The present disclosure is generally directed to an apparatus for filling capsules with pharmaceutical products and, more particularly, to various improvements to an apparatus for filling capsules with pharmaceutical products to increase machine production.
In the pharmaceutical industry, machines for filling capsules with pharmaceutical products are known. Such machines are configured to dose powders, pellets, liquids, and tablets into hard gelatin capsules. The powder and pellet dosing units feature dosators and pistons that move down in the powder bowl, picking up the product by means of compression and/or vacuum.
More specifically, a typical capsule filling machine includes a capsule loading station for loading the capsules from a hopper into the machine so that the capsules can be separated and then filled, a powder loading station for gathering the powdered pharmaceutical product to be loaded into the capsule and providing the powdered pharmaceutical product to the capsule, a capsule closing station for closing the filled capsule, and an ejection station for ejecting the filled capsules from the machine and gathering the filled capsules. Typical capsule filling machines may also include a rejection station where the capsules that were not properly separated are eliminated. In addition, a cleaning station may be provided after the ejection station for cleaning components of the machine of excess powder with an air jet.
The known machines for filling capsules with pharmaceutical products of the above-described type, although widely tried and tested, have some drawbacks and the machine production and output can be increased.
The present disclosure relates to several improvements to an apparatus for filling capsules with a pharmaceutical product that increase the output of the apparatus. Specifically, in accordance with one aspect of the present disclosure, provided is a magazine for use with an apparatus for filling capsules with at least one product, the magazine including a body, a first row of openings provided on a top portion of the body, a plurality of first passages extending parallel with a longitudinal axis of the body to a bottom portion of the body, one first passage in communication with each of the openings in the first row of openings, a second row of openings provided parallel to the first row of openings on the top portion of the body, and a plurality of second passages extending at an angle relative to the longitudinal axis of the body and through the body to the bottom portion of the body, one second passage in communication with each of the openings of the second row of openings.
In one example, the first row of openings comprises five openings and the second row of openings comprises five openings parallel to the first row openings. Each of the openings of the first and second row of openings have a tapered diameter. The second passages extend at an angle of about 4 to 5 degrees through the body to the bottom portion of the body. The first passages and the second passages form a single row of openings at the bottom portion of the body.
In another example, a dosator head used with an apparatus for filling capsules with at least one product includes a solid piston block comprising a base member and a body member, the piston block being mounted for rotation around a vertical axis such that the dosator head is configured to retrieve powder from a powder bowl when in a first position and deliver powder to a capsule when in a second position; a plurality of passages machined into the piston block for individually receiving pistons with a helix-shaped opening formed along the length of each of the passages and configured to force the piston to rotate as the piston travels along the passage, wherein the dosator head is configured to deliver powder from the powder bowl into a body of the capsule.
In another example, ten passages are machined into the piston block. The pistons are configured to interact with an ejection pin comprising a three-piece main body. The main body includes a first pin portion having an opening for receiving a ball and a compression pin operatively connected to the ball. The helix-shaped openings are formed to twist along an entire length of the helix-shaped opening. Front and rear sides of the passages include a helix-shaped opening. The body member is substantially curved.
In another example, a capsule filling station for an apparatus for filling capsules with at least one product includes a dosator head configured to deliver powder from a powder bowl into a body of the capsules, the powder bowl comprising: a vacuum hopper bowl having groups of holes arranged in circular patterns around a perimeter of the vacuum hopper bowl such that when a vacuum is applied to a bottom of the vacuum hopper bowl, a vacuum is provided at each hole; and an assembly positioned over each group of holes to spread the vacuum provided at each hole.
In another example, the assembly comprises an upper plate, a screen, a middle plate, and a lower shim. The lower shim and the middle plate are positioned over one of the groups of holes on the vacuum hopper bowl to provide an area for the vacuum to spread out, such that the vacuum is applied to a plurality of slots formed in the middle plate. The screen and the upper plate transfer the vacuum to the powder in the vacuum hopper bowl. The upper plate defines a plurality of slots to transfer the vacuum to the powder in the vacuum hopper bowl. The upper plate includes three posts that pass through the screen and the middle plate and are held in a surface of the vacuum hopper bowl. The plurality of slots formed in the middle plate are substantially arcuate in shape. A number of slots formed in the middle plate corresponds to a number of dosator tubes that are provided in the dosator head.
Further aspects will now be described in the following numbered clauses.
Clause 1: A magazine for use with an apparatus for filling capsules with at least one product, the magazine comprising: a body; a first row of openings provided on a top portion of the body; a plurality of first passages extending parallel with a longitudinal axis of the body to a bottom portion of the body, one first passage in communication with each of the openings in the first row of openings; a second row of openings provided parallel to the first row of openings on the top portion of the body; and a plurality of second passages extending at an angle relative to the longitudinal axis of the body and through the body to the bottom portion of the body, one second passage in communication with each of the openings of the second row of openings.
Clause 2: The magazine of Clause 1, wherein the first row of openings comprises five openings and the second row of openings comprises five openings parallel to the first row of openings.
Clause 3: The magazine of one of Clauses 1 and 2, wherein each of the openings of the first and second row of openings has a tapered diameter.
Clause 4: The magazine of any of Clauses 1-3, wherein the second passages extend at an angle of about 4 to 5 degrees through the body to the bottom portion of body.
Clause 5: The magazine of any of Clauses 1-4, wherein the first passages and the second passages form a single row of openings at the bottom portion of the body.
Clause 6: A dosator head used with an apparatus for filling capsules with at least one product, the dosator head comprising: a solid piston block comprising a base member and a body member, the piston block being mounted for rotation around a vertical axis such that the dosator head is configured to retrieve powder from a powder bowl when in a first position and deliver powder to a capsule when in a second position; a plurality of passages machined into the piston block for individually receiving pistons with a helix-shaped opening formed along the length of each of the passages and configured to force the piston to rotate as the piston travels along the passage, wherein the dosator head is configured to deliver powder from the powder bowl into a body of the capsule.
Clause 7: The dosator head of Clause 6, wherein ten passages are machined into the piston block.
Clause 8: The dosator head of any of Clauses 6 and 7, wherein the pistons are configured to interact with an ejection pin comprising a three-piece main body.
Clause 9: The dosator head of Clause 8, wherein the main body comprises a first pin portion having an opening for receiving a ball and a compression pin operatively connected to the ball.
Clause 10: The dosator head of any of Clauses 6-9, wherein the helix-shaped openings are formed to twist along an entire length of the helix-shaped opening.
Clause 11: The dosator head of any of Clauses 6-10, wherein front and rear sides of the passages include a helix-shaped opening.
Clause 12: The dosator head of any of Clauses 6-11, wherein the body member is substantially curved.
Clause 13. A capsule filling station for an apparatus for filling capsules with at least one product, the capsule filling station comprising: a dosator head configured to deliver powder from a powder bowl into a body of the capsules, the powder bowl comprising: a vacuum hopper bowl having groups of holes arranged in circular patterns around a perimeter of the vacuum hopper bowl such that when a vacuum is applied to a bottom of the vacuum hopper bowl, a vacuum is provided at each hole; and an assembly positioned over each group of holes to spread the vacuum provided at each hole.
Clause 14: The capsule filling station of Clause 13, wherein the assembly comprises an upper plate, a screen, a middle plate, and a lower shim.
Clause 15: The capsule filling station of Clause 14, wherein the lower shim and the middle plate are positioned over one of the groups of holes on the vacuum hopper bowl to provide an area for the vacuum to spread out, such that the vacuum is applied to a plurality of slots formed in the middle plate.
Clause 16: The capsule filling station of Clause 15, wherein the screen and the upper plate transfer the vacuum to the powder in the vacuum hopper bowl.
Clause 17: The capsule filling station of Clause 16, wherein the upper plate defines a plurality of slots to transfer the vacuum to the powder in the vacuum hopper bowl.
Clause 18: The capsule filling station of any of Clauses 14-17, wherein the upper plate comprises three posts that pass through the screen and the middle plate and are held in a surface of the vacuum hopper bowl.
Clause 19: The capsule filling station of any of Clauses 15-18, wherein the plurality of slots formed in the middle plate are substantially arcuate in shape.
Clause 20: The capsule filling station of any of Clauses 15-19, wherein a number of slots formed in the middle plate corresponds to a number of dosator tubes that are provided in the dosator head.
These and other features and characteristics of the present invention, as well as the methods of operation and functions of the related elements of structures and the combination of parts and economies of manufacture, will become more apparent upon consideration of the following description and the appended claims with reference to the accompanying drawings, all of which form a part of this specification, wherein like reference numerals designate corresponding parts in the various figures. It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended as a definition of the limits of the invention. As used in the specification and the claims, the singular form of “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise.
For the purpose of facilitating understanding of the invention, the accompanying drawings and description illustrate preferred embodiments thereof, from which the invention, various embodiments of its structures, construction and method of operation, and many advantages may be understood and appreciated.
For purposes of the description hereinafter, the terms “upper”, “lower”, “right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “lateral”, “longitudinal”, and derivatives thereof shall relate to the invention as it is oriented in the drawing figures. However, it is to be understood that the invention may assume alternative variations and step sequences, except where expressly specified to the contrary. It is also to be understood that the specific devices and processes illustrated in the attached drawings, and described in the following specification, are simply exemplary embodiments of the invention. Hence, specific dimensions and other physical characteristics related to the embodiments disclosed herein are not to be considered as limiting.
With reference to
With reference to
At step B, the center hub 15 rotates clockwise to the powder loading station 5. As the hub 15 rotates from the capsule loading station 3 to the powder loading station 5, the lower bushing plate moves outward from the center hub 15 which allows for the loading of a powder pharmaceutical product into the body of the capsule. At the powder loading station 5, powder is picked up by the dosator head 23 from the powder bowl 25. The dosator head 23 is then rotated 180 degrees in order to deposit powder into the body of the capsule.
At step C, the center hub 15 rotates clockwise to the rejection station 7, the capsules that did not separate at step A are eliminated as follows. If capsules did not separate, the body of the capsule is still inserted into the cap. A pin (not shown) of the rejection station 7 moves upward toward the capsule hitting the body bottom and pushes the unopened capsule into a capsule rejection box (not shown). If the body is separated from the cap, the pin moves upward inside the cap without touching resulting in no movement of the cap.
At step D, the center hub 15 rotates from the rejection station 7 to the closing station 9. At the closing station 9, the lower bushing moves inward toward the center of the center hub 15 resulting in the upper and lower bushings being lined up. A pin (not shown) then pushes the body of the capsule into the cap, thereby closing the capsule.
At step E, the center hub 15 rotates from the closing station 9 to the ejection station 11. At the ejection station 11, a pin (not shown) moves upward to hit the bottom of the assembled capsule pushing it out of the upper bushing into a discharge chute 27 where air forces the capsule down the chute 27.
Finally, at step F, the center hub 15 rotates from the ejection station 11 to the cleaning station 13. At the cleaning station 13, a hollow pin (not shown) with an air jet moves upward through the lower and upper bushings blowing out excess powder to clean the bushings. The rotating center hub 15 then rotates to the capsule loading station 3 and the process is repeated.
Optionally, between steps A and B, a beading loading station 29 may be provided. At the beading loading station 29, beads from a bead dosator head can be added to the body of the capsule.
Several improvements to the above described apparatus 1 for filling capsules with a pharmaceutical product that increase the output of the apparatus will now be described. With reference to
In one aspect of the disclosure, the openings 33, 41 and the passages 37, 43 have a substantially circular cross-section and are sized to receive the capsules from the lower hopper support 19. The top portion 35 of the body 31 may have a larger thickness than the bottom portion 39 of the body 31. Due to the differences in thickness between the top portion 35 and the bottom portion 39 of the body 31, an extension surface 32 is defined on the body 31. The extension surface 32 provides an extended portion of the body 31 that assists in permitting angled passages 43 to be defined therein. The plurality of openings 41 may be offset from the plurality of openings 33 such that the center of the openings 41 are positioned between each of the center of the corresponding openings 33. Each of the openings 33, 41 may include a chamfered surface 36 that assists in directing the capsules into the openings 33, 41 and into the passages 37, 43. The chamfered surfaces 37 may be sloped such that the openings 33, 41 may have a larger diameter in an upper portion of the openings 33, 41 and a smaller diameter in a lower portion of the openings 33, 41 such that the diameter of the openings 33, 41 is gradually reduced from the upper portion to the lower portion of the openings 33, 41. The diameter of the openings 33, 41 at the lower portion is substantially equal to the diameter of the corresponding passages 37, 43. The passages 37, 43 may have a substantially constant diameter along the length of the passages 37, 43.
As shown in
With reference to
The helix shape opening 51 defined in the passages 47 assists in removing the slug of powder from the piston 49. In one aspect of the disclosure, the term “helix” indicates that the opening 51 is substantially twisted or curved about the longitudinal axis of the passage 47. In one aspect, the upper end of the opening 51 is defined in a first angular position on the outer circumference of the passage 47 and a lower end of the opening 51 is defined in a second angular position on the outer circumference of the passage 47. A portion 56 of the piston 49 extends through the opening 51 such that the portion 56 is directed and rides along the surface defined by the opening 51 when the piston 49 is moved vertically within the passage 47. As the portion 56 rides along the surface of the opening 51, the piston 49 is twisted within the passage 47 due to the twisting configuration of the opening 51. The piston 49 is twisted relative to the slug held in the dosator tube 53 such that the rotation of the piston 49 assists in disconnecting the slug from an end of the piston 49 so the slug can be deposited into a capsule. Therefore, unlike conventional piston blocks that include substantially linear openings defined in the passages in which the slugs will often stick to the end of the piston pin resulting in an underweight capsule, the helix-shaped openings 51 of the passages 47 of the present piston block 23 assist in easily disconnecting the slug from the end of the piston 49 by rotating the piston 49 relative to the slug.
In addition, with reference to
By using the dosator head 23 having ten (10) dosator tubes 53 as described above, a need exists for an assembly to be provided to an existing powder bowl to accommodate the ten dosator tubes 53 while also providing ten flat areas for the compression of the powder. The flat area is required because the dosator tube 53 moves downwardly over the flat area and compression of the powder occurs with the dosator piston 49.
With reference to
Although the invention has been described in detail for the purpose of illustration based on what is currently considered to be the most practical and preferred embodiments, it is to be understood that such detail is solely for that purpose and that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover modifications and equivalent arrangements. For example, it is to be understood that the present invention contemplates that, to the extent possible, one or more features of any embodiment can be combined with one or more features of any other embodiment.
This application claims the benefit of U.S. Provisional Patent Application No. 62/363,416, filed Jul. 18, 2016, the disclosure of which is incorporated herein by reference in its entirety.
Number | Date | Country | |
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62363416 | Jul 2016 | US |