Claims
- 1. A compound of the formula ##STR65## or a pharmaceutically acceptable salt or an enantiomer thereof wherein, R.sub.1 is H or OH,
- R is ##STR66## wherein, R.sub.3 is ##STR67## wherein, R.sub.4 and R.sub.5 are independently selected from H and C.sub.1 -C.sub.3 alkyl,
- Y is CH.sub.2, (CH.sub.2).sub.2, (CH.sub.2).sub.3, (CH.sub.2).sub.4 or --CH.sub.2 --O--,
- R.sub.6 is H, OH, OCH.sub.3, halogen, methylenedioxy or C.sub.1 -C.sub.3 alkyl and
- n is 1 or 2.
- 2. A compound of the formula ##STR68## or pharmaceutically acceptable salt or an enantiomer thereof wherein, R.sub.1 is H and
- R is ##STR69##
- 3. A compound of claim 2 having the formula ##STR70## or a tautomer thereof.
- 4. A pharmaceutical composition for (a) reducing intraocular eye pressure, (b) treating hypertension or (c) effecting bronchodilation containing a compound of claim 1.
- 5. A method for (a) reducing intraocular eye pressure, (b) treating hypertension or (c) effecting bronchodilation by administering an effective amount of a compound of claim 1 in a suitable dosage form.
- 6. A method for effecting .alpha.- and .beta.-adrenergic blocking activity comprising administering an effective .alpha.- and .beta.-adrenergic blocking amount of the compound of claim 1 in a suitable dosage form.
REFERENCE TO RELATED APPLICATIONS
This is a continuation-in-part of Ser. No. 783,972, filed Oct. 3, 1985, now U.S. Pat. No. 4,686,222, which in term is a division of the copending application Ser. No. 361,673, filed Mar. 25, 1982, now U.S. Pat. No. 4,568,679, which in turn is a division of application Ser. No. 219,725, filed Dec. 23, 1980, now U.S. Pat. No. 4,358,455.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4171214 |
Balasubramanyan et al. |
Oct 1979 |
|
4560756 |
Brunnmueller et al. |
Dec 1985 |
|
Divisions (2)
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Number |
Date |
Country |
Parent |
361673 |
Mar 1981 |
|
Parent |
219725 |
Dec 1980 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
783972 |
Oct 1985 |
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