Claims
- 1. An aromatic 2-aminoalkyl-1,2-benzoisothiozol-3(2H)one-1,1-dioxide derivative having the formula ##STR16## wherein n is an integer of from 2 to 5;
- X is ##STR17## wherein A is .dbd.NR' and B is .dbd.NR" wherein R' is hydrogen or methyl and R" is hydrogen or methyl, or a pharmaceutically acceptable acid addition salt thereof.
- 2. An aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivative of claim 1 wherein n is an integer of from 2 to 4.
- 3. An aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivative of claim 1 wherein n is the integer 4.
- 4. An aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivative of claim 1 wherein both R' and R" are hydrogen.
- 5. An aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivative of claim 4 wherein n is an integer of from 2 to 4.
- 6. An aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivative of claim 4 wherein n is the integer 4.
- 7. A method for relieving the symptoms of anxiety in a patient in need thereof, which comprises the administration to said patient of an anxiolytic effective amount of a compound of one of claims 1-6.
- 8. A method for lowering blood pressure in a person in need thereof, which comprises the administration to said patient of an antihypertensive effective amount of a compound of one of claims 1-6.
- 9. An anxiolytic composition comprising an anxiolytic effective amount of a compound according to one of claims 1-6, or a pharmaceutically acceptable acid addition salt thereof, in combination with a pharmaceutically acceptable carrier or diluent.
- 10. An antihypertensive composition comprising an antihypertensive effective amount of a compound according to one of claims 1-6, or a pharmaceutically acceptable acid addition salt thereof, in combination with a pharmaceutically acceptable carrier or diluent.
Parent Case Info
This is a divisional of Ser. No. 366,824, filed June 15, 1989, now U.S. Pat. No. 4,920,118 which is a divisional of Ser. No. 244,894, filed Sept. 12, 1988, now U.S. Pat. No. 4,857,526, issued Aug. 15, 1989, which is a divisional of Ser. No. 158,432, filed Feb. 22, 1988, now U.S. Pat. No. 4,789,676, issued Dec. 6, 1988, which is a divisional of Ser. No. 836,276, filed Mar. 5, 1986, now U.S. Pat. No. 4,748,182, issued May 31, 1988.
Divisions (4)
|
Number |
Date |
Country |
Parent |
366824 |
Jun 1989 |
|
Parent |
244894 |
Sep 1988 |
|
Parent |
158432 |
Feb 1988 |
|
Parent |
836276 |
Mar 1986 |
|