Claims
- 1. A compound of the formula IV where Z′ and Z″ are —(CH2)mP wherein each m is independently 0, 1 or 2 and each P is independently a substituted or unsubstituted member selected from the group consisting of phenyl, cyclohexenyl, cyclopentyl, cyclohexanyl, cyclopentanyl, indanyl, naphthyl, furyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazoyl, imidazolinyl, imidazolidinyl, pyridyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl and bicyclic rings.
- 2. A compound as defimed in claim 1, having the stereochemistry:
- 3. A compound according to claim 1, wherein Z′ and Z″ are each independently benzyl, 2-fluorobenzyl, 2-methylbenzyl, 2,4-difluorobenzyl, 4-fluorobenzyl, 4-bromobenzyl, 4-phenylbenzyl, 4-thiophenylbenzyl, 4-(4′-nitrophenyl)benzyl, 4-thienylbenzyl, 4-thiazolylbenzyl or 4-(pyridyl)benzyl.
- 4. A compound according to claim 1 wherein both Z′ and Z″ are identical.
- 5. The compound according to claim 1, wherein the carbo- or heterocyclic moiety of Z′ and Z″ each independently contains one to three substituents selected from the group consisting of halo, amino, mercapto, oxo, nitro, NHC1-C6 alkyl, N (C1-C6 alkyl)2, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 alkanoyl, C1-C6 alkoxy, thioC1-C6 alkyl, thioC1-C6 alkoxy, hydroxy, hydroxyC1-C6 alkyl, haloC1-C6 alkyl, aminoC1-C6 alkyl, C1-C6 alkyl, cyano, carboxyl, carbalkoxy, carboxamide, carbamoyl, sulfonylamide, benzyloxy, morpholyl-C1-C6 alkyloxy, phenyl, cyclohexenyl, cyclopentyl, cyclohexanyl, cyclopentanyl, indanyl, napthyl, furyl, thienyl, pyranyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazoyl, imidazolinyl, imidazolidinyl, pyridyl, piperidiniyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazoly, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, bicyclic rings of the above fused to a phenyl ring.
- 6. The compound according to claim 5, wherein said substituent is spaced by an alkyl.
- 7. The compound according to claim 6, wherein said substituent is a C1-3 alkylaryl.
- 8. The compound according to claim 1, wherein Z′ and Z″ are each independently substituted or unsubstituted benzyl.
- 9. The compound according to claim 8, wherein each said benzyl independently contains 1, 2 or 3 substituents selected from the group consisting of fluoro, chloro, hydroxy, amino, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, —NPh(C1-6 alkyl), —NHPh, methoxy, cyano, hydroxymethyl, aminomethyl, alkysulfonyl, carbamoyl morpholinethoxy, benzyloxy, and benzylamide.
- 10. The compound according to claim 6, wherein said benzyl contains 1 or 2 fluoro substituents.
- 11. The compound according to claim 3, wherein Z′ and Z″ are each independently 2-fluorobenzyl or 2,4-fluorobenzyl.
- 12. The compound according to claim 1, wherein said bicyclic ring is comprised of a phenyl ring fused to a substituted or unsubstituted member selected from the group consisting of phenyl, cyclobexenyl, cyclopentanyl, indanyl, napthyl, furyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazoyl, imidazolinyl, imidazolidinyl, pyridyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, and isothiazolidinyl.
- 13. The compound according to claim 12, wherein said bicyclic ring is indolyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzothiazolyl, benzoxazolyl or benzothienyl.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9701245 |
Apr 1997 |
SE |
|
Parent Case Info
This application is a 371 of PCT/SE98/00622, filed Apr. 3, 1998.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/SE98/00622 |
|
WO |
00 |
12/14/1999 |
12/14/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/45330 |
10/15/1998 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5142056 |
Kempe et al. |
Aug 1992 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0398669 A2 |
Nov 1990 |
EP |
0480714 A3 |
Apr 1992 |
EP |
WO 9413629 |
Jun 1994 |
WO |