Claims
- 1. A compound of formula: ##STR20## wherein Ar is: ##STR21## the N-oxide thereof, a pharmaceutically acceptable salt thereof or both the N-oxide and pharmaceutically acceptable salt thereof.
- 2. A pharmaceutical and/or veterinary composition comprising (a) a therapeutically effective amount of a compound of formula: ##STR22## wherein Ar is: ##STR23## the N-oxide thereof, a pharmaceutically acceptable salt thereof or both the N-oxide and pharmaceutically acceptable salt thereof, and (b) a suitable carrier therefor.
- 3. A composition according to claim 2, wherein the compound is R-(+)-4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide or a pharmaceutically acceptable salt thereof.
- 4. A composition according to claim 2, wherein the compound is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-2,4-dimethoxybenzamide or a pharmaceutically acceptable salt thereof.
- 5. A method of controlling anxiety in warm blooded animals which comprises internally administering thereto an anxiolytic effective amount of a compound of formula I ##STR24## wherein: X represents oxygen or sulphur;
- each of R.sup.1 and R.sup.3 independently represents hydrogen or a C.sub.1 -C.sub.4 alkyl group;
- Ar represents:
- a phenyl ring substituted by one, two or three C.sub.1 -C.sub.4 alkoxy groups, one or two halogen atoms, or both one, two or three C.sub.1 -C.sub.4 alkoxy groups and one or two halogen atoms;
- a phenyl ring of the formula ##STR25## wherein R.sup.2 represents halogen, 4,5-benzo, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.4 alkylcarbonyl or Am, wherein Am represents amino, methylamino or dimethylamino,
- R.sup.4 represents C.sub.1 -C.sub.8 alkyl,
- n is 1 or 2; or a pyrimidinyl moiety of formula ##STR26## wherein R.sup.5 is C.sub.1 -C.sub.4 alkyl; or an N-oxide thereof, a pharmaceutically acceptable salt thereof, or both an N-oxide and a pharmaceutically acceptable salt thereof.
- 6. A method as claimed in claim 5, wherein compound I is R-(+)-4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide or a pharmaceutically acceptable salt thereof.
- 7. A method as claimed in claim 5, wherein compound I is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide or a pharmaceutically acceptable salt thereof.
- 8. A method as claimed in claim 5, wherein compound I is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-2-methoxybenzamide or a pharmaceutically acceptable salt thereof.
- 9. A method as claimed in claim 5, wherein compound I is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-2,4-dimethoxybenzamide or a pharmaceutically acceptable salt thereof.
- 10. A method as claimed in claim 5, wherein compound I is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-2 propoxybenzamide or a pharmaceutically acceptable salt thereof.
- 11. A method as claimed in claim 5, wherein compound I is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-3-methoxy-2-naphthalenecarboxamide or a pharmaceutically acceptable salt thereof.
- 12. A compound as claimed in claim 1, wherein said compound is R-(+)-4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide or a pharmaceutically acceptable salt thereof.
- 13. A compound as claimed in claim 1, wherein said compound is R-N-(1-azabicyclo[2.2.2]oct-3-yl)-2,4-dimethoxy-benzamide or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
87402321 |
Oct 1987 |
EPX |
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Parent Case Info
This application is a continuation, of application Ser. No. 609,018, filed Oct. 31, 1990, abandoned which is a continuation of Ser. No. 257,632, filed Oct. 14, 1988, abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4717563 |
Alphin et al. |
Jan 1988 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
609018 |
Oct 1990 |
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Parent |
257632 |
Oct 1988 |
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