Claims
- 1. A compound having a structural formula:
- 2. The compound of claim 1 wherein L is a bond.
- 3. The compound of claim 1 wherein L is NR7 or NR8 (CR92)nNR8.
- 4. The compound of claim 1 wherein m is 0 and L-Q is selected from the group consisting of:
- 5. The compound of claim 1 wherein Q is an oxazolidinone group.
- 6. The compound of claim 1 wherein Q is an isoxazoline group.
- 7. The compound of claim 1 wherein Q is an isoxazolinone group.
- 8. The compound of claim 1 wherein Y2 , Y3, and Y4 are C.
- 9. The compound of claim 1 wherein Y2 is N, and Y3 and Y4 are C.
- 10. The compound of claim 1 wherein Y2 and Y3 are N, and Y4 is C.
- 11. A compound having a structural formula:
- 12. A compound having a structural formula:
- 13. A compound having a structural formula:
- 14. A compound having a structural formula:
- 15. A compound having a structural formula:
- 16. A compound having a structural formula:
- 17. A compound having a structural formula:
- 18. The compound of claim 1 wherein the compound is an optically pure enantiomer having the S-configuration at C5 of the oxazolidinone or isoxazoline ring.
- 19. The compound of claim 12 wherein the compound is an optically pure enantiomer having the S-configuration at C5 of the oxazolidinone ring.
- 20. A compound selected from the group consisting of 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate, (5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one, [(5R)-3-(4-bromo-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl 3-nitrobenzene sulfonate, and tert-butyl [(5S)-3-(4-bromo-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl] methylcarbamate.
- 21. A compound having a general structural formula:
- 22. A method of preparing a boronic acid having a general structural formula:
- 23. The method of claim 22 wherein the alkylborate is trimethylborate.
- 24. A method of preparing compound having a general structural formula:
- 25. The method of claim 24 wherein the palladium catalyst is dichlorobis(triphenylphosphine)palladium(II).
- 26. A pharmaceutical composition comprising a compound of claim 1 in admixture with a pharmaceutically acceptable adjuvant, diluent, or carrier.
- 27. A method of treating a microbial infection in a warm blooded animal comprising administering a therapeutically effective amount of a compound of claim 1 to the animal.
- 28. The method of claim 27 wherein the animal is a human.
- 29. A method of treating a microbial infection in a warm blooded animal comprising administering a therapeutically effective amount of a composition comprising a compound of claim 1 in admixture with a pharmaceutically acceptable adjuvant, diluent, or carrier, to the animal.
- 30. The method of claim 29 wherein the animal is a human.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of provisional patent application Serial No. 60/257,904, filed Dec. 21, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60257904 |
Dec 2000 |
US |