Claims
- 1. A pharmaceutical composition comprised of the compound of formula 1: or a derivatve thereof, and at least one of an alkylating agent, an antimetabolite, a spindle poison, an epidophyllotoxin, an antibiotic, an enzyme, a topoisomerase inhibitor, a platinum coordination complex, a biological response modifier or a growth factor inhibitor.
- 2. The pharmaceutical composition according to claim 1 wherein the antibiotic agent is chosen from daunorubicin, doxorubicin, bleomycin and mitomycin.
- 3. The pharmaceutical composition according to claim 1 wherein the spindle poison is chosen from vinca alkaloids, their synthetic or semi-synthetic analogues, estramustine or navelbine.
- 4. The pharmaceutical composition according to claim 1 wherein the topoisomerase inhibitor is chosen from camptothecin and its derivatives including CPT-11, topotecan and pyridobenzoindole derivatives.
- 5. The pharmaceutical composition according to claim 1 wherein the platinum coordinating complex is chosen from cisplatin and carboplatin.
- 6. The pharmaceutical composition according to anyone of claims 2 to 5, further comprising growth factors of the haematopoietic type.
- 7. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and simultaneous.
- 8. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and sequential.
- 9. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and spaced out over time.
- 10. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula: and doxorubicin.
- 11. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula: and navelbine.
- 12. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula: and cisplatin.
- 13. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula: and CPT 11.
- 14. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered simultaneously.
- 15. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and simultaneously.
- 16. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and semi-simultaneously.
- 17. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and sequentially.
- 18. The pharmaceutical composition of claim 10 or claim 11 wherein the neoplastic disease is breast cancer.
- 19. The pharmaceutical composition of claim 12 or claim 13 wherein the neoplastic disease is colon cancer.
Parent Case Info
This application is a continuation-in-part of U.S. patent application Ser. No. 09/705,739, filed Nov. 6, 2000, which is a divisional application of application Ser. No. 09/371,520, filed Aug. 10, 1999, now U.S. Pat. No. 6,214,863, which is a continuation application of application Ser. No. 09/182,900, filed Oct. 30, 1998, now abandoned, which is a divisional application of application Ser. No. 08/967,036, filed Nov. 10, 1997, now U.S. Pat. No. 5,908,835, which is a divisional application of application Ser. No. 08/424,470, filed May 9, 1995, now U.S. Pat. No. 5,728,687.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9219765 |
Nov 1992 |
WO |
Non-Patent Literature Citations (9)
Entry |
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Continuations (1)
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Number |
Date |
Country |
Parent |
09/182900 |
Oct 1998 |
US |
Child |
09/371520 |
|
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/705739 |
Nov 2000 |
US |
Child |
09/813018 |
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US |