Alexander et al., "Investigation of (Oxodioxolenyl)methly Carbamates as Nonchiral Bioreversible Prodrug Moieties for Chiral Amines", 39:480-486, J Med Chem, 1996. |
Arimilli et al., "Synthesis, in vitro biological evaluation and oral bioavailability of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) prodrugs", 8(6):557-567, Antiviral Chem & Chemo, 1997. |
Arimilli et al., "Orally Bioavailable Acyclic Nucleoside Phosphonate Prodrugs: Adefovir Dipivoxil and Bis(POC)PMPA", vol. 3 (accepted for publication), ADV Antiviral Drug Design, 1998. |
Benzaria et al., "New Prodrugs of 9-(2-Phosphonomethoxyethyl) Adenine [PMEA]: Synthesis and Stability Studies", 14(3-5):563-565, NUCLS & NUCLT, 1995. |
Cannon, Joseph G. (Reviewer), "The Chemistry of the Carbonyl Group", vol. II, Edited by Saul Patai, Book Review, Sep.-1966. |
Davidsen et al, "N-(Acyloxyalkyl)pyridinium Salts as Soluble Prodrugs of a Potent Platelet Activating Factor Antagonist", 37(26):4423-4429, J Med Chem, Dec.-23-1994. |
Engel, R., "Phosphonates as Analogues of Natural Phosphates", 77(3):349-367, Chem Rev, 1977. |
Farquhar et al, "Biologically Reversible Phosphate-Protective Groups", 72:324-325, J Pharm Sci, 1983. |
Flaherty et al., "Synthesis and Selective Monoamine Oxidase B-Inhibiting Properties of 1-Methyl-1,2,3,6-tetrahydropryrid-4-yl Carbamate Derivatives: Potential Prodrugs of (R)-and (s)-Nordeprenyl", 39:4759-4761, J Med Chem, 1996. |
Folkmann et al., "Acyloxymethyl Carbonochloridates. New Intermediates in Prodrug Synthesis", pp. 1159-1166, Synthesis, Dec.-1990. |
Hammer et al., "Ether, Carbonate and Urethane Deoxynucleoside Derivatives as Prodrugs", 50:609-622, Acta Chemica Scandinavia, 1996. |
Ikeda et al., "Studies on Prodrugs, III. A Convenient and Practical Preparation of Ampicillin Prodrugs", 32:4316-4322, Chem Phar Bull, 1984. |
Iyer et al., "Synthesis of Acyloxyalkyl Acylphosphonates as Potential Prodrugs of the Antiviral, Trisodium Phosphonoformate (Foscarnet Sodium)", 30(51):7141:7144, TET LETT, 1989. |
Jones et al., "Minireview: nucleotide prodrugs", 27:1-17, Antiviral Res, 1995. |
Krise et al, "Prodrugs of phosphates, phosphonates, and phosphinates", 19:287-310, Advanced Drug Delivery Reviews, May-22-1996. |
Landgrebe, John A., "Crystallization and Filtration", 3rd edition, pp. 65-77, Theory and Practice in the Organic Laboratory, 1982. |
Lindahl et al., "Synthesis of an Acyloxymethyl Prodrug of the Inositol Phosphate Alpha-Trinositol", 15(5):549-554, J Carbohydrate Chemistry, 1996. |
Maillard et al., "Adenosine Receptor Prodrugs: Synthesis and Biological Activity of Derivatives of Potent, A1-Selective Agonists", 83(1):46-53, J Pharm Sci, Jan.-1994. |
Myerson, Allan S. (editor), "Solutions and Solution Properties", pp. 1 -165, Handbook of Industrial Crystallization, 1993. |
Naesens et al., "Antiretroviral Activity and Pharmacokinetics in Mice of Oral Bis(Pivaloyloxymethyl)-9-(2-Phosphonylmethoxyethyl)Adenine, the Bis(Pivaloyloxymethly) Ester Prodrug of 9-(2Phosphonylmethoxyethl)Adenine", 40(1)22-28, Antimicro AG & CHEMO, Jan.-1996. |
Robinson et al, "Discovery of the Hemifumarate and (alpha-L-Alanyloxy)methly Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group", 39:10-18, J Med Chem, 1996. |
Safadi et al, "Phosphoryloxymethyl Carbamates and Carbonates--Novel Water-Soluble Prodrugs or Amines and Hindered Alcohols", 10(9):1350-1355, Pharm Res, 1993. |
Sakamoto et al, "Studies on Prodrugs II. Preparation and Characterization of (5-Substituted 2-Oxo-1,3-dioxolen-4-yl)methyl Esters of Ampicillin", 32(6):2241-2248, Chem Pharm Bull, Aug.-19-1983. |
Samara et al., "Pharmacokinetic Analysis of Diethylcarbonate Prodrugs of Ibuprofen and Naproxen", 16:201-210, Biopharmaceutics & Drug Disposition, 1995. |
Shaw et al., "Metabolism and Pharmacokinetics of Novel Oral Prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in Dogs", 14(12):1824-1829, Pharm Res, 1997. |
Srinivas et al., "Metabolism and In Vitro Antiretroviral Activities of Bis(Pivaloyloxmethyl) Prodrugs of Acyclic Nucleoside Phosphonates", 37(10:2247-2250, ANTIMICRO AG & CHEMO, Oct.-1993. |
Srivastva et al, "Bioreversible Phosphate Protective Groups: Synthesis and Stability of Model Acyloxymethyl Phosphates", 12:118-129, Bioorg Chem, 1984. |
Starrett et al, "Synthesis and in vitro evaluation of a phosphonate prodrug: bis (pivaloyloxymethyl)9-(2-phosphonylmethoxyethyl)adenine", 19:267-273, Antiviral Res, 1992. |
Starrett et al., "Synthesis, Oral Bioavailability Determination, and in Vitro Evaluation of Prodrug of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)", 37:1857-1864, J Med Chem, 1994. |
Sueoka et al., "Pharmacokinetics of Alkoxycarbonyloxy Ester Prodrugs of PMPA in Dogs", Abstract, American Association of Pharmaceutical Science, Western Regional Meeting, Apr. 24-25, 1997. |
Sueoka et al., "Pharmacokinetics of Alkoxycarbonyloxy Ester Prodrugs of PMPA in Dogs", Poster, American Association of Pharmaceutical Science, Western Regional Meeting, Apr. 24-25, 1997. |
Tsai et al., "Effect of (R)-9-(2-Phosphonylmethoxypropyl)adenine Monotherapy on Chronic SIV Infection in Macaques", 13(8):707-712, AIDS RES & HUM RETRO, 1997. |
Tsai et al., "Prevention of SIV Infection in Macaques by (R)-9-(2-Phosphonylmethoxypropyl)adenine", 270:1197-1199, Science, Nov.-17-1995. |
Weller et al., "Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes a Prodrugs of Amidines", 39:3139-3147, J Med Chem, Dec.-20-1995. |