Claims
- 1. A compound having the structure: ##STR20## wherein: R.sup.2 is selected from the group consisting of alkylsulfonyl having one to four carbon atoms, alkanoyl having two to five carbon atoms and benzoyl;
- A is ethylene or cis-vinylene;
- Z is alpha-hydroxy or beta-hydroxy;
- each R is methyl;
- and the pharmacologically acceptable salts thereof when R.sup.2 is alkylsulfonyl.
- 2. A compound of claim 1 wherein R.sup.2 is methanesulfonyl.
- 3. A compound of claim 1 wherein R.sup.2 is acetyl.
- 4. A compound of claim 1 wherein R.sup.2 is benzoyl.
- 5. N-(Methanesulfonyl)-9-oxo-11.alpha.,15.alpha.-dihydroxy-16,16-dimethyl-17-oxa-cis-5-trans-13-prostadienamide according to claim 2.
- 6. N-(Methanesulfonyl)-9-oxo-11.alpha.,15.alpha.-dihydroxy-16,16-dimethyl-17-oxa-trans-13-prostenamide according to claim 2.
- 7. N-(Acetyl)-9-oxo-11.alpha.,15.alpha.-dihydroxy-16,16-dimethyl-17-oxa-cis-5-trans-13-prostadienamide according to claim 3.
- 8. N-(Acetyl)-9-oxo-11.alpha.,15.alpha.-dihydroxy-16,16-dimethyl-17-oxa-trans-13-prostenamide according to claim 3.
- 9. A method to combat peptic ulceration which comprises administering orally or intravenously to a patient in need of such treatment an antisecretory effective amount of a prostaglandin of claim 1.
- 10. An antisecretory composition comprising a prostaglandin of claim 1 and an antisecretory effective amount of pharmaceutically acceptable carrier.
Parent Case Info
This is a continuation-in-part of application Ser. No. 727,463 filed Sept. 28, 1976, and now abandoned.
US Referenced Citations (8)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1345934 |
Feb 1974 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Collins et al., ". . . . Prostaglandins," Tetrahedron Letters, No. 48, pp. 4217-4220, 1975. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
727463 |
Sep 1976 |
|