Claims
- 1. A compound of the general formula
- 2. A compound according to claim 1 in which R1 represents a C1-12 alkyl or C6-14 aryl group, each group being optionally substituted by one or more substituents selected from the group consisting of halogen atoms, nitro, cyano, hydroxyl, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy groups.
- 3. A compound according to claim 1 in which R2 represents a hydrogen atom or a C1-12 alkyl or C6-14 aryl group, each group being optionally substituted by one or more substituents selected from the group consisting of halogen atoms, nitro, cyano, hydroxyl, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy groups.
- 4. A compound according to claim 1 in which W and X each independently represents a hydrogen, chlorine or bromine atom.
- 5. A compound according to claim 1 in which R1 represents a methyl group, R2 represents a hydrogen atom and W and X both represent a hydrogen atom or both represent a chlorine atom.
- 6. 3,4-Dichloro-6-hydroxy-1-methyl-2,5-dioxo-1,6-dihydropyridine.
- 7. A process for the preparation of a compound according to claim 1, which comprises reacting a compound of the general formula
- 8. A compound of the general formula IIA or IIB
- 9. A compound according to claim 8 in which Y represents a hydrogen atom, a hydroxyl group or a group -OM where M represents a sodium or potassium atom.
- 10. A compound according to claim 8 in which R1 represents a methyl group, R2 represents a hydrogen atom, W and X both represent a hydrogen atom or both represent a chlorine atom, and Y represents a hydroxyl group.
- 11. (Z)-2,3-dichloro-4-[N-formyl-N-methylamino]4-oxo-but-2-enoic acid.
- 12. A process for the preparation of a compound according to claim 8, which comprises reacting with a base a compound of the general formula
- 13. A compound of the general formula IV
- 14. A compound according to claim 13 in which R3 represents a C1-6 alkyl group optionally substituted by one or more halogen atoms.
- 15. A compound according to claim 13 in which R3 represents a chloromethyl or dichloromethyl group.
- 16. 5-[N-formyl-N-methylamino]-3,4-dichloro-2-furyl-2,2-dichloroacetate.
- 17. A process for the preparation of a compound according to claim 13, which comprises reacting a compound of the general formula
- 18. A pharmaceutical composition comprising a carrier and one or more compounds according to claim 1, 8 or 13.
- 19. A method for treating proliferative diseases, microbial diseases or viral diseases comprising administering to a patient a therapeutically effective amount of a compound according to claim 1, 8 or 13.
- 20. A method according to claim 19 for inhibiting tumour growth.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0106137.3 |
Mar 2001 |
GB |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of PCT GB02/01119, filed Dec. 3, 2002, and published in English on Sep. 19, 2002 as WO 02/072553. PCT GBO2101119 claimed the priority of British application 0106137.3, filed Dec. 3, 2001. The disclosures of both are incorporated herein by reference.
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/GB02/01119 |
Mar 2002 |
US |
Child |
10662555 |
Sep 2003 |
US |