The present invention relates to audio signal decoding and audio signal processing, and, in particular, to a decoder and methods for adapting audio information in spatial-audio-object-coding (SAOC).
In modern digital audio systems, it is a major trend to allow for audio-object related modifications of the transmitted content on the receiver side. These modifications include gain modifications of selected parts of the audio signal and/or spatial re-positioning of dedicated audio objects in case of multi-channel playback via spatially distributed speakers. This may be achieved by individually delivering different parts of the audio content to the different speakers.
In other words, in the art of audio processing, audio transmission, and audio storage, there is an increasing desire to allow for user interaction on object-oriented audio content playback and also a demand to utilize the extended possibilities of multi-channel playback to individually render audio contents or parts thereof in order to improve the hearing impression. By this, the usage of multi-channel audio content brings along significant improvements for the user. For example, a three-dimensional hearing impression can be obtained, which brings along an improved user satisfaction in entertainment applications. However, multi-channel audio content is also useful in professional environments, for example, in telephone conferencing applications, because the talker intelligibility can be improved by using a multi-channel audio playback. Another possible application is to offer to a listener of a musical piece to individually adjust playback level and/or spatial position of different parts (also termed as “audio objects”) or tracks, such as a vocal part or different instruments. The user may perform such an adjustment for reasons of personal taste, for easier transcribing one or more part(s) from the musical piece, educational purposes, karaoke, rehearsal, etc.
The straightforward discrete transmission of all digital multi-channel or multi-object audio content, e.g., in the form of pulse code modulation (PCM) data or even compressed audio formats, demands very high bitrates. However, it is also desirable to transmit and store audio data in a bitrate efficient way. Therefore, one is willing to accept a reasonable tradeoff between audio quality and bitrate requirements in order to avoid an excessive resource load caused by multi-channel/multi-object applications.
Recently, in the field of audio coding, parametric techniques for the bitrate-efficient transmission/storage of multi-channel/multi-object audio signals have been introduced by, e.g., the Moving Picture Experts Group (MPEG) and others. One example is MPEG Surround (MPS) as a channel oriented approach [MPS, BCC], or MPEG Spatial Audio Object Coding (SAOC) as an object oriented approach [JSC, SAOC, SAOC1, SAOC2]. Another object-oriented approach is termed as “informed source separation” [ISS1, ISS2, ISS3, ISS4, ISS5, ISS6]. These techniques aim at reconstructing a desired output audio scene or a desired audio source object on the basis of a downmix of channels/objects and additional side information describing the transmitted/stored audio scene and/or the audio source objects in the audio scene.
The estimation and the application of channel/object related side information in such systems is done in a time-frequency selective manner. Therefore, such systems employ time-frequency transforms such as the Discrete Fourier Transform (DFT), the Short Time Fourier Transform (STFT) or filter banks like Quadrature Mirror Filter (QMF) banks, etc. The basic principle of such systems is depicted in
In case of the STFT, the temporal dimension is represented by the time-block number and the spectral dimension is captured by the spectral coefficient (“bin”) number. In case of QMF, the temporal dimension is represented by the time-slot number and the spectral dimension is captured by the sub-band number. If the spectral resolution of the QMF is improved by subsequent application of a second filter stage, the entire filter bank is termed hybrid QMF and the fine resolution sub-bands are termed hybrid sub-bands.
As already mentioned above, in SAOC the general processing is carried out in a time-frequency selective way and can be described as follows within each frequency band, as depicted in
At the encoding side, the audio signal is compressed by an audio coding scheme (typically exploiting perceptual effects) and Parametric Side Information (PSI) is computed (see encoder 601). The resulting bitstream consisting of coded audio signal and PSI are stored (or transmitted) to the decoder side, where they can be decoded by various decoder instances 620, 621, 622, labeled as “A”, “B”, etc. in
State of the art coding schemes are not capable to adapt the PSI to a specific target application scenario or platform in an efficient way. This can lead into higher (than necessitated) computational complexity at the decoder side or can result in compatibility problems.
According to an embodiment, an apparatus for adapting input audio information, encoding one or more audio objects, to obtain adapted audio information, wherein the input audio information includes two or more input audio downmix channels and further includes input parametric side information, wherein the adapted audio information includes one or more adapted audio downmix channels and further includes adapted parametric side information, may have: a downmix signal modifier for adapting, depending on adaptation information, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels, and a parametric side information adapter for adapting, depending on the adaptation information, the input parametric side information to obtain the adapted parametric side information, wherein the adaptation information includes an adaptation matrix, wherein the downmix signal modifier is configured to adapt, depending on the adaptation matrix, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels, wherein the parametric side information adapter is configured to adapt, depending on the adaptation matrix, the input parametric side information to obtain the adapted parametric side information.
According to another embodiment, an apparatus for generating one or more audio channels from input audio information encoding one or more audio objects may have: an inventive apparatus for adapting the input audio information to obtain adapted audio information, wherein the input audio information includes two or more input audio downmix channels and further includes input parametric side information, wherein the adapted audio information includes one or more adapted audio downmix channels and further includes adapted parametric side information, and a decoder instance for decoding, depending on the adapted parametric side information, the one or more adapted audio downmix channels to obtain the one or more audio channels.
According to another embodiment, a method for adapting input audio information, encoding one or more audio objects, to obtain adapted audio information, wherein the input audio information includes s two or more input audio downmix channels and further includes input parametric side information, wherein the adapted audio information includes one or more adapted audio downmix channels and further includes adapted parametric side information, may have the steps of: adapting, depending on adaptation information, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels, and adapting, depending on the adaptation information, the input parametric side information to obtain the adapted parametric side information, wherein the adaptation information includes an adaptation matrix, wherein the step of adapting the two or more input audio downmix channels includes s adapting, depending on the adaptation matrix, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels, wherein the step of adapting the input parametric side information includes adapting, depending on the adaptation matrix, the input parametric side information to obtain the adapted parametric side information.
Another embodiment may have a computer program for implementing the inventive method when being executed by a computer or signal processor.
An apparatus for adapting input audio information, encoding one or more audio objects, to obtain adapted audio information is provided. The input audio information comprises two or more input audio downmix channels and further comprises input parametric side information. The adapted audio information comprises one or more adapted audio downmix channels and further comprises adapted parametric side information.
The apparatus comprises a downmix signal modifier for adapting, depending on adaptation information, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels.
Moreover, the apparatus comprises a parametric side information adapter for adapting, depending on the adaptation information, the input parametric side information to obtain the adapted parametric side information.
According to an embodiment, the downmix signal modifier may be configured to adapt the two or more input audio downmix channels depending on the adaptation information, such that the number of the one or more adapted audio downmix channels is smaller than the number of the two or more input audio downmix channels.
In an embodiment, the adaptation information may depend on a decoder instance. The downmix signal modifier may be configured to adapt the two or more input audio downmix channels depending on the decoder instance. Here and in the following, the terms “decoder”, and “decoder instance” have the same meaning.
According to an embodiment, the decoder instance may be capable of decoding at most a maximum number of downmix channels. The adaptation information may depend on said maximum number of downmix channels. Moreover, the downmix signal modifier may be configured to adapt the two or more input audio downmix channels depending on the adaptation information to obtain the one or more adapted audio downmix channels, such that the number of the one or more adapted downmix channels is equal to said maximum number of downmix channels.
According to an embodiment, the adaptation information may comprise an adaptation matrix (DdmxDSM).
In an embodiment, the downmix signal modifier may be configured to adapt, depending on the adaptation matrix (DdmxDSM), the two or more input audio downmix channels (XdmxENC) to obtain DSM the one or more adapted audio downmix channels (XdmxDSM).
According to an embodiment, the downmix signal modifier may be configured to adapt, depending on the adaptation matrix DdmxDSM, the two or more input audio downmix channels XdmxENC to obtain the one or more adapted audio downmix channels XdmxDSM by applying the formula:
X
dmx
DSM
=D
dmx
DSM
X
dmx
ENC.
In an embodiment, the parametric side information adapter may be configured to adapt, depending on the adaptation matrix (DdmxDSM), the input parametric side information (DdmxENC) to obtain the adapted parametric side information (DdmxPSI).
According to an embodiment, the parametric side information adapter may be configured to adapt, depending on the adaptation matrix DdmxDSM, the input parametric side information DdmxENC to obtain the adapted parametric side information DdmxPSI by applying the formula:
D
dmx
PSI
=D
dmx
DSM
D
dmx
ENC.
In an embodiment, the input parametric side information (Ddmxenc) may indicate an initial downmix matrix, such that by applying the initial downmix matrix (Ddmxenc) on the one or more audio objects (S), the two or more input audio downmix channels (Xdmxenc) are obtained. The parametric side information adapter may be configured to determine an adapted downmix matrix (DdmxPSI) as the adapted parametric side information, such that by applying the adapted downmix matrix (DdmxPSI) on the one or more audio objects (S), the one or more adapted audio downmix channels (XdmxDSM) are obtained.
Moreover, according to an embodiment, an apparatus for generating one or more audio channels from input audio information encoding one or more audio objects is provided.
The apparatus for generating the one or more audio channels comprises an apparatus according to one of the above-described embodiments for adapting the input audio information to obtain adapted audio information, wherein the input audio information comprises two or more input audio downmix channels and further comprises input parametric side information, wherein the adapted audio information comprises one or more adapted audio downmix channels and further comprises adapted parametric side information.
Moreover, the apparatus for generating the one or more audio channels comprises a decoder instance, for decoding, depending on the adapted parametric side information, the one or more adapted audio downmix channels to obtain the one or more audio channels.
According to an embodiment, the parametric side information adapter of the apparatus for adapting the input audio information may be configured to receive an input bit stream comprising the input parametric side information. The parametric side information adapter of the apparatus for adapting the input audio information may be configured to adapt the input parametric side information to obtain the adapted parametric side information, and to feed the adapted parametric side information into the decoder instance. The decoder instance may be configured to decode the one or more adapted audio downmix channels depending on the adapted parametric side information.
In another embodiment, the parametric side information adapter of the apparatus for adapting the input audio information may be configured to receive an input bit stream comprising the input parametric side information. The parametric side information adapter of the apparatus for adapting the input audio information may be configured to substitute the input parametric side information within the input bit stream by the adapted parametric side information to obtain a modified bit stream. The parametric side information adapter of the apparatus for adapting the input audio information may be configured to feed the modified bit stream into the decoder instance. Moreover, the decoder instance may be configured to decode the one or more adapted audio downmix channels depending on the modified bit stream.
Furthermore, a method for adapting input audio information, encoding one or more audio objects, to obtain adapted audio information is provided. The input audio information comprises two or more input audio downmix channels and further comprises input parametric side information. The adapted audio information comprises one or more adapted audio downmix channels and further comprises adapted parametric side information. The method comprises:
Moreover, a computer program for implementing the above-described method when being executed by a computer or signal processor is provided.
Embodiments of the present invention will be detailed subsequently referring to the appended drawings, in which:
Before describing embodiments of the present invention, more background on state-of-the-art-SAOC systems is provided.
In the case of a stereo downmix, the channels of the downmix signal 18 are denoted L0 and R0, in case of a mono downmix same is simply denoted L0. In order to enable the SAOC decoder 12 to recover the individual objects s1 to sN, side-information estimator 17 provides the SAOC decoder 12 with side information including SAOC-parameters. For example, in case of a stereo downmix, the SAOC parameters comprise object level differences (OLD), inter-object correlations (IOC) (inter-object cross correlation parameters), downmix gain values (DMG) and downmix channel level differences (DCLD). The side information 20, including the SAOC-parameters, along with the downmix signal 18, forms the SAOC output data stream received by the SAOC decoder 12.
The SAOC decoder 12 comprises an up-mixer which receives the downmix signal 18 as well as the side information 20 in order to recover and render the audio signals ŝ1 and ŝN onto any user-selected set of channels ŷ1 to ŷM, with the rendering being prescribed by rendering information 26 input into SAOC decoder 12.
The audio signals s1 to sN may be input into the encoder 10 in any coding domain, such as, in time or spectral domain. In case the audio signals s1 to sN are fed into the encoder 10 in the time domain, such as PCM coded, encoder 10 may use a filter bank, such as a hybrid QMF bank, in order to transfer the signals into a spectral domain, in which the audio signals are represented in several sub-bands associated with different spectral portions, at a specific filter bank resolution. If the audio signals s1 to sN are already in the representation expected by encoder 10, same does not have to perform the spectral decomposition.
As outlined above, side information extractor 17 of
The side information extractor 17 depicted in
wherein the sums and the indices n and k, respectively, go through all temporal indices 34, and all spectral indices 30 which belong to a certain time/frequency tile 42, referenced by the indices I for the SAOC frame (or processing time slot) and m for the parameter band. Thereby, the energies of all sub-band values xi of an audio signal or object i are summed up and normalized to the highest energy value of that tile among all objects or audio signals. xin,k* denotes the complex conjugate of xin,k.
Further, the SAOC side information extractor 17 is able to compute a similarity measure of the corresponding time/frequency tiles of pairs of different input objects s1 to sN. Although the SAOC side information extractor 17 may compute the similarity measure between all the pairs of input objects s1 to sN, side information extractor 17 may also suppress the signaling of the similarity measures or restrict the computation of the similarity measures to audio objects s1 to sN which form left or right channels of a common stereo channel. In any case, the similarity measure is called the inter-object cross-correlation parameter IOCi,jl,m. The computation is as follows
with again indices n and k going through all sub-band values belonging to a certain time/frequency tile 42, i and j denoting a certain pair of audio objects s1 to sN, and Re{ } denoting the operation of discarding the imaginary part of the complex argument.
The downmixer 16 of
This downmix prescription is signaled to the decoder side by means of downmix gains DMGi and, in case of a stereo downmix signal, downmix channel level differences DCLDi.
The downmix gains are calculated according to:
DMGi=20 log10(di+ε),(mono downmix),
DMGi=10 log10(d1,i2+d2,i2+ε),(stereo downmix),
where ε is a small number such as 10−9.
For the DCLDs the following formula applies:
In the normal mode, downmixer 16 generates the downmix signal according to:
for a mono downmix, or
for a stereo downmix, respectively.
Thus, in the abovementioned formulas, parameters OLD and IOC are a function of the audio signals and parameters DMG and DCLD are a function of d. By the way, it is noted that d may be varying in time and in frequency.
Thus, in the normal mode, downmixer 16 mixes all objects s1 to sN with no preferences, i.e., with handling all objects s1 to sN equally.
At the decoder side, the upmixer performs the inversion of the downmix procedure and the implementation of the “rendering information” 26 represented by a matrix R (in the literature sometimes also called A) in one computation step, namely, in case of a two-channel downmix
where matrix E is a function of the parameters OLD and IOC, and the matrix D contains the downmixing coefficients as
The matrix E is an estimated covariance matrix of the audio objects s1 to sN. In current SAOC implementations, the computation of the estimated covariance matrix E is typically performed in the spectral/temporal resolution of the SAOC parameters, i.e., for each (l,m), so that the estimated covariance matrix may be written as El,m. The estimated covariance matrix El,m is of size N×N with its coefficients being defined as
e
i,j
l,m=√{square root over (OLDil,mOLDjl,m)}IOCi,jl,m.
Thus, the matrix El,m with
has along its diagonal the object level differences, i.e., ei,jl,m=OLDil,m for i=j, since OLDil,m=OLDjl,m and IOCi,jl,m=1 for i=j. Outside its diagonal the estimated covariance matrix E has matrix coefficients representing the geometric mean of the object level differences of objects i and j, respectively, weighted with the inter-object cross correlation measure IOCi,jl,m.
In the following, embodiments of the present invention are described.
The input audio information comprises two or more input audio downmix channels and further comprises input parametric side information. The adapted audio information comprises one or more adapted audio downmix channels and further comprises adapted parametric side information.
The apparatus comprises a downmix signal modifier (DSM) 110 for adapting, depending on adaptation information, the two or more input audio downmix channels to obtain the one or more adapted audio downmix channels.
Moreover, the apparatus comprises a parametric side information adapter (PSIA) 120 for adapting, depending on the adaptation information, the input parametric side information to obtain the adapted parametric side information.
In an embodiment, the adaptation information may depend on a decoder instance, and the downmix signal modifier 110 may be configured to adapt the two or more input audio downmix channels depending on the decoder instance.
For example, the downmix signal modifier 110 of
According to an embodiment, the downmix signal modifier 110 may be configured to adapt the two or more input audio downmix channels depending on the adaptation information, such that the number of the one or more adapted audio downmix channels is smaller than the number of the two or more input audio downmix channels.
For example, in the embodiment of
E.g., 22.2 input audio downmix channels (=24 input audio downmix channels) may be reduced to 7.1 adapted audio downmix channels (=8 adapted audio downmix channels).
Or, for example, 5.1 input audio downmix channels (=6 input audio downmix channels) are reduced to 2.0 adapted audio downmix channels (=2 adapted audio downmix channels).
Or, for example, 2 input audio downmix channels are reduced to 1 adapted audio downmix channel.
Various other combinations of input audio downmix channels and adapted audio downmix channels are possible
According to an embodiment, the decoder instance may be capable of decoding at most a maximum number of downmix channels. The adaptation information may depend on said maximum number of downmix channels. Moreover, the downmix signal modifier 110 may be configured to adapt the two or more input audio downmix channels depending on the adaptation information to obtain the one or more adapted audio downmix channels, such that the number of the one or more adapted downmix channels is equal to said maximum number of downmix channels.
For example, the downmix signal modifier 110 of
According to an embodiment, the adaptation information may, for example, comprise an adaptation matrix (DdmxDSM).
The parametric side information adapter 120 may, e.g., adapt the PSI to correspond to the modified downmix in order to decrease the computational complexity for the decoder, and to reduce the corresponding data bitstream size/bitrate without producing negative influence on the decoder output audio quality.
For example, the PSIA 120 modifies the corresponding PSI bitstream substituting the information representing the initial downmix matrix by the updated information describing the resulting downmix (accounting for the DSM modifications) to correspond to the particular specification of the decoder.
For example, an SAOC encoder provides the stereo downmix signal XdmxENC resulting from application of the encoder downmix matrix DdmxENC to the input audio object signals S:
X
dmx
ENC
=D
dmx
ENC
S.
According to an embodiment, the downmix signal modifier 110 may be configured to adapt, depending on the adaptation matrix DdmxDSM, the two or more input audio downmix channels XdmxENC to obtain the one or more adapted audio downmix channels XdmxDSM. In an embodiment, this is realized, for example, by applying the formula XdmxDSM=DdmxDSMXdmxENC.
For example, in an embodiment, where it is assumed that the particular SAOC decoder instance supports only mono downmix (e.g. SAOC Low Delay profile/Level 1). In this case, the DSM 110 converts the stereo downmix XdmxENC to the mono signal XdmxDSM using a predefined downmix matrix DdmxDSM as follows:
X
dmx
DSM
=D
dmx
DSM
X
dmx
ENC.
According to an embodiment, the parametric side information adapter 120 may be configured to adapt, depending on the adaptation matrix DdmxDSM, the input parametric side information DdmxENC to obtain the adapted parametric side information DdmxPSI. In an embodiment, this may, for example, be realized by applying the formula: DdmxPSI=DdmxDSMDdmxENC.
For example, according to an embodiment, the PSIA 120 parses the corresponding PSI bitstream; extracts information that describes the downmix matrix DdmxENC; substitutes these data by updated information that describes the new downmix matrix DdmxPSI:
D
dmx
PSI
=D
dmx
DSM
D
dmx
ENC
Thus, according to an embodiment, the input parametric side information (Ddmxenc) may indicate an initial downmix matrix, such that by applying the initial downmix matrix (Ddmxenc) on the one or more audio objects (S), the two or more input audio downmix channels (Xdmsenc) are obtained. The parametric side information adapter may be configured to determine an adapted downmix matrix (DdmxPSI) as the adapted parametric side information, such that by applying the adapted downmix matrix (DdmxPSI) on the one or more audio objects (S), the one or more adapted audio downmix channels (XdmxDSM) are obtained.
In an embodiment, the PSIA formats the new modified bitstream or directly passes these parameters to the decoder.
This encoding and decoding process performed by the PSIA can also include conversion of different downmix matrix representation formats (e.g. polar- to Cartesian-coordinate system, etc.).
This described function of the PSIA can solve potential compatibility issues and reduce the size of the corresponding bitstream.
The apparatus 700 for generating the one or more audio channels comprises an apparatus 710 according to one of the above-described embodiments for adapting the input audio information to obtain adapted audio information. The input audio information comprises two or more input audio downmix channels and further comprises input parametric side information. The adapted audio information comprises one or more adapted audio downmix channels and further comprises adapted parametric side information.
The apparatus 710 according to one of the above-described embodiments for adapting the input audio information comprises a downmix signal modifier 110 and a parametric side information adapter 120.
Moreover, the apparatus 700 for generating the one or more audio channels comprises a decoder instance 720, for decoding, depending on the adapted parametric side information, the one or more adapted audio downmix channels to obtain the one or more audio channels.
According to an embodiment, the parametric side information adapter 120 of the apparatus 710 for adapting the input audio information may be configured to receive an input bit stream comprising the input parametric side information. The parametric side information adapter 120 of the apparatus 710 for adapting the input audio information may be configured to adapt the input parametric side information to obtain the adapted parametric side information, and to feed the adapted parametric side information into the decoder instance 720. The decoder instance 720 may be configured to decode the one or more adapted audio downmix channels depending on the adapted parametric side information.
In another embodiment, the parametric side information adapter 120 of the apparatus 710 for adapting the input audio information may be configured to receive an input bit stream comprising the input parametric side information. The parametric side information adapter 120 of the apparatus 710 for adapting the input audio information may be configured to substitute the input parametric side information within the input bit stream by the adapted parametric side information to obtain a modified bit stream. The parametric side information adapter 120 of the apparatus 710 for adapting the input audio information may be configured to feed the modified bit stream into the decoder instance 720. Moreover, the decoder instance 720 may be configured to decode the one or more adapted audio downmix channels depending on the modified bit stream.
In particular,
The joint (integrated) implementation of the apparatus for adapting input audio information can be realized in order to reduce computational complexity for decoding (see
In particular,
The disjoint (separated) implementation of the apparatus for adapting input audio information can be realized in order to reduce the corresponding data bitstream size/bitrate, see
Although some aspects have been described in the context of an apparatus, it is clear that these aspects also represent a description of the corresponding method, where a block or device corresponds to a method step or a feature of a method step. Analogously, aspects described in the context of a method step also represent a description of a corresponding block or item or feature of a corresponding apparatus.
The inventive decomposed signal can be stored on a digital storage medium or can be transmitted on a transmission medium such as a wireless transmission medium or a wired transmission medium such as the Internet.
Depending on certain implementation requirements, embodiments of the invention can be implemented in hardware or in software. The implementation can be performed using a digital storage medium, for example a floppy disk, a DVD, a CD, a ROM, a PROM, an EPROM, an EEPROM, or a FLASH memory, having electronically readable control signals stored thereon, which cooperate (or are capable of cooperating) with a programmable computer system such that the respective method is performed.
Some embodiments according to the invention comprise a non-transitory data carrier having electronically readable control signals, which are capable of cooperating with a programmable computer system, such that one of the methods described herein is performed.
Generally, embodiments of the present invention can be implemented as a computer program product with a program code, the program code being operative for performing one of the methods when the computer program product runs on a computer. The program code may for example be stored on a machine readable carrier.
Other embodiments comprise the computer program for performing one of the methods described herein, stored on a machine readable carrier.
In other words, an embodiment of the inventive method is, therefore, a computer program having a program code for performing one of the methods described herein, when the computer program runs on a computer.
A further embodiment of the inventive methods is, therefore, a data carrier (or a digital storage medium, or a computer-readable medium) comprising, recorded thereon, the computer program for performing one of the methods described herein.
A further embodiment of the inventive method is, therefore, a data stream or a sequence of signals representing the computer program for performing one of the methods described herein. The data stream or the sequence of signals may for example be configured to be transferred via a data communication connection, for example via the Internet.
A further embodiment comprises a processing means, for example a computer, or a programmable logic device, configured to or adapted to perform one of the methods described herein.
A further embodiment comprises a computer having installed thereon the computer program for performing one of the methods described herein.
In some embodiments, a programmable logic device (for example a field programmable gate array) may be used to perform some or all of the functionalities of the methods described herein. In some embodiments, a field programmable gate array may cooperate with a microprocessor in order to perform one of the methods described herein. Generally, the methods are performed by any hardware apparatus.
While this invention has been described in terms of several advantageous embodiments, there are alterations, permutations, and equivalents which fall within the scope of this invention. It should also be noted that there are many alternative ways of implementing the methods and compositions of the present invention. It is therefore intended that the following appended claims be interpreted as including all such alterations, permutations, and equivalents as fall within the true spirit and scope of the present invention.
This application is a continuation of copending International Application No. PCT/EP2013/063703, filed Jun. 28, 2013, which is incorporated herein by reference in its entirety, and additionally claims priority from U.S. Application No. 61/681,732, filed Aug. 10, 2012, which is also incorporated herein by reference in its entirety.
Number | Date | Country | |
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61681732 | Aug 2012 | US |
Number | Date | Country | |
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Parent | PCT/EP2013/063703 | Jun 2013 | US |
Child | 14616374 | US |