Claims
- 1. A compound of Formula I or a pharmaceutically acceptable acid addition salt or solvate thereof ##STR15## wherein Ar is ##STR16## R.sup.1 is a substituent selected from --COR.sup.2, --CONHR.sup.3, --CO.sub.2 R.sup.4, --OH, --NR.sup.2 COR.sup.4, --NR.sup.2 SO.sub.2 R.sup.3, --SO.sub.2 R.sup.4, and --SO.sub.2 NHR.sup.3, with the proviso that R.sup.1 is not CONHR.sup.3 when Ar is ##STR17## R.sup.2 is hydrogen and lower alkyl; R.sup.3 is hydrogen, lower alkyl and phenyl-lower-alkylene;
- R.sup.4 is lower alkyl;
- R.sup.5 is hydrogen, halogen, or lower alkoxy;
- m is zero or 1;
- n is an integer from 1 to 3;
- p is zero or an integer from 1 to 4; and
- the solid and dotted line represent either a single or double covalent bond.
- 2. A compound of claim 1 wherein R.sup.1 is --CONHR.sup.3.
- 3. A compound of claim 1 wherein n is 2.
- 4. A compound of claim 1 wherein Ar is ##STR18##
- 5. A compound of claim 2 selected from the group consisting of 3-[4-[N-[2-(pyridin-2-yl)ethyl]amino]cyclohexen-1-yl]-1H-indole-5-carboxamide and 3-[4-[N-[2-pyridin-3-yl)ethyl]amino]cyclohexen-1-yl]-1H-indole-5-carboxamide.
- 6. A compound of claim 1 selected from the group consisting of 5-acetyl-3-[4-[N-(2-phenylethyl)amino]cyclohexen-1-yl]-1H-indole and 5-carboxymethyl-3-[4-[N-(2-phenylethyl)amino]cyclohexen-1-yl]-1H-indole.
- 7. The method for treating vascular headaches by administering a therapeutically effective amount of a compound claimed in claim 1 to a person suffering from a vascular headache.
- 8. A pharmaceutical composition in unit dosage form suitable for systemic administration to a person at risk of or suffering a vascular headache, the composition comprising a pharmaceutical carrier and from about 1 to 500 mg of a compound claimed in claim 1.
CROSS-REFERENCE TO RELATED APPLICATION
This is a division of application U.S. Ser. No. 08/178,079 filed Jan. 6, 1994 now U.S. Pat. No. 5,468,768.
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Divisions (1)
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Number |
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Parent |
178079 |
Jan 1994 |
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