Apparatus and computer program for assessing a patient's extravascular lung water volume

Abstract

A method and apparatus for assessing extravascular lung water volume (EVLW) of a patient after lung resection is adapted to provide a transpulmonary thermodilution curve, is capable to derive the patient's intrathoracic thermal volume (ITTV) and approximated intrathoracic blood volume (ITBVapprox) from the transpulmonary thermodilution curve, and is capable to determine the extravascular lung water volume (EVLW) by correcting by the degree of lung resection (c), wherein making use of the equation EVLW=f(ITTV, ITBVapprox, c), or EVLW=f(ITTV, GEDV, c). Further, a computer program for assessing extravascular lung water volume (EVLW) of a patient after lung resection, has instructions adapted to carry out the steps of generating a transpulmonary thermodilution curve on basis of provided measurement data collected at the patient, deriving the patient's intrathoracic thermal volume (ITTV) and approximated intrathoracic blood volume (ITBVapprox) from the transpulmonary thermodilution curve, and determining the extravascular lung water volume (EVLW) by correcting by the degree of lung resection (c), wherein making use of the equation EVLW=f(ITTV, ITBVapprox, c) or EVLW=f(ITTV, GEDV, c), when run on a computer.

Description

BRIEF DESCRIPTION OF THE DRAWING

In the following the invention is explained on the basis of a preferred embodiment with reference to the drawing. In the drawing shows FIG. 1 a model of a pulmonary circulation.

DETAILED DESCRIPTION

FIG. 1 shows a model of a pulmonary circulation comprising a heart and a lung. The right atrium RA of the heart, the right ventricle RV of the heart, the left atrium LA of the heart and the left ventricle LV of the heart define the sum of blood volumes outside the lung. This sum of blood volumes outside the lung defines the global end-diastolic volume GEDV designated with 1.

Further, the model of the pulmonary circulation comprises the pulmonary blood volume PBV designated with 2, and the extravascular lung water EVLW designated with 3.

To assess the extravascular lung water volume EVLW, a transpulmonary thermodilution method is used. A device as disclosed in U.S. Pat. No. 5,526,817, hereby incorporated by reference herein, can be used to perform the transpulmonary thermodilution method. The method is based on the physiologic relationship between the global end-diastolic volume GEDV and the intrathoracic blood volume ITBV. The global end-diastolic volume GEDV is derived from the mathematical analysis of the transpulmonary thermodilution curve.

It has been established that the intrathoracic blood volume ITBV and the global end-diastolic volume GEDV are closely related and that the intrathoracic blood volume ITBV can be approximated from the global end-diastolic volume GEDV by using the equation

ITBV _approx =a GEDV+b,

wherein a and b are parameters, for example set to be a=1.25 and b=0.0.

The intrathoracic blood volume ITBV can be approximated from the global end-diastolic volume GEDV measurements. Therefore, the extravascular lung water volume EVLW can be estimated as the difference between the intrathoracic thermal volume ITTV and the approximated intrathoracic blood volume ITBV_approx.

However, when a patient undergoes lung resection, the accuracy of this approximation from transpulmonary thermodilution is affected by the lung resection.

In FIG. 1 a lung resection cut which separates a part of the lung and of pulmonary blood volume PBV is shown and designated with 4.

The estimation of the extravascular lung water volume EVLW by the thermodilution method is based on the approximation of the intrathoracic blood volume ITBV from the global end-diastolic volume GEDV by using the equation

ITBV _approx =a GEDV+b.

Further, the approximated pulmonary blood volume PBV_approx is defined by the difference between the approximated intrathoracic blood volume ITBV_approx and the global end-diastolic volume GEDV, i.e.

PBV _approx =ITBV _approx −GEDV.

When taking above equations into account, the pulmonary blood volume PBV can be expressed by

PBV_approx=a GEDV+b−GEDV=b+(a−1)GEDV.

In case of lung resection, the pulmonary blood volume PBV is actually much lower than predicted by this equation. Therefore, in particular this decrease in pulmonary blood volume PBV affects the estimation of the intrathoracic blood volume ITBV and hence the estimation of the extravascular lung water volume EVLW.

Taking above equations into account, the intrathoracic blood volume ITBV is calculated as

ITBV _approx =a GEDV+b=GEDV+PBV _approx

1.=GEDV+b+(a−1)GEDV,

wherein [b+(a−1)GEDV] represents the approximated pulmonary blood volume PBV_approx.

Most patients undergoing a lung resection are evaluated pre-operatively by a perfusion lung scan allowing a quantification of the actual perfusion of each lung (or lung lobe). From this distribution of pulmonary perfusion the relative perfusion of the removed part of the lung can be estimated. For example, if 55% of pulmonary perfusion was going to the right lung and 45% of the pulmonary perfusion to the left lung, it can be assumed that after resection of the right lung the pulmonary blood volume will be decreased by 55%.

This assumption can be done in a similar way for each of the three right lung lobes and each of the two left lung lobes. Therefore, the decrease in pulmonary blood volume PBV after the lobe resection can be also predicted. For example, if it is known from the preoperative perfusion lung scan that the inferior right lobe collects 25% of the pulmonary perfusion, it could be assumed that inferior right lobe surgical resection will reduce the pulmonary blood volume by 25%. This expected reduction of pulmonary blood volume PBV in relation to the pre-operative pulmonary blood volume PBV could be used as degree of resection c of total pulmonary perfusion caused by the resection representing the lung or lung lobe removed during the surgical procedure.

In case a perfusion lung scan is not available (e.g. use of transpulmonary thermodilution of a patient who underwent lung resection surgery several years ago), post-operative pulmonary blood volume PBV and the degree of resection c can be estimated from the normal anatomical distribution of pulmonary blood volume in human beings.

In order to improve the calculation of the intrathoracic blood volume ITBV, the degree of resection c has to be taken into consideration.

In general, a corrected intrathoracic blood volume ITBV|_corrected could be derived from the approximated intrathoracic blood volume ITBV|_approx and the degree of resection c, i.e.

ITBV| _corrected =f(ITBV|_approx, c).

When using the transpulmonary thermodilution method known from U.S. Pat. No. 5,526,817, the pulmonary blood volume PBV can be calculated as

PBV _corrected=(b+(a−1)GEDV)×(100%−c[%])

and the intrathoracic blood volume ITBV can be calculated as

ITBV| _corrected =GEDV+PBV _corrected=

1.=GEDV+(b+(a−1)GEDV)(100%−c[%]).

or as

ITBV| _corrected =ITBV| _approx −c[%](b+(a−1)GEDV).

For example, if a=1.25, b=0.0, and c=45% (e.g. surgical resection of a left lung representing 45% of the total pulmonary perfusion on a preoperative lung scan), the corrected intrathoracic blood volume ITBV_corrected is calculated as

ITBV| _corrected=1.1375GEDV

Therefore, modifying the equation to derive ITBV_corrected from GEDV according to the degree of resection c easily overcomes the current limitation of the transpulmonary thermodilution method in estimating the extravascular lung water volume EVLW after lung resection.

Taking above mentioned and described modelling into account, a process for assessing extravascular lung water volume EVLW of a patient after lung resection comprises the steps of:

Generating a transpulmonary thermodilution curve on basis of provided measurement data collected from the patient.

Deriving the patient's intrathoracic thermal volume ITTV and approximated intrathoracic blood volume ITBV_approx from the transpulmonary thermodilution curve based on relations derived with unresected lungs.

Estimating the degree of lung resection c by making use of an empirical average value of the reduction of pulmonary perfusion of the resected lung compared to the pre-operative lung of the patient, or, in case of a resected right lung, estimating the degree of lung resection c as being 55%, or, in case of a resected left lung, estimating the degree of lung resection c as being 45%. Or estimating the degree of lung resection c by comparing the pulmonary perfusion before and after the lung resection, wherein the pulmonary perfusion values are provided by making use of pre-operative perfusion lung scans and dividing the density of areas which will be resected by the density of the whole unresected lung. Or in case of resected lobes, estimating the degree of lung resection c as being the sum of normal perfusion rates of the resected lobes.

Normal perfusion rate right lung:

Right superior lobe 18%

Right middle lobe 12%

Right inferior lobe 25%

Normal perfusion rate left lung:

Left superior lobe 25%

Left inferior lobe 20%

Determining the corrected intrathoracic blood volume ITBV_corrected by correcting for the degree of lung resection c, wherein making use of the equation

ITBV _corrected =f(ITBV_approx, c).

Making use of the equation

EVLW=ITTV−ITBV| _corrected,

wherein ITBV|_corrected is the value of the intrathoracic blood volume ITBV corrected by the degree of lung resection c.

Making use of equating the degree of lung resection c with the degree of reduction of pulmonary blood volume PBV caused by the lung resection.

Deriving the global end-diastolic volume GEDV of the patient from the transpulmonary thermodilution curve.

Making use of the equation

ITBV| _corrected =GEDV+PBV| _corrected,

wherein PBV|_corrected is the value of the pulmonary blood volume PBV corrected by the degree of lung resection c.

Making use of the equation

PBV| _corrected=((a−1)GEDV+b)(100%−c%),

wherein a and b are parameters.

Setting the parameters a and b to be

a=1.25 and b=0.0.

The device as disclosed in U.S. Pat. No. 5,526,817 can be modified by programming a processor to calculate the EVLW, or a processor can be provided to receive inputs from such a device and this processor can calculate the EVLW.

Claims

1. An apparatus for assessing extravascular lung water volume (EVLW) of a patient after lung resection, comprising: a device adapted to provide a transpulmonary thermodilution curve, capable of deriving the difference between the patient's intrathoracic thermal volume (ITTV) and approximated intrathoracic blood volume (ITBVapprox) from the transpulmonary thermodilution curve, and capable of determining the extravascular lung water volume (EVLW) by correcting by a degree of lung resection (c), wherein making use of the equation EVLW=f(ITTV, ITBVapprox, c), orEVLW=f(ITTV, GEDV, c),GEDV being a global end-diastolic volume.

2. The apparatus according to claim 1, wherein the device is adapted to estimate the degree of lung resection (c) by making use of an empirical average value of the reduction of pulmonary perfusion of the resected lung compared to the pre-operative lung of the patient.

3. The apparatus according to claim 1, wherein in case of a resected right lung the device is adapted to estimate the degree of lung resection (c) as being 55%, or in case of a resected left lung the apparatus is adapted to estimate the degree of lung resection (c) as being 45%, and/or in case of a resected lobes, estimating the degree of lung resection c as being a sum of normal perfusion rates of the resected lobes.

4. The apparatus according to claim 1, wherein the device is adapted to estimate the degree of lung resection (c) by comparing the pulmonary perfusion before and after the lung resection, wherein the pulmonary perfusion values are provided by making use of pre-operative perfusion lung scans.

5. The apparatus according to claim 1, wherein the device is adapted to make use of the equation EVLW=ITTV−ITBV|corrected,

6. The apparatus according to claim 2, wherein the device is adapted make use of equating the degree of lung resection (c) with a degree of reduction of pulmonary blood volume (PBV) caused by the lung resection.

7. The apparatus according to claim 6, wherein the apparatus is adapted to derive the global end-diastolic volume (GEDV) of the patient from the transpulmonary thermodilution curve and is adapted to make use of the equation ITBV|corrected=GEDV+PBV|corrected,

8. The apparatus according to claim 7, wherein the apparatus is adapted to make use of the equation PBV|corrected=((a−1)GEDV+b)(100%−c[%]),

9. The apparatus according to claim 8, wherein the parameters a and b are set to be a=1.25 and b=0.0.

10. A computer program for assessing extravascular lung water volume (EVLW) of a patient after lung resection, comprising instructions adapted to carry out the following steps: generating a transpulmonary thermodilution curve on basis of provided measurement data collected at the patient,deriving an intrathoracic thermal volume (ITTV) of the patient and approximated intrathoracic blood volume (ITBVapprox) from the transpulmonary thermodilution curve, anddetermining the extravascular lung water volume (EVLW) by correcting by the degree of lung resection (c), wherein making use of the equation EVLW=f(ITTV, ITBVapprox, c), orEVLW=f(ITTV, GEDV, c),

11. The computer program according to claim 10, further comprising instructions adapted to carry out the step of estimating the degree of lung resection (c) by making use of an empirical average value of the reduction of pulmonary perfusion of the resected lung compared to the pre-operative lung of the patient.

12. The computer program according to claim 10, further comprising instructions adapted to carry out the steps of: in case of a resected right lungestimating the degree of lung resection (c) as being 55%,or in case of a resected left lungestimating the degree of lung resection (c) as being 45%,and/or in case of resected lobesestimating the degree of lung resection (c) as being the sum of normal perfusion rates of the resected lobes.

13. The computer program according to claim 10, further comprising instructions adapted to carry out the step of estimating the degree of lung resection (c) by comparing the pulmonary perfusion before and after the lung resection, wherein the pulmonary perfusion values are provided by making use of pre-operative perfusion lung scans.

14. The computer program according to claim 11, further comprising having instructions adapted to carry out the step of making use of the equation EVLW=ITTV−ITBV|corrected,

15. The computer program according to claim 11, further comprising instructions adapted to carry out the step of making use of equating the degree of lung resection (c) with the degree of reduction of pulmonary blood volume (PBV) caused by the lung resection.

16. The computer program according to claim 15, further comprising instructions adapted to carry out the steps of: deriving the global end-diastolic volume (GEDV) of the patient from the transpulmonary thermodilution curve andmaking use of the equation ITBV|corrected=GEDV+PBV|corrected,

17. The computer program according to claim 16, further comprising instructions adapted to carry out the step of making use of the equation PBV|corrected=((a−1)GEDV+b)(100%−c[%]),

18. The computer program according to claim 17, further comprising instructions adapted to carry out the step of setting the parameters a and b to be a=1.25 and b=0.0.

19. A processor for implementing the computer program according to claim 10.

20. A method for assessing extravascular lung water volume (EVLW) of a patient after lung resection, comprising: providing a transpulmonary thermodilution curve;deriving a difference between the patient's intrathoracic thermal volume (ITTV) and approximated intrathoracic blood volume (ITBV) from the transpulmonary thermodilution curve, anddetermining the extravascular lung water volume (EVLW) by correcting by the degree of lung resection (c), wherein making use of the equation EVLW=f(ITTV, ITBVapprox, c), orEVLW=f(ITTV, GEDV, c).