Claims
- 1. A method of granulating a finely divided solid material, comprising the steps of:
- a. preparing an aqueous granulating solution by dissolving an alkali metal salt of an edible organic acid selected from the group consisting of trisodium citrate, tripotassium citrate, dipotassium fumarate and sodium potassium tartrate in water;
- b. mixing an amount of the aqueous granulating solution effective to produce a moist mass on mixing with a finely divided solid material requiring granulation, the solid material selected from the group consisting of potassium bicarbonate, acetaminophen, calcium carbonate, sodium bicarbonate, ketoprofen and a combination thereof; and
- c. granulating and drying the mixture.
- 2. A granulation mixture composed of:
- a. an aqueous solution of a bicarbonate chosen from sodium or potassium bicarbonate and an alkali metal salt selected from the group consisting of trisodium citrate, tripotassium citrate, dipotassium fumarate and sodium potassium tartrate which aqueous solution is present in an amount effective to produce a moist mass on mixing; and
- b. a finely divided solid chosen from the group consisting of potassium bicarbonate, acetaminophen, calcium carbonate, sodium bicarbonate, ketoprofen or a combination thereof.
- 3. A method of preparing an effervescent tablet formulation, comprising the steps of:
- a. preparing an aqueous granulating solution by dissolving an alkali metal salt of an edible organic acid selected from the group consisting of trisodium citrate, tripotassium citrate, dipotassium fumarate and sodium potassium tartrate in water;
- b. mixing the aqueous granulating solution in an amount effective to produce a moist mass on mixing with a finely divided solid material requiring granulation, the solid material selected from the group consisting of potassium bicarbonate, acetaminophen, calcium carbonate, sodium bicarbonate, ketoprofen and a combination thereof;
- c. granulating and drying the mixture; and
- d. forming an effervescent tablet.
- 4. A method of granulating a finely divided solid material comprising the steps of:
- a. preparing an aqueous granulating solution by dissolving a sodium or potassium or a mixed sodium or potassium salt of an edible organic acid chosen from the group consisting of citric acid, fumaric acid, tartaric acid and malic acid;
- b. mixing an amount of the aqueous granulating solution effective to produce a moist mass on mixing with a nonacid or slightly acidic, finely divided, medically effective solid ingredient requiring granulation;
- c. granulating and drying the mixture.
Parent Case Info
This is a continuation of application Ser. No. 639,908, filed Jan. 10, 1991, now abandoned, which is a continuation-in-part of U.S. Ser. No. 349,060 filed May 9, 1989, now abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (4)
Number |
Date |
Country |
085376 |
Oct 1982 |
DEX |
8402468 |
Jul 1984 |
FRX |
882567 |
Nov 1961 |
GBX |
1475861 |
Jun 1977 |
GBX |
Continuations (1)
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Number |
Date |
Country |
Parent |
639908 |
Jan 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
349060 |
May 1989 |
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