Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient

Abstract

Treatment methods are disclosed which utilize antiphlogistic/antipyretic/analgesic agents containing as active ingredient theobromine and theophylline derivatives represented by the general formula: ##STR1## wherein one of A and B is --CH.sub.3 and the other of A and B is ##STR2## wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula ##STR3## wherein X.sub.1 and X.sub.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; or (3) a group of the formula: ##STR4## wherein Y.sub.1 and Y.sub.2 may be the same or different and Y.sub.1 and Y.sub.2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that when (i) A is --CH.sub.3, m is 2, and (ii) when A is ##STR5## Z is not pyridyl and X is nitrogen, and acid addition salts thereof.

Description

This invention relates to antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as the active ingredient thereof. More specifically, the invention relates to treatment methods which utilize antiphlogistic/antipyretic/analgesic agents containing as active ingredients theobromine and theophylline derivatives of the general formula: ##STR6## wherein one of A and B is --CH.sub.3 and the other of A and B is ##STR7## wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula ##STR8## wherein X.sub.1 and X.sub.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; and (3) a group of the formula: ##STR9## wherein Y.sub.1 and Y.sub.2 are the same or different and Y.sub.1 and Y.sub.2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that (i) when A is --CH.sub.3, m is 2, and (ii) when A is ##STR10## Z is not pyridyl and X is nitrogen, and acid addition salts thereof. More particularly, preferred compounds used in this invention have the following general formulas: ##STR11## wherein R is a hydrogen atom or a lower alkyl group, Z is a group represented by the formula: ##STR12## wherein X.sub.1 and X.sub.2 can be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, or a group represented by the formula: ##STR13## wherein Y.sub.1 and Y.sub.2 can be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, and n is an integer of 2 to 10,

and acid addition salts thereof, and ##STR14## wherein R is a hydrogen atom or a lower alkyl group, Z is a group represented by the formula: ##STR15## wherein X.sub.1 and X.sub.2 can be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, a pyridyl group or a group represented by the formula: ##STR16## wherein Y.sub.1 and Y.sub.2 can be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, X is a nitrogen or carbon atom, and n is an integer of 2 to 10, and acid addition salts thereof.

The lower alkyl groups and lower alkoxy groups in the above definitions of R, X.sub.1, X.sub.2, Y.sub.1 and Y.sub.2 in the general formulas (I) and (II) are straight-chain or branched alkyl groups having 1 to 6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methylpropyl, tert-butyl, n-pentyl, 1-ethylpropyl, isoamyl, n-hexyl or the like, and the corresponding alkoxy groups. The halogen atoms in the above definitions are chlorine, bromine, iodine or fluorine atoms.

The compounds (I) and (II) of this invention can be easily converted into acid addition salts by reacting said compounds with a pharmacologically acceptable inorganic or organic acid. Examples of inorganic acids usable for this purpose are hydrochloric acid, hydrobromic acid, hydriodic acid, sulfuric acid and the like. Examples or organic acids usable for this purpose are maleic acid, fumaric acid, succinic acid, acetic acid, malonic acid, citric acid, benzoic acid and the like.

Typical examples of compounds of formula (II), which are theophylline compounds of this invention, are listed below, but of course the present invention is not limited to the use of these compounds.

7-(2-(4-p-chlorobenzhydrylpiperazinyl-(1))-ethyl)theophylline 7-(3-(4-p-chlorobenzhydrylpiperazinyl-(1))-n-propyl)theophylline 7-(4-(4-p-chlorobenzhydrylpiperazinyl)-(1))-n-butyl)theophylline 7-(5-(4-p-methylbenzhydrylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-p-methoxybenzhydrylpiperazinyl-(1))-n-hexyl)theophylline 7-(7-(4-o-trifluoromethylbenzhydrylpiperazinyl-(1))-n-heptyl)theophylline 7-(8-(4-benzhydrylpiperazinyl)-(1))-n-octyl)theophylline 7-(9-(4-p-chlorobenzhydrylpiperazinyl-(1))-n-nonyl)theophylline 7-(10-(4-p-ethoxybenzhydrylpiperazinyl-(1))-n-decyl)theophylline 7-(4-(4-(4',4"-dichlorodiphenylmethyl)piperazinyl-(1))-n-butyl)theophylline 7-(2-((4-phenyl)piperazinyl-(1))ethyl)theophylline 7-(3-((4-phenyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-((4-phenyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-((4-phenyl)piperazinyl)-(1))-n-pentyl)theophylline 7-(6-((4-phenyl)piperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-o-methylphenylpiperazinyl(1))ethyl)theophylline 7-(3-(4-o-methylphenylpiperazinyl-(1))-n-propyl)theophylline 7-(5-(4-o-methylphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(2-(4-m-methylphenylpiperazinyl-(1))ethyltheophylline 7-(4-(4-m-methylphenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-m-methylphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-m-methylphenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-(2,3-dimethylphenyl)piperazinyl-(1))ethyl)theophylline 7-(2-(4-(2,6-dimethylphenyl)piperazinyl)-(1))ethyl)theophylline 7-(3-(4-(2,6-dimethylphenyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-(4-(2,6-dimethylphenyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-(4-(2,6-dimethylphenyl)piperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-(2,6-dimethylphenyl)piperazinyl-(1))-n-hexyl)theophylline 7-(3-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-(4-(2,3-dimethylphenyl)piperazinyl)-(1))-n-pentyl)theophylline 7-(6-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-(2,5-dimethylphenyl)piperazinyl)-(1))ethyl)theophylline 7-(3-(4-(2,5-dimethylphenyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-(4-(2,5-dimethylphenyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-(4-(2,5-dimethylphenyl)piperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-(2,5-dimethylphenyl)piperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-o-methoxyphenylpiperazinyl-(1))ethyl)theophylline 7-(3-(4-o-methoxyphenylpiperazinyl-(1))-n-propyl)theophylline 7-(4-(4-o-methoxyphenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-o-methoxyphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-o-methoxyphenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-m-methoxyhenylpiperazinyl-(1))ethyl)theophylline 7-(3-(4-m-methoxyphenylpiperazinyl-(1))-n-propyl)theophylline 7-(4-(4-m-methoxyphenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-m-methoxyphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-m-methoxyphenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-p-methoxyphenylpiperazinyl-(1))-ethyl)theophylline 7-(4-(4-p-methoxyphenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-p-methoxyphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-p-methoxyphenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-o-chlorophenylpiperazinyl-(1))ethyl)theophylline 7-(4-(4-o-chlorophenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-o-chlorophenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-o-chlorophenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-m-chlorophenylpiperazinyl-(1))ethyl)theophylline 7-(4-(4-m-chlorophenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-m-chlorophenylpiperazinyl-(1))-n-pentyl)theophylline 7-(2-(4-o-chlorophenylpiperazinyl-(1))-ethyl)theophylline 7-(4-(4-o-chlorophenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-o-chlorophenylpiperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-o-chlorophenylpiperazinyl-(1))-n-hexyl)theophylline 7-(2-(4-(3,4-dichlorophenyl)piperazinyl-(1))ethyl)theophylline 7-(3-(4-(3,4-dichlorophenyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-(4-(3,4-dichlorophenyl)piperazinyl-(1))-n-butyl)theophylline 7-(3-(4-p-fluorophenylpiperazinyl-(1))-n-propyl)theophylline 7-(4-(4-p-fluorophenylpiperazinyl)-(1))-n-butyl)theophylline 7-(3-(4-m-trifluoromethylphenylpiperazinyl-(1))-n-propyl)theophylline 7-(4-(4-m-trifluoromethylphenylpiperazinyl-(1))-n-butyl)theophylline 7-(5-(4-m-trifluoromethylphenylpiperazinyl-(1))-n-pentyl)theophylline 7-(4-(4-o-trifluoromethylphenylpiperazinyl-(1))-n-butyl)theophylline 7-(3-(4-p-trifluoromethylphenylpiperazinyl-(1))-n-propyl)theophylline 7-(2-(4-(2-pyridyl)piperazinyl-(1))ethyl)theophylline 7-(3-(4-(2-pyridyl)piperazinyl-(1))-n-propyl)theophylline 7-(4-(4-(2-pyridyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-(4-(2-pyridyl)piperazinyl-(1))-n-pentyl)theophylline 7-(6-(4-(2-pyridyl)piperazinyl-(1))-n-hexyl)theophylline 7-(7-((3-methyl-4-m-methylphenyl)piperazinyl-(1))-n-heptyl)theophylline 7-(2-((3-methyl-4phenyl)piperazinyl-(1))ethyl)theophylline 7-(4-((3-methyl-4-phenyl)piperazinyl-(1))-n-butyl)theophylline 7-(5-((3-methyl-4-phenyl)piperazinyl-(1))-n-pentyl)theophylline 7-(2-((3-methyl-4-p-methoxyphenyl)piperazinyl-(1))-ethyl)theophylline 7-(5-((3-methyl-4-p-methoxyphenyl)piperazinyl-(1))-n-pentyl)theophylline 7-(6-((3-ethyl-4-p-methoxyphenyl)piperazinyl-(1))-n-hexyl)theophylline 7-(7-(4-m-chlorophenylpiperazinyl-(1))-n-heptyl)theophylline 7-(8-(4-(3,4-dimethylphenyl)piperazinyl-(1))-n-octyl)theophylline 7-(9-(4-(2,3-diethylphenyl)piperazinyl-(1))-n-nonyl)theophylline 7-(10-(4-m-ethoxyphenylpiperazinyl)-(1))-n-decyl)theophylline 7-(7-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-heptyl)theophylline

7-(7-(4-(2-methyl-3-ethylphenyl)piperazinyl-(1))-n-heptyl)theophylline

7-(3-(4-(2-methyl-3-n-propylphenyl)piperazinyl-(1))-n-propyl)theophylline 7-(2-((4-phenyl)piperidinyl)ethyl)theophylline 7-(3-((4-phenyl)piperidinyl)-n-propyl)theophylline 7-(4-((4-phenyl)piperidinyl)-n-butyl)theophylline 7-(5-((4-p-chlorophenyl)piperidinyl)-n-pentyl)theophylline 7-(5-(4-(3,4-dichlorophenyl)piperazinyl-(1))-n-pentyl)theophylline 7-(7-(4-(2-methyl-5-chlorophenyl)piperazinyl-(1))-n-heptyl)theophylline 7-(10-((4-o-methoxyphenyl)piperazinyl-(1))-n-decyl)theophylline 7-(10-(4-(2-methyl-5-chlorophenyl)piperazinyl-(1))-n-decyl)theophylline 7-(10-(3-methyl-4-m-methylphenylpipeazinyl-(1))-n-decyl)theophylline 7-(10-(4-3,4-dimethylphenyl)piperazinyl-(1))-n-decyl)theophylline

The present inventors have carried out studies on said theobromine and theophylline derivatives of formulas (I) and (II) as pharmaceuticals and unexpectedly found that said derivatives have excellent analgesic, antipyretic and antiphlogistic activities, and the present invention was attained on the basis of these findings. The theobromine and theophylline derivatives used in the treatment methods of this invention are strikingly different in chemical structure from conventional antipyretic/analgesic or antiphlogistic agents.

The compounds of formula (I) of this invention, which are theobromine compounds, can be prepared by various processes, of which one typical example may be expressed as follows: ##STR17## wherein X is a halogen atom or a p-toluene-sulfonyloxy group, and R and n are the same as defined above. Thus, essentially, the compounds of formula (I) of this invention can be obtained by reacting compounds of the general formula (III) with those of the general formula (IV).

The compounds of formula (II) of this invention, which are theophylline compounds, can be prepared by various processes, of which one typical example may be expressed as follows: ##STR18## wherein A is a halogen atom or a p-toluene-sulfonyloxy group, and R, X, Z and n are as defined above.

Thus, the compounds of formula (II) of this invention can be obtained by reacting compounds of formula (V) with those of formula (VI).

The foregoing reactions used to produce the compounds of formulas (I) and (II) of this invention can be performed in the absence of a solvent, or in the presence of a suitable solvent selected from lower alcohols such as methanol, ethanol, propanol, or isopropanol, aromatic solvents such as benzene, toluene, or xylene, or ethers such as diethyl ether or tetrahydrofuran, which take no part in the reaction. Although the reaction can proceed at room temperature, it is desirable to heat the reaction system to the boiling point of the solvent used. Addition of an acid trapping agent, such as triethylamine, an alkali bicarbonate, an alkali carbonate, or pyridine to the reaction system allows the reaction to be conducted with enhanced smoothness.

The pharmacological effects and toxicities of the compounds of this invention will be shown below by reference to test examples.

TEST EXAMPLE

1. Test method

(1) Analgesic activity

(a) Acetic acid writhing method.sup.1

A 0.7% acetic acid solution was injected intraperitoneally to ddy-strain male mice (20 to 25 g) in an amount of 0.1 ml per 10 g mouse body weight to cause a writhing syndrome typified by stretching of the hind legs. The inhibitory action of each test compound against said symptom was observed as a measure of the analgesic activity of the compound. In the tests, each of the compounds of this invention and each of the control drugs listed below were administered orally to each test animal, and 50 minutes later said acetic acid solution was injected in the manner described above and the total number of typical writhes was determined over a period of 15 minutes. The Litchfield-Wilcoxon's method (See note 2) was used for determining the 50% effective dose (ED.sub.50).

Notes: (1) Hendershot, L. C. and Forsaith, J.: J. Pharmacol. Exp. Ther., 125, 237 (1959). (2) Litchfield, Jr., J. T. and Wilcoxon, F.: J. Pharmacol. Exp. Ther., 96, 99 (1949). (b) Bradykinin-induced pain response.sup.3,4

A polyethylene tube was inserted into a common right carotid artery of SD male rats (250 to 350 g) and 0.5 microngram per 0.1 ml of bradykinin was injected into the artery through said tube. Response induced by bradykinin such as flexin of the right forelimb, dextro-rotation of the head and rearing were considered as being indices of pain response, and the analgesic action of each test compound was determined by observing its inhibition of responses such symptoms.

Notes: (3) T. Abe, T. Kaneko and H. Takagi: Japan Pharm. Soc. Bul., 67, 9-14 (1971) (4) G. F. Blane: J. Pharma. Pharmacol., 19, 367 (1967)

(2) Antipyretic activity

A 2% suspension of dry yeast was injected subcutaneously to SD male rats of 250 to 300 g body weight in an amount of 2 ml/animal to cause a fever, and 4 hours later, the compounds of this invention and control drugs were administered orally. The rectal temperature of each rat was measured periodically, and the dosage of each compound required to reduce the fever by more than 1.degree. C. at the peak of its activity was determined.

(3) Antiphlogistic activity.sup.5

Each test compound of this invention was administered orally to Wistar rats of about 300 g body weight, and 30 minutes later 0.05 ml of a 1% carrageenin solution was injected into a paw of each rat. After three hours, the paw volume was measured to determine the degree of edema formation and the 30% effective dose (ED.sub.30) was calculated from the inhibition rate relative to a control group.

Note: (5) R. Vinegar et al: J. Pharmacol. Exp. Ther., 166, 96 (1969)

(4) Acute toxicity

The acute toxicity of the compounds of the invention was examined using ddy male mice and SD male rats, and the 50% lethal dose (LD.sub.50) was determined. Ten mice were used for each dose and morality was determined for 3 days after administration of each test compound of the invention. In the case of the rats, 5 rats were used for each dose and morality was determined 7 days after administrations.

2A. Test compounds of formula (II)

Compound A: 7-(4-(4-p-fluorophenylpiperazinyl-(1))-n-butyl)theophylline.2HCl ##STR19## Compound B: 7-(5-(4-p-chlorophenylpiperazinyl-(10))-n-pentyl)theophylline.2HCl ##STR20## Compound C: 7-(3-(4-(3,4-dimethylphenyl)piperazinyl-(1))-n-propyl)theophylline.2HCl ##STR21## Compound D: 7-(4-(4-p-chlorophenylpiperazinyl-(1))-n-butyl)theophylline.2HCl ##STR22## Compound E: 7-(4-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-butyl)theophylline.2HCl ##STR23## Compound F: 7-(5-(4-m-trifluoromethylphenylpiperazinyl-(1))-n-pentyl)theophylline.2HCl ##STR24##

In the above structural formulae, Ty stands for ##STR25## Control drug I: Mepirizole (4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine)

Control drug II: Thiaramide (4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol) Control drug III: Perisoxal (3-(1-hydroxy-2-piperadinoethyl)-5-phenyl-isoxazole)

2B. Test compounds of Formula (I)

Compound A': 1-(3-(4-(3,4-dichlorophenyl)piperazinyl-(1))-n-propyl)theobromine ##STR26## Compound B': 1-(2-(4-(2,3-dimethylphenyl)piperazinyl-(1))-ethyl)theobromine.2HCl ##STR27## Compound C': 1-(3-(4-o-chlorophenylpiperazinyl-(1))-n-propyl)theobromine.2HCl ##STR28## Compound D': 1-(4-(4-o-methoxyphenylpiperazinyl-(1))-n-butyl)theobromine.2HCl ##STR29## Compound E': 1-(4-(4-p-fluoropenylpiperazinyl-(1))-n-butyl)theobromine.2HCl ##STR30## Compound F': 1-(4-(4-(3,4-dichlorophenyl)piperazinyl-(1))-n-butyl)theobromine.2HCl ##STR31## Compound G': 1-(5-(4-m-methylphenylpiperazinyl-(1))-n-pentyl)theobromine.2HCl ##STR32##

In the above structural formulae, Tb stands for the following formula: ##STR33##

3. Results

(1) Analgesic activity and acute toxicity

The analgesic activity (ED.sub.50), 50% lethal dose (LD.sub.50) and safety margin (LD.sub.50 /ED.sub.50) as determined in the tests on the mice for compounds A to F are shown in Table 1.

It is clear from Table 1 that the compounds of formula (II) used in this invention, as compared with the control drugs, have a strong analgesic activity (2.5 to 24 times that of the control drugs) and also have a wide safety margin.

Table 2 shows the analgesic activity (ED.sub.50), 50% lethal dose (LD.sub.50) and safety margin (LD.sub.50 /ED.sub.50) as determined in the tests on the rats for compounds A to F.

It is apparent from Table 2 that the compounds of formula (II) of this invention, as compared with the control drugs, have a strong analgesic activity more than 3 times that of the control drugs.

TABLE 1______________________________________ Analgesic Acute activity ED.sub.50 toxicity LD.sub.50 Safety marginTest compounds mg/kg p.o. mg/kg p.o. (LD.sub.50 /ED.sub.50)______________________________________Compound A 10 344 34Compound B 13.8 704 51Compound C 13.3 800.ltoreq. 60<Compound D 26.0 575 22Compound F 14.5 408 28Compound F 27.1 800.ltoreq. 30.ltoreq.Control drug I 240 1,022* 4.3Control drug II 66 664* 8.5Control drug III 120 612* 5.1______________________________________ Note *LD.sub.50 's of control drugs I, II and III are those given in Japan National Formulary, 6th Ed. (1982). TABLE 2______________________________________ Analgesic Acute activity ED.sub.50 toxicity LD.sub.50 Safety marginTest compounds mg/kg p.o. mg/kg p.o. (LD.sub.50 /ED.sub.50)______________________________________Compound A 47 353-500 7.5-10.6Compound B 40 353-500 8.8-12.5Compound C 57 770 13.6Compound D 68 505 7.6Compound E 66 353-500 7.6-5.3Compound F 63 660 10.5Control drug I 160.ltoreq. 526* 3.gtoreq.Control drug II 160.ltoreq. 3,600* 23.gtoreq.Control drug III 160 1,978* 12______________________________________ Note *LD.sub.50 's of the control drug I, II and III are those given in Japan National Formulary, 6th Ed. (1982).

The analgesic activity (ED.sub.50), 50% lethal dose (LD.sub.50) and safety margin (LD.sub.50 /ED.sub.50) as determined in the tests on the mice for compounds A' to G' are shown in Table 3.

It is clear from Table 3 that the compounds of formula (I) used in this invention, as compared with the control drugs, also have a strong analgesic activity (2 to 90 times that of the control drugs) and have a wide safety margin.

Table 4 shows the analgesic activity (ED.sub.50), 50% lethal dose (LD.sub.50) and safety region (LD.sub.50 /ED.sub.50) as determined in the tests on the rats for compounds A'-G'.

It is apparent from Table 4 that the theobromine compounds for formula (I) of this invention, as compared with the control drugs, have a strong analgesic activity which is 4 to 8 times that of the control drugs. As a further unexpected result, it was observed that the theobromine compounds of formula (I) were several times more potent in their analgesic effects than the theophylline compounds of formula (II). For analgesic treatments according to this invention, it is therefore particularly preferred to use compounds of the formula (I), wherein R is a hydrogen atom and Z is ##STR34## with the proviso that at least one of X.sub.1 and X.sub.2 is not hydrogen.

TABLE 3______________________________________ Analgesic Acute activity ED.sub.50 toxicity LD.sub.50 Safety marginTest compounds mg/kg p.o. mg/kg p.o. (LD.sub.50 /ED.sub.50)______________________________________Compound A' 7.2 800< .phi.>Compound B' 2.6 600 230Compound C' 3.3 200 61Compound D' 3.1 400-800 130-258Compound E' 7.8 200 26Compound F' 7.8 400-800 51-103Compound G' 13.5 300 22Control drug I 240 1022* 4.3Control drug II 66 564* 8.5Control drug III 120 612* 5.1______________________________________ Note *LD.sub.50 's of control drugs I, II and III are those given Japan National Formulary, 6th Ed. (1982). TABLE 4______________________________________ Analgesic Acute activity ED.sub.50 toxicity LD.sub.50 Saftety marginTest compounds mg/kg p.o. mg/kg p.o. (LD.sub.50 /ED.sub.50)______________________________________Compound A' 40 2,000.ltoreq. 50.ltoreq.Compound B' 20 2,000.ltoreq. 100.ltoreq.Control drug I 160.ltoreq. 526* 3.gtoreq.Control drug II 160.ltoreq. 3,600* 23.gtoreq.Control drug III 160 1,978* 12______________________________________ Note *LD.sub.50 's of control drug I, II and III are those given in Japan National Formulary, 6th, Ed. (1982).

2. Antipyretic activity

The results for the test compounds of formula (II) are given in Table 5.

For compounds A to F, Table 5 shows that the compounds of formula (II) used in this invention showed an antipyretic activity at a dosage of from 10 to 40 mg/kg p.o. and are equal to or about 4 times as strong as the control drugs in antipyretic action.

TABLE 5______________________________________ ED*Test compounds mg/kg p.o.______________________________________Compound A 10Compound B 40Compound C 10Compound D 40Compound E 40Compound F 10Control drug I 40Control drug II 40Control drug III 160______________________________________ Note *Effective dose for reducing the fever by more than 1.degree. C. when the compound action is at the peak.

The results of examinations on Compound A', a typical compound of formula (I) of this invention, were that its effective dose ED* (mg/kg p.o.) for reducing the fever by more than 1.degree. C. at the peak of its activity was 40 mg/kg p.o. Comparing this with the similarly-determined ED values for the control drugs, 40 mg/kg p.o. for control drug I, 40 mg/kg p.o. for control drug II and 160 mg/kg p.o. for control drug III, it is noted that the antipyretic activity of Compound A' is equal to or about 4 times greater than the antipyretic activities of the control drugs.

As to the method of treating a fever according to the present invention, compounds of the formulas (I) and (II) wherein R is a hydrogen atom and Z is ##STR35## with the proviso that one of X.sub.1 and X.sub.2 is not hydrogen, are particularly preferred.

(3) Antiphlogistic activity

The results are given in Tables 6 and 7.

As seen from Table 6, the compounds of formula (II) of this invention showed an antiphlogistic activity at doses of from 10 to 50 mg/kg.

TABLE 6______________________________________ ED.sub.30Test compounds mg/kg p.o.______________________________________Compound A 10Compound B 50Compound D 25Compound E 25Compound F 25______________________________________

Table 7 shows that the compounds of formula (I) of this invention which were tested showed an antiphlogistic activity at doses of from 10 to 25 mg/kg. The foregoing dosage range is preferred but not critical to the method of treating inflammation and swelling of tissues according to the present invention.

TABLE 7______________________________________ ED.sub.30Test compounds mg/kg p.o.______________________________________Compound A' 25Compound C' 10Compound E' 25Compound G' 25______________________________________

Compounds of the formulas (I) and (II) wherein R is hydrogen, Z is ##STR36## and at least one of X.sub.1 and X.sub.2 is not hydrogen are preferred for use in the method of treating inflammation and swelling of tissues and/or bones and joints of the present invention.

As is apparent from the foregoing test results, the theophylline and theobromine derivatives used in this invention possess strong analgesic, antipyretic and antiphlogistic activities and are useful as antiphlogistic/antipyretic/analgesic agents, and thus the present invention is of high pharmaceutical value.

The compounds of this invention can be administered either perorally or parenterally, particularly intramuscularly, subcutaneously or intravenously. Effective dosages vary depending on the type of disease, the severity of the symptoms, age of the patient and other factors, but usually it is preferable, though not critical, to administer the compound in dosages of from about 1 to 1,000 mg, more preferably about 3 to 100 mg, per day for adult human beings.

The compounds used in this invention can be incorporated into any suitable pharmaceutical preparations, such as tablets, granules, powders, capsules, injection solutions, or suppositories, by the conventional methods known in the art of drug formulation.

When a peroral solid pharmaceutical is prepared, for instance, the active compound is mixed with an excipient and, if necessary, further mixed with other adjuncts, such as a binder, a disintegrator, a lubricant, a coloring agent, a taste and smell improver and the like, and the resulting mixture is then worked up into a suitable drug unit dosage form, such as a tablet, a coated tablet, granules, a powder, or a capsule in the conventional way.

As the excipient, there can be used, for example, lactose, corn starch, white sugar, dextrose, sorbitol, crystalline cellulose or the like, and as the binder, there can be used polyvinyl alcohol, polyvinyl ether, ethylcellulose, methylcellulose, gum arabic, tragacanth, gelatin, shellac, hydroxypropylcellulose, hydroxypropyl-starch, polyvinylpyrrolidone or the like. As the disintegrator, there can be used starch, agar-agar, gelatin powder, crystalline cellulose, calcium carbonate, sodium bicarbonate, calcium citrate, dextrin, pectin or the like, and as the lubricant, magnesium stearate, talc, polyethylene glycol, silica, hardened vegetable oils or the like can be used. As for the coloring agent, it is impossible to use any materials suitable for addition to drugs. As the taste and smell improver, there can be used cocoa powder, menthol, aromatic acids, peppermint oil, borneo camphor, cinnamon powder or the like. Tablet and granular preparations can be suitably coated with sugar, gelatin or the like.

For the preparation of injectable solutions, a pH adjuster, a buffer agent, a stabilizer, a preservative and other necessary adjuvants are added to the active ingredient, and the mixture may then be made into a desired type of injection solution, such as solutions for subcutaneous, intramuscular, or intravenous injection in the conventional way.

Synthesis examples of the present invention are given below.

SYNTHESIS EXAMPLE 1

7-(2-(4-p-Chlorobenzhydrylpiperazinyl-(1))ethyl)theophylline hydrochloride

6.3 g of 7-(2-bromoethyl)theophylline, 5.7 g of 1-(p-chlorobenzhydryl)piperazine and 4.0 g of triethylamine was stirred in benzene under reflux for 18.5 hours. The triethylamine hydrochloride formed was then filtered off and the filtrate was extracted with dilute hydrochloric acid. The extract was made alkaline with dilute sodium hydroxide and then further extracted with chloroform. The chloroform layer was washed with water and dried over anhydrous potassium carbonate. The solvent was distilled off and the resulting crude crystals were converted into the hydrochloride thereof by a conventional method and then recrystallized from methyl cellosolve and water to obtain 4.8 g of the product compound 7-(2-(4-p-chlorobenzhydrylpiperazinyl-(1))ethyl)theophylline hydrochloride (yield: 42.5%).

Melting point: 250.degree.-252.degree. C.

______________________________________Elemental analysis for C.sub.26 H.sub.29 O.sub.2 N.sub.6.2HCl: C H N______________________________________Calculated (%): 55.16 5.53 14.85Found (%): 55.19 5.38 14.87______________________________________

SYNTHESIS EXAMPLE 2

7-(4-(4-o-Methoxyphenylpiperazinyl-(1))-n-butyl)theophylline

6.9 g of 7-(4-bromo-n-butyl)theophylline, 3.8 g of 1-(o-methoxyphenyl)piperazine and 4.0 g of triethylamine were stirred in benzene under reflux for 18 hours and the mixture was then treated in the same way as in Synthesis Example 1, except that the hydrochloride conversion step was omitted. Recrystallization from ethanol gave 3.8 g of the product compound 7-(4-(4-o-methoxyphenylpiperazinyl-(1))-n-butyl)theophylline (yield: 37.6%).

Melting point: 117.degree.-118.degree. C.

______________________________________Elemental analysis for C.sub.22 H.sub.30 O.sub.3 N.sub.6 : C H N______________________________________Calculated (%): 61.94 7.10 19.71Found (%): 62.10 7.21 19.86______________________________________

SYNTHESIS EXAMPLE 3

7-(5-(4-(2,3-Dimethylphenyl)piperazinyl-(1))-n-pentyl)theophylline

9.9 g of 7-(5-bromo-n-pentyl)theophylline, 3.8 g of 1-(2,3-dimethylphenyl)piperazine and 4.0 g of triethylamine were stirred in toluene under reflux for 11.5 hours and then treated in the same manner as in Synthesis Example 1, except that the hydrochloride conversion step was omitted. Recrystallization from ethanol gave 4.3 g of the desired compound 7-(5-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-pentyl)theophylline.

Melting point: 115.degree.-117.degree. C.

______________________________________Elemental analysis for C.sub.24 H.sub.34 O.sub.2 N.sub.6 : C H N______________________________________Calculated (%): 65.71 7.38 19.16Found (%): 65.42 7.92 19.31______________________________________

SYNTHESIS EXAMPLE 4

7-(7-((3-Methyl-4-(m-methylphenyl))piperazinyl-(1))-n-heptyl)theophylline hydrochloride

7.8 g of 7-(7-bromoheptyl)theophylline, 3.8 g of N-(m-methylphenyl)-2-methylpiperazine and 4.0 g of triethylamine were stirred in toluene under reflux for 11 hours and the mixture was treated in the same manner as in Synthesis Example 1 to obtain 10 g of crude crystals. The crystals were purified by silica gel column chromatography and converted into a hydrochloride thereof by a conventional method to obtain 5.3 g of the desired compound 7-(7-((3-methyl-(4-m-methylphenyl))piperazinyl-(1))-n-heptyl)theophylline hydrochloride.

Melting point: 222.degree.-225.degree. C.

______________________________________Elemental analysis for C.sub.26 H.sub.38 O.sub.2 N.sub.6 Cl.sub.2.1/2H.sub.2 O: C H N______________________________________Calculated (%): 57.02 7.38 15.35Found (%): 57.00 7.88 15.20______________________________________

SYNTHESIS EXAMPLES 5-95

The compounds shown in Table 8 below were obtained by processes analogous to that of Synthesis Example 1. The compounds below are species according to general formula (II):

TABLE 8__________________________________________________________________________ ##STR37## Elemental analysis ExampleSynthesis zationRecrystalli- Melting point ##STR38##No. n X R Z solvent (.degree.C.) Molecular formula C (%) H N__________________________________________________________________________ (%)5 2 N H ##STR39## ethanol 228-234 (decomposed) C.sub.19 H.sub.24 O.sub.2 N.sub.6 2HCl 51.70 51.53 9.45 9.16 19.04 18.706 3 N H ##STR40## methanol 143-145 C.sub.20 H.sub.26 O.sub.2 62.79 62.66 6.87 6.90 21.98 22.017 4 N H ##STR41## ethanol 114-115 C.sub.21 H.sub.28 O.sub.2 63.60 63.61 7.13 7.25 21.20 21.348 5 N H ##STR42## ethanol/iso- propyl ether 112-113 C.sub.22 H.sub.30 O.sub.2 64.35 64.44 7.38 7.49 20.47 20.439 6 N H ##STR43## ethanol/iso- propyl ether 200-203 (decomposed) C.sub.23 H.sub.32 O.sub.2 N.sub.6 2HCl 55.52 55.26 6.90 6.71 16.90 16.5910 2 N H ##STR44## ethanol 149-150 C.sub.20 H.sub.26 O.sub.2 62.80 62.52 6.85 6.85 21.98 21.8111 3 N H ##STR45## ethanol 114-116 C.sub.21 H.sub.28 O.sub.2 63.60 63.26 7.13 7.21 21.20 20.7512 5 N H ##STR46## ethanol/iso- propyl ether 113-114 C.sub.23 H.sub.32 O.sub.2 65.05 65.08 7.61 7.80 19.80 19.7513 2 N H ##STR47## ethanol 121-122 C.sub.20 H.sub.26 O.sub.2 62.80 62.98 6.85 6.83 21.98 21.9714 4 N H ##STR48## ethanol 237-239 (decomposed) C.sub.22 H.sub.30 O.sub.2 N.sub.6 2HCl 54.66 54.57 6.67 6.69 17.39 17.4715 5 N H ##STR49## methanol 239-241 (decomposed) C.sub.23 H.sub.32 O.sub.2 N.sub.6 2HCl 55.30 55.32 6.87 6.90 16.83 16.9816 6 N H ##STR50## methanol 224-226 (decomposed) C.sub.24 H.sub.34 O.sub.2 N.sub.6 2HCl 56.35 56.05 7.09 7.10 16.43 16.4217 2 N H ##STR51## ethanol/iso- propyl ether 103-106 C.sub.21 H.sub.28 O.sub.2 63.61 63.64 7.12 7.03 21.20 21.0518 3 N H ##STR52## ethanol 116-118 C.sub.22 H.sub.30 O.sub.2 64.35 64.31 7.38 7.48 20.47 20.5219 4 N H ##STR53## ethanol 275-276 (decomposed) C.sub.23 H.sub.32 N.sub.6 O.sub.2.HCl 59.92 59.54 7.21 7.26 18.23 18.0520 5 N H ##STR54## ethanol 136-138 C.sub.24 H.sub.34 O.sub.2 65.71 66.00 7.83 7.94 19.16 19.1321 6 N H ##STR55## ethanol/iso- propyl ether 167-170 (decomposed) C.sub.25 H.sub.36 O.sub.2 N.sub.6 2HCl 57.14 56.75 7.30 7.50 15.99 16.4422 2 N H ##STR56## ethanol 151-152 C.sub.21 H.sub.28 O.sub.2 63.61 63.93 7.12 7.17 21.20 21.2623 3 N H ##STR57## methanol 153-155 C.sub.22 H.sub.30 O.sub.2 64.36 64.08 7.38 7.46 20.48 20.1024 4 N H ##STR58## ethanol 114-116 C.sub.23 H.sub.32 O.sub.2 65.05 64.63 7.61 7.53 19.80 19.7925 5 N H ##STR59## ethanol 115-117 C.sub.24 H.sub.34 O.sub.2 65.71 65.42 7.38 7.97 19.16 19.3126 2 N H ##STR60## ethanol 140-141 C.sub.21 H.sub.28 O.sub.2 63.61 63.46 7.12 6.96 21.20 21.1327 3 N H ##STR61## ethanol 128-129 C.sub.22 H.sub.30 O.sub.2 64.36 63.71 7.37 7.43 20.47 20.3428 4 N H ##STR62## ethanol 251-252 (decomposed) C.sub.23 H.sub.34 O.sub.2 N.sub.6 HCl 59.92 59.99 7.21 7.33 18.23 18.3329 5 N H ##STR63## ethanol/iso- propyl ether 80-83 C.sub.24 H.sub.34 O.sub.2 N.sub.6 1/2HCl 64.39 64.63 7.90 7.92 18.78 19.2630 2 N H ##STR64## methyl cellosolve 272-273 (decomposed) C.sub.20 H.sub.26 O.sub.3 N.sub.6 2HCl 50.95 50.76 6.00 5.68 17.83 17.5231 3 N H ##STR65## methanol 240-243 (decomposed) C.sub.21 H.sub.28 O.sub.3 N.sub.6 2HCl 51.95 51.76 6.24 6.15 17.31 16.9832 4 N H ##STR66## ethanol 117-118 C.sub.22 H.sub.30 O.sub.3 61.94 62.10 7.10 7.21 19.71 19.8633 5 N H ##STR67## ethanol 120-121 C.sub.23 H.sub.32 O.sub.3 N.sub.6.H.sub.2 O 60.23 60.50 7.49 7.20 18.33 18.3734 6 N H ##STR68## ethanol/iso- propyl ether 213-215 (decomposed) C.sub.24 H.sub.34 O.sub.3 N.sub.6 2HCl 54.63 54.61 6.89 6.58 15.93 15.4935 2 N H ##STR69## methyl cellosolve 170-171 C.sub.20 H.sub.26 O.sub.3 60.28 60.58 6.58 6.63 21.09 21.1436 3 N H ##STR70## methyl cellosolve 161-163 C.sub.21 H.sub.28 O.sub.3 61.13 61.12 6.85 6.85 20.38 20.5837 4 N H ##STR71## methanol 211-212 (decomposed) C.sub.22 H.sub.30 O.sub.3 N.sub.6 HCl 57.07 56.99 6.75 6.64 18.15 18.0538 5 N H ##STR72## ethanol 120-121 C.sub.23 H.sub.32 O.sub.3 N.sub.6 H.sub.2 O 60.23 60.50 7.49 7.20 18.33 18.3739 6 N H ##STR73## ethanol 208-210 (decomposed) C.sub.24 H.sub.34 O.sub.3 N.sub.6 2HCl 54.64 54.51 6.88 6.91 15.93 15.9940 2 N H ##STR74## ethanol 155-156 C.sub.20 H.sub.26 O.sub.3 60.28 60.12 6.58 6.59 21.09 21.0541 3 N H ##STR75## methyl cellosolve 165-167 C.sub.21 H.sub.28 O.sub.3 61.13 61.18 6.85 6.92 20.38 20.2642 4 N H ##STR76## ethanol 115-116 C.sub.22 H.sub.30 O.sub.3 61.94 61.77 7.10 7.20 19.71 19.4643 5 N H ##STR77## ethanol 127-129 C.sub.23 H.sub.32 O.sub.3 62.69 7.33 7.33 19.08 19.4144 2 N H ##STR78## ethanol/meth- yl cello- solve 161-162 C.sub.19 H.sub.23 O.sub.2 N.sub.6 Cl 56.64 56.79 5.77 5.60 20.86 20.9345 3 N H ##STR79## ethanol 121-122 C.sub.20 H.sub.25 O.sub.2 N.sub.6 Cl 57.61 57.64 6.06 5.97 20.16 20.2346 5 N H ##STR80## acetone 117-119 C.sub.22 H.sub.29 O.sub.2 N.sub.6 Cl 59.37 59.53 6.58 6.80 18.89 19.1147 2 N H ##STR81## methyl cellosolve 134-136 C.sub.19 H.sub.23 O.sub.2 N.sub.6 Cl 56.63 56.86 5.77 5.93 20.86 20.6348 3 N H ##STR82## ethanol 109-111 C.sub.20 H.sub.25 O.sub.2 N.sub.6 Cl 57.61 57.55 6.06 6.35 20.16 19.0049 4 N H ##STR83## isopropanol/ isopropyl ether 96-98 C.sub.21 H.sub.27 O.sub.2 N.sub.6 Cl 58.52 58.82 6.33 6.41 19.51 19.2650 5 N H ##STR84## ethanol/ methanol 151-154 C.sub.22 H.sub.31 O.sub.2 N.sub.6 l.1/2H.sub.2 O 50.04 50.02 6.13 6.17 16.23 15.9351 2 N H ##STR85## methyl cellosolve 167-169 C.sub.19 H.sub.23 O.sub.2 N.sub.6 Cl 56.63 56.66 5.77 5.81 20.86 20.9152 3 N H ##STR86## methyl cellosolve 241-244 (decomposed) C.sub.20 H.sub.25 O.sub.2 N.sub.6 Cl .2HCl 49.03 48.66 5.57 5.20 17.16 16.8453 4 N H ##STR87## ethanol 107-109 C.sub.21 H.sub.27 O.sub.2 N.sub.6 Cl 58.52 58.77 6.33 6.38 19.50 19.4454 5 N H ##STR88## isopropanol/ ether 127-130 C.sub.22 H.sub.29 O.sub.2 N.sub.6 Cl .2HCl 51.01 50.49 6.05 6.20 16.23 16.0255 6 N H ##STR89## methanol 110-111 C.sub.23 H.sub.31 O.sub.2 N.sub.6 Cl 60.17 60.20 6.82 6.96 18.31 18.6856 2 N H ##STR90## methyl cellosolve 146-147 C.sub.19 H.sub.22 O.sub.2 N.sub.6 Cl.sub.2 52.18 52.23 5.07 4.95 19.22 19.3957 3 N H ##STR91## methyl cellosolve 124-126 C.sub.20 H.sub.24 O.sub.2 N.sub.6 Cl.sub.2 53.21 53.50 5.37 5.32 18.62 18.5258 4 N H ##STR92## methanol 130-132 C.sub.21 H.sub.26 O.sub.2 N.sub.6 Cl.sub.2 54.19 54.44 5.64 5.73 18.06 18.2159 3 N H ##STR93## methanol 128-129 C.sub.20 H.sub.25 O.sub.2 N.sub.6 F 59.97 59.94 6.30 6.31 20.99 21.1260 4 N H ##STR94## methanol 223-226 (decomposed) C.sub.21 H.sub.27 O.sub.2 N.sub.6 F .2HCl 51.74 51.65 6.00 5.84 17.25 16.9461 5 N H ##STR95## ethanol/ methanol 140-141 C.sub.22 H.sub.29 O.sub.2 N.sub.6 F 61.65 61.32 6.83 6.77 19.61 19.6762 3 N H ##STR96## methanol 115-116 C.sub.21 H.sub.25 O.sub.2 N.sub.6 F.sub.3 55.98 56.46 5.60 18.66 19.2663 4 N H ##STR97## ethanol/iso- propyl ether 215-218 C.sub.22 H.sub.27 O.sub.2 N.sub.6 F.sub.3 .2HCl 49.16 49.25 5.26 5.42 15.64 16.2164 5 N H ##STR98## ethanol/iso- propyl ether 114-115 C.sub.23 H.sub.29 O.sub.2 N.sub.6 F.sub.3 57.72 57.55 6.12 6.13 17.56 17.7165 2 N H ##STR99## methanol 153-155 C.sub.18 H.sub.23 O.sub.2 58.51 58.48 6.29 6.38 26.54 26.2266 3 N H ##STR100## ethanol 139-140 C.sub.19 H.sub.25 O.sub.2 59.50 59.52 6.58 6.65 25.57 25.8067 4 N H ##STR101## ethanol 120-121 C.sub.20 H.sub.27 O.sub.2 60.42 60.14 6.06 24.67 24.4068 5 N H ##STR102## ethanol/iso- propyl ether 102-104 C.sub.21 H.sub.20 O.sub.2 61.28 61.26 7.12 7.11 23.83 23.6669 6 N H ##STR103## ethanol 96-97 C.sub.22 H.sub.31 O.sub.2 62.08 62.01 7.36 7.46 23.04 23.3570 3 N H ##STR104## methyl cellosolve 252-254 C.sub.27 H.sub.32 O.sub.2 N.sub.6 2HCl 59.44 59.28 6.29 6.42 15.41 15.5971 4 N H ##STR105## ethanol/ methanol 238-240 C.sub.28 H.sub.34 O.sub.2 N.sub.6 2HCl 60.09 59.14 6.50 6.48 15.02 14.9372 5 N H ##STR106## methyl 115-117 (decomposed) C.sub.29 H.sub.36 O.sub.2 69.56 69.87 7.26 7.39 16.79 16.7073 6 N H ##STR107## ethanol 212-214 C.sub.30 H.sub.38 O.sub.2 N.sub.6 2HCl 61.30 61.27 6.87 7.04 14.30 14.5174 2 N H ##STR108## methyl cellosolve 250-252 C.sub.26 H.sub.29 O.sub.2 N.sub.6 Cl .2HCl 55.16 55.19 5.53 5.38 14.85 14.8775 3 N H ##STR109## methyl cellosolve 222 (decomposed) C.sub.27 H.sub.31 O.sub.2 N.sub.6 Cl .2HCl.H.sub.2 O 54.22 53.64 5.91 5.92 14.06 14.0976 4 N H ##STR110## methanol 208-210 C.sub.28 H.sub.33 O.sub.2 N.sub.6 Cl .2HCl 56.61 56.97 5.95 6.04 14.15 13.9277 5 N H ##STR111## ethanol/iso- propyl ether 117-119 C.sub.29 H.sub.35 O.sub.2 N.sub.6 Cl 65.08 65.23 6.60 6.64 15.70 16.0278 6 N H ##STR112## ethanol 201-203 C.sub.30 H.sub.37 O.sub.2 N.sub.6 Cl .2HCl.1/2H.sub.2 O 57.09 57.00 6.40 6.54 13.32 13.9079 2 N CH.sub.3 ##STR113## ethanol 128-130 C.sub.20 H.sub.26 O.sub.2 62.80 62.73 6.85 6.87 21.98 21.9180 4 N CH.sub.3 ##STR114## isopropanol 99-100 C.sub.22 H.sub.30 O.sub.2 64.36 64.51 7.37 7.47 20.47 20.8781 N CH.sub.3 ##STR115## acetone/iso- propyl ether 111-113 C.sub.21 H.sub.28 O.sub.2 63.28 63.74 7.09 7.12 21.09 21.3582 2 N CH.sub.3 ##STR116## ethanol 117-118 C.sub.21 H.sub.29 N.sub.6 61.14 61.00 6.84 6.94 20.38 20.2383 5 N CH.sub.3 ##STR117## isopropanol 85-87 C.sub.24 H.sub.35 O.sub.3 63.82 63.56 6.93 7.69 18.61 18.6384 2 C H ##STR118## methanol 155-156 C.sub.20 H.sub.25 O.sub.2 65.36 65.69 6.87 6.00 19.06 19.1785 3 C H ##STR119## methyl cellosolve 157-159 C.sub.21 H.sub.27 O.sub.2 66.10 66.05 7.15 7.16 18.36 18.5586 4 C H ##STR120## ethanol 117-118 C.sub.22 H.sub.29 O.sub.2 66.80 67.01 7.40 7.51 17.71 17.7087 7 N CH.sub.3 ##STR121## ethanol/iso- propyl ether 200-204 C.sub.25 H.sub.35 O.sub.2 N.sub.6 l.HCl.H.sub.2 O 55.44 55.36 7.09 6.88 15.52 15.9288 7 N H ##STR122## hydrous methanol 239-241 C.sub.26 H.sub.38 O.sub.2 N.sub.6 2HCl.1/2H.sub.2 O 57.02 57.46 7.38 7.45 15.35 15.7789 8 N H ##STR123## hydrous ethanol 181-183 C.sub.27 H.sub.40 N.sub.6 O.sub.2 2HCl 58.79 58.71 7.68 7.58 15.24 15.2290 5 N H ##STR124## ethanol/iso- propyl ether 112-114 C.sub.22 H.sub.28 O.sub.2 N.sub.6 2HCl 55.11 55.09 5.90 5.93 17.53 17.3191 7 N H ##STR125## hydrous methanol 223-226 (decomposed) C.sub.25 H.sub.35 O.sub.2 N.sub.6 Cl .2HCl 53.90 53.49 6.17 6.60 15.09 15.5092 10 N H ##STR126## ethanol 207-209 (decomposed) C.sub.28 H.sub.42 O.sub.3 N.sub.6 2HCl 57.71 57.76 7.45 7.91 14.43 14.1193 10 N H ##STR127## ethanol 211-213 (decomposed) C.sub.28 H.sub.41 O.sub.2 N.sub.6 Cl .HCl 59.45 59.31 7.50 7.50 14.80 14.6994 10 N CH.sub.3 ##STR128## methanol/iso- propyl ether 211-214 (decomposed) C.sub.29 H.sub.44 O.sub.2 N.sub.6 2HCl.2H.sub.2 O 56.38 56.12 8.17 7.76 13.60 13.4695 10 N H ##STR129## methanol/iso- propyl ether 187-190 (decomposed) C.sub.29 H.sub.44 O.sub.2 N.sub.6 2HCl 59.87 59.42 7.99 7.96 14.45 14.09__________________________________________________________________________

SYNTHESIS EXAMPLE 96

1-(4-(4-(2,3 Dimethylphenyl)piperazinyl-(1))-n-butyl)theobromine

9.5 g of 1-(4-bromo-n-butyl)theobromine, 3.8 g of N-(2,3-dimethylphenyl)piperazine and 4.0 g of triethylamine were stirred in toluene under reflux for 13 hours. The triethylamine hydrochloride formed was then filtered off and the filtrate was extracted with dilute hydrochloric acid. The extract was then made alkaline with dilute sodium hydroxide and extracted with chloroform. The chloroform layer was then washed with water and dried over anhydrous calcium carbonate. The solvent was distilled off and the resulting crude crystals were recrystallized from methyl cellosolve to yield 3.7 g of the product compound 1-(4-(4-(2,3-dimethylphenyl)piperazinyl-(1))-n-butyl)theobromine (yield: 43.64%).

Melting point: 134.degree.-135.degree. C.

______________________________________Elemental analysis for C.sub.23 H.sub.32 O.sub.2 N.sub.6 : C H N______________________________________Calculated (%): 65.05 7.61 19.80Found (%): 65.11 7.72 19.46______________________________________

SYNTHESIS EXAMPLE 97

1-(5-(4-Benzhydrylpiperazinyl-(1))-n-pentyl)theobromine hydrochloride

7.9 g of 1-(5-bromo-n-pentyl)theobromine, 5.0 g of N-benzylhydrylpiperazine and 4 g of triethylamine were stirred in toluene under reflux for 30 hours, and the mixture was then subjected to the same treatment as in Synthesis Example 96. The resulting crude crystals were converted into a hydrochloride by a known method and the latter was recrystallized from isopropyl alcohol to obtain 4.9 g of the desired compound 1-(5-(4-benzhydrylpiperazinyl-(1))-n-pentyl)theobromine hydrochloride (yield: 40.9%).

Melting point: 262.degree.-264.degree. C. (decomposed)

______________________________________Elemental analysis for C.sub.29 H.sub.36 O.sub.2 N.sub.6.2HCl: C H N______________________________________Calculated (%): 60.93 6.71 14.71Found (%): 60.57 7.15 14.65______________________________________

SYNTHESIS EXAMPLE 98

1-(7-(4-o-Methoxyphenylpiperazinyl-(1))-n-heptyl)theobromine

7.5 g of 1-(7-bromo-n-heptyl)theobromine, 3.8 g of N-o-methoxyphenylpiperazine and 4.0 g of triethylamine were stirred in toluene under reflux for 11.5 hours, and treated in the same manner as in Synthesis Example 96 to obtain crude crystals. The crystals were purified by silica gel chromatography to obtain 4.6 g of the product compound 1-(7-(4-o-methoxyphenylpiperazinyl-(1))-n-heptyl)theobromine (yield: 49.1%).

Melting point: 97.degree.-98.degree. C.

______________________________________Elemental analysis for C.sub.25 H.sub.36 O.sub.3 N.sub.6 : C H N______________________________________Calculated (%): 64.08 7.74 17.94Found (%): 60.46 6.43 21.15______________________________________

SYNTHESIS EXAMPLE 99

1-(2-(4-p-Methoxyphenylpiperazinyl-(1))ethyl)theobromine

6.9 g of 1-(2-bromoethyl)theobromine, 3.8 g of N-p-methoxyphenylpiperazine and 4.0 g of triethylamine were stirred in benzene under reflux. The triethylamine hydrochloride formed was filtered off and the filtrate was then extracted with dilute hydrochloric acid. The resulting extract was made alkaline with dilute sodium hydroxide and further extracted with chloroform. The resulting chloroform layer was washed with water and dried over anhydrous calcium carbonate. The solvent was then distilled off and the resulting crude crystals were recrystallized from methanol to obtain 4.9 g of the product substance 1-(2-(4-p-methoxyphenylpiperazinyl-(1))-ethyl)theobromine (yield: 61.3%).

Melting point: 157.degree.-159.degree. C.

______________________________________Elemental analysis for C.sub.20 H.sub.26 O.sub.3 N.sub.6 : C H N______________________________________Calculated (%): 60.27 6.59 21.09Found (%): 60.46 6.43 21.15______________________________________

SYNTHESIS EXAMPLE 100

1-(3-(4-o-Methylphenylpiperazinyl-(1))-n-propyl)theobromine

7.2 g of 1-(3-bromo-n-propyl)theobromine, 3.5 g of N-o-methylphenylpiperazine and 4.0 g of triethylamine were stirred in a benzene solvent under reflux for 16 hours and the mixture was treated in the same way as in Synthesis Example 99. The resulting crude crystals were recrystallized from ethanol to obtain 6.3 g of the objective compound 1-(3-(4-o-methylphenylpiperazinyl-(1))-n-propyl)theobromine (yield: 91.3%).

Melting point: 152.degree.-154.degree. C.

______________________________________Elemental analysis for C.sub.21 H.sub.28 O.sub.2 N.sub.6 : C H N______________________________________Calculated (%): 63.60 7.13 21.20Found (%): 63.40 7.20 21.31______________________________________

SYNTHESIS EXAMPLE 101

1-(4-(4-p-Chlorobenzylhomopiperazinyl-(1))-n-butyl)theobromine

7.5 g of 1-(4-bromo-n-butyl)theobromine, 4.5 g of N-p-chlorobenzylhomopiperazine and 4.0 g of triethylamine were stirred in a benzene solvent under reflux and then treated in the same manner as in Synthesis Example 4. To the obtained oily substance was added isopropyl ether and left under ice cooling to have it crystallized. The formed crude crystals were recrystallized from ethanol to obtain 5.8 g of 1-(4-(4-p-chlorobenzylhomopiperazinyl-(1))-n-butyl)theobromine (yield: 67.5%).

Melting point: 71.degree.-73.degree. C.

______________________________________Elemental analysis for C.sub.23 H.sub.31 O.sub.2 N.sub.6 Cl: C H N______________________________________Calculated (%): 60.17 6.82 18.31Found (%): 59.94 6.86 18.43______________________________________

SYNTHESIS EXAMPLE 102

1-(5-(4-piperidoneethyleneketal)yl-(1))-n-pentyl)theobromine

7.9 g of 1-(5-bromo-n-pentyl)theobromine, 3.5 g of 4-piperidone ethylene ketal and 4.0 g of triethylamine were stirred in a benzene solvent under reflux and the reaction mixture was washed with water and dried over anhydrous potassium carbonate. The solvent was distilled off and the resulting crude crystals were recrystallized from acetone/isopropyl to obtain 5.3 g of the objective compound 1-(5-(4-(piperidoneethyleneketal)yl-(1))-n-pentyl)theobromine (yield: 69.0%).

Melting point: 95.degree.-96.degree. C.

______________________________________Elemental analysis for C.sub.19 H.sub.29 O.sub.4 N.sub.5 : C H N______________________________________Calculated (%): 58.29 7.48 17.88Found (%): 58.06 7.54 18.02______________________________________

SYNTHESIS EXAMPLES 103 TO 193

The compounds shown in Table 9 were obtained using procedures similar to the procedures used in Synthesis Example 96.

TABLE 9__________________________________________________________________________ ##STR130## Example No.Synthesis n R Z (.degree.C.)pointMelting Molecular formula ##STR131##__________________________________________________________________________103 6 H ##STR132## 197-198 (decomposed) C.sub.24 H.sub.34 N.sub.6 O.sub.2.2HCl.2H.sub .2 O 52.65 52.64 7.01 7.10 15.35 15.28104 2 H ##STR133## 251 (decomposed) C.sub.20 H.sub.26 O.sub.2 N.sub.6.2HCl 52.75 52.41 6.21 6.11 18.46 18.31105 5 H ##STR134## 133-135 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 65.03 7.61 7.62 19.80 19.82106 6 H ##STR135## 206-208 (decomposed) C.sub.24 H.sub.34 O.sub.2 N.sub.6.2HCl.2H.sub .2 O 52.65 53.10 7.01 6.91 15.35 15.44107 2 H ##STR136## 151-153 C.sub.21 H.sub.28 O.sub.2 N.sub.6 63.60 63.60 7.13 7.05 21.20 21.28108 3 H ##STR137## 154-156 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.36 64.13 7.37 7.49 20.47 20.32109 4 H ##STR138## 124-126 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 65.03 7.61 7.61 19.80 19.82110 5 H ##STR139## 121-123 C.sub.24 H.sub.34 O.sub.2 N.sub.6 65.71 65.68 7.38 7.73 19.16 19.36111 2 H ##STR140## 161-162 C.sub.21 H.sub.28 O.sub.2 N.sub.6 63.60 63.67 7.13 7.07 21.20 21.16112 3 H ##STR141## 124-126 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.36 63.65 7.37 7.20 20.47 20.32113 4 H ##STR142## 134-135 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 65.11 7.61 7.72 19.80 19.46114 5 H ##STR143## 118-120 C.sub.24 H.sub.34 O.sub.2 N.sub.6 65.71 65.65 7.38 7.95 19.16 18.94115 6 H ##STR144## 91-93 C.sub.25 H.sub.30 O.sub.2 N.sub.6 66.34 65.84 8.02 8.31 18.57 18.50116 2 H ##STR145## 139-141 C.sub.21 H.sub.28 O.sub.2 N.sub.6 63.61 63.73 7.12 7.30 21.20 21.21117 3 H ##STR146## 137-139 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.36 64.19 7.37 7.44 20.47 20.36118 4 H ##STR147## 148-150 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 64.44 7.61 7.52 19.80 19.70119 5 H ##STR148## 99-101 C.sub.24 H.sub.34 O.sub.2 N.sub.6 65.71 65.33 7.38 7.79 19.16 19.12120 6 H ##STR149## 89-90 C.sub.25 H.sub.36 O.sub.2 N.sub.6 66.33 66.26 8.03 8.21 18.57 18.24121 5 H ##STR150## 165-166 (decomposed) C.sub.23 H.sub.32 O.sub.3 N.sub.6.HCl 57.91 57.81 6.97 7.19 17.62 17.21122 6 H ##STR151## 79-81 C.sub.24 H.sub.34 O.sub.3 N.sub.6 63.40 63.35 7.55 7.70 18.49 18.69123 2 H ##STR152## 122-124 C.sub.19 H.sub.23 O.sub.2 N.sub.6 Cl 56.63 56.67 5.77 5.67 20.86 21.19124 4 H ##STR153## 111-113 C.sub.21 H.sub.27 O.sub.2 N.sub.6 Cl.1/2H.sub .2 O 57.33 57.53 6.65 6.29 19.10 19.14125 6 H ##STR154## 106-107 C.sub.23 H.sub.31 O.sub.2 N.sub.6 Cl 60.17 60.21 6.82 6.97 18.31 18.63126 2 CH.sub.3 ##STR155## 176-178 C.sub.20 H.sub.26 O.sub.2 N.sub.6 62.79 63.19 6.87 6.89 21.98 22.03127 3 CH.sub.3 ##STR156## 126-128 C.sub.21 H.sub.28 O.sub.2 N.sub.6 63.61 63.56 7.12 7.28 21.20 21.54128 4 CH.sub.3 ##STR157## 120-122 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.35 64.81 7.38 7.47 20.47 20.37129 5 CH.sub.3 ##STR158## 102-104 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.07 65.10 7.60 7.77 19.80 19.82130 6 CH.sub.3 ##STR159## 101-103 C.sub.24 H.sub.34 O.sub.2 N.sub.6 65.71 65.64 7.38 7.95 19.16 19.19131 2 CH.sub.3 ##STR160## 118-119 C.sub.21 H.sub.28 O.sub.3 N.sub.6.1/2H.sub.2 O 60.27 60.73 6.28 6.81 20.09 20.15132 3 CH.sub.3 ##STR161## 142-143 C.sub.22 H.sub.30 O.sub.3 N.sub.6 61.95 61.95 7.09 7.13 19.71 19.91133 4 CH.sub.3 ##STR162## 108-110 C.sub.23 H.sub.32 O.sub.3 N.sub.6 62.70 62.84 7.32 7.39 19.08 19.24134 3 H ##STR163## 162-163 C.sub.20 H.sub.24 O.sub.2 N.sub.6 Cl.sub.2 53.21 53.11 5.37 18.62 18.62135 4 H ##STR164## 140-142 C.sub.21 H.sub.26 O.sub.2 N.sub.6 Cl.sub.2 54.19 54.24 5.64 5.71 18.06 17.91136 5 H ##STR165## 132-134 C.sub.22 H.sub.28 O.sub.2 N.sub.6 Cl.sub.2 55.11 55.03 5.90 5.86 17.53 17.65137 6 H ##STR166## 144-145 C.sub.23 H.sub.30 O.sub.2 N.sub.6 Cl.sub.2 55.57 56.04 6.14 6.32 17.03 17.09138 2 H ##STR167## 175-176 C.sub.26 H.sub.30 O.sub.2 N 68.10 68.20 6.59 6.57 18.33 18.50139 3 H ##STR168## 150-151 C.sub.27 H.sub.32 O.sub.2 N.sub.6 68.62 68.66 6.83 17.79 17.85140 4 H ##STR169## 163-165 C.sub.28 H.sub.34 O.sub.2 N.sub.6 69.10 68.96 7.06 7.00 17.27 17.22141 5 H ##STR170## 262-264 C.sub.29 H.sub.36 O.sub.2 N.sub.6.2HCl 60.93 60.57 6.71 7.15 14.71 14.65142 2 H ##STR171## 228-230 (decomposed) C.sub.26 H.sub.29 O.sub.2 N.sub.6 Cl.2HCl.H.s ub.2 O 53.48 54.05 5.70 5.45 14.40 14.35143 3 H ##STR172## 194-195 (decomposed) C.sub.27 H.sub.31 O.sub.2 N.sub.6 Cl.2HCl.2H. sub.2 O 52.64 53.21 5.74 5.95 13.64 13.74144 4 H ##STR173## 142-144 C.sub.28 H.sub.33 O.sub.2 N.sub.6 Cl 64.53 64.76 6.40 6.52 16.13 16.16145 5 H ##STR174## 85-87 C.sub.29 H.sub.35 O.sub.2 N.sub.6 Cl.2HCl 57.47 56.96 6.17 6.68 13.87 13.73146 6 H ##STR175## 85-88 C.sub.30 H.sub.37 O.sub.2 N.sub.6 Cl.2HCl 57.92 57.56 6.33 6.69 13.51 13.14147 7 H ##STR176## 81-83 C.sub.24 H.sub.33 O.sub.2 N.sub.6 F 63.12 62.69 7.30 7.33 18.41 18.33148 7 H ##STR177## 90-91 C.sub.25 H.sub.36 O.sub.2 N.sub.6 66.34 66.24 8.02 8.03 18.57 18.54149 3 H ##STR178## 252-253 (decomposed) C.sub.20 H.sub.25 N.sub.6 O.sub.2 Cl.HCl.1/2H .sub.2 O 51.96 51.98 5.89 6.11 18.18 18.17150 8 H ##STR179## 173-177 C.sub.26 H.sub.38 N.sub.6 O.sub.3.2HCl.H.sub. 2 O 54.44 54.19 7.38 7.37 14.65 14.67151 8 H ##STR180## 228-230 C.sub.27 H.sub.40 N.sub.6 O.sub.2.HCl 62.95 62.91 8.62 8.04 16.32 16.41152 10 H ##STR181## 147-150 C.sub.29 H.sub.44 N.sub.6 O.sub.2.2HCl.H.sub. 2 O 58.08 58.28 8.07 8.08 14.02 13.94153 10 CH.sub.3 ##STR182## 154-157 C.sub.29 H.sub.44 N.sub.6 O.sub.3.2HCl.1/2H.s ub.2 O 57.44 57.32 7.81 7.92 13.86 13.84154 4 H ##STR183## 221-222 (decomposed) C.sub.22 H.sub.30 N.sub.6 O.sub.3.2HCl.H.sub. 2 O 51.06 50.93 6.43 6.53 16.24 16.23155 4 H ##STR184## 205-206 (decomposed) C.sub.21 H.sub.26 N.sub.6 O.sub.2 Cl.sub.2.HC l.H.sub.2 O 48.51 48.25 5.62 5.62 16.17 16.22156 2 H ##STR185## 164-166 C.sub.20 H.sub.26 O.sub.3 N.sub.6 60.27 60.45 6.59 6.53 21.09 20.97157 2 H ##STR186## 145-146 C.sub.20 H.sub.26 O.sub.3 N.sub.6 60.27 60.33 6.59 6.66 21.09 21.10158 2 H ##STR187## 115-117 C.sub.20 H.sub.26 O.sub.2 N.sub.6 62.79 62.63 6.87 7.04 21.98 21.83159 2 H ##STR188## 199-200 C.sub.19 H.sub.23 O.sub.2 N.sub.6 Cl 56.63 56.61 5.77 5.79 20.86 20.83160 2 H ##STR189## 171-172 C.sub.19 H.sub.25 O.sub.2 N.sub.6 Cl 56.63 56.80 5.77 5.61 20.86 20.90161 2 H ##STR190## 183-185 C.sub.19 H.sub.23 O.sub.2 N.sub.6 F 59.04 58.93 6.01 5.97 21.75 21.67162 2 H ##STR191## 156-158 C.sub.20 H.sub.23 O.sub.2 N.sub.6 F.sub.3.1/2 H.sub.2 O 53.92 53.57 5.21 5.26 18.87 19.03163 3 H ##STR192## 142-144 C.sub.20 H.sub.26 O.sub.2 N.sub.6 62.79 62.86 6.87 6.93 21.98 22.17164 3 H ##STR193## 180-182 C.sub.21 H.sub.28 O.sub.3 N.sub.6 61.13 61.05 6.85 6.72 20.38 20.41165 3 H ##STR194## 94-96 C.sub.21 H.sub.28 O.sub.3 N.sub.6 61.13 61.00 6.85 6.93 20.38 20.35166 3 H ##STR195## 164-167 C.sub.21 H.sub.28 O.sub.3 N.sub.6 61.13 61.35 6.85 6.67 20.38 20.67167 3 H ##STR196## 151-152 C.sub.20 H.sub.25 O.sub.2 N.sub.6 Cl 57.60 57.84 6.05 6.17 20.16 20.25168 3 H ##STR197## 165-167 C.sub.20 H.sub.25 O.sub.2 N.sub.6 Cl 57.58 57.63 6.06 6.08 20.17 20.21169 3 H ##STR198## 160-161 C.sub.20 H.sub.25 O.sub.2 N.sub.6 F 59.95 59.90 6.31 6.27 20.99 21.17170 3 H ##STR199## 116-118 C.sub.21 H.sub.25 O.sub.2 N.sub.6 F.sub.3 55.98 55.88 5.60 5.63 18.66 18.68171 4 H ##STR200## 156-158 C.sub.21 H.sub.28 O.sub.2 N.sub.6 63.60 63.68 7.13 7.12 21.20 21.10172 4 H ##STR201## 126-127 C.sub.22 H.sub.30 O.sub.3 N.sub.6 61.94 62.10 7.10 7.08 19.70 19.50173 4 H ##STR202## 69-73 C.sub.22 H.sub.30 O.sub.3 N.sub.6 61.94 61.98 7.10 7.00 19.70 19.63174 4 H ##STR203## 145-146 C.sub.22 H.sub.30 O.sub.3 N.sub.6 61.94 62.11 7.10 6.95 19.70 19.76175 4 H ##STR204## 132-134 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.35 64.80 7.38 7.52 20.47 20.79176 4 H ##STR205## 125 C.sub.21 H.sub.27 O.sub.2 N.sub.6 Cl 58.52 58.54 6.33 6.31 19.53 19.51177 4 H ##STR206## 170-171 C.sub.21 H.sub.27 O.sub.2 N.sub.6 Cl 58.52 58.67 6.33 6.23 19.53 19.55178 4 H ##STR207## 129-131 C.sub.21 H.sub.27 O.sub.2 N.sub.6 F 60.84 60.82 6.58 6.52 20.28 20.19179 4 H ##STR208## 120-122 C.sub.22 H.sub.27 O.sub.2 N.sub.6 F.sub.3 56.88 56.84 5.87 5.84 18.09 18.01180 5 H ##STR209## 113-115 C.sub.22 H.sub.30 O.sub.2 N.sub.6 64.36 64.20 7.37 7.41 20.47 20.58181 5 H ##STR210## 98-99 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 64.92 7.61 7.56 19.80 19.69182 5 H ##STR211## 135-137 C.sub.23 H.sub.32 O.sub.3 N.sub.6 62.69 62.53 7.34 7.43 19.08 19.07183 5 H ##STR212## 120-121 C.sub.23 H.sub.32 O.sub.3 N.sub.6 62.69 62.89 7.33 7.38 19.08 18.95184 5 H ##STR213## 163-164 C.sub.22 H.sub.29 O.sub.2 N.sub.6 Cl 59.37 59.55 6.58 6.57 18.89 18.73185 5 H ##STR214## 168-170 C.sub.22 H.sub.29 O.sub.2 N.sub.6 Cl 59.37 59.48 6.58 6.52 18.89 18.85186 5 H ##STR215## 130-132 C.sub.22 H.sub.29 O.sub.2 N.sub.6 F 61.65 61.56 6.83 6.79 19.61 19.73187 5 H ##STR216## 133-135 C.sub.23 H.sub.29 O.sub.2 N.sub.6 F.sub.3 57.72 57.63 6.12 6.16 17.56 17.53188 6 H ##STR217## 106-107 C.sub.23 H.sub.32 O.sub.2 N.sub.6 65.05 65.11 7.61 7.52 19.80 19.58189 6 H ##STR218## 108-109 C.sub.24 H.sub.34 O.sub.3 N.sub.6 63.40 63.14 7.55 7.34 18.49 18.37190 6 H ##STR219## 105-107 C.sub.24 H.sub.34 O.sub.3 N.sub.6 63.40 62.98 7.55 7.23 18.49 18.16191 6 H ##STR220## 159-160 C.sub.23 H.sub.31 O.sub.2 N.sub.6 Cl 60.17 60.34 6.82 6.90 18.31 18.46192 6 H ##STR221## 135-136 C.sub.23 H.sub.31 O.sub.2 N.sub.6 F 62.41 62.46 7.07 7.05 18.99 18.95193 6 H ##STR222## 110-111 C.sub.24 H.sub.31 O.sub.2 N.sub.6 F.sub.3 58.51 58.45 6.36 6.32 17.06 17.10__________________________________________________________________________

Some typical examples of pharmaceutical preparations used in the present invention are given below.

EXAMPLE 1: Tablet

______________________________________7-(3-(4-(3,4-Dimethyl)phenyl- 10.0 partspiperazinyl-(1))-n-propyl)-theophylline.2HClLactose 53.5 partsCrystallite cellulose 18.0 partsCorn starch 18.0 partsCalcium stearate 0.5 parts______________________________________

The above materials were mixed, granulated and compression molded according to a conventional method to obtain tablets weighing 100 mg each.

EXAMPLE 2: Capsule

______________________________________7-(5-(4-m-trifluoromethyl- 10.0 partsphenylpiperazinyl-(1))-n-pentyl)theophylline.2HClLactose 70.0 partsCorn starch 20.0 parts______________________________________

The above materials were processed according to the conventional method to prepare capsules weighing 100 mg each.

EXAMPLE 3: Tablet

______________________________________1-(3-(4-(3,4-Dichloro)phenyl- 10.0 partspiperazinyl-(1))-n-propyl)-theobromineLactose 53.5 partsCrystallite cellulose 18.0 partsCorn starch 18.0 partsCalcium stearate 0.5 parts______________________________________

The above materials were mixed, granulated and then compression molded to obtain tablets each weighing 100 mg each according to a conventional method.

EXAMPLE 4: Capsule

______________________________________1-(5-(4-m-Methylphenyl- 10.0 partspiperazinyl-(1))-n-pentyl)theobromineLactose 70.0 partsCorn starch 20.0 parts______________________________________

The above materials were processed according to the conventional method to prepare capsules weighing 100 mg each.

Claims

1. A method for treating a subject suffering from at least one of the symptoms of pain, fever, and tissue and/or bone and joint inflammation, which comprises administering to the subject a pharmaceutical composition which comprises a therapeutically effective amount of at least one compound of the general formula: ##STR223## wherein one of A and B is --CH.sub.3 and the other of A and B is ##STR224## wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula ##STR225## wherein X.sub.1 and X.sub.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; and (3) a group of the formula: ##STR226## wherein Y.sub.1 and Y.sub.2 are the same or different and Y.sub.1 and Y.sub.2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that (i) when A is --CH.sub.3, m is 2, (ii) when A is ##STR227## Z is not pyridyl and X is nitrogen and (iii) when X is nitrogen, m is 3, and acid addition salts thereof, for analgesic, antiphlogistic, and antipyretic purposes, in combination with a pharmaceutically effective carrier.

2. A method as claimed in claim 1 in which said subject suffers from pain.

3. A method as claimed in claim 1 in which said subject suffers from fever.

4. A method as claimed in claim 1 in which said subject suffers from tissue and/or bone and joint inflammation.

5. A method as claimed in claim 3, wherein said compound has the formula ##STR228##

6. A method as claimed in claim 4, wherein said compound has the formula ##STR229##

7. A method as claimed in claim 1, wherein said compound is administered to said subject in a dosage of from 1 to 1,000 mg per day.

8. A method as claimed in claim 2, wherein said compound is administered to said subject in a dosage of 1 to 1,000 mg per day.

9. A method as claimed in claim 3, wherein said compound is administered to said subject in a dosage of 1 to 1,000 mg per day.

10. A method as claimed in claim 4, wherein said compound is administered to said subject in a dosage of 1 to 1,000 mg per day.

11. A method according to claim 1 wherein said compound is selected from the group consisting of

7-(2-((4-phenyl)piperidinyl)ethyl)theophylline,

7-(3-((4-phenyl)piperidinyl)-n-propyl)theophylline,

7-(4-((4-phenyl)piperidinyl)-n-butyl)theophylline, and

7-(5-((4-p-chlorophenyl)piperidinyl)-n-pentyl)theophylline.

12. A method according to claim 1 wherein said compound is

1-(4-(4-p-chlorobenzylhomopiperazinyl-(1)-n-butyl)theobromine.