The present invention relates to an apparatus for the storage and retrieval of large volumes of test tubes.
Nowadays, in the context of laboratory automation systems used for handling test tubes containing samples of biological material, the need is increasingly felt to have suitably refrigerated warehouses within the system itself in which the analyzed biological samples can be stored for a more or less long period, so as to make them available to the system again, when needed, to repeat the analysis by the modules connected to the automation.
Patent application MI2012A002011 by the same Applicant describes an apparatus for automatically depositing, storing and retrieving samples of biological material in/from a refrigerated warehouse using two distinct static robots.
Disadvantageously, the apparatus described in said patent application is not suitable for large-sized warehouses.
On the other hand, given the ever-increasing operating volumes of a laboratory, it is desirable that the storage and subsequent retrieval involves as many samples as possible.
The object of the present invention is to provide an apparatus for the storage and retrieval of large volumes of test tubes in/from large-sized warehouses ensuring the same throughput as the storage solutions already known.
A further object of the present invention is that said apparatus can carry out a selective retrieval of samples, even if positioned in different and very far areas of the warehouse.
Moreover, since the test tubes inserted in the warehouse may require, depending on the type of biological sample they contain, different storage times, yet a further object of the present invention is that said apparatus is capable of storing substantially at the same time all the test tubes containing samples of the same type, so as to have a certain uniformity in the processing times of the same and thus be able to retrieve them easily when their storage time comes to an end; in other words, in the event that the life time of the samples ends without the need to direct them again along the automation for new analysis, these must be disposed of all together in the most practical possible manner.
These and other objects are achieved by an apparatus for the storage and retrieval of large volumes of test tubes in/from a warehouse, characterized in that it comprises
an input/output module of test tubes from/to an automation system for the transport of said test tubes in transport devices of single test tubes, which includes two distinct coplanar locations for a first and a second container of a plurality of test tubes,
a multiple pick up device adapted to pick up said test tubes from a plurality of transport devices of single test tubes queued in a secondary lane of said automation system, and to release them in the first container positioned on an input/output module,
a single pick up device adapted to pick up said test tubes from the second container positioned on said input/output module and to release them in said transport devices of single test tubes on said automation system,
a first station for the provisional allocation of said containers on distinct locations of a same shelf comprising one or more shelves and interfaced with said input/output module,
a second station of the provisional allocation of the first container on one or more shelves, interfaced with a discharge device of test tubes to be disposed,
a motorized traveling lift able to simultaneously transport on two distinct coplanar locations said first and second container, and adapted to move bidirectionally said first and second container of test tubes between said first station for the provisional allocation and said warehouse, and only said first container between said warehouse and said second station for the provisional allocation.
These and other features of the present invention will appear more clearly from the following detailed description of an embodiment thereof, shown by way of a non-limiting example in the accompanying drawings, in which:
An apparatus 1 for the automatic deposit, storage and retrieval of samples of biological material in/from a refrigerated warehouse 2, whose temperature typically ranges from −2 to +6° C., is shown in
Warehouse 2 is facing a laboratory automation system 3 which carries samples of biological material contained in test tubes 4 inserted in turn into transport devices 5. The interfacing between warehouse 2 and system 3, with relative exchange of test tubes 4, is implemented by means of a sample input/output module 6.
Moreover, along the automation system 3 and upstream of the interface with warehouse 2, one or more stations 7 may be provided for the provisional allocation of biological samples, i.e. test tubes 4 contained in the relative transport devices 5 of single test tubes 4, similar to those described in Italian patent application MI2012A 001218 (
A motorized traveling lift 8 (
The traveling lift 8, moving along appropriate rails inside warehouse 2 itself, is able to position itself in front of any of locations 11 of warehouse 2 adapted to accommodate a container 9, and at this point two opposite operations may be carried out: a container 9 may be removed from location 11 and positioned on the traveling lift 8, so that one or more test tubes 4 are picked up from it, or conversely if the traveling lift 8 is already carrying a container 9 (filled with test tubes 4 just unloaded from the automation system 3), it is moved to location 11 for medium/long term storage.
Along the face of warehouse 2 opposite the one which interfaces with the automation system 3 is a discharge device 13 of the test tubes 4 which have reached the end of their life cycle and which therefore, containing samples that cannot be meaningful anymore for new analysis, must be disposed of (
To this end, an apparatus with multiple racks 14 may be provided underneath such a discharge device for collecting the disposed test tubes 4, similar to that described by Italian patent application MI2012A 001111 (
Describing in more detail the operation of apparatus 1, the test tubes 4 traveling along the automation system 3 and which must be allocated in warehouse 2 are suitably diverted from a main lane 30 to a secondary lane 31 of system 3, so as to form a queue of transport devices 5 with single test tube 4 in the sampling point of the input/output module 6 (
The transport devices 5 with test tube 4, before interfacing with the input/output module 6, as mentioned, may also be diverted even more upstream in one or more stations 7 for the provisional allocation of biological samples. Each of said stations 7 is designed to allocate test tubes 4, preferably containing samples homogeneous by type, and which therefore once released and directed to the interface with the input/output module 6 typically require similar storage times inside warehouse 2 (
The test tubes 4 contained in the queued transport devices 5 are at this point picked up by a multiple pick up device 60 wherein the distance between each of the single pick up devices 600 is suitably calibrated on the distance between the test tubes 4 of two adjacent transport devices 5 in the queue (
Meanwhile, the queue of transport devices 5 advances and the pick up device 60 returns to the interface with the secondary lane 31 of system 3, to pick up new test tubes 4 which are then inserted into container 9, in the remaining locations on the same row. This is made possible by the fact that, along the direction parallel to system 3, the pick up device 60 is able to perform a further movement, controlled by a pneumatic cylinder 61 and of width equal to half the pitch between two pick up fingers (
In the embodiment shown, the multiple pick up device 60 is provided with ten single pick up devices 600 (
Through the repetition of this cycle, the entire container 9 is preferably but not necessarily filled; during this operation, container 9 is locked in position by a rubber buffer 63 acting laterally in relation to container 9, and is pushed by a pneumatic cylinder 64 (
The input/output module 6 likewise has similar locking devices for container 10, which shall be discussed in more detail hereafter, i.e. a rubber buffer 67 pushed by a cylinder 68 and an antenna 69 for identifying container 10 itself (
Container 9, once full, must then be directed to warehouse 2: therefore, a sliding door 20 is raised and container 9 is made to slide on a first station 70 for the provisional allocation of containers 9, 10 provided with a certain number (in this example, four) of different shelves 71, each consisting of a space for accommodating a container 9 and a narrower container 10 (
As regards container 9, the sliding takes place by means of a sliding mechanism 12 directly present on hoard of the input/output module 6, which also seats a similar sliding mechanism 120 dedicated instead to the sliding of a container 10 (
The sliding mechanism 12 is provided with a pusher 121 (
The sliding mechanism 120 (
At the first station 70 for the provisional allocation (
The vertical movement of shelves 71 of the first station 70 is carried out thanks to two pneumatic cylinders 72 and 73 aligned in height. The two cylinders have a different height, and being both able to take both a high and a low position, the four possible combinations that can be achieved (“low-low”; “low-high”; “high-low”; “high-high”) give rise to the four different heights of the first station 70 (
Returning to the path of container 9 full of test tubes 4 just picked up from system 3, it therefore is on the first station 70 for the provisional allocation, facing the traveling lift 8 which then picks it up thanks to a sliding mechanism 12 that it accommodates on board (
On the traveling lift 8 there are also a locking mechanism of container 9 on a shelf 80 intended to receive it, comprising a rubber buffer 84 pushed by a pneumatic cylinder 85, and a mechanism for detecting the identifier of container 9 through an antenna 86 with pneumatic cylinder 87 (
At this point, the traveling lift 8 is designed to move container 9 which it has on board towards the appropriate shelf inside warehouse 2. To do so, the traveling lift 8 moves first along a first pair of rails 81 thanks to the action of a first motor 810, to position itself at a specific lane in which then it penetrates, being driven by a second motor 820, along a second pair of rails 82 present at each lane (
Afterwards, in order to complete the positioning operation, shelf 80 of the traveling lift 8, where container 9 is accommodated, is lifted by means of a third motor 830 (
The insertion of container 9 into location 11 can proceed only if a correct alignment is ensured between the traveling lift 8 (and in particular shelf 80 thereof, which carries container 9) and location 11 which must receive container 9.
Such an alignment is basically already achieved in the first instance, but nevertheless it requires a “fine-tuning” system before proceeding to the actual translation of container 9. This final adjustment, which has extreme precision requirements, can be carried out by providing the traveling lift 8 with a reader 83 which frames an identifier 111 (typically a two-dimensional barcode or “data matrix”) positioned on the side of each of locations 11 of each shelf and which therefore uniquely defines location 11 itself inside warehouse 2 (
The adjustment system, detecting the deviation of the traveling lift 8 with respect to a known position and referred to a perfect centering according to this framing, is able to command slight deviations in the two directions to motors 820 and 830 (
Since upon the penetration of the traveling lift 8 inside one of the lanes of warehouse 2 it is located between two shelves facing each other, in both of which it can insert or withdraw containers 9, it is possible to have a second adjustment system, and therefore a second reader 83 (
Once the perfect positioning of the traveling lift 8 is ensured, the sliding mechanism 12 on board of the traveling lift 8 inserts the full container 9 into location 11; in order to do so, a pneumatic cylinder 89 is also involved, also located on hoard of the traveling lift 8, which lifts a safety latch 110 located on the side of each location 11 and which would normally prevent the insertion of a container 9 into location 11 (
This ensures the retention of container 9 into location 11, even in case of stresses (such as seismic) to which warehouse 2 may be subject.
The sliding mechanism 12 on board of the traveling lift 8 (
In order to make this possible, pusher 121 of the sliding mechanism 12, when in “low” position, can slide along rack 125 substantially passing underneath container 9 hosted by shelf 80, to then hook container 9 itself, after having moved to the “high” position thanks to the pneumatic cylinder 122, and drag in the opposite direction. In fact, the sliding mechanism 12 of the traveling lift 8 is slightly modified by the presence of magnets 124 on both sides of pusher 121 (
The difference with the sliding mechanism 12 described above with reference to the input/output module 6 (
On the other hand, there are no substantial differences between the sliding mechanism 120 used in the traveling lift 8 (
The traveling lift 8, after unloading a container 9 into the appropriate location 11 of warehouse 2, may provide for the retrieval of some test tubes 4 already stored in the other shelves of warehouse 2, because for example some analysis must be carried out of such samples. Optionally, it can also provide to the retrieval of a new empty container 9 (if available) to be then positioned on the input/output module 6.
The need to proceed immediately with such operations depends on the specific requirements, but the trend must be of course to optimize as much as possible the operation flow of the traveling lift 8, before it returns towards the input/output module 6 and thus towards the automation system 3.
For the retrieval of the test tubes 4, the traveling lift 8 (which in the meantime has suitably moved in front of a location 11 of a specific shelf, also thanks to the adjustment system described above) releases the safety latch 110 of the location 11 concerned (
At this point, a single pick up device 800 of test tubes, i.e. a Cartesian robot, present on the traveling lift 8 selectively picks up one or more test tubes 4 from container 9 to move them into container 10 for the test tubes to be retrieved, locked into position by a rubber buffer 801 pushed by cylinder 802, integral with an antenna 803 for the recognition of the identifier (barcode) of container 10 (
It is noted that container 10 is on the traveling lift 8, typically because it has previously translated as well (via the sliding mechanisms 120) from the input/output module 6 to the first station 70 of the provisional allocation and from this to the traveling lift 8.
Once the selective retrieval of test tubes 4 from container 9 has ended, it is inserted back into its location 11 and the pick up can certainly continue on other test tubes 4 of another container 9 in another location 11 of warehouse 2, in front of which the traveling lift 8 moves in the meantime, always with the partially filled container 10 on board. The cycle is typically (but not necessarily) repeated up to the total filling of container 10.
Finally, the traveling lift 8 as said can also load a new empty container 9, to be then directed to the input/output module 6 so that it can accommodate new test tubes 4 therein from the automation system 3.
The traveling lift 8 with the empty container 9 and the full container 10 on board now returns to the automation system 3, and in particular it unloads both the empty container 9 and the full container 10 on the first station 70 for the provisional allocation, which then makes available the two containers 9, 10 to the input/output module 6, depending on its filling conditions at steady state; all is carried out by suitably coordinating the vertical movements of shelves 71 of the first station 70 (
Once container 10 has reached the input/output module 6 and has been suitably locked by the buffer rubber 67, pushed by cylinder 68 and identified by antenna 69 (in
The pick up device 62 has two different pick up positions on container 10 as well, in order to draw test tubes 4 in both locations on the same row. The movement of the pick up device 62 is therefore also controlled by a pneumatic cylinder 620 (
Each of the test tubes 5 concerned, once returned on the automation system 3, is typically identified (for example by means of a barcode reader combined with a device for rotating the transport device 5) so as to create the proper association with the transport device 5 that has just received it, and then directed along other modules for possible new analysis.
Apparatus 1 also includes, as mentioned, the discharge of test tubes 4 that, having exhausted their lifetime, have no reason anymore to be stored into warehouse 2.
The disposal relates to one container 9 at a time, regardless of whether it is, as preferable, completely full of test tubes 4 or partially empty.
The storage time in warehouse 2 after which there is the need to dispose of a given container 9, and therefore of all the test tubes 4 which it contains, is configurable and is typically in the order of a few days.
It is again the traveling lift 8 that picks up container 9 to be disposed of, and to direct it towards the area of warehouse 2 opposite to that which interfaces with the automation system 3, where the discharge device 13 of test tubes 4 is positioned (
The directing of containers 9 with test tubes 4 to be disposed of to the discharge device 13 uses a second station 74 for the provisional allocation (
Container 9 picked up by the traveling lift 8 is suitably dragged by the sliding mechanism 12 of the traveling lift 8 itself on the second station 74 for the provisional allocation, and hence subsequently picked up, through a sliding door 20, by a sliding mechanism 12 similar to those already seen but located on board of the discharge device 13 (
During this operation, container 9 is locked for a few moments to be as usual identified by an antenna 130.
Once arrived into the appropriate discharge position 131, container 9 is turned upside down thanks to a pneumatic cylinder 132 which, by actuating a gear comprising a pinion 133 and a rack 134, causes the overturning of the surface on which container 9 is resting (
The test tubes 4 therefore end up in a position below, where as said there may be an apparatus with multiple racks 14 (
The discharge device 13 may comprise a pushing mechanism for each test tube 4 in each of the seats of container 9, comprising plugs 135 actuated by a pneumatic cylinder 136 which act after the overturning of container 9 so as to ensure with certainty the simultaneous expulsion of all the test tubes 4 from the respective seats (
Container 9, once emptied, is overturned again to be returned to the initial position; then, plugs 135 are retracted and then the sliding mechanism 12 returns container 9 first on the second station 74 for the provisional allocation, then on the traveling lift 8 and finally in one of the shelves of warehouse 2.
Apparatus 1 may be provided with a spare input/output module 6000 (
The same applies to the insertion into warehouse 2 of an equally spare traveling lift 8000 (
If in fact the traveling lift 8 breaks down, for its maintenance it is preferable to move it outside warehouse 2, for a twofold safety requirement of maintainers, who are thus not forced to work inside warehouse 2, possibly at low temperatures, also preventing the risk of interfering with the movement of the traveling lift 8000 which meanwhile has been activated. To extract the traveling lift 8, when broken, from warehouse 2, the latter is provided with a door 200 (
The innovative aspect of the invention is therefore represented by the substantial increase, compared to known apparatus that use a traveling lift 8 for the storage of objects and in particular of containers 9 of test tubes 4, in the throughput of storage/retrieval of samples; this is undoubtedly thanks to the simultaneous loading of multiple test tubes 4 at a time (ten, in the embodiment shown) from an automation system 3 to an input/output module 6 and vice versa, but also thanks to the particular configuration of the traveling lift 8, which simultaneously accommodates containers 9 of test tubes to be stored and containers 10 of test tubes to be retrieved, and suitably parallelizes the storage/retrieval operations according to the variable needs of the moment.
The increased throughput makes it possible indirectly to build a larger warehouse 2 in terms of number of containers 9 of test tubes that it can accommodate.
Moreover, as regards in particular the retrieval of samples to re-enter along the automation system 3, particularly innovative is the possibility, where appropriate, to can out such a retrieval not on the entire quantity of test tubes 4 stored in a same container 9, but possibly also on single test tubes 4 belonging to different containers 9 and then directed towards the automation system 3 using container 10 of test tubes to be retrieved.
Moreover, thanks to the safety latch 110 which locks each container 9 inserted into locations 11 of warehouse 2, each of such containers 9 remains locked inside the shelf, on the other side there being the wall of warehouse 2 itself; the lock is ensured even in case of earthquake.
Several changes and variations may be made to the invention thus conceived, all felling within the scope of the inventive concept.
In the practice, the materials used as well as shapes and sizes, may be any, according to the requirements.
Number | Date | Country | Kind |
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MI2014A0984 | May 2014 | IT | national |
Filing Document | Filing Date | Country | Kind |
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PCT/EP2015/061643 | 5/27/2015 | WO | 00 |
Publishing Document | Publishing Date | Country | Kind |
---|---|---|---|
WO2015/181202 | 12/3/2015 | WO | A |
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