Claims
- 1. A method of treating rheumatism, comprising administering an effective amount of diethyl L-lysylcromoglycate or a nontoxic salt thereof to a patient.
- 2. A method of treating rheumatism, comprising administering a pharmaceutical composition to a patient, wherein the pharmaceutical composition comprises diethyl L-lysylcromoglycate or a nontoxic salt thereof and a pharmaceutically acceptable carrier.
- 3. The method of claim 1, wherein the diethyl L-lysylcromoglycate or the nontoxic salt thereof is administered orally.
- 4. The method of claim 2, wherein the pharmaceutical composition is administered orally.
- 5. The method of claim 2, wherein the pharmaceutical composition further comprises an organic acid.
- 6. The method of claim 5, wherein the organic acid is at least one organic carboxylic acid selected from the group consisting of maleic acid, fumaric acid, tartaric acid, citric acid, succinic acid, malic acid, oxalic acid, mandelic acid, malonic acid, and benzoic acid.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8-149549 |
Jun 1996 |
JPX |
|
Parent Case Info
This application is a 371 of PCT/JP97/01974, filed Jun. 6, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP97/01974 |
6/6/1997 |
|
|
12/10/1998 |
12/10/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/47297 |
12/18/1997 |
|
|
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4066756 |
Orr et al. |
Jan 1978 |
|
4847286 |
Tamaki et al. |
Jul 1989 |
|
Non-Patent Literature Citations (2)
Entry |
Yoshimi et al Importance of Hydrolysis of Amino Acid Moiety in Water-Soluble Prodrugs of Disodium Cromoglycate for Increased Oral Bioavailability 1992 J. Pharmacobio-Dyn 15:339-345. |
Mori et al Pro-drugs for the Oral Deliver of Disodium Cromoglycate 1988 Chem. Pharm. Bull. 36:338-344. |