Claims
- 1. An araliphatic dihalogen comound of the formula ##STR9## wherein R.sup.1 and R.sup.2 are F, Cl or Br; Q is --CH(CH.sub.3)--CH.sub.2 --, -- C(OH)(CH.sub.3)--CH.sub.2 -- or --C(CH.sub.3).dbd.CH--; and n is 0 or 1, and physiologically acceptable salts thereof.
- 2. A compound of claim 1, wherein n is 0.
- 3. A compound of claim 1, wherein n is 1.
- 4. A compound of claim 1, wherein R.sup.1 and R.sup.2 are F.
- 5. A compound of claim 1, wherein Q is --CH(CH.sub.3)--CH.sub.2 --.
- 6. A compound of claim 5 wherein n is 0.
- 7. A compound of claim 5 wherein n is 1.
- 8. A compound of claim 1, wherein Q is -- C(OH)(CH.sub.3)--CH.sub.2 --.
- 9. A compound of claim 8 wherein n is 0.
- 10. A compound of claim 8 wherein n is 1.
- 11. A compound of claim 1, wherein Q is --C(CH.sub.3).dbd.CH--.
- 12. A compound of claim 11 wherein n is 0.
- 13. A compound of claim 11 wherein n is 1.
- 14. A compound of claim 1, wherein Z is 2',4'-difluoro-4-biphenylyl.
- 15. 3-(2',4'-Difluoro-4-biphenylyl)butyric acid, a compound of claim 1.
- 16. 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid, a compound of claim 1.
- 17. 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid, a compound of claim 1.
- 18. 3-(2',4'-Dichloro-4-biphenylyl)butyric acid, a compound of claim 1.
- 19. 3-(2',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid, a compound of claim 1.
- 20. 3-(2',4'-Dichloro-4-biphenylyl)-2-butenoic acid, a compound of claim 1.
- 21. 3-(2',4'-Dibromo-4-biphenylyl)butyric acid, a compound of claim 1.
- 22. 3-(2',4'-Dibromo-4-biphenylyl)-3-hydroxybutyric acid, a compound of claim 1.
- 23. 3-(2',4'-Dibromo-4-biphenylyl)-2-butenoic acid, a compound of claim 1.
- 24. 3-(p-2,4-dichlorophenoxyphenyl)-3-hydroxybutyric acid, a compound of claim 1.
- 25. An anti-inflammatory pharmaceutical composition comprising an anti-inflammatorily effective amount per unit dosage of a compound of claim 1, in admixture with a pharmaceutically-acceptable carrier.
- 26. The composition of claim 25, wherein the compound is 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid sodium salt.
- 27. The composition of claim 25, wherein the compound is 3-(p-2,4-dichlorophenoxyphenyl)-2-butenoic acid.
- 28. A method of relieving inflammation in a patient afflicted therewith comprising administering to the patient an anti-inflammatorily effective amount of a compound of claim 1, in admixture with a pharmaceutically-acceptable carrier.
- 29. The method of claim 28, wherein the compound is administered orally.
- 30. The method of claim 28, wherein the effective amount is a daily dose of 0.2-20 mg./kg. of body weight.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2528958 |
Jun 1975 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 695,804 filed June 14, 1976, now U.S. Pat. No. 4,057,647.
US Referenced Citations (8)
Non-Patent Literature Citations (2)
Entry |
Chem. Abst. 76-14118a-(1972). |
Chem. Abst. 78-3966r-(1973). |
Divisions (1)
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Number |
Date |
Country |
Parent |
695804 |
Jun 1976 |
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