buffering solution buffers the antimicrobial containing solution and to a pH of about 7.
- 45. The lens of claim 31 wherein the buffering solution is a borate solution.
- 46. A method of storing an antimicrobial lens without an antimicrobial host comprising placing a lens in a packing solution, wherein the lens is prepared according to claim 1, and the antimicrobial component does not complex with ingredients of the packing solution.
- 47. The method of claim 46 wherein the packing solution comprises sodium chloride, boric acid and sodium borate.
- 48. The method of claim 47 wherein the sodium chloride is present at about 0.85%, the boric acid is present at about 0.93% and the sodium borate is present at about 0.19%.
- 49. The method of claim 48 wherein the antimicrobial component is soluble in the packing solution.
- 50. The method of claim 49 wherein the antimicrobial component comprises at least one metal ion which suppresses microbiological activity in the packing solution.
- 51. The method of claim 48 wherein the lens is stored for up to about 2 years.
- 52. The method of claim 48 wherein the lens is stored for at least about 6 months.
- 53. An antimicrobial lens comprising a contact lens with silver, in the absence of an antimicrobial host, incorporated in and on the lens by exposure to a silver nitrate solution with a borate buffering solution, said exposure comprises placing the lens in the solution and heating the lens and solution.
RELATED PATENT APPLICATIONS
[0001] This patent application claims priority of a provisional application, U.S. Ser. No. 60/309,642 which was filed on Aug. 2, 2001, and non-provisional application, U.S. Serial No. 10/029,526, which was filed on Dec. 21, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60309642 |
Aug 2001 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10029526 |
Dec 2001 |
US |
Child |
10183883 |
Jun 2002 |
US |